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506

Total database: 17430
Struktur (SMILES)
477 (94.3%)
Target
400 (79.1%)
Genomik
2 (0.4%)
Referensi
506 (100.0%)

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Hasil Pencarian (506)

Halaman 6 / 11
small molecule | CAS: 13058-04-3

Deskripsi belum tersedia.

Kategori:
OrganophosphatesOrganophosphorus CompoundsPotential QTc-Prolonging Agents +2
Target Protein:
Squalene synthaseProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaProtein farnesyltransferase subunit beta +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
OrganophosphatesOrganophosphorus CompoundsPotential QTc-Prolonging Agents +2
Target Protein:
Geranylgeranyl pyrophosphate synthaseMevalonate kinaseDehydrosqualene synthase +1
Waktu Paruh-
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Genetik -
Fenthion DB11412
small molecule | CAS: 55-38-9

Fenthion is an _organothiophosphate_ drug used as an insecticide, avicide, and acaricide. Its mode of action is explained by cholinesterase enzyme inhibition, which is similar to other organophosphates. Fenthion is listed as a restricted use compound by the U…

Kategori:
AgrochemicalsCholinergic AgentsCholinesterase Inhibitors +13
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Genetik -
Ferric cation Approved DB13949
small molecule | CAS: 20074-52-6

Iron is a transition metal with a symbol Fe and atomic number 26. By mass, it is the most common element on Earth. Iron is an essential element involved in various metabolic processes, including oxygen transport, deoxyribonucleic acid (DNA) synthesis, and ene…

Kategori:
Iron CompoundsParenteral Iron ReplacementPhosphate Binder +2
Target Protein:
Transferrin receptor protein 1Iron(3+)-hydroxamate-binding protein FhuD
Waktu ParuhThe pharmacokinetic…
Vol. DistribusiLess than 65% of ir…
KlirensThe rate of iron lo…
Genetik -
Ferric glycerophosphate Approved DB15934
small molecule | CAS: 1301-70-8

Deskripsi belum tersedia.

Waktu Paruh-
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Ferric maltol Approved DB15598
small molecule | CAS: 33725-54-1

Ferric maltol is an iron(III) atom complexed with 3 maltol molecules to increase the bioavailability compared to iron(II), without depositing it in the duodenum as insoluble ferric hydroxide and phosphate.[A189288] Ferric maltol has been described in literatu…

Kategori:
Antianemic PreparationsBlood and Blood Forming OrgansHematinics +8
Target Protein:
Integrin beta-3Natural resistance-associated macrophage protein 2
Waktu ParuhMaltol has a half l…
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
small molecule | CAS: 10058-44-3

Ferric pyrophosphate is an iron replacement product. Free iron presents several side effects as it can catalyze free radical formation and lipid peroxidation as well as the presence of interactions of iron in plasma. The ferric ion is strongly complexed by py…

Kategori:
AcidsAcids, NoncarboxylicAnions +13
Target Protein:
Ferritin light chainHemoglobin subunit alphaHemoglobin subunit beta
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Ferric pyrophosphate citrate Approved DB13995
small molecule | CAS: 1802359-96-1

Ferric pyrophosphate citrate is a soluble iron replacement product. Free iron presents several side effects as it can catalyze free radical formation and lipid peroxidation as well as the presence of interactions of iron in plasma. The ferric ion is strongly …

Kategori:
EnzymesEnzymes and CoenzymesHydrolases +3
Target Protein:
Ferritin light chainFerritin heavy chainHemoglobin subunit alpha +1
Waktu ParuhThe half-life of fe…
Vol. DistribusiThe apparent volume…
KlirensThe mean clearance …
Genetik -
FF-10501-01 DB17554
small molecule

FF-10501-01 is a novel, selective inosine monophosphate dehydrogenase (IMPDH) inhibitor with anticancer activity.[A257306] FF-10501-01 is under investigation in clinical trial NCT03486353 (A Study of FF-10501-01 in Combination With Azacitidine in Patients Wit…

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Fingolimod Approved DB08868
small molecule | CAS: 162359-55-9

Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects.[A176474] Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remittin…

Kategori:
AlcoholsAminesAmino Alcohols +16
Target Protein:
D(3) dopamine receptorSphingosine kinase 1Sphingosine 1-phosphate receptor 5 +4
Waktu ParuhThe half-life of fi…
Vol. DistribusiThe volume of distr…
KlirensFingolimod blood cl…
Genetik -
Flavin adenine dinucleotide Approved DB03147
small molecule | CAS: 146-14-5

A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972) Flavin adenine dinucleotide is approved f…

Kategori:
Adenine NucleotidesBiological FactorsCoenzymes +13
Target Protein:
Ribosyldihydronicotinamide dehydrogenase [quinone]Nitric oxide synthase 1Dihydropyrimidine dehydrogenase [NADP(+)] +83
Waktu Paruh-
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Genetik -
Flavin mononucleotide Approved DB03247
small molecule | CAS: 146-17-8

A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.

Kategori:
Biological FactorsCoenzymesEnzymes and Coenzymes +11
Target Protein:
Flavin reductase (NADPH)2-Hydroxyacid oxidase 1Pyridoxine-5'-phosphate oxidase +51
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Floxuridine Approved DB00322
small molecule | CAS: 50-91-9

An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusi…

Kategori:
AntimetabolitesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +18
Target Protein:
Thymidylate synthaseThymidylate synthase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
FM-VP4 DB05449
small molecule

FM-VP4, is a novel hydrophilic phytostanol analogue representing a new class in cholesterol-lowering drugs called cholesterol absorption inhibitors. FM-VP4 has been shown to inhibit cholesterol absorption and to lower plasma LDL-cholesterol and total choleste…

Target Protein:
ATP-dependent translocase ABCB1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fobrepodacin DB18409
small molecule | CAS: 1384984-31-9

Deskripsi belum tersedia.

Target Protein:
DNA gyrase subunit B
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
AMP nucleosidase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Fosbretabulin DB12577
small molecule | CAS: 222030-63-9

Fosbretabulin has been investigated for the treatment of Anaplastic Thyroid Cancer.

Kategori:
Antineoplastic AgentsAntineoplastic Agents, PhytogenicBenzene Derivatives +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fosciclopirox DB18772
small molecule | CAS: 1380539-06-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Fosdenopterin Approved DB16628
small molecule | CAS: 150829-29-1

Molybdenum cofactor deficiency (MoCD) is an exceptionally rare autosomal recessive disorder resulting in a deficiency of three molybdenum-dependent enzymes: sulfite oxidase (SOX), xanthine dehydrogenase, and aldehyde oxidase.[A230088] Signs and symptoms begin…

Kategori:
Alimentary Tract and MetabolismBiological FactorsCyclic Pyranopterin Monophosphate +9
Target Protein:
Molybdenum cofactor biosynthesis protein 1Xanthine dehydrogenase/oxidase
Waktu ParuhThe mean half-life …
Vol. DistribusiThe volume of distr…
KlirensTotal body clearanc…
Genetik -
Fosfructose DB13863
small molecule | CAS: 488-69-7

Deskripsi belum tersedia.

Kategori:
Antiarrhythmic agentsCarbohydratesCardiac Therapy +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Foslevodopa Approved DB16683
small molecule | CAS: 97321-87-4

Foslevodopa is under investigation in clinical trial NCT04750226 (Study to Assess Adverse Events and Change in Disease Activity of 24-hour Continuous Subcutaneous Infusion of ABBV-951 in Adult Participants With Advanced Parkinson's Disease).

Kategori:
Anti-Parkinson DrugsDopa and Dopa DerivativesDopamine Agents +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Fosmanogepix DB15183
small molecule | CAS: 2091769-17-2

Fosmanogepix is under investigation in clinical trial NCT03604705 (An Efficacy and Safety Study of APX001 in Non-Neutropenic Patients With Candidemia).

Waktu Paruh-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Glucosamine-6-phosphate deaminase 1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 643-13-0

Deskripsi belum tersedia.

Kategori:
CarbohydratesHexosephosphatesSugar Phosphates
Target Protein:
Fructose-1,6-bisphosphatase 1Fructose-1,6-bisphosphatase isozyme 26-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 +3
Waktu Paruh-
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Genetik -
small molecule | CAS: 2956-16-3

A nucleoside diphosphate sugar which can be epimerized into UDPglucose for entry into the mainstream of carbohydrate metabolism. Serves as a source of galactose in the synthesis of lipopolysaccharides, cerebrosides, and lactose.

Kategori:
CarbohydratesGlycosidesNucleic Acids, Nucleotides, and Nucleosides +8
Target Protein:
Histo-blood group ABO system transferaseUDP-glucose 4-epimeraseBeta-1,4-galactosyltransferase 1 +1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Galsulfase Approved DB01279
biotech | CAS: 552858-79-4

Galsufase is a variant form of the polymorphic human enzyme N-acetylgalactosamine 4-sulfatase of recombinant DNA origin. Galsulfase is a glycoprotein with a molecular weight of approximately 56 kD. The recombinant protein is comprised of 495 amino acids and c…

Kategori:
Alimentary Tract and MetabolismAmino Acids, Peptides, and ProteinsArylsulfatases +9
Target Protein:
Dermatan sulfate
Waktu Paruh9 (6 to 21) minutes…
Vol. DistribusiWeek 1: 56-323 mL/k…
Klirens-
Genetik -
small molecule

Adenylic acid. Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. [PubChem]

Target Protein:
NH(3)-dependent NAD(+) synthetaseGlycerol kinase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gandotinib DB13040
small molecule | CAS: 1229236-86-5

Gandotinib has been used in trials studying the treatment of Myelofibrosis, Polycythemia Vera, Primary Myelofibrosis, Thrombocythemia, Essential, and Myeloproliferative Disorders, among others.

Kategori:
Janus Kinase 2, antagonists & inhibitorsJanus Kinases, antagonists & inhibitors
Target Protein:
Tyrosine-protein kinase JAK2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GDP-L-fucose DB18689
small molecule | CAS: 15839-70-0

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicAnions +8
Target Protein:
Farnesyl pyrophosphate synthase2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthasePrenyltransferase +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
OrganophosphatesOrganophosphorus CompoundsPhosphate salts +3
Target Protein:
Farnesyl pyrophosphate synthaseProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaProtein farnesyltransferase subunit beta +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
Amino SugarsCarbohydratesHexosamines +2
Target Protein:
Ferrichrome-iron receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
Amino SugarsCarbohydratesHexosamines +2
Target Protein:
Ferrichrome-iron receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 3616-42-0

Deskripsi belum tersedia.

Kategori:
Amino SugarsCarbohydratesGlucosephosphates +3
Target Protein:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]N-acetylglucosamine-6-phosphate deacetylase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 56-73-5

An ester of glucose with phosphoric acid, made in the course of glucose metabolism by mammalian and other cells. It is a normal constituent of resting muscle and probably is in constant equilibrium with fructose-6-phosphate. (Stedman, 26th ed)

Kategori:
CarbohydratesGlucosephosphatesHexosephosphates +1
Target Protein:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Glucose-6-phosphate isomerase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Kategori:
Aldehyde OxidoreductasesEnzymesEnzymes and Coenzymes +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 17181-54-3

Deskripsi belum tersedia.

Kategori:
AlcoholsCarbohydratesLipids +5
Target Protein:
Triosephosphate isomerase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Guanosine DB02857
small molecule | CAS: 118-00-3

Guanosine is a nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a ?-N9-glycosidic bond. Guanosine can be phosphorylated to become GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP (guanosine diphosphate) and G…

Kategori:
Heterocyclic Compounds, Fused-RingNucleic Acids, Nucleotides, and NucleosidesNucleosides +3
Target Protein:
DNA polymerase catalytic subunitDNA polymerase catalytic subunitPurine nucleoside phosphorylase +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 117-68-0

Deskripsi belum tersedia.

Kategori:
Guanine NucleotidesHeterocyclic Compounds, Fused-RingIsomerism +5
Target Protein:
RibonucleaseBifunctional protein PyrR
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Adenylosuccinate synthetaseBifunctional (p)ppGpp synthase/hydrolase RelA
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 33503-72-9

Guanosine tetraphosphate is a guanine nucleotide containing four phosphate groups. Two phosphate groups are esterified to the sugar moiety in the 5' position and the other two in the 2' or 3' position. This nucleotide serves as a messenger to turn off the syn…

Kategori:
Guanine NucleotidesHeterocyclic Compounds, Fused-RingNucleic Acids, Nucleotides, and Nucleosides +4
Target Protein:
Hypoxanthine-guanine-xanthine phosphoribosyltransferaseXanthine phosphoribosyltransferaseGTPase Obg
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 130-50-7

Deskripsi belum tersedia.

Kategori:
Guanine NucleotidesHeterocyclic Compounds, Fused-RingIsomerism +5
Target Protein:
Guanyl-specific ribonuclease Sa
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
ADP-ribosylation factor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 146-91-8

A guanine nucleotide containing two phosphate groups esterified to the sugar moiety. [PubChem]

Target Protein:
Protein-glutamine gamma-glutamyltransferase 2Elongation factor 1-alphaAdenylosuccinate synthetase +49
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
GDP-mannose 4,6 dehydratase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 85-32-5

Guanosine 5'-monophosphate. A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature. [PubChem]

Target Protein:
Hypoxanthine-guanine-xanthine phosphoribosyltransferaseDNA polymerase catalytic subunitDNA polymerase catalytic subunit +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 86-01-1

Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety. [PubChem]

Target Protein:
GTP cyclohydrolase 1Genome polyproteinRNA-directed RNA polymerase +18
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Haemophilus influenzae type b strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen is a vaccine for intramuscular injection used in the prevention of invasive disease caused by *Haemophilus influenzae* type b. *H. influenzae* is a Gram-negativ…

Kategori:
Actively Acquired ImmunityHaemophilus VaccinesInactivated Haemophilus Influenzae B Vaccine
Waktu Paruh-
Vol. Distribusi-
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Genetik -
biotech

Haemophilus influenzae type b strain 20752 capsular polysaccharide tetanus toxoid conjugate antigen is an active immunization as a booster dose given intramuscularly to pediatric patients who have received a primary series with a Haemophilus b Conjugate Vacci…

Kategori:
Actively Acquired ImmunityHaemophilus VaccinesInactivated Haemophilus Influenzae B Vaccine +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Glycogen phosphorylase, muscle form
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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