Digital Pharmacy - Dashboard Peneliti

Stavudine Approved DB00649

small molecule | CAS: 3056-17-5

A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.

Kategori:

Agents Causing Muscle ToxicityAnti-HIV AgentsAnti-Infective Agents +23

Target Protein:

Gag-Pol polyproteinReverse transcriptase/RNaseH

Waktu Paruh0.8-1.5 hours (in a…

Vol. Distribusi* 46 ± 21 L

Klirens* Renal cl=272 mL/m…

Genetik -

Succimer Approved DB00566

small molecule | CAS: 304-55-2

A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them.

Kategori:

Acids, AcyclicAntidotesChelating Agents +9

Target Protein:

LeadMercuryCadmium +1

Waktu Paruh48 hours

Vol. Distribusi-

Klirens-

Genetik -

SYD-003 DB17106

small molecule | CAS: 249937-52-8

Deskripsi belum tersedia.

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

TAK-733 DB12241

small molecule | CAS: 1035555-63-5

TAK-733 has been used in trials studying the treatment of Advanced Metastatic Melanoma, Advanced Nonhematologic Malignancies, and Advanced Non-hematologic Malignancies.

Kategori:

PyridinesPyrimidines

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Tasimelteon Approved DB09071

small molecule | CAS: 609799-22-6

Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD). Occurring commonly in blind individuals without light perception, this condition is often characterized by periods of night-ti…

Kategori:

Central Nervous System DepressantsCycloparaffinsCytochrome P-450 CYP1A2 Substrates +11

Target Protein:

Melatonin receptor type 1AMelatonin receptor type 1B

Waktu ParuhThe observed mean e…

Vol. DistribusiThe apparent oral v…

Klirens-

Genetik -

Tebapivat DB19338

small molecule

Tebapivat is under investigation in clinical trial NCT05490446 (A Study of Tebapivat (AG-946) in Participants With Anemia Due to Lower-risk Myelodysplastic Syndromes (LR-MDS)).

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Temoporfin Approved DB11630

small molecule | CAS: 122341-38-2

Temoporfin is a photosensitizing agent used in the treatment of squamous cell carcinoma of the head and neck [FDA Label]. It was first authorized for market by the European Medicines Agency in October 2001. It is currently available under the brand name Fosca…

Kategori:

Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBiological Factors +8

Waktu ParuhTerminal plasma hal…

Vol. DistribusiThe volume of distr…

KlirensTemoporfin is clear…

Genetik -

Terameprocol DB12226

small molecule | CAS: 24150-24-1

Terameprocol has been investigated for the treatment of Brain and Central Nervous System Tumors.

Kategori:

Benzene DerivativesBenzyl CompoundsCatechols +2

Target Protein:

Transcription factor Sp1

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

tert-butyl [(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]carbamate DB07481

small molecule

Deskripsi belum tersedia.

Target Protein:

Queuine tRNA-ribosyltransferase

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Tienilic acid DB04831

small molecule | CAS: 40180-04-9

Tienilic acid, or ticrynafen, is a diuretic drug with uric acid-lowering action which was marketed for the treatment of hypertension. It was withdrawn in 1982 after case reports in the United States suggested a link between ticrynafen and hepatitis. (Manier e…

Kategori:

AcetatesAcids, AcyclicAntigout Preparations +16

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Toyocamycin DB13916

small molecule | CAS: 606-58-6

4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is an analog of adenosine, blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry.

Kategori:

Antibiotics, AntineoplasticAntimetabolitesAntineoplastic Agents +5

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

U-0126 DB17060

small molecule | CAS: 218601-62-8

U-0126 is a direct inhibitor of the mitogen-activated protein-kinase kinase family members, MEK-1 and MEK-2.[A253162]

Kategori:

AlkadienesAlkenesEnzyme Inhibitors +2

Target Protein:

Mitogen-activated protein kinase kinase kinase 2Mitogen-activated protein kinase kinase kinase 1

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

VEGFR 2 Kinase inhibitor I DB17061

small molecule | CAS: 15966-93-5

Deskripsi belum tersedia.

Target Protein:

Vascular endothelial growth factor receptor 2

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

WIN 55212-2 DB13950

small molecule | CAS: 131543-22-1

WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure. It is a potent cannabinoid receptor agonist th…

Kategori:

Agents causing hyperkalemiaAgents producing tachycardiaAnalgesics +21

Target Protein:

Cannabinoid receptor 1Cannabinoid receptor 2

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Zanamivir Approved DB00558

small molecule | CAS: 139110-80-8

A guanido-neuraminic acid that is used to inhibit neuraminidase.

Kategori:

Acids, AcyclicAmidinesAmino Sugars +15

Target Protein:

NeuraminidaseNeuraminidaseSialidase-2

Waktu Paruh2.5-5.1 hours

Vol. Distribusi-

Klirens* 2.5 - 10.9 L/h [F…

Genetik -

Ziftomenib DB17171

small molecule | CAS: 2134675-36-6

Deskripsi belum tersedia.

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

[(5R)-5-(2,3-dibromo-5-ethoxy-4-hydroxybenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid DB06998

small molecule

Deskripsi belum tersedia.

Target Protein:

DNA polymerase III subunit beta

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

[5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE DB08424

small molecule

Deskripsi belum tersedia.

Target Protein:

Mitogen-activated protein kinase 14

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

[{2-bromo-4-[(2R)-3-oxo-2,3-diphenylpropyl]phenyl}(difluoro)methyl]phosphonic acid DB07263

small molecule

Deskripsi belum tersedia.

Target Protein:

Tyrosine-protein phosphatase non-receptor type 1

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

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