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3253

Total database: 17430
Struktur (SMILES)
2451 (75.3%)
Target
1833 (56.3%)
Genomik
35 (1.1%)
Referensi
3253 (100.0%)

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Hasil Pencarian (3253)

Halaman 59 / 66
Tedatioxetine DB12641
small molecule | CAS: 508233-95-2

Tedatioxetine has been used in trials studying the treatment of Major Depressive Disorder.

Target Protein:
5-hydroxytryptamine receptor 2C
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tedizolid Approved DB14569
small molecule | CAS: 856866-72-3

Drug-resistant bacteria, such as methicillin-resistant _Staphylococcus aureus_, vancomycin-resistant _Enterococcus faecium_, and penicillin-resistant _Streptococcus penumoniae_, represent a massive public health threat.[A199086, A199131] Tedizolid is a member…

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntibacterials for Systemic Use +5
Target Protein:
23S ribosomal RNA
Waktu ParuhTedizolid has a hal…
Vol. DistribusiThe volume of distr…
KlirensTedizolid has an ap…
Genetik -
Tedizolid phosphate Approved DB09042
small molecule | CAS: 856867-55-5

Drug-resistant bacteria, such as methicillin-resistant _Staphylococcus aureus_, vancomycin-resistant _Enterococcus faecium_, and penicillin-resistant _Streptococcus penumoniae_, represent a massive public health threat.[A199086, A199131] Tedizolid is a member…

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntidepressive Agents +10
Target Protein:
23S ribosomal RNA
Waktu ParuhTedizolid has a hal…
Vol. DistribusiThe volume of distr…
KlirensTedizolid has an ap…
Genetik -
Teduglutide Approved DB08900
biotech | CAS: 197922-42-2

Teduglutide is a glucagon-like peptide-2 (GLP-2) analogue. It is made up of 33 amino acids and is manufactured using a strain of Escherichia coli modified by recombinant DNA technology. Teduglutide differs from GLP-2 by one amino acid (alanine is substituted …

Kategori:
Alimentary Tract and MetabolismAmino Acids, Peptides, and ProteinsAnalogs/Derivatives +15
Target Protein:
Glucagon-like peptide 2 receptor
Waktu ParuhTerminal half-life,…
Vol. DistribusiVd, healthy subject…
KlirensPlasma clearance, h…
Genetik -
Tegavivint DB17109
small molecule | CAS: 1227637-23-1

Deskripsi belum tersedia.

Waktu Paruh-
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Tegoprazan DB16690
small molecule | CAS: 942195-55-3

Tegoprazan (also known as CJ-12420) is a novel therapeutic developed by CJ Healthcare Corp for treating acid-related gastrointestinal diseases.[A234215, A234220] This drug is a potent and high-selective potassium-competitive acid blocker (P-CAB) with a fast o…

Kategori:
Alimentary Tract and MetabolismDrugs for Acid Related DisordersDrugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) +2
Target Protein:
Sodium/Potassium Transporting ATPase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Telaprevir Approved DB05521
small molecule | CAS: 402957-28-2

Telaprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine…

Kategori:
Amino Acids, Peptides, and ProteinsAntiinfectives for Systemic UseAntiviral Agents +21
Target Protein:
Genome polyproteinGenome polyproteinSolute carrier organic anion transporter family member 1B1 +1
Waktu ParuhTelaprevir has a ha…
Vol. DistribusiThe estimated appar…
KlirensTelaprevir has an e…
Genetik -
Telatinib DB15393
small molecule | CAS: 332012-40-5

Telatinib is under investigation in clinical trial NCT03817411 (Telatinib in Combination With Capecitabine/ Oxaliplatin in 1st Line Gastric or GEJ Cancer).

Target Protein:
Vascular endothelial growth factor receptor 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Telazorlimab DB16374
biotech | CAS: 2126777-87-3

Telazorlimab is under investigation in clinical trial NCT03568162 (Phase 2b Study to Evaluate the Efficacy and Safety of ISB 830 in Adults With Moderate to Severe Atopic Dermatitis).

Waktu Paruh-
Vol. Distribusi-
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Telbermin DB12639
biotech | CAS: 205887-54-3

Telbermin has been used in trials studying the treatment of Foot Ulcer, Foot Ulcer, Diabetic, and Amyotrophic Lateral Sclerosis.

Waktu Paruh-
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Telbivudine Approved DB01265
small molecule | CAS: 3424-98-4

Telbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects.

Kategori:
Anti-Infective AgentsAntiinfectives for Systemic UseAntiviral Agents +13
Target Protein:
DNAProtein P
Waktu ParuhApproximately 15 ho…
Vol. Distribusi-
Klirens* 7.6 +/- 2.9 L/h […
Genetik -
Telcagepant DB12228
small molecule | CAS: 781649-09-0

Telcagepant has been investigated for the treatment of Migraine. It is an antagonist of the receptor for calcitonin gene-related peptide (CGRP), a primary neuropeptide involved in the pathophysiology of migraine. CGRP and its receptors are found in areas of t…

Target Protein:
Calcitonin gene-related peptide type 1 receptorCalcitonin gene-related peptide 1Calcitonin gene-related peptide 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Telinavir DB12178
small molecule | CAS: 143224-34-4

Telinavir has been used in trials studying the treatment of HIV Infections.

Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Telisotuzumab DB14838
biotech | CAS: 1781223-80-0

Telisotuzumab is under investigation in clinical trial NCT01472016 (Study of ABT-700 in Subjects With Advanced Solid Tumors).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Telitacicept DB18312
biotech | CAS: 2136630-26-5

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsProteinsRecombinant Proteins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Telotristat ethyl Approved DB12095
small molecule | CAS: 1033805-22-9

Telotristat ethyl is a prodrug of telotristat that was approved by the FDA in March 2017 as Xermelo.[L43342] It was previously referred to as telotristat etiprate, the hippurate salt form; however, the FDA recommends the use of the name of the neutral form ra…

Kategori:
AntidiarrhealsCytochrome P-450 CYP2B6 InducersCytochrome P-450 CYP2B6 Inducers (strength unknown) +20
Target Protein:
Tryptophan 5-hydroxylase 2Tryptophan 5-hydroxylase 1
Waktu ParuhFollowing a single …
Vol. DistribusiThe estimated appar…
KlirensThe apparent total …
Genetik -
Temefos DB12231
small molecule | CAS: 3383-96-8

Diphos has been used in trials studying the treatment of Plasmodium Falciparum Malaria.

Kategori:
AgrochemicalsCompounds used in a research, industrial, or household settingInsecticides +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Temocillin Approved DB12343
small molecule | CAS: 66148-78-5

Temocillin has been investigated in Infection, Liver Dysfunction, and Urinary Tract Infection.

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Temoporfin Approved DB11630
small molecule | CAS: 122341-38-2

Temoporfin is a photosensitizing agent used in the treatment of squamous cell carcinoma of the head and neck [FDA Label]. It was first authorized for market by the European Medicines Agency in October 2001. It is currently available under the brand name Fosca…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBiological Factors +8
Waktu ParuhTerminal plasma hal…
Vol. DistribusiThe volume of distr…
KlirensTemoporfin is clear…
Genetik -
Tempol DB12449
small molecule | CAS: 2226-96-2

Tempol has been used in trials studying the treatment of Anal Cancer.

Kategori:
AntioxidantsBiological FactorsCentral Nervous System Agents +9
Target Protein:
Superoxide dismutase [Cu-Zn]
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Temsavir DB14675
small molecule | CAS: 701213-36-7

Deskripsi belum tersedia.

Kategori:
HIV Fusion Inhibitors
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tenapanor Approved DB11761
small molecule | CAS: 1234423-95-0

Tenapanor is a novel, small molecule medication approved in September 2019 for the treatment of constipation-predominant irritable bowel-syndrome (IBS-C).[L8558] It was first designed and synthesized in 2012.[A185492] As an inhibitor of the sodium/hydrogen ex…

Kategori:
Alimentary Tract and MetabolismCytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 Substrates +8
Target Protein:
Sodium/hydrogen exchanger 3
Waktu ParuhTenapanor's FDA lab…
Vol. Distribusi-
Klirens-
Genetik -
Tenidap DB13481
small molecule | CAS: 120210-48-2

Deskripsi belum tersedia.

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAlkaloids +19
Target Protein:
Polyunsaturated fatty acid 5-lipoxygenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tenivastatin DB14714
small molecule | CAS: 121009-77-6

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tenofovir DB14126
small molecule | CAS: 147127-20-6

Tenofovir is an acyclic nucleotide diester analog of adenosine monophosphate.[A37693] In the most strict sense and due to the fact that it presents a phosphate group bound to the nitrogenous base, it is determined as an actual nucleotide analog.[A37693] The a…

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +16
Target Protein:
Reverse transcriptase/RNaseHGag-Pol polyproteinReverse transcriptase +1
Waktu ParuhThe reported half-l…
Vol. DistribusiAccumulation of ten…
KlirensThe clearance of te…
Genetik -
small molecule | CAS: 911208-73-6

Tenofovir exalidex is under investigation in clinical trial NCT01080820 (A Safety, Tolerability and Pharmacokinetic Study of a Single Dose of CMX157 in Healthy Volunteers).

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +4
Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1208229-58-6

Deskripsi belum tersedia.

Target Protein:
Nuclear factor NF-kappa-B p105 subunitTranscription factor RelBNuclear factor NF-kappa-B p100 subunit +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Teprasiran DB15064
biotech | CAS: 1231737-88-4

Teprasiran is under investigation in clinical trial NCT03510897 (QPI-1002 Phase 3 for Prevention of Major Adverse Kidney Events (MAKE) in Subjects at High Risk for AKI Following Cardiac Surgery).

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Teprotumumab Approved DB06343
biotech | CAS: 1036734-93-6

Teprotumumab is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor.[L11359] Following a clinical trial in which its efficacy in the treatment of thyroid eye disease (TED) was assessed, it received "breakthr…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +13
Target Protein:
Insulin-like growth factor 1 receptor
Waktu ParuhThe half-life of te…
Vol. DistribusiFollowing the stand…
KlirensThe estimated mean …
Genetik -
Terameprocol DB12226
small molecule | CAS: 24150-24-1

Terameprocol has been investigated for the treatment of Brain and Central Nervous System Tumors.

Kategori:
Benzene DerivativesBenzyl CompoundsCatechols +2
Target Protein:
Transcription factor Sp1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Terbinafine Approved DB00857
small molecule | CAS: 91161-71-6

Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues.[A1279] Like other allylamines, terbinafine inhibits ergosterol synthesis by inh…

Kategori:
Agents Causing Muscle ToxicityAllylamine AntifungalAllylamines +24
Target Protein:
Squalene monooxygenaseSqualene monooxygenase
Waktu ParuhOral terbinafine ha…
Vol. DistribusiA single 250mg oral…
KlirensA single 250mg oral…
Genetik -
Terbogrel DB12204
small molecule | CAS: 149979-74-8

Terbogrel has been used in trials studying the treatment of Hypertension, Pulmonary.

Target Protein:
Thromboxane A2 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Terizidone Approved DB12954
small molecule | CAS: 25683-71-0

Terizidone has been used in trials studying the treatment of Tuberculosis, HIV Infections, Multidrug Resistant Tuberculosis, and Extensively-drug Resistant Tuberculosis.

Kategori:
Antiinfectives for Systemic UseAntimycobacterialsDrugs for Treatment of Tuberculosis +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Terlipressin Approved DB02638
biotech | CAS: 14636-12-5

Terlipressin is a synthetic analogue of vasopressin, which is an endogenous neurohormone that acts as a vasoconstrictor.[A2601] It is a prodrug of [lypressin], or lysine vasopressin. Compared to endogenous vasopressin, terlipressin has a longer half life and …

Kategori:
Amino Acids, Peptides, and ProteinsCardiovascular AgentsHormones +18
Target Protein:
Vasopressin V1a receptorVasopressin V1b receptorVasopressin V2 receptor
Waktu ParuhThe terminal half-l…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of te…
Genetik -
Teropavimab DB18916
biotech | CAS: 2417213-72-8

Teropavimab is under investigation in clinical trial NCT05729568 (A Study of GS-5423 and GS-2872 in Combination With Capsid Inhibitor Lenacapavir in Virologically Suppressed Adults With HIV-1 Infection).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Terpinen-4-ol DB12816
small molecule | CAS: 562-74-3

Terpinen-4-ol is under investigation in clinical trial NCT01647217 (Demodex Blepharitis Treatment Study).

Kategori:
Cytochrome P-450 CYP2A6 SubstratesCytochrome P-450 Substrates
Target Protein:
AcetylcholinesteraseApoptosis regulator Bcl-2E3 ubiquitin-protein ligase XIAP +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tertomotide DB12747
biotech | CAS: 915019-08-8

Tertomotide is under investigation in clinical trial NCT01223209 (A Study, Combination, Immunologic Study of LTX-315 as adjunct to tertomotide in Patients Following Curative Surgery for Carcinoma). It is a peptide vaccine that activates the immune system so t…

Target Protein:
Telomerase reverse transcriptase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Tesetaxel DB12019
small molecule | CAS: 333754-36-2

Tesetaxel has been used in trials studying the treatment of Cancer, Melanoma, Prostate Cancer, Gastric Carcinoma, and Advanced Melanoma, among others.

Kategori:
CyclodecanesCycloparaffinsDiterpenes +1
Waktu Paruh-
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Klirens-
Genetik -
Testolactone Approved DB00894
small molecule | CAS: 968-93-4

An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer.

Kategori:
AndrostadienesAndrostanesAndrostenes +7
Target Protein:
Aromatase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1255-49-8

Deskripsi belum tersedia.

Kategori:
AndrostanesAndrostenesAndrostenols +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 12279-90-2

Tetraarsenic tetrasulfide is under investigation in clinical trial NCT05682131 (South China Children Cancer Group - Relapsed-acute Lymphoblastic Leukemia 2022 Protocol).

Kategori:
AnionsElectrolytesHydrogen Sulfide +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tetracosactide Approved DB01284
small molecule | CAS: 16960-16-0

Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the…

Kategori:
AdrenalsAdrenocortical InsufficiencyAdrenocorticotropic Hormone +16
Target Protein:
Adrenocorticotropic hormone receptor
Waktu ParuhAbout 15 minutes fo…
Vol. Distribusi-
Klirens-
Genetik -
Tetracycline Approved DB00759
small molecule | CAS: 60-54-8

Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from b…

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismAnti-Bacterial Agents +32
Target Protein:
30S ribosomal protein S730S ribosomal protein S1430S ribosomal protein S3 +6
Waktu Paruh6-12 hours
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 21340-02-3

Deskripsi belum tersedia.

Target Protein:
Myosin-14Protein RecAAcetylglutamate kinase +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 31262-37-0

Tetrahydrocannabivarin (THCV) is a propyl analogue of tetrahydrocannabinol (?9-THC), one of the primary pharmacological components of [Medical Cannabis]. ?9-THC is currently available in several synthetic forms, including [Dronabinol], while purified or isola…

Kategori:
Agents that produce hypertensionAntidepressive AgentsCentral Nervous System Depressants +3
Target Protein:
Transient receptor potential cation channel subfamily V member 3Cannabinoid receptor 1G-protein coupled receptor 55 +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 483-14-7

Tetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity).

Kategori:
Adrenergic AgentsAgents causing hyperkalemiaAlkaloids +29
Target Protein:
D(1A) dopamine receptorD(2) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tetrahydropyran DB02412
small molecule | CAS: 142-68-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 18771-50-1

Tetrahydrouridine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Sickle Cell Disease, and Head and Neck Cancer, among others.

Kategori:
AntimetabolitesNoxaeNucleic Acids, Nucleotides, and Nucleosides +5
Target Protein:
Cytidine deaminase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 103694-84-4

Tetrakis (2-methoxyisobutylisocyanide) copper (I) tetrafluoroborate is a component of Cardiolite, a technetium Tc99m-based imaging agent used for assessing myocardial perfusion.[L12744]

Waktu Paruh-
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Tetramethrin DB13752
small molecule | CAS: 7696-12-0

Deskripsi belum tersedia.

Kategori:
AgrochemicalsAntiparasitic Products, Insecticides and RepellentsCompounds used in a research, industrial, or household setting +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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