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17430

Total database: 17430
Struktur (SMILES)
12313 (70.6%)
Target
9368 (53.7%)
Genomik
112 (0.6%)
Referensi
17430 (100.0%)

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Hasil Pencarian (17430)

Halaman 58 / 349
AD 337 DB05725
small molecule

AD 337 was under investigation in clinical trial NCT00377039 (A Multicentre Trial to Determine the Efficacy and Safety of AD-337 in the Treatment of Fibromyalgia). The drug was created by Sosei pharmaceuticals to treat Fibromyalgia in female patients.

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AD-114 DB18285
biotech

Deskripsi belum tersedia.

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AD-214 DB18412
biotech

Deskripsi belum tersedia.

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Ad-CEA vaccine DB17581
biotech

Ad-CEA vaccine is a cancer immunotherapy composed of carcinoembryonic antigen (CEA). Ad-CEA vaccine is under investigation in clinical trial NCT03050814 (Standard of Care Alone or in Combination With Ad-cea Vaccine and Avelumab in People With Previously Untre…

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Ad-ISF35 DB17181
biotech

Deskripsi belum tersedia.

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Ad-RTS-hIL-12 DB17177
biotech

Deskripsi belum tersedia.

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Ad-SGE-REIC DB17183
biotech

Deskripsi belum tersedia.

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Ad5-nCoV DB15655
biotech

Ad5-nCoV is a recombinant adenovirus type-5 vector (Ad5) vaccine currently being investigated for prophylaxis against SARS-CoV-2.[L12675,L12678] It is being developed by CanSino Biologics Inc., in partnership with the Beijing Institute of Biotechnology, who i…

Kategori:
Experimental Unapproved Treatments for COVID-19
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Adafosbuvir DB14906
small molecule | CAS: 1613589-09-5

Adafosbuvir is under investigation in clinical trial NCT02894905 (A Study to Evaluate the Effect of Renal Impairment on the Pharmacokinetics of AL-335).

Kategori:
AcidsAcids, NoncarboxylicAmino Acids +13
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biotech | CAS: 1458687-85-8

Adagloxad simolenin is under investigation in clinical trial NCT03562637 (Study of Adagloxad Simolenin (OBI-822)/OBI-821 in the Adjuvant Treatment of Patients With Globo H Positive TNBC).

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Adagrasib Approved DB15568
small molecule | CAS: 2326521-71-3

Adagrasib (MRTX849) is an oral, small-molecule KRAS inhibitor developed by Mirati Therapeutics. KRAS mutations are highly common in cancer and account for approximately 85% of all RAS family mutations.[A254941] However, the development of KRAS inhibitors has …

Kategori:
Antineoplastic AgentsAntineoplastic Agents, ImmunologicalAntineoplastic and Immunomodulating Agents +21
Target Protein:
GTPase KRas
Waktu ParuhAdagrasib has a ter…
Vol. DistribusiAdagrasib has an ap…
KlirensAdagrasib has an ap…
Genetik -
Adalimumab Approved DB00051
biotech | CAS: 331731-18-1

Adalimumab is a subcutaneously administered biological disease modifier for the treatment of rheumatoid arthritis and other chronic debilitating diseases mediated by tumor necrosis factor.[A39984,A39999] It was originally launched by Abbvie in the U.S. and ap…

Kategori:
Agents reducing cytokine levelsAmino Acids, Peptides, and ProteinsAnti-Inflammatory Agents +19
Target Protein:
Tumor necrosis factor
Waktu ParuhThe mean terminal h…
Vol. DistribusiThe distribution vo…
KlirensThe single-dose pha…
Genetik -
ADAM I-123 DB19213
small molecule | CAS: 305352-16-3

ADAM I-123 is under investigation in clinical trial NCT01160263 (Study of Dopamine and Serotonin Transporters in Patients With Amyotrophic Lateral Sclerosis and Controls).

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Adamantane DB03627
small molecule

A tricyclo bridged hydrocarbon. [PubChem]

Kategori:
Bridged-Ring CompoundsCycloparaffins
Target Protein:
Camphor 5-monooxygenase
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small molecule

Deskripsi belum tersedia.

Target Protein:
Camphor 5-monooxygenase
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small molecule

Deskripsi belum tersedia.

Target Protein:
Camphor 5-monooxygenase
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Adamantanone DB02125
small molecule | CAS: 700-58-3

Deskripsi belum tersedia.

Kategori:
Bridged-Ring CompoundsCycloparaffins
Target Protein:
Camphor 5-monooxygenase
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Adapalene Approved DB00210
small molecule | CAS: 106685-40-9

Acne vulgaris is a multifactorial disorder of the pilosebaceous unit involving increased sebum production, inflammation, and hyperproliferation/hyperkeratinization of the follicular infundibulum. It is also associated with _Cutibacterium acnes_ (also known as…

Kategori:
Anti-Acne PreparationsAnti-Acne Preparations for Topical UseAnti-Inflammatory Agents +5
Target Protein:
Retinoic acid receptor betaRetinoic acid receptor gammaRetinoic acid receptor RXR-beta +6
Waktu ParuhIn one clinical stu…
Vol. Distribusi-
KlirensAdapalene is rapidl…
Genetik -
Adavosertib DB11740
small molecule | CAS: 955365-80-7

MK-1775 has been used in trials studying the treatment of LYMPHOMA, Neoplasms, Ovarian Cancer, Tongue Carcinoma, and Adult Glioblastoma, among others.

Kategori:
Enzyme InhibitorsPyrimidines
Target Protein:
Wee1-like protein kinase
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ADC4022 DB05195
small molecule

ADC4022 is an investigational medicine for the treatment of Chronic Obstructive Pulmonary Disease (COPD) and severe asthma.

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Adebrelimab DB16412
biotech | CAS: 2247114-85-6

Adebrelimab is under investigation in clinical trial NCT03711305 (Study of Carboplatin Plus Etoposide With or Without SHR-1316 in Participants With Untreated Extensive-stage (ES) Small Cell Lung Cancer (SCLC)).

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Adecatumumab DB05006
biotech | CAS: 503605-66-1

Adecatumumab is a recombinant human monoclonal antibody of the IgG1 subclass with a binding specificity to epithelial cell adhesion molecule (EpCAM). EpCAM (CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types,…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +14
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Adefovir DB13868
small molecule | CAS: 106941-25-7

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsAntiviral AgentsEnzyme Inhibitors +8
Target Protein:
Protein PDNA polymerase catalytic subunit
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Adefovir dipivoxil Approved DB00718
small molecule | CAS: 142340-99-6

Adefovir dipivoxil, previously called bis-POM PMEA, with trade names Preveon and Hepsera, is an orally-administered acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) used for treatment of hepatitis B. It is ineffective against HIV-1. Adefovir …

Kategori:
Anti-Infective AgentsAntiinfectives for Systemic UseAntiviral Agents +14
Target Protein:
Protein P
Waktu ParuhPlasma adefovir con…
Vol. Distribusi* 392 ± 75 mL/kg [V…
Klirens* 469 ± 99.0 mL/min…
Genetik -
Adegramotide DB17248
small molecule | CAS: 1252802-98-4

Deskripsi belum tersedia.

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Adelmidrol DB16083
small molecule | CAS: 1675-66-7

Adelmidrol is under investigation in clinical trial NCT01420510 (Saginil in vs. Placebo for Gynecologic Oncology Patients Affected by Vaginitis).

Kategori:
Acids, AcyclicFatty AcidsLipids
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Ademetionine Approved DB00118
small molecule | CAS: 29908-03-0

Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)

Kategori:
Alimentary Tract and MetabolismAmino AcidsAmino Acids and Derivatives +14
Target Protein:
Catechol O-methyltransferaseCap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1Arsenite methyltransferase +5
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Adenine Approved DB00173
small molecule | CAS: 73-24-5

A purine base and a fundamental unit of adenine nucleotides.

Kategori:
Dietary SupplementsHeterocyclic Compounds, Fused-RingPurines +2
Target Protein:
Adenine phosphoribosyltransferaseDNAS-methyl-5'-thioadenosine phosphorylase +9
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Adenosine Approved DB00640
small molecule | CAS: 58-61-7

The structure of adenosine was first described in 1931,[A229823] though the vasodilating effects were not described in literature until the 1940s.[A229828] Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy,[L31983] thou…

Kategori:
Adenosine, antagonists & inhibitorsAgents producing tachycardiaAlkenes +32
Target Protein:
Adenosine receptor A1Adenosine receptor A2aAdenosine receptor A2b +1
Waktu ParuhThe half life of ad…
Vol. DistribusiData regarding the …
KlirensData regarding the …
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small molecule | CAS: 1053-73-2

Deskripsi belum tersedia.

Kategori:
Adenine NucleotidesHeterocyclic Compounds, Fused-RingIsomerism +5
Target Protein:
Heparan sulfate glucosamine 3-O-sulfotransferase 1Sulfotransferase 2B1Non-secretory ribonuclease +9
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small molecule | CAS: 3768-14-7

Deskripsi belum tersedia.

Kategori:
5'-Nucleotidase, antagonists & inhibitorsAdenine NucleotidesEnzyme Inhibitors +6
Target Protein:
5'-nucleotidaseDNARibose-phosphate pyrophosphokinase +2
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small molecule | CAS: 485-84-7

5'-Adenylic acid, monoanhydride with sulfuric acid. The initial compound formed by the action of ATP sulfurylase on sulfate ions after sulfate uptake. Synonyms: adenosine sulfatophosphate; APS.

Kategori:
Adenine NucleotidesHeterocyclic Compounds, Fused-RingNucleic Acids, Nucleotides, and Nucleosides +4
Target Protein:
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1ATP sulfurylase (Sulfate adenylyltransferase)
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small molecule | CAS: 35094-46-3

A nucleoside triphosphate analogue that is ATP in which one of the oxygens attached to 3-phosphate group is replaced by sulfur.

Kategori:
Adenine NucleotidesAffinity LabelsCompounds used in a research, industrial, or household setting +8
Target Protein:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2Synapsin-1Branched-chain alpha-ketoacid dehydrogenase kinase +11
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small molecule

Deskripsi belum tersedia.

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small molecule | CAS: 58-64-0

Deskripsi belum tersedia.

Kategori:
Adenine NucleotidesHeterocyclic Compounds, Fused-RingNucleic Acids, Nucleotides, and Nucleosides +4
Target Protein:
P2Y purinoceptor 6Transient receptor potential cation channel subfamily M member 4P2Y purinoceptor 12
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Bis(5'-adenosyl)-triphosphatase
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Adenosine phosphate Approved DB00131
small molecule | CAS: 61-19-8

Adenosine phosphate, or adenylic acid, is an adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. Adenosine phosphate was withdrawn by the FDA since it was considered neither safe nor ef…

Kategori:
Adenine NucleotidesDietary SupplementsHeterocyclic Compounds, Fused-Ring +6
Target Protein:
5'-AMP-activated protein kinaseAdenosine kinase5'-AMP-activated protein kinase subunit beta-1 +11
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small molecule

Deskripsi belum tersedia.

Kategori:
AcetatesAcids, AcyclicAdenine Nucleotides +8
Target Protein:
Nucleoside diphosphate kinase A
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small molecule

Deskripsi belum tersedia.

Target Protein:
Eosinophil cationic proteinRibonuclease pancreaticNon-secretory ribonuclease
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Nuclease P1
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small molecule

Deskripsi belum tersedia.

Kategori:
Vanadates
Target Protein:
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
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small molecule

Deskripsi belum tersedia.

Target Protein:
Adenosine 5'-monophosphoramidase HINT1
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small molecule

Serves as the glycosyl donor for formation of bacterial glycogen, amylose in green algae, and amylopectin in higher plants. [PubChem]

Target Protein:
ADP-L-glycero-D-manno-heptose-6-epimerase
Waktu Paruh-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Diadenosine hexaphosphate hydrolase
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Acetyl-coenzyme A synthetase
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Adenylate cyclase
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Folylpolyglutamate synthase
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small molecule

Deskripsi belum tersedia.

Target Protein:
Insulin receptorFolylpolyglutamate synthaseChemotaxis protein CheA +11
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small molecule

Deskripsi belum tersedia.

Target Protein:
NAD-dependent protein deacylase sirtuin-5, mitochondrialp-hydroxybenzoate hydroxylaseADP-ribose pyrophosphatase +8
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Genetik -
biotech

Deskripsi belum tersedia.

Kategori:
Actively Acquired ImmunityAdenovirus VaccinesLive Human Adenovirus Type 7 Vaccine +3
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Vol. Distribusi-
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Genetik -
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