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3253

Total database: 17430
Struktur (SMILES)
2451 (75.3%)
Target
1833 (56.3%)
Genomik
35 (1.1%)
Referensi
3253 (100.0%)

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Halaman 57 / 66
Sprifermin DB12616
biotech | CAS: 890058-52-3

Sprifermin has been used in trials studying the treatment of Osteoarthritis, Knee and Cartilage Injury of Knee.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsIntercellular Signaling Peptides and Proteins +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 2892-62-8

Squaric acid dibutyl ester is under investigation in clinical trial NCT01971385 (Safety and Efficacy of Squaric Acid Dibutyl Ester for the Treatment of Herpes Labialis).

Kategori:
Adjuvants, ImmunologicAllergensAntigens +3
Waktu Paruh-
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SR 121463 DB05455
small molecule

SR 121463 is a nonpeptide aquaretic compound with potent selective antagonism of the vasopressin V2 (V1b) receptor subtype. It is a candidate for control of hyponatremia and in the treatment of syndrome of inappropriate secretion of anti-diuretic hormone (SIA…

Target Protein:
Vasopressin V1b receptor
Waktu Paruh-
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SR-123781A DB05361
biotech | CAS: 232602-93-6

SR-123781A is a synthetic hexadecasaccharide Factor IIa and Xa antagonist. It is under investigation by Sanofi-Aventis and Organon for the treatment of thrombosis and acute coronary syndromes (ACS).

Kategori:
AnticoagulantsCarbohydratesHeparin and similars
Target Protein:
Coagulation factor XProthrombinAntithrombin-III +1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
SR11254 DB02258
small molecule

Deskripsi belum tersedia.

Target Protein:
Retinoic acid receptor gamma
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SR12813 DB04466
small molecule | CAS: 126411-39-0

Deskripsi belum tersedia.

Target Protein:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseNuclear receptor subfamily 1 group I member 2
Waktu Paruh-
Vol. Distribusi-
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Genetik -
SRT-2104 DB12186
small molecule | CAS: 1093403-33-8

SRT2104 has been investigated for the basic science and treatment of Sepsis, PSORIASIS, Atrophy, Muscular, and Diabetes Mellitus, Type 2.

Kategori:
Enzyme ActivatorsHeterocyclic Compounds, Fused-Ring
Target Protein:
NAD-dependent protein deacetylase sirtuin-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SRX-1177 DB17126
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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SRX-246 DB16968
small molecule | CAS: 512784-93-9

Deskripsi belum tersedia.

Kategori:
Antidiuretic Hormone Receptor AntagonistsAzetinesNatriuretic Agents
Target Protein:
Vasopressin V1a receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SSR-126517E DB05362
small molecule

SSR-126517E is a second generation synthetic pentasaccharide that binds antithrombin with such high affinity that it assumes a plasma half-life of 80 hours.

Target Protein:
Coagulation factor X
Waktu Paruh-
Vol. Distribusi-
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Genetik -
ST-101 DB12621
biotech | CAS: 887603-94-3

ST-101 is a small peptide antagonist of C/EBP? and T-type calcium channel activator. ST101 has been used in trials studying the treatment of Essential Tremor and Alzheimer's Disease.[A260411]

Kategori:
Indenes
Waktu Paruh-
Vol. Distribusi-
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Stannsoporfin DB04912
small molecule | CAS: 106344-20-1

Stannsoporfin is a competitive heme oxygenase (HO) inhibitor being developed by InfaCare, a subsidiary of WellSpring Pharmaceuticals, for the prevention of hyperbilirubinemia in infants at risk of developing jaundice.

Kategori:
Biological FactorsCoordination ComplexesEnzyme Inhibitors +4
Target Protein:
Heme oxygenase 1Heme oxygenase 2
Waktu Paruh3.8 hours following…
Vol. Distribusi-
Klirens-
Genetik -
Stearyl alcohol DB15953
small molecule | CAS: 112-92-5

Deskripsi belum tersedia.

Kategori:
AlcoholsLipids
Waktu Paruh-
Vol. Distribusi-
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Stem bromelain Approved DB12249
biotech | CAS: 37189-34-7

The primary therapeutic use for which stem bromelain is currently and formally indicated is as a burn wound eschar debridement agent that has been approved by the EMA since 2012 and marketed under the brand name Nexobrid [FDA Label]. Bromelain itself belon…

Kategori:
Cysteine EndopeptidasesCysteine ProteasesEndopeptidases +4
Waktu ParuhThe estimated plasm…
Vol. DistribusiNo readily accessib…
KlirensNo readily accessib…
Genetik -
Steviolbioside Approved DB12434
small molecule | CAS: 41093-60-1

Steviolbioside has been used in trials studying the treatment of HIV-1 Infection.

Kategori:
AlkaloidsCompounds used in a research, industrial, or household settingDiet, Food, and Nutrition +10
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biotech

Streptococcus pneumoniae type 12f capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 12f of *Streptococcus pneumoniae*. It is an active immunization for intramuscular or subc…

Kategori:
Actively Acquired ImmunityInactivated Pneumococcal Vaccine
Waktu Paruh-
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Genetik -
biotech

Streptococcus pneumoniae type 12F capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of *Streptococcus pneumoniae* serotype 12F individually conjugated to the CRM197 prot…

Kategori:
Inactivated Pneumococcal Vaccine
Waktu Paruh-
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Strontium chloride Sr-89 Approved DB09498
small molecule | CAS: 38270-90-5

Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer.[A31264] Bone meta…

Kategori:
ElementsMetalsMetals, Alkaline Earth +6
Waktu ParuhStrontium chloride …
Vol. DistribusiThere have been sev…
KlirensStrontium chloride …
Genetik -
Succinic acid Approved DB00139
small molecule | CAS: 110-15-6

A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condens…

Kategori:
Acids, AcyclicDicarboxylic AcidsDietary Supplements +3
Target Protein:
Succinate-semialdehyde dehydrogenase, mitochondrialSuccinate receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Steroid Delta-isomerase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Succinimide DB13376
small molecule | CAS: 123-56-8

Deskripsi belum tersedia.

Kategori:
Genito Urinary System and Sex HormonesImidesPyrrolidines +2
Waktu Paruh-
Vol. Distribusi-
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Sulbentine DB13671
small molecule | CAS: 350-12-9

Deskripsi belum tersedia.

Kategori:
Antifungals for Dermatological UseAntifungals for Topical UseDermatologicals
Waktu Paruh-
Vol. Distribusi-
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Sulconazole Approved DB06820
small molecule | CAS: 61318-90-9

Sulconazole, brand name Exelderm, is a broad-spectrum anti-fungal agent available as a topical cream and solution. Sulconazole nitrate, the active ingredient, is an imidazole derivative that inhibits the growth of common pathogenic dermatophytes, making it an…

Kategori:
Anti-Infective AgentsAntifungal AgentsAntifungals for Dermatological Use +11
Target Protein:
Lanosterol 14-alpha demethylase
Waktu Paruh-
Vol. Distribusi-
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Sulfabenzamide Approved DB09355
small molecule | CAS: 127-71-9

Sulfabenzamide is an antimicrobial agent often used in conjunction with sulfathiazole and sulfacetamide as a topical intravaginal antibacterial preparation.

Kategori:
AmidesSulfonesSulfur Compounds
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Sulfacytine Approved DB01298
small molecule | CAS: 17784-12-2

Sulfacytine is a short-acting sulfonamide. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamide…

Kategori:
AmidesAminesAniline Compounds +5
Target Protein:
Dihydropteroate synthase
Waktu Paruh-
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Sulfadimethoxine Approved DB06150
small molecule | CAS: 122-11-2

Sulfadimethoxine is a sulfonamide antibiotic. Sulfadimethoxine is used to treat many infections, including treatment of respiratory, urinary tract, enteric, and soft tissue infections. It is most frequently used in veterinary medicine, although it is approved…

Kategori:
AmidesAminesAniline Compounds +16
Waktu Paruh-
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Sulfadoxine Approved DB01299
small molecule | CAS: 2447-57-6

A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections.

Kategori:
AmidesAminesAniline Compounds +15
Target Protein:
Dihydropteroate synthetaseAmine oxidase [flavin-containing] BDihydropteroate synthase +1
Waktu Paruh-
Vol. Distribusi-
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Sulfamerazine Approved DB01581
small molecule | CAS: 127-79-7

A sulfanilamide that is used as an antibacterial agent.

Kategori:
AmidesAminesAniline Compounds +16
Target Protein:
Dihydropteroate synthase
Waktu Paruh-
Vol. Distribusi-
Klirens-
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Sulfanitran DB11463
small molecule | CAS: 122-16-7

Deskripsi belum tersedia.

Kategori:
AmidesAminesAniline Compounds +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sulfisoxazole Approved DB00263
small molecule | CAS: 127-69-5

A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.

Kategori:
AmidesAminesAniline Compounds +26
Target Protein:
Dihydropteroate synthase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sulforaphane DB12422
small molecule | CAS: 142825-10-3

Sulforaphane is under investigation for the treatment of Autism Spectrum Disorder. It is a naturally occurring isothiocyanate found in high concentration in a variety of broccoli.

Kategori:
Anticarcinogenic AgentsAntineoplastic AgentsCompounds used in a research, industrial, or household setting +3
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Sulopenem DB15284
small molecule | CAS: 120788-07-0

Sulopenem is a penem antibacterial. It is marketed as the prodrug [sulopenem etzadroxil] in combination with [probenecid].[L51768]

Kategori:
Amides
Waktu Paruh-
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Genetik -
Sulprostone DB12708
small molecule | CAS: 60325-46-4

Sulprostone has been used in trials studying Abortion, Induced.

Kategori:
Abortifacient AgentsAbortifacient Agents, NonsteroidalAutacoids +13
Waktu Paruh-
Vol. Distribusi-
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Sultamicillin Approved DB12127
small molecule | CAS: 76497-13-7

Sultamicillin has been used in trials studying the prevention and treatment of Ventilator Associated Pneumonia and Chronic Obstructive Pulmonary Disease (COPD).

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +9
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Sunitinib Approved DB01268
small molecule | CAS: 557795-19-4

Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stroma…

Kategori:
Angiogenesis InhibitorsAngiogenesis Modulating AgentsAntineoplastic Agents +31
Target Protein:
Platelet-derived growth factor receptor betaVascular endothelial growth factor receptor 1Mast/stem cell growth factor receptor Kit +6
Gen Terkait:
CYP3A4
Waktu ParuhFollowing administr…
Vol. Distribusi* 2230 L (apparent …
Klirens* 34 - 62 L/h [Tota…
Genetik 1 Varian
Sunobinop DB18955
small molecule | CAS: 1126793-40-5

Sunobinop is under investigation in clinical trial NCT04035200 (Safety, Tolerability and Efficacy Study of V117957 in Subjects With Insomnia Associated With Alcohol Cessation).

Waktu Paruh-
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Sunvozertinib DB18925
small molecule | CAS: 2370013-12-8

Sunvozertinib is under investigation in clinical trial NCT03974022 (Assessing an Oral EGFR Inhibitor, Sunvozertinib in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR or HER2 Mutation (WU-KONG1)).

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Suptavumab DB12759
biotech | CAS: 1629615-23-1

Suptavumab has been used in trials studying the treatment and basic science of Respiratory Syncytial Virus Infections.

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Suratadenoturev DB18672
biotech | CAS: 1268642-13-2

Suratadenoturev is a gene-modified oncolytic adenovirus expressing the telomerase reverse transcriptase gene.

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Surotomycin DB12076
small molecule | CAS: 1233389-51-9

Surotomycin has been used in trials studying the treatment of Diarrhea and Clostridium Difficile Infection. It is a benzenebutanoic acid derivative patented by Cubist Pharmaceuticals, Inc. as antibacterial agents for the treatment of Gram-positive infections.…

Kategori:
Amino Acids, Peptides, and ProteinsLipidsPeptides
Waktu Paruh-
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Susoctocog alfa Approved DB11606
biotech | CAS: 1339940-90-7

Intravenous susoctocog alfa is a recombinant, B-domain deleted, porcine sequence antihaemophilic factor VIII (FVIII) product that has recently been approved for the treatment of bleeding episodes in adults with acquired haemophilia A (AHA). AHA is a rare blee…

Kategori:
Blood and Blood Forming OrgansBlood Coagulation FactorsHemostatics
Target Protein:
von Willebrand factor
Waktu ParuhThe terminal half-l…
Vol. DistribusiFollowing intraveno…
KlirensFollowing intraveno…
Genetik -
Sutetinib DB18841
small molecule | CAS: 1259519-20-4

Sutetinib is under investigation in clinical trial NCT05168566 (Study to Evaluate Sutetinib Maleate Capsule in Locally Advanced or Metastatic Non-small Cell Lung Cancer).

Waktu Paruh-
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Sutilain Approved DB09379
biotech | CAS: 12211-28-8

Sutilain is a member of the keratase family which includes agents such as papain. It is able to dissolve the intercellular matrix which helps with desquamation. Sutilain contains proteolytic enzymes derived from _Bacillus subtilis_ and it is available as a cr…

Kategori:
EndopeptidasesEnzymesEnzymes and Coenzymes +4
Waktu ParuhThis pharmacokineti…
Vol. DistribusiThis pharmacokineti…
KlirensThis pharmacokineti…
Genetik -
Suvecaltamide DB19139
small molecule | CAS: 953778-58-0

Suvecaltamide is under investigation in clinical trial NCT05122650 (A Study to Assess the Safety and Efficacy of JZP385 in the Treatment of Adults With Moderate to Severe Essential Tremor (ET)).

Waktu Paruh-
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SUVN-502 DB06140
small molecule | CAS: 701205-60-9

SUVN-502 is a novel, potent, safe, highly selective and orally active antagonist at a central nervous system serotonin receptor site 5-HT6 intended for treatment of cognitive disorders such as Alzheimer’s and Schizophrenia, an unmet medical need.

Kategori:
Antidepressive AgentsCentral Nervous System DepressantsHeterocyclic Compounds, Fused-Ring +3
Target Protein:
5-hydroxytryptamine receptor 6
Waktu Paruh-
Vol. Distribusi-
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Genetik -
SVV-001 DB06129
biotech

SVV-001 is investigated for use/treatment in cancer/tumors and lung cancer. SVV-001 is a solid. SVV-001 (Seneca Valley Virus) is a novel native picornavirus being developed as a systemically deliverable oncolytic virus for treatment of human cancers with neur…

Waktu Paruh-
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SynOV1.1 DB17539
biotech

SynOV1.1 is an investigational cancer immunotherapy developed by SyngenTech. It is a recombinant oncolytic adenovirus, controlled by synthetic gene circuit, encoding the human immunostimulating factor cytokine granulocyte-macrophage colony-stimulating factor …

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T-62 DB12919
small molecule | CAS: 40312-34-3

T-62 has been used in trials studying the treatment of Postherpetic Neuralgia.

Target Protein:
Adenosine receptor A2a
Waktu Paruh-
Vol. Distribusi-
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T-900607 DB12068
small molecule | CAS: 261944-52-9

T900607 has been used in trials studying the treatment of Liver Cancer and Gastric Cancer.

Kategori:
AmidesSulfonesSulfur Compounds
Waktu Paruh-
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Genetik -
small molecule | CAS: 2412170-98-8

Tabirafusp tedromer is under investigation in clinical trial NCT06556368 (A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer and Tabirafusp Tedromer Compared to Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneratio…

Waktu Paruh-
Vol. Distribusi-
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Genetik -
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