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14494

Total database: 17430
Struktur (SMILES)
9687 (66.8%)
Target
7525 (51.9%)
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112 (0.8%)
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14494 (100.0%)

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Hasil Pencarian (14494)

Halaman 55 / 290
ATHX-105 DB06008
small molecule

ATHX-105 is an investigational selective 5HT2c receptor agonist developed by Athersys Inc. for the treatment of Obesity.

Target Protein:
5-hydroxytryptamine receptor 2C
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ATI-1013 DB18185
biotech

ATI-1013 is a fully human nicotine-specific monoclonal antibody.

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Atibuclimab DB06546
biotech | CAS: 2417175-94-9

Atibuclimab (IC14) is a chimeric CD14 antibody investigated for the treatment of patients with severe sepsis.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Target Protein:
Monocyte differentiation antigen CD14
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Aticaprant DB12341
small molecule | CAS: 1174130-61-0

Aticaprant has been used in trials studying the health services research and basic science of Anxiety Disorders and Alcohol Dependence.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +5
Target Protein:
Kappa-type opioid receptor
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Atidarsagene autotemcel Approved DB17538
biotech

Atidarsagene autotemcel, sold under the brand name Libmeldy, is a gene therapy comprising genetically modified autologous CD34+ enriched hematopoietic stem and progenitor cells transduced _ex vivo_ using a lentiviral vector encoding the human arylsulfatase A …

Kategori:
Alimentary Tract and MetabolismAutologous Cultured CellAutologous Hematopoietic Stem Cell-Based Gene Therapy +2
Target Protein:
Human Arylsulfatase A mRNA
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Atilotrelvir DB19439
small molecule | CAS: 2850365-55-6

Atilotrelvir is under investigation in clinical trial NCT05041907 (Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV)).

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Atipamezole DB11481
small molecule | CAS: 104054-27-5

Atipamezole is a synthetic ?2 adrenoceptor antagonistused to reverse the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. It has also been undergone research as a potential anti-Parkinsonian drug for humans.

Kategori:
Adrenergic AgentsAdrenergic alpha-2 Receptor AntagonistsAdrenergic alpha-Antagonists +3
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Atiprimod DB05513
small molecule | CAS: 123018-47-3

Deskripsi belum tersedia.

Target Protein:
Signal transducer and activator of transcription 3Interleukin-6Tumor necrosis factor
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ATIR101 DB18650
biotech

ATIR101 is a haploidentical, naïve cell-enriched T-cell therapy.

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Atisnolerbart DB19418
biotech | CAS: 2456308-79-3

Atisnolerbart is under investigation in clinical trial NCT06602739 (A Study to Demonstrate the Effect of REGN5713-5715 on Reducing Ocular Allergy Signs and Symptoms in Adult Participants With Birch Pollen Allergy).

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ATL-104 DB05670
biotech

ATL-104 is a potent mitogen for epithelial cells of the gastrointestinal tract. In animal models, ATL-104 aids regeneration of the gastrointestinal tract after treatment with chemotherapeutic agents.

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ATL-2502 DB05340
small molecule

ATL-2502(Colal-Pred) is an old drug (prednisolone metasulphobenzoate, a steroid) with a new delivery system that releases the medication only in the colon. Releasing the drug directly into the colon reduces the potential for significant side effects often exp…

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ATL1101 DB05023
small molecule

ATL1101 is a second-generation antisense drug designed to block the synthesis of the IGF-1 receptor, a protein involved in the regulation of cell overgrowth in psoriasis. ATL1101 is being developed as a cream for the topical treatment of mild to moderate case…

Target Protein:
Insulin-like growth factor 1 receptor
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ATL1102 DB04997
small molecule

ATL1102 is a second-generation antisense inhibitor of CD49d, an immunesystem protein known as VLA-4, an immune cell molecule. It works by entering cells and targeting genes.

Target Protein:
Integrin alpha-4
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Atl146e DB05191
small molecule

ATL146e is an anti-inflammatory compounds which is an agonist of A2A adenosine receptors.

Kategori:
Acids, CarbocyclicAdenosine A receptor agonistsAdenosine A2 Receptor Agonists +3
Target Protein:
Adenosine receptor A2a
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Atlantic cod Approved DB10861
biotech

Atlantic cod allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
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Atlantic halibut Approved DB15549
biotech

Atlantic halibut allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
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Atlantic mackerel Approved DB15542
biotech

Atlantic mackerel allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
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Atlantic salmon Approved DB10621
biotech

Atlantic salmon allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
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ATN-161 DB05491
small molecule | CAS: 262438-43-7

ATN-161 is a non-RGD based integrin binding peptide targeting alpha-5 beta-1 and alpha-v beta-3. It inhibits the migration and adhesion of particular integrins on activated endothelial cells that play a critical role in tumor angiogenesis. This approach targe…

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
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Atogepant Approved DB16098
small molecule | CAS: 1374248-81-3

Atogepant is an oral antagonist of calcitonin gene-related peptide (CGRP) receptors indicated for the prevention of episodic migraine headaches. It was developed by AbbVie and received FDA approval under the brand name Qulipta in September 2021.[L38814] While…

Kategori:
AnalgesicsAntimigraine PreparationsBCRP/ABCG2 Substrates +14
Target Protein:
Calcitonin gene-related peptide type 1 receptor
Waktu ParuhThe elimination hal…
Vol. DistribusiThe mean apparent v…
KlirensThe mean apparent o…
Genetik -
Atoltivimab Approved DB15898
biotech | CAS: 2135632-29-8

Ebola virus (EBOV) remains an important human pathogen within the _Ebolavirus_ genus, having been responsible for at least 17 known outbreaks with an average case fatality rate of 43.92%.[A221825] Immune therapy using monoclonal antibodies (mAbs) is becoming …

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAntibodies +10
Target Protein:
Envelope glycoprotein
Waktu ParuhAtoltivimab adminis…
Vol. DistribusiAtoltivimab adminis…
KlirensAtoltivimab adminis…
Genetik -
Atomoxetine Approved DB00289
small molecule | CAS: 83015-26-3

Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educ…

Kategori:
Adrenergic AgentsAgents producing tachycardiaAgents that produce hypertension +17
Target Protein:
Sodium-dependent noradrenaline transporterSodium-dependent serotonin transporterNMDA receptor +2
Gen Terkait:
CYP2D6 CYP2D6 CYP2D6 +3
Waktu ParuhThe reported half-l…
Vol. DistribusiThe reported volume…
KlirensThe clearance rate …
Genetik 6 Varian
Atopaxar DB12046
small molecule | CAS: 751475-53-3

Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome.

Kategori:
Receptors, Thrombin, antagonists & inhibitors
Target Protein:
Proteinase-activated receptor 1
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Atorvastatin Approved DB01076
small molecule | CAS: 134523-00-5

Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiova…

Kategori:
Agents Causing Muscle ToxicityAnticholesteremic AgentsBSEP/ABCB11 Substrates +37
Target Protein:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseDipeptidyl peptidase 4Aryl hydrocarbon receptor +2
Gen Terkait:
KIF6 HMGCR CYP3A4
Waktu ParuhThe half-life of at…
Vol. DistribusiThe reported volume…
KlirensThe registered tota…
Genetik 3 Varian
Atosiban Approved DB09059
small molecule | CAS: 90779-69-4

Atosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used intravenously to halt premature labor. Although initial studies suggested it could be used as a nasal spray and hence would not require hospital admission, it is not used in that fo…

Kategori:
Amino Acids, Peptides, and ProteinsGenito Urinary System and Sex HormonesHormone Antagonists +8
Target Protein:
Oxytocin receptorVasopressin V1a receptorVasopressin V1b receptor +1
Waktu ParuhAtosiban does not c…
Vol. DistribusiAtosiban has a mean…
KlirensAtosiban has a mean…
Genetik -
Atovaquone Approved DB01117
small molecule | CAS: 95233-18-4

Atovaquone is a hydroxynaphthoquinone, or an analog of ubiquinone, that has antimicrobial and antipneumocystis activity. It is being used in antimalarial protocols.

Kategori:
Anti-Infective AgentsAntibiotics for Pneumocystis PneumoniaAntimalarials +16
Target Protein:
Cytochrome bDihydroorotate dehydrogenase (quinone), mitochondrialDihydroorotate dehydrogenase (quinone), mitochondrial
Waktu Paruh2.2 to 3.2 days
Vol. Distribusi* 0.60 ± 0.17 L/kg
Klirens* 10.4 +/- 5.5 ml/m…
Genetik -
ATP DB00171
small molecule | CAS: 56-65-5

An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.

Kategori:
Adenine NucleotidesAdenosine TriphosphateDietary Supplements +7
Target Protein:
Tyrosine-protein kinase ABL1ATP-binding cassette sub-family C member 6ATP-binding cassette sub-family C member 4 +39
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Atpenin A5 DB04631
small molecule | CAS: 119509-24-9

Deskripsi belum tersedia.

Kategori:
Pyridines
Target Protein:
Succinate dehydrogenase iron-sulfur subunitSuccinate dehydrogenase cytochrome b556 subunitSuccinate dehydrogenase hydrophobic membrane anchor subunit +1
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Atractylodes japonica root Approved DB11261
small molecule

Deskripsi belum tersedia.

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biotech

Atractylodes japonica root oil is obtained from the roots of Atractylodes japonica, which is a herb native to eastern Asia. It is present in some cosmetic products such as whitening creams as an active ingredient and lubricant for skin irritation. Atractylode…

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Atractylodes lancea root Approved DB14693
biotech

Deskripsi belum tersedia.

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Atractylodes lancea root oil Approved DB14338
biotech

Atractylodes lancea root oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

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Atracurium Approved DB13295
small molecule | CAS: 64228-79-1

Deskripsi belum tersedia.

Kategori:
Anticholinergic AgentsBenzylisoquinolinesCentral Nervous System Depressants +13
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Atracurium besylate Approved DB00732
small molecule | CAS: 64228-81-5

A non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for elimination provide clinical advantage over alternate non-depolarizing neuromu…

Kategori:
Anticholinergic AgentsBenzylisoquinolinesCentral Nervous System Depressants +10
Target Protein:
Neuronal acetylcholine receptor subunit alpha-2
Waktu ParuhThe elimination hal…
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Atrasentan DB06199
small molecule | CAS: 173937-91-2

Atrasentan is a substance that is being studied in the treatment of cancer. It belongs to the family of drugs called endothelin-1 protein receptor antagonists. It is a novel, selective endothelin A receptor antagonist (SERA).

Kategori:
Antineoplastic AgentsBenzodioxolesDioxoles +5
Target Protein:
Endothelin-1 receptor
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Atrazine DB07392
small molecule | CAS: 1912-24-9

Atrazine is a selective triazine herbicide. Inhalation hazard is low and there are no apparent skin manifestations or other toxicity in humans. Acutely poisoned sheep and cattle may show muscular spasms, fasciculations, stiff gait, increased respiratory rates…

Kategori:
AgrochemicalsCompounds used in a research, industrial, or household settingHerbicides +3
Target Protein:
Photosynthetic reaction center cytochrome c subunitReaction center protein H chainReaction center protein L chain +1
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Atreleuton DB12758
small molecule | CAS: 154355-76-7

Atreleuton has been used in trials studying the treatment of Atherosclerosis and Coronary Artery Disease.

Kategori:
AmidesEnzyme InhibitorsLipoxygenase Inhibitors
Target Protein:
Polyunsaturated fatty acid 5-lipoxygenase
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biotech | CAS: 85637-73-6

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAtrial Natriuretic FactorCardiovascular Agents +6
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Atriplex canescens pollen Approved DB10767
biotech

Atriplex canescens pollen is the pollen of the Atriplex canescens plant. Atriplex canescens pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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biotech

Atriplex confertifolia pollen is the pollen of the Atriplex confertifolia plant. Atriplex confertifolia pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Atriplex lentiformis pollen Approved DB10760
biotech

Atriplex lentiformis pollen is the pollen of the Atriplex lentiformis plant. Atriplex lentiformis pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Atriplex polycarpa pollen Approved DB10756
biotech

Atriplex polycarpa pollen is the pollen of the Atriplex polycarpa plant. Atriplex polycarpa pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Atriplex wrightii pollen Approved DB10391
biotech

Atriplex wrightii pollen is the pollen of the Atriplex wrightii plant. Atriplex wrightii pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Atropine Approved DB00572
small molecule | CAS: 51-55-8

Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be admini…

Kategori:
Adjuvants, AnesthesiaAgents producing tachycardiaAgents that produce hypertension +32
Target Protein:
Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M2Muscarinic acetylcholine receptor M3 +5
Waktu ParuhFollowing intraveno…
Vol. DistribusiAtropine is distrib…
KlirensFollowing intraveno…
Genetik -
ATSN-101 DB18327
biotech

ATSN-101 is a adeno-associated virus serotype 5 encoding human retinal guanylate cyclase 1 gene (AAV5-GUCY2D)

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Attapulgite Approved DB01574
small molecule | CAS: 12174-11-7

Attapulgite is a magnesium aluminium phyllosilicate which occurs in a type of clay soil common to the Southeastern United States. When used in medicine, it physically binds to acids and toxic substances in the stomach and digestive tract. For that reason, it …

Kategori:
Alimentary Tract and MetabolismAntidiarrheals, Intestinal Antiinflammatory/antiinfective AgentsAntidotes +3
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ATU-027 DB12171
biotech | CAS: 1415935-22-6

Atu027 has been used in trials studying the treatment of Advanced Solid Tumors.

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Atuliflapon DB19029
small molecule | CAS: 2041075-86-7

Atuliflapon is under investigation in clinical trial NCT05251259 (Study to Assess the Efficacy and Safety of Atuliflapon in Moderate-to-severe Uncontrolled Asthma).

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Atuzaginstat DB19030
small molecule | CAS: 2211981-76-7

Atuzaginstat is under investigation in clinical trial NCT03823404 (GAIN Trial: Phase 2/3 Study of COR388 in Subjects With Alzheimer's Disease).

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