Hasil Filter

6694

Total database: 17430
Struktur (SMILES)
4518 (67.5%)
Target
3751 (56.0%)
Genomik
81 (1.2%)
Referensi
6694 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (6694)

Halaman 54 / 134
small molecule | CAS: 1623-14-9

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicAnions +7
Target Protein:
CholinesteraseParathion hydrolase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ethyl ferulate Approved DB11285
small molecule | CAS: 4046-02-0

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicCinnamates
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ethyl hydroxybenzoate Approved DB13628
small molecule | CAS: 120-47-8

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAntifungals for Dermatological UseAntifungals for Topical Use +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ethyl macadamiate Approved DB11243
small molecule

Ethyl macadamiate is derived from Macadamia terifolia seed oil. It is a non-volatile ester of ethyl alcohol and the fatty acids. Ethyl macadamiate is used in cosmetics and personal care products such as sunscreen, hair care products and skin care products as …

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 24393-56-4

Deskripsi belum tersedia.

Kategori:
Sunscreen Agents
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ethyl nitrite DB16560
small molecule | CAS: 109-95-5

Deskripsi belum tersedia.

Kategori:
AnionsElectrolytesIons +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ethyl pyruvate DB05869
small molecule | CAS: 617-35-6

CTI-01 (ethyl pyruvate) is a novel anti-inflammatory agent for the treatment of critical inflammatory conditions. CTI-01 shows a potent anti-inflammatory and tissue protection activity in multiple animal models of disease including pancreatitis, ischemia-rep…

Kategori:
Keto Acids
Target Protein:
Tumor necrosis factorHigh mobility group protein B1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ethyl salicylate Approved DB15576
small molecule | CAS: 118-61-6

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicBenzene DerivativesBenzoates +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Shiga-like toxin 1 subunit B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ethylenediamine Approved DB14189
small molecule | CAS: 107-15-3

Ethylenediamine is an organic compound that is used as a building block for the production of many other chemical products. It is also used as an excipient in many pharmacological preparations such as creams. Notably, ethylenediamine is a contact sensitizer c…

Kategori:
AllergensAminesAntigens +6
Target Protein:
Dihydropteroate synthase
Waktu ParuhEthylenediamine has…
Vol. DistribusiVd = 0.133 l/kg [A3…
Klirens-
Genetik -
small molecule | CAS: 148-61-8

Ethylmercurithiosalicylic acid is a topical antiseptic used on skin and mucous membranes. It is also used as a preservative in pharmaceuticals.

Target Protein:
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrialSensor histidine kinase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etidronic acid Approved DB01077
small molecule | CAS: 2809-21-4

Etidronic acid is a first generation bisphosphonate similar to [clodronic acid] and [tiludronic acid].[A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification.[A1923] Etidronate’s use has decr…

Kategori:
BisphosphonatesBone Density Conservation AgentsDrugs Affecting Bone Structure and Mineralization +4
Target Protein:
HydroxylapatiteReceptor-type tyrosine-protein phosphatase SV-type proton ATPase catalytic subunit A +3
Waktu ParuhThe half life of et…
Vol. DistribusiEtidronic acid has …
KlirensEtidronic acid has …
Genetik -
Etifoxine DB08986
small molecule | CAS: 21715-46-8

Etifoxine is an anxiolytic and anticonvulsant drug developed by Hoechst in the 1960s. It is used in anxiety disorders and to promote peripheral nerve healing. It does not bind to the benzodiazepine receptor though the effects are similar to that of benzodiaze…

Kategori:
Anti-Anxiety AgentsCentral Nervous System AgentsCentral Nervous System Depressants +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 199331-40-3

Etiprednol dicloacetate (BNP-166) is a soft corticosteroid with anti-inflammatory properties that has been indicated in the treatment of asthma and Chron's disease. Anti-asthmatic effects were associated with decreased cytokine production in lipopolysaccharid…

Kategori:
HormonesHormones, Hormone Substitutes, and Hormone Antagonists
Target Protein:
Glucocorticoid receptorInterleukin-1 beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 848779-32-8

Etirinotecan pegol is under investigation in clinical trial NCT01663012 (Phase II NKTR-102 In Bevacizumab-Resistant High Grade Glioma).

Kategori:
AlcoholsAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etodolac Approved DB00749
small molecule | CAS: 41340-25-4

Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rhe…

Kategori:
Acetic Acid Derivatives and Related SubstancesAgents causing hyperkalemiaAgents that produce hypertension +29
Target Protein:
Prostaglandin G/H synthase 2Prostaglandin G/H synthase 1Retinoic acid receptor RXR-alpha
Waktu ParuhTerminal t<sub>1/2<…
Vol. Distribusi* 390 mL/kg
Klirens* Oral cl=49.1 mL/h…
Genetik -
Etofibrate DB08983
small molecule | CAS: 31637-97-5

Etofibrate is a fibrate produced by the combination of clofibrate ester linked to niacin. These components separate in the body slowly allowing for pharmacokinetics similar to controlled-release formulations.

Kategori:
Acids, AcyclicAgents Causing Muscle ToxicityAnticholesteremic Agents +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etoglucid DB13339
small molecule | CAS: 1954-28-5

Deskripsi belum tersedia.

Kategori:
Alkylating DrugsAntineoplastic AgentsAntineoplastic Agents, Alkylating +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etomidate Approved DB00292
small molecule | CAS: 33125-97-2

Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic.

Kategori:
Adrenergic AgonistsAdrenergic alpha-2 Receptor AgonistsAdrenergic alpha-Agonists +11
Target Protein:
Gamma-aminobutyric acid receptor subunit gamma-3Gamma-aminobutyric acid receptor subunit alpha-1Alpha-2B adrenergic receptor +1
Waktu Paruh75 minutes.
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 433304-61-1

Deskripsi belum tersedia.

Kategori:
Topoisomerase Inhibitors
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etoricoxib Approved DB01628
small molecule | CAS: 202409-33-4

Etoricoxib is a new COX-2 selective inhibitor. Current therapeutic indications are: treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout. Like any other COX-2 selective inhibitor, Etoricoxib sel…

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAnalgesics +34
Target Protein:
Prostaglandin G/H synthase 2
Waktu Paruh22 hours
Vol. Distribusi-
Klirens-
Genetik -
Etorphine DB01497
small molecule | CAS: 14521-96-1

A narcotic analgesic morphinan used as a sedative in veterinary practice. In certain countries, etorphine is classified as a Schedule 1 drug and hence, in these countries, it can be used legally only by health professionals and for research purposes. Etorphin…

Kategori:
AlkaloidsAnalgesicsCentral Nervous System Agents +10
Target Protein:
Mu-type opioid receptorDelta-type opioid receptorKappa-type opioid receptor +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etranacogene dezaparvovec Approved DB16791
biotech | CAS: 2156583-26-3

Hemophilia B - also called factor IX deficiency or Christmas disease - is an X-linked genetic disorder resulting in an absence or deficiency of clotting factor IX.[L44176] Clotting factors, including factor IX, are necessary components of the signaling cascad…

Kategori:
Adeno-associated Viral Vector TherapiesBlood and Blood Forming OrgansBlood Coagulation Factors +2
Target Protein:
Coagulation factor IX
Waktu Paruh-
Vol. DistribusiIn a study to evalu…
KlirensIn a clinical study…
Genetik -
Etrasimod Approved DB14766
small molecule | CAS: 1206123-37-6

Etrasimod is a synthetic next-generation selective Sphingosine 1-phosphate (S1P) receptor modulator that targets the S1P<sub>1,4,5</sub> with no detectable activity on S1P<sub>2</sub> and S1P<sub>3</sub> receptors. S1P receptors are membrane-derived lysophosp…

Kategori:
Acids, AcyclicAntineoplastic and Immunomodulating AgentsCytochrome P-450 CYP2C19 Substrates +11
Target Protein:
Sphingosine 1-phosphate receptor 1Sphingosine 1-phosphate receptor 4Sphingosine 1-phosphate receptor 5
Waktu ParuhThe mean plasma eli…
Vol. DistribusiThe mean apparent v…
KlirensThe apparent steady…
Genetik -
Etravirine Approved DB06414
small molecule | CAS: 269055-15-4

Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the …

Kategori:
Anti-Infective AgentsAnti-Retroviral AgentsAntiinfectives for Systemic Use +24
Target Protein:
Gag-Pol polyproteinGag-Pol polyproteinReverse transcriptase/RNaseH
Waktu ParuhHalf life of 9.05-4…
Vol. DistribusiDistribution of etr…
KlirensRenal clearance of …
Genetik -
Etretinate DB00926
small molecule | CAS: 54350-48-0

Etretinate is a medication used to treat severe psoriasis. It is a synthetic aromatic retinoid. The mechanism of action of etretinate is still incompletely understood although, like retinoic acid, it is thought to interfere with the terminal differentiation o…

Kategori:
AlkenesAntipsoriaticsAntipsoriatics for Systemic Use +12
Target Protein:
Retinoic acid receptor alphaRetinoic acid receptor RXR-alphaRetinoic acid receptor beta +3
Waktu ParuhIn one study, the a…
Vol. Distribusi-
Klirens-
Genetik -
Etrolizumab DB12189
biotech | CAS: 1044758-60-2

Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is typified by a chronic gastrointestinal inflammatory microenvironment, driven in part by the excessive infiltration and retention of intestinal-homing lymphocytes.[A244564, …

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +10
Target Protein:
Integrin beta-7
Waktu ParuhEtrolizumab adminis…
Vol. DistribusiModelling of etroli…
KlirensEtrolizumab has a m…
Genetik -
Etryptamine DB01546
small molecule | CAS: 2235-90-7

In the 1960's, alpha-ethyltryptamine (?ET), a non hydrazine reversible monoamine oxidase inhibitor, was developed in the United States by the Upjohn chemical company for use as an antidepressant. ?ET was an FDA approved antidepressant under the name Monase. H…

Kategori:
AminesBiogenic AminesBiogenic Monoamines +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ETX101 DB18579
biotech

ETX101 is a non-replicating recombinant adeno associated viral vector, serotype 9, designed to promote increased transcription of SCN1A gene.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eucalyptol DB03852
small molecule | CAS: 470-82-6

Eucalyptol is naturally produced cyclic ether and monoterpenoid. Eucalyptol is an ingredient in many brands of mouthwash and cough suppressant. It controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition. Eucalyptol is an effe…

Kategori:
AgrochemicalsAlcoholsAnti-Infective Agents +29
Target Protein:
Transient receptor potential cation channel subfamily M member 8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eucalyptus oil Approved DB11114
biotech | CAS: 8000-48-4

Eucalyptus oil is a distilled oil derived from the leaves of the tree Eucalyptus. It is shown to be effective in reducing pain, swelling, and inflammation via its modulatory effect on the immune response. It is also shown to exhibit antibacterial activity aga…

Kategori:
Biological ProductsComplex MixturesDrugs that are Mainly Renally Excreted +6
Waktu ParuhStudies have determ…
Vol. DistribusiStudies have determ…
KlirensStudies have determ…
Genetik -
Eugenol Approved DB09086
small molecule | CAS: 97-53-0

Eugenol is a naturally occurring phenolic molecule found in several plants such as cinnamon, clove, and bay leaves. It has been used as a topical antiseptic as a counter-irritant and in dental preparations with zinc oxide for root canal sealing and pain contr…

Kategori:
Acids, CarbocyclicAlkenesAllyl Compounds +11
Target Protein:
Amine oxidase [flavin-containing] BEstrogen receptorEstrogen receptor beta +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Evacetrapib DB11655
small molecule | CAS: 1186486-62-3

Evacetrapib has been used in trials studying the basic science and treatment of Dyslipidemia, Hyperlipidemia, Hypercholesterolemia, Hepatic Insufficiency, and Cardiovascular Disease.

Kategori:
Anticholesteremic AgentsBenzazepinesCholesterol Ester Transfer Proteins, antagonists & inhibitors +3
Target Protein:
Cholesteryl ester transfer protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Evalstotug DB19410
biotech | CAS: 2460399-39-5

Evalstotug is under investigation in clinical trial NCT05271604 (A Phase 2 Open Label Study of BA3021 in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 308064-97-3

Evening primrose oil comes from the extraction from _Oenothera biennis_ seeds and it is commonly used as an alternative source for omega-6 essential fatty acids. In its composition it presents some fatty acids such as [DB00132] and [DB13854].[A33131] Evening …

Kategori:
Agents that reduce seizure thresholdAngiospermsAnti-Inflammatory Agents +26
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Evernia prunastri Approved DB14172
biotech

Evernia prunastri allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseStandardized Chemical Allergen
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Evernimicin DB06431
small molecule | CAS: 109545-84-8

Deskripsi belum tersedia.

Kategori:
Anti-Bacterial AgentsCarbohydratesGlycosides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Everolimus Approved DB01590
small molecule | CAS: 159351-69-6

Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other m…

Kategori:
Anti-Bacterial AgentsAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +32
Target Protein:
Serine/threonine-protein kinase mTOR
Waktu Paruh~30 hours.
Vol. DistribusiThe blood-to-plasma…
KlirensFollowing a 3 mg ra…
Genetik -
Evinacumab Approved DB15354
biotech | CAS: 1446419-85-7

Evinacumab is a recombinant human IgG4 monoclonal antibody targeted against angiopoietin-like protein 3 (ANGPTL3) and the first drug of its kind. The ANGPTL family of proteins serve a number of physiologic functions - including involvement in the regulation o…

Kategori:
Amino Acids, Peptides, and ProteinsAngiopoietin-like 3 InhibitorAngiopoietin-like 3 Inhibitors +8
Target Protein:
Angiopoietin-related protein 3
Waktu ParuhThe elimination hal…
Vol. DistribusiThe volume of distr…
Klirens-
Genetik -
Evofosfamide DB06091
small molecule | CAS: 918633-87-1

TH-302 is a novel cancer therapeutic specifically activated under the low oxygen or "hypoxic" conditions typical of solid tumor cancer cells. TH-302 is a nitroimidazole-linked prodrug of a brominated derivative of an isophosphoramide mustard previously used i…

Kategori:
Hydrocarbons, HalogenatedImidazolesMustard Compounds +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Evolocumab Approved DB09303
biotech | CAS: 1256937-27-5

Evolocumab is a monoclonal antibody designed for the treatment of hyperlipidemia by Amgen. It is a subcutaneous injection approved by the FDA for individuals on maximum statin therapy who still require additional LDL-cholesterol lowering. It is approved for b…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +18
Target Protein:
Proprotein convertase subtilisin/kexin type 9
Waktu Paruh-
Vol. Distribusi-
KlirensEvolocumab showed n…
Genetik -
Evorpacept DB17573
biotech | CAS: 2484949-51-9

evorpacept is under investigation in clinical trial NCT04755244 (A Study of Evorpacept (ALX148) With Venetoclax and Azacitidine for Acute Myeloid Leukemia (ASPEN-05)).

Kategori:
Amino Acids, Peptides, and ProteinsBlood ProteinsGlobulins +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
EW-A-401 DB05525
biotech

EW-A-401 is a circle of genetic material (plasmid DNA) that instructs the body to produce a genetically-engineered transcription factor, a protein that regulates expression of genes. This specific transcription factor has been shown in animal studies to incre…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Holoclar (_ex vivo_ expanded autologous human corneal epithelial cells containing stem cells) is a stem cell therapy used to treat limbal stem cell deficiencies.[L48375]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Exagamglogene autotemcel Approved DB15572
biotech

Sickle cell disease (SCD) is a genetic disorder characterized by the production of abnormal sickle-shaped red blood cells (called hemoglobin S, HbS) that initiate a pathophysiology resulting in severe pain, progressive multi-organ damage, and premature death.…

Kategori:
Autologous Cultured CellBlood and Blood Forming Organs
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Excindogen DB18754
small molecule

Excindogen is an investigational immunotherapy.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Exenatide Approved DB01276
biotech | CAS: 141758-74-9

Exenatide is a glucagon-like peptide-1 (GLP-1) analog[L42690]. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control[L42690]. Exenatide was given FDA approval on A…

Kategori:
Alimentary Tract and MetabolismAmino Acids, Peptides, and ProteinsAnti-Obesity Agents +16
Target Protein:
Glucagon-like peptide 1 receptor
Waktu Paruh2.4 hours[Label]
Vol. Distribusi28.3L[Label].
Klirens9.1 L/hour[Label].
Genetik -
Exisulind DB06246
small molecule | CAS: 59973-80-7

Deskripsi belum tersedia.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Inflammatory Agents +10
Target Protein:
cGMP-specific 3',5'-cyclic phosphodiesteraseGlutathione S-transferase PAldo-keto reductase family 1 member B1 +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Exlinkibart DB17474
biotech | CAS: 2642171-64-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 2651–2700 dari 6694
Sebelumnya Halaman 54 / 134 Berikutnya