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16618

Total database: 17430
Struktur (SMILES)
11654 (70.1%)
Target
8974 (54.0%)
Genomik
112 (0.7%)
Referensi
16618 (100.0%)

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Hasil Pencarian (16618)

Halaman 54 / 333
Aclerastide DB12631
small molecule | CAS: 227803-63-6

Aclerastide has been investigated for the treatment of Diabetic Foot, Diabetic Foot Ulcers, and Foot Ulcer, Diabetic.

Kategori:
Amino Acids, Peptides, and ProteinsAngiotensinsAutacoids +10
Target Protein:
Proto-oncogene Mas
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aclidinium Approved DB08897
small molecule | CAS: 727649-81-2

Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012.

Kategori:
Adrenergics, InhalantsAgents producing tachycardiaAgents to Treat Airway Disease +9
Target Protein:
Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M2Muscarinic acetylcholine receptor M3 +2
Waktu ParuhPlasma half-life = …
Vol. DistribusiFollowing IV admini…
KlirensTotal clearance, IV…
Genetik -
Aclimostat DB16079
small molecule | CAS: 2082752-83-6

Aclimostat is under investigation in clinical trial NCT03254368 (Study to Assess the Effects and Safety of ZGN-1061 in Overweight and Obese Participants With Type 2 Diabetes).

Kategori:
Anti-Obesity AgentsAzetinesEnzyme Inhibitors +1
Target Protein:
Methionine aminopeptidase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acolbifene DB16080
small molecule | CAS: 182167-02-8

Acolbifene is under investigation in clinical trial NCT01452373 (Dehydroepiandrosterone (DHEA) + Acolbifene Against Vasomotor Symptoms (Hot Flushes) in Postmenopausal Women).

Target Protein:
Estrogen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acoltremon DB19202
small molecule | CAS: 68489-09-8

Acoltremon is under investigation in clinical trial NCT05493111 (A Long-term Safety Study Evaluating the Safety and Systemic Exposure of AR-15512).

Kategori:
AlcoholsAmidesAmines +10
Target Protein:
Transient receptor potential cation channel subfamily M member 8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aconiazide DB17731
small molecule | CAS: 13410-86-1

Deskripsi belum tersedia.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsDrugs for Treatment of Tuberculosis +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aconitate Ion DB04351
small molecule

Deskripsi belum tersedia.

Target Protein:
Aconitate hydratase, mitochondrialAconitate hydratase B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acoramidis DB17999
small molecule | CAS: 1446711-81-4

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAmyloidosis, prevention & controlBenzene Derivatives
Target Protein:
Transthyretin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Acorus calamus root is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
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Acotiamide DB12482
small molecule | CAS: 185106-16-5

Acotiamide has been used in trials studying the treatment of Dyspepsia and Functional Dyspepsia.

Kategori:
Acids, CarbocyclicAlimentary Tract and MetabolismAmides +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acoziborole DB13086
small molecule | CAS: 1266084-51-8

SCYX-7158 has been used in trials studying the treatment of Trypanosomiasis, Parasitic Diseases, Protozoan Infections, and Trypanosomiasis, African.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
ACP-015 DB17824
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
ACR-16 DB05371
small molecule

ACR-16 is under investigation by NeuroSearch. ACR16 has been successfully investigated in a Phase II multi-centre, randomised and placebo-controlled trial in patients with Huntington’s disease as well as in three Phase Ib studies within Huntington’s disease, …

Waktu Paruh-
Vol. Distribusi-
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ACR325 DB05196
small molecule

ACR325 is developed for the treatment of Parkinson’s disease and psychoses, including bipolar disorder, for which disease existing therapies have only limited effect and considerable adverse side effects. ACR325 is a dopaminergic stabiliser, which has demonst…

Waktu Paruh-
Vol. Distribusi-
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Acremonium strictum Approved DB10423
biotech

Acremonium strictum is a fungus which can provoke allergic reactions. Acremonium strictum extract is used in allergenic testing.

Waktu Paruh-
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Genetik -
small molecule | CAS: 89459-25-6

Acridine Carboxamide has been used in trials studying the treatment of Lung Cancer and Brain and Central Nervous System Tumors.

Kategori:
Antineoplastic AgentsEnzyme InhibitorsHeterocyclic Compounds, Fused-Ring +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acriflavine DB13373
small molecule | CAS: 65589-70-0

Deskripsi belum tersedia.

Kategori:
AcridinesAminoacridinesAnti-Infective Agents +10
Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acrivastine Approved DB09488
small molecule | CAS: 87848-99-5

Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histami…

Kategori:
Antihistamines for Systemic UseDrugs that are Mainly Renally ExcretedHistamine Agents +7
Target Protein:
Histamine H1 receptor
Waktu ParuhThe mean terminal h…
Vol. Distribusi0.46 ± 0.05 L/kg
Klirens2.9 ± 0.7 mL/min/kg
Genetik -
Acrizanib DB16081
small molecule | CAS: 1229453-99-9

Acrizanib is under investigation in clinical trial NCT02355028 (LHA510 Proof-of-concept Study as a Maintenance Therapy for Patients With Wet Age-related Macular Degeneration).

Kategori:
Compounds used in a research, industrial, or household settingEnzyme InhibitorsHeterocyclic Compounds, Fused-Ring +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acrothecium robustum Approved DB10840
biotech

Acrothecium robustum is a fungus which can provoke allergic reactions. Acrothecium robustum extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acrylic Acid DB02579
small molecule | CAS: 79-10-7

A ?,?-unsaturated monocarboxylic acid that is ethene substituted by a carboxy group.

Kategori:
Acids, AcyclicCompounds used in a research, industrial, or household settingEquipment and Supplies +3
Target Protein:
Beta-lactamase SHV-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ACT-1 peptide DB18201
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ACT-101 DB17000
biotech

ACT-101 is a recombinant human alpha-fetoprotein or rhAFP.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ACT-451840 DB13054
small molecule | CAS: 1839508-99-4

ACT-451840 has been used in trials studying Malaria.

Kategori:
Acids, AcyclicAcrylatesAmides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Actelion-1 DB05367
small molecule

Actelion-1 is a tissue-targeting Endothelin Receptor Antagonist that has been discovered by Actelion Pharmaceuticals.

Kategori:
AmidesEndothelin A Receptor AntagonistsEndothelin B Receptor Antagonists +3
Target Protein:
Endothelin-1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acteoside DB12996
small molecule | CAS: 61276-17-3

Acteoside is under investigation in clinical trial NCT02662283 (Validity and Security of Reh-acteoside Therapy for Patients of IgA Nephropathy).

Kategori:
Anti-Infective AgentsAntineoplastic AgentsAntineoplastic Agents, Phytogenic +13
Target Protein:
Protein kinase C alpha type
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Actinium DB12860
small molecule | CAS: 7440-34-8

Actinium has been investigated for the treatment of Breast Cancer and Pulmonary Disease, Chronic Obstructive.

Kategori:
Actinoid Series ElementsElementsElements, Radioactive +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Activated charcoal Approved DB09278
small molecule | CAS: 64365-11-3

Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from incomplete combustion of carbonaceous organic matter. It is activated by an oxidizing gas flow at high temperature passed over its surface to make a fine network of pores, p…

Kategori:
AdsorptionAlimentary Tract and MetabolismAnions +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

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Actoxumab DB16376
biotech | CAS: 1245634-25-6

Actoxumab is under investigation in clinical trial NCT01241552 (A Study of MK-3415, MK-6072, and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-001)).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Neutralizing +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ACTUS-101 DB17658
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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ACTX-401 DB18504
biotech

ACTX-401 is a single-stranded, non-replicating recombinant adeno-associated viral vector serotype 9 containing the human immunoglobulin u-binding protein 2 cDNA.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acumapimod DB15448
small molecule | CAS: 836683-15-9

Acumapimod is under investigation in clinical trial NCT02926326 (The Effect of Azithromycin on BCT197 Exposure in Healthy Male Volunteers).

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ACV tripeptide DB02025
small molecule | CAS: 32467-88-2

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ACY001 DB06355
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acyclovir Approved DB00787
small molecule | CAS: 59277-89-3

Acyclovir is a deoxynucleoside analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster, herpes labialis, and acute herpetic keratitis.[L7303,L7315,L7318,L7321,L7324,L7327] Acyclovir is generally used first line in the treatment of the…

Kategori:
Acyclovir and prodrugAnti-Infective AgentsAntiinfectives for Systemic Use +28
Target Protein:
DNA polymerase catalytic subunitDNA polymerase catalytic subunit
Waktu ParuhThe clearance of ac…
Vol. DistribusiThe volume of distr…
KlirensThe renal clearance…
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Beta-lactamaseBeta-lactamaseRegulatory protein BlaR1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acyline DB11906
small molecule | CAS: 170157-13-8

Acyline has been investigated for the prevention and treatment of Hypogonadism and Contraception.

Kategori:
Amino Acids, Peptides, and ProteinsGonadotropin-Releasing Hormone, antagonists & inhibitorsHormone Antagonists +2
Target Protein:
Gonadotropin-releasing hormone receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AD 337 DB05725
small molecule

AD 337 was under investigation in clinical trial NCT00377039 (A Multicentre Trial to Determine the Efficacy and Safety of AD-337 in the Treatment of Fibromyalgia). The drug was created by Sosei pharmaceuticals to treat Fibromyalgia in female patients.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
AD-114 DB18285
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
AD-214 DB18412
biotech

Deskripsi belum tersedia.

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Ad-CEA vaccine DB17581
biotech

Ad-CEA vaccine is a cancer immunotherapy composed of carcinoembryonic antigen (CEA). Ad-CEA vaccine is under investigation in clinical trial NCT03050814 (Standard of Care Alone or in Combination With Ad-cea Vaccine and Avelumab in People With Previously Untre…

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Genetik -
Ad-ISF35 DB17181
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Ad-RTS-hIL-12 DB17177
biotech

Deskripsi belum tersedia.

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Genetik -
Ad-SGE-REIC DB17183
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Ad5-nCoV DB15655
biotech

Ad5-nCoV is a recombinant adenovirus type-5 vector (Ad5) vaccine currently being investigated for prophylaxis against SARS-CoV-2.[L12675,L12678] It is being developed by CanSino Biologics Inc., in partnership with the Beijing Institute of Biotechnology, who i…

Kategori:
Experimental Unapproved Treatments for COVID-19
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Adafosbuvir DB14906
small molecule | CAS: 1613589-09-5

Adafosbuvir is under investigation in clinical trial NCT02894905 (A Study to Evaluate the Effect of Renal Impairment on the Pharmacokinetics of AL-335).

Kategori:
AcidsAcids, NoncarboxylicAmino Acids +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 1458687-85-8

Adagloxad simolenin is under investigation in clinical trial NCT03562637 (Study of Adagloxad Simolenin (OBI-822)/OBI-821 in the Adjuvant Treatment of Patients With Globo H Positive TNBC).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Adagrasib Approved DB15568
small molecule | CAS: 2326521-71-3

Adagrasib (MRTX849) is an oral, small-molecule KRAS inhibitor developed by Mirati Therapeutics. KRAS mutations are highly common in cancer and account for approximately 85% of all RAS family mutations.[A254941] However, the development of KRAS inhibitors has …

Kategori:
Antineoplastic AgentsAntineoplastic Agents, ImmunologicalAntineoplastic and Immunomodulating Agents +21
Target Protein:
GTPase KRas
Waktu ParuhAdagrasib has a ter…
Vol. DistribusiAdagrasib has an ap…
KlirensAdagrasib has an ap…
Genetik -
Adalimumab Approved DB00051
biotech | CAS: 331731-18-1

Adalimumab is a subcutaneously administered biological disease modifier for the treatment of rheumatoid arthritis and other chronic debilitating diseases mediated by tumor necrosis factor.[A39984,A39999] It was originally launched by Abbvie in the U.S. and ap…

Kategori:
Agents reducing cytokine levelsAmino Acids, Peptides, and ProteinsAnti-Inflammatory Agents +19
Target Protein:
Tumor necrosis factor
Waktu ParuhThe mean terminal h…
Vol. DistribusiThe distribution vo…
KlirensThe single-dose pha…
Genetik -
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