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14494

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Halaman 53 / 290
Artemisia californica pollen Approved DB10909
biotech

Artemisia californica pollen is the pollen of the Artemisia californica plant. Artemisia californica pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Pollen Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Artemisia douglasiana pollen Approved DB10761
biotech

Artemisia douglasiana pollen is the pollen of the Artemisia douglasiana plant. Artemisia douglasiana pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Artemisia dracunculus pollen Approved DB10921
biotech

Artemisia dracunculus pollen is the pollen of the Artemisia dracunculus plant. Artemisia dracunculus pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Artemisia frigida pollen Approved DB10493
biotech

Artemisia frigida pollen is the pollen of the Artemisia frigida plant. Artemisia frigida pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Pollen Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Artemisia ludoviciana pollen Approved DB10762
biotech

Artemisia ludoviciana pollen is the pollen of the Artemisia ludoviciana plant. Artemisia ludoviciana pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Pollen Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Artemisia tridentata pollen Approved DB10390
biotech

Artemisia tridentata pollen is the pollen of the Artemisia tridentata plant. Artemisia tridentata pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Pollen Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Artemisia vulgaris pollen Approved DB10372
biotech

Artemisia vulgaris pollen is the pollen of the Artemisia vulgaris plant. Artemisia vulgaris pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Pollen Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Artemisia vulgaris root Approved DB14170
biotech

Artemisia vulgaris root allergenic extract is used in allergenic testing.

Kategori:
Non-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Artemisinin DB13132
small molecule | CAS: 63968-64-9

Artemisinin has been used in trials studying the treatment of Schizophrenia, Malaria, Falciparum, and Plasmodium Falciparum.

Kategori:
Anti-Infective AgentsAntimalarialsAntiparasitic Products, Insecticides and Repellents +13
Target Protein:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Artemisone DB16097
small molecule | CAS: 255730-18-8

Artemisone is under investigation in clinical trial NCT00936767 (Artemisone for the Treatment of Uncomplicated Falciparum Malaria in Western Cambodia).

Kategori:
Free RadicalsPeroxidesReactive Oxygen Species +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Artemotil Approved DB13851
small molecule | CAS: 75887-54-6

Artemotil, also known as ?-arteether, is a semi-synthetic derivative of artemisinin and a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant _Plasmodium falciparum_ malaria and cerebral malaria cases.

Kategori:
AmebicidesAnti-Infective AgentsAntimalarials +11
Waktu Paruh-
Vol. Distribusi-
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Artenimol Approved DB11638
small molecule | CAS: 71939-50-9

Artenimol is an artemisinin derivative and antimalarial agent used in the treatment of uncomplicated *Plasmodium falciparum* infections [FDA Label]. It was first authorized for market by the European Medicines Agency in October 2011 in combination with [DB139…

Kategori:
Anti-Infective AgentsAntimalarialsAntiparasitic Agents +16
Target Protein:
Actin, cytoplasmic 2Alpha-aminoadipic semialdehyde dehydrogenaseAnnexin A2 +188
Waktu ParuhArtenimol was repor…
Vol. DistribusiArtenimol was obser…
KlirensArtenimol was obser…
Genetik -
Arterolane DB19027
small molecule | CAS: 664338-39-0

Arterolane is under investigation in clinical trial NCT03452475 (Comparison of Arterolane-piperaquine Versus Arterolane-piperaquine+mefloquine Versus Artemether-lumefantrine in Kenyan Children).

Kategori:
AnionsAntimalarialsAntiparasitic Products, Insecticides and Repellents +7
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Artesunate Approved DB09274
small molecule | CAS: 88495-63-0

Artesunate is indicated for the initial treatment of severe malaria.[L14099] The World Health Organization recommends artesunate as first line treatment for severe malaria.[L890] Artesunate was developed out of a need for a more hydrophilic derivative of [art…

Kategori:
Acids, AcyclicAnionsAnthelmintics +28
Target Protein:
Malaria protein EXP-1
Waktu ParuhThe elimination hal…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of ar…
Genetik -
Articaine Approved DB09009
small molecule | CAS: 23964-58-1

Articaine is a dental local anesthetic. Articaine is widely used around the world and is the most popular local anesthetic in many European countries.

Kategori:
AmidesAnestheticsAnesthetics, Local +11
Target Protein:
Voltage-gated sodium channel alpha subunit
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Artichoke Approved DB10638
biotech

Artichoke allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Arundic acid DB05343
small molecule | CAS: 185517-21-9

Arundic acid has been investigated for the treatment of Amyotrophic Lateral Sclerosis (ALS).

Kategori:
Acids, AcyclicFatty AcidsLipids
Target Protein:
Beta-3 adrenergic receptorProtein S100-B
Waktu Paruh-
Vol. Distribusi-
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Genetik -
ARX201 DB05082
small molecule

ARX201 (PEG-ahGH) is a recombinant form of human growth hormone that has been modified using Ambrx’s patented ReCODE™ technology to achieve precise spatial positioning of the site of polyethylene glycol (PEG) attachment to human growth hormone, by biosyntheti…

Waktu Paruh-
Vol. Distribusi-
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Arylacenamide DB05792
small molecule | CAS: 132173-07-0

Arylacenamide (SR31747) is a peripheral [sigma] ligand that binds four proteins in human cells, i.e. SRBP-1, [sigma]-2, HSI and its relative SRBP-2. It is a dual agent with both immunomodulatory and antiproliferative activities.

Kategori:
CycloparaffinsEnzyme InhibitorsImmunologic Factors +1
Target Protein:
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomeraseHCG20471, isoform CRA_c
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Arylomycin A2 DB01934
small molecule

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
Target Protein:
Signal peptidase I
Waktu Paruh-
Vol. Distribusi-
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Genetik -
AS-8112 DB09207
small molecule

AS-8112 is a synthetic compound that acts as a selective antagonist at the dopamine receptor subtypes D2 and D3, and the serotonin receptor 5-HT3. It has been shown to exert potent antiemetic effects in animal studies and has been investigated for potential m…

Kategori:
Dopamine AgentsDopamine AntagonistsDopamine D2 Receptor Antagonists +1
Target Protein:
D(2) dopamine receptorD(3) dopamine receptor5HT3 serotonin receptor
Waktu Paruh-
Vol. Distribusi-
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Genetik -
AS1409 DB05182
small molecule

AS1409 is a genetically engineered fusion protein made up of two distinct components. One is the cytokine IL12, which has anti-cancer activity. The other is an antibody that targets tumours. It is developed by Antisoma is in a phase I of clinical trial for th…

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Vol. Distribusi-
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ASC-618 DB18423
biotech

ASC-618 is a recombinant adeno-associated virus serotype 8 (rAAV2/8) vector expressing bioengineered B domain deleted liver-codon-optimized human factor VIII.

Waktu Paruh-
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ASC-JM-17 DB16931
small molecule | CAS: 1039760-91-2

Deskripsi belum tersedia.

Kategori:
AlkanesBenzene DerivativesCatechols +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Asciminib Approved DB12597
small molecule | CAS: 1492952-76-7

Asciminib is a tyrosine kinase inhibitor (TKI) used in the treatment of chronic-phase Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). More specifically, it is an inhibitor of the ABL1 kinase activity of the BCR-ABL1 fusion protein[L38995]…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBcr-Abl Tyrosine Kinase Inhibitors +26
Target Protein:
Tyrosine-protein kinase ABL1
Waktu ParuhThe terminal elimin…
Vol. DistribusiAt steady-state, th…
KlirensThe total apparent …
Genetik -
biotech

Deskripsi belum tersedia.

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Ascorbic acid Approved DB00126
small molecule | CAS: 50-81-7

A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functio…

Kategori:
Acids, AcyclicAlimentary Tract and MetabolismAntioxidants +20
Target Protein:
Solute carrier family 23 member 2Solute carrier family 23 member 1Hyaluronate lyase +23
Waktu Paruh16 days (3.4 hours …
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 129499-78-1

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicCarbohydratesHydroxy Acids +1
Waktu Paruh-
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Genetik -
Ascorbyl phosphate Approved DB11352
small molecule

Ascorbyl phosphate is a synthetic form of Vitamin C and is found in different salt forms such as magnesium ascorbyl phosphate and sodium ascorbyl phosphate. These salts are present in cosmetic products at concentrations ranging from 0.001 % to 3% [A27211]. As…

Kategori:
Acids, AcyclicCarbohydratesHydroxy Acids +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ascrinvacumab DB12261
biotech | CAS: 1463459-96-2

Ascrinvacumab has been used in trials studying the treatment and basic science of Neoplasms, Advanced Solid Tumors, Carcinoma, Hepatocellular, and Malignant Pleural Mesothelioma.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Asenapine Approved DB06216
small molecule | CAS: 65576-45-6

Developed by Schering-Plough after its merger with Organon International, asenapine is a sublingually administered, atypical antipsychotic for treatment of schizophrenia and acute mania associated with bipolar disorder. Asenapine also belongs to the dibenzo-o…

Kategori:
Acid ReducersAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +41
Target Protein:
5-hydroxytryptamine receptor 2AD(2) dopamine receptor5-hydroxytryptamine receptor 1A +17
Waktu Paruh24 hours (range of …
Vol. Distribusi20-25 L/kg
Klirens-
Genetik -
Asfotase alfa Approved DB09105
biotech | CAS: 1174277-80-5

Asfotase alfa is a first-in-class bone-targeted enzyme replacement therapy designed to address the underlying cause of hypophosphatasia (HPP)—deficient alkaline phosphatase (ALP). Hypophosphatasia is almost always fatal when severe skeletal disease is obvious…

Kategori:
Alimentary Tract and MetabolismAmino Acids, Peptides, and ProteinsAntibodies +16
Target Protein:
Pyrophosphate
Waktu ParuhApproximately 5 day…
Vol. Distribusi-
Klirens-
Genetik -
ASI402 DB06373
biotech | CAS: 372075-37-1

ASI402 is a monoclonal antibody that targets an aberrantly glycosylated antigen Mucin 1. It is being investigated in cancers.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Target Protein:
Mucin-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Asiatic acid DB14054
small molecule | CAS: 464-92-6

From Centella asiatica and other plants; shows a variety of bioactivities.

Kategori:
TerpenesTriterpenes
Target Protein:
Glycogen phosphorylase, muscle form
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Asiaticoside DB14081
small molecule | CAS: 16830-15-2

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsTerpenes
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Genetik -
Asimadoline DB05104
small molecule | CAS: 153205-46-0

Asimadoline is a proprietary small molecule therapeutic, originally discovered by Merck KGaA of Darmstadt, Germany. Asimadoline was originally developed to treat peripheral pain such as arthritis. Asimadoline is an orally administered agent that acts as a kap…

Kategori:
AcetatesAcids, AcyclicAmides
Target Protein:
Kappa-type opioid receptor
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Asm-024 cation DB19385
small molecule | CAS: 1609534-88-4

Asm-024 cation is under investigation in clinical trial NCT01855230 (Safety, Tolerability, and Clinical Activity of ASM-024 Administered to Patients With GOLD 2 or GOLD 3 Chronic Obstructive Pulmonary Disease (COPD)).

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Genetik -
Asoprisnil DB06680
small molecule | CAS: 199396-76-4

Asoprisnil (J867) is a selective progesterone receptor modulator. It can be used to treat progesterone sensitive myomata.

Kategori:
AminesEstranesFused-Ring Compounds +2
Target Protein:
Progesterone receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ASP-2138 DB18473
biotech

ASP-2138 is a bispecific antibody directed against CLDN18.2 and T cell receptor complex CD3

Waktu Paruh-
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ASP-3026 DB12729
small molecule | CAS: 1097917-15-1

ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Positive for Proto-Oncogene Tyrosine-Protein Kinase ROS.

Kategori:
Sulfur Compounds
Target Protein:
ALK tyrosine kinase receptor
Waktu Paruh-
Vol. Distribusi-
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Genetik -
ASP-4058 DB11819
small molecule | CAS: 952565-91-2

ASP4058 has been used in trials studying Food Effect of ASP4058 and Pharmacokinetics of ASP4058.

Kategori:
Heterocyclic Compounds, Fused-RingOxazoles
Target Protein:
Sphingosine 1-phosphate receptor 1Sphingosine 1-phosphate receptor 5
Waktu Paruh-
Vol. Distribusi-
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Genetik -
ASP-7317 DB18549
biotech

ASP-7317 consists of human embryonic stem cell-derived retinal pigment epithelium cells.

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ASP-8731 DB17696
small molecule | CAS: 2488255-42-9

ASP-8731 is a novel BACH1 inhibitor that potentially induces fetal hemoglobin (HbF). Developed by Mitobridge, it is being investigated for the treatment of sickle cell disease.[L46093]

Waktu Paruh-
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Aspacytarabine DB17226
small molecule | CAS: 2098942-53-9

Deskripsi belum tersedia.

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Genetik -
biotech | CAS: 1349719-22-7

Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cel…

Kategori:
AmidohydrolasesAntineoplastic AgentsAsparaginase +7
Waktu ParuhThe apparent half-l…
Vol. DistribusiThe volume of distr…
KlirensThe geometric mean …
Genetik -
biotech | CAS: 9015-68-3

Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate…

Kategori:
AmidohydrolasesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +7
Target Protein:
L-asparagine
Waktu ParuhPlasma half life of…
Vol. DistribusiApparent volume of …
Klirens-
Genetik -
Asparagine Approved DB00174
small molecule | CAS: 70-47-3

A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from aspartic acid and ammonia by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd …

Kategori:
Amino AcidsAmino Acids, BasicAmino Acids, Diamino +5
Target Protein:
Sodium-coupled neutral amino acid transportersNeutral amino acid transporter B(0)Asparagine synthetase [glutamine-hydrolyzing] +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Asparagus Approved DB10503
biotech

Asparagus allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aspartame DB00168
small molecule | CAS: 22839-47-0

Flavoring agent sweeter than sugar, metabolized as phenylalanine and aspartic acid.

Kategori:
Amino Acids, Peptides, and ProteinsCompounds used in a research, industrial, or household settingDiet, Food, and Nutrition +13
Target Protein:
Taste receptor type 1 member 3Taste receptor type 1 member 2Transient receptor potential cation channel subfamily V member 1
Waktu ParuhAt room temperature…
Vol. Distribusi-
Klirens-
Genetik -
Aspartic acid Approved DB00128
small molecule | CAS: 56-84-8

One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.

Kategori:
Amino AcidsAmino Acids, AcidicAmino Acids, Dicarboxylic +5
Target Protein:
Glutamate receptor ionotropic, NMDA 2AGlutamate receptor ionotropic, NMDA 2BGlutamate receptor ionotropic, NMDA 1 +18
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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