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3253

Total database: 17430
Struktur (SMILES)
2451 (75.3%)
Target
1833 (56.3%)
Genomik
35 (1.1%)
Referensi
3253 (100.0%)

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Hasil Pencarian (3253)

Halaman 51 / 66
Rabusertib DB11662
small molecule | CAS: 911222-45-2

Rabusertib has been used in trials studying the treatment of Cancer, Solid Tumors, Advanced Cancer, Pancreatic Neoplasms, and Non Small Cell Lung Cancer.

Kategori:
AmidesAntineoplastic AgentsBenzene Derivatives +1
Target Protein:
Serine/threonine-protein kinase Chk1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Racemetyrosine DB16306
small molecule | CAS: 658-48-0

Racemetyrosine is under investigation in clinical trial NCT03512756 (A Randomized Phase 2/3 Multi-center Study of SM-88 in Patients With Metastatic Pancreatic Cancer).

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Racepinephrine Approved DB11124
small molecule | CAS: 329-65-7

Racepinephrine is a racemic mixture consisting of d-[DB00668] and l-[DB00668] enantiomers. Epinephrine is a non-selective ?- and ?-adrenergic receptor agonist. It is a bronchodilator used in the temporary relief of mild symptoms of intermittent asthma includi…

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-1 Receptor Agonists +30
Target Protein:
Alpha-1A adrenergic receptorAlpha-1B adrenergic receptorAlpha-2A adrenergic receptor +6
Waktu ParuhTo refer to the pha…
Vol. DistribusiTo refer to the pha…
KlirensTo refer to the pha…
Genetik -
Racivir DB12753
small molecule | CAS: 143491-54-7

Racivir, also known as RCV, is an oxothiolane nucleoside reverse transcriptase inhibitor similar to emtricitabine and lamivudine. Racivir is a 50:50 mixture of [emtricitabine] and its positive enantiomer. Racivir has been used in trials studying the preventio…

Kategori:
Anti-Infective AgentsAntiviral AgentsDeoxycytidine +5
Target Protein:
Reverse transcriptase/RNaseH
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Raclopride DB12518
small molecule | CAS: 84225-95-6

Raclopride has been used in trials studying Parkinson Disease.

Kategori:
Acids, CarbocyclicAmidesAntipsychotic Agents +13
Target Protein:
Insulin receptorD(2) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Radalbuvir DB12065
small molecule | CAS: 1314795-11-3

Radalbuvir has been used in trials studying the treatment of Chronic Hepatitis C, Chronic HCV Infection, and Chronic Hepatitis C Infection.

Kategori:
Sulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Radavirsen DB15332
biotech | CAS: 1228284-45-4

Radavirsen is under investigation in clinical trial NCT01375985 (Safety Study of Single Administration Intravenous Treatment for Influenza).

Kategori:
Anti-Infective AgentsAntiviral AgentsMorpholines +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Radezolid DB12339
small molecule | CAS: 869884-78-6

Radezolid has been used in trials studying the treatment of Abscess, Bacterial Skin Diseases, Streptococcal Infections, Infectious Skin Diseases, and Staphylococcal Skin Infections, among others.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsOxazoles
Target Protein:
Ribosome-binding protein 150S ribosomal protein L1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Radicicol DB03758
small molecule | CAS: 12772-57-5

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsAntifungal AgentsAntiparasitic Agents +5
Target Protein:
Heat shock protein HSP 90-alphaHeat shock protein HSP 90-betaEndoplasmin +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Radiprodil DB12260
small molecule | CAS: 496054-87-6

Radiprodil has been used in trials studying the treatment of Infantile Spasms (IS) and Diabetic Peripheral Neuropathic Pain.

Kategori:
AcetatesAcids, AcyclicAmides
Target Protein:
Glutamate receptor ionotropic, NMDA 2B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Radium Ra-223 DB12813
small molecule | CAS: 15623-45-7

Radium 223 is under investigation in clinical trial NCT02463799 (Ph 2 Study of Sipuleucel-T W/ or W/O Radium-223 in Men With Asymptomatic or Minimally Symptomatic Bone-MCRPC).

Kategori:
ElementsElements, RadioactiveIsotopes +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Radotermin DB19127
biotech | CAS: 575458-75-2

Radotermin is under investigation in clinical trial NCT01182337 (A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal Rhgdf-5 for the Treatment of Early Stage Lumbar Disc Degeneration).

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Radotinib DB12323
small molecule | CAS: 926037-48-1

Radotinib is under investigation for the treatment of Leukemia, Myelogenous, Chronic, BCR-ABL Positive.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +2
Target Protein:
Tyrosine-protein kinase ABL1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Raffinose DB16839
small molecule | CAS: 512-69-6

Deskripsi belum tersedia.

Kategori:
CarbohydratesOligosaccharidesPolysaccharides +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ralinepag DB12462
small molecule | CAS: 1187856-49-0

Ralinepag has been used in trials studying the treatment of Pulmonary Arterial Hypertension.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +1
Target Protein:
Prostacyclin receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ralmitaront DB19128
small molecule | CAS: 2133417-13-5

Ralmitaront is under investigation in clinical trial NCT04512066 (A Trial of the Efficacy and the Safety of RO6889450 (Ralmitaront) vs Placebo in Patients With an Acute Exacerbation of Schizophrenia or Schizoaffective Disorder).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Raltegravir Approved DB06817
small molecule | CAS: 518048-05-0

Raltegravir is an antiretroviral drug produced by Merck & Co., used to treat HIV infection. It received approval by the U.S. Food and Drug Administration (FDA) on 12 October 2007, the first of a new class of HIV drugs, the integrase inhibitors, to receive suc…

Kategori:
Agents Causing Muscle ToxicityAnti-HIV AgentsAnti-Infective Agents +13
Target Protein:
Gag-Pol polyproteinIntegrase
Waktu Paruh9 hours
Vol. DistribusiApproximately 83% b…
KlirensThe major mechanism…
Genetik -
Raltitrexed Approved DB00293
small molecule | CAS: 112887-68-0

Raltitrexed (brand name Tomudex®) is a chemotherapy drug manufactured AstraZeneca Company, is an antimetabolite used in chemotherapy. It is an inhibitor of thymidylate synthase.

Kategori:
AntimetabolitesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +11
Target Protein:
Thymidylate synthaseThymidylate synthaseFolylpolyglutamate synthase, mitochondrial
Waktu Paruh198 hours
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 2610074-57-0

Raludotatug deruxtecan is under investigation in clinical trial NCT06660654 (A Study of Raludotatug Deruxtecan in Participants With Advanced/metastatic Solid Tumors (Rejoice-pantumor01)).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Raluridine DB12894
small molecule | CAS: 119644-22-3

Raluridine has been used in trials studying the treatment of HIV Infections.

Kategori:
DeoxyribonucleosidesNucleic Acids, Nucleotides, and NucleosidesNucleosides
Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ranibizumab Approved DB01270
biotech | CAS: 347396-82-1

Ranibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment directed against human vascular endothelial growth factor A (VEGF-A), which is a glycoprotein implicated in the pathophysiology of age-related macular degeneration.[A2301, …

Kategori:
Amino Acids, Peptides, and ProteinsAngiogenesis InhibitorsAngiogenesis Modulating Agents +19
Target Protein:
Vascular endothelial growth factor A, long form
Waktu ParuhThe estimated avera…
Vol. DistribusiThe apparent volume…
KlirensIn patients with re…
Genetik -
RAV12 DB05140
biotech

RAV12 is investigated for use/treatment in solid tumors. RAV12 is a solid. RAV12 is a chimeric antibody that recognizes RAAG12, an N-linked carbohydrate antigen found on gastric, colon, pancreatic, prostate, ovarian, breast, and kidney cancer cells.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ravidasvir DB15652
small molecule | CAS: 1242087-93-9

Ravidasvir is under investigation in clinical trial NCT02961426 (Sofosbuvir Plus Ravidasvir for the Treatment of HCV Chronic Infection).

Kategori:
Amino AcidsAmino Acids, Branched-ChainAmino Acids, Peptides, and Proteins +6
Target Protein:
Genome polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Raxibacumab Approved DB08902
biotech | CAS: 565451-13-0

Raxibacumab is a human IgG1? monoclonal antibody that binds the protective antigen (PA) component of B. anthracis toxin. Raxibacumab has a molecular weight of approximately 146 kilodaltons. Raxibacumab is produced by recombinant DNA technology in a murine cel…

Kategori:
Amino Acids, Peptides, and ProteinsAnthrax Protective Antigen-directed AntibodyAnthrax Protective Antigen-directed Antibody Interactions +12
Target Protein:
Protective antigen
Waktu ParuhMean terminal elimi…
Vol. DistribusiSteady state volume…
KlirensClearance values we…
Genetik -
Razupenem DB12587
small molecule | CAS: 426253-04-5

Razupenem has been used in trials studying the treatment of Skin Infections.

Kategori:
Amidesbeta-LactamsHeterocyclic Compounds, Fused-Ring +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Recanaclotide DB15417
biotech | CAS: 1667762-62-0

Recanaclotide is under investigation in clinical trial NCT01712412 (Phase 2a Study of IW-9179 to Treat Functional Dyspepsia).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Recaticimab DB19302
biotech | CAS: 2361290-85-7

Recaticimab is under investigation in clinical trial NCT06467617 (Adebrelimab Plus Chemo and Recaticimab Perioperative Treatment for Resectable NSCLC).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Recoflavone DB12058
small molecule | CAS: 203191-10-0

Recoflavone has been used in trials studying the treatment of Acute Gastritis, Dry Eye Syndrome, and Chronic Gastritis.

Kategori:
BenzopyransChromonesHeterocyclic Compounds, Fused-Ring +1
Target Protein:
Nuclear factor NF-kappa-B p105 subunitTranscription factor RelBNuclear factor NF-kappa-B p100 subunit +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 122320-05-2

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsEnzyme InhibitorsPeptides +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Redaporfin DB17219
small molecule | CAS: 1224104-08-8

Deskripsi belum tersedia.

Kategori:
AmidesBiological FactorsHeterocyclic Compounds, Fused-Ring +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Redasemtide DB19121
biotech | CAS: 1606186-88-2

Redasemtide is under investigation in clinical trial NCT05953480 (A Phase 2b, Randomized, Double-blind Study of Redasemtide (S-005151) in Adult Participants With Acute Ischemic Stroke).

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Refanezumab DB14908
biotech | CAS: 1233953-61-1

Refanezumab is under investigation in clinical trial NCT00833989 (Safety Escalating Repeat IV, in Stroke Patients).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Regorafenib Approved DB08896
small molecule | CAS: 755037-03-7

Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Reg…

Kategori:
AmidesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +31
Target Protein:
Vascular endothelial growth factor receptor 1Vascular endothelial growth factor receptor 2Vascular endothelial growth factor receptor 3 +15
Waktu ParuhRegorafenib, 160 mg…
Vol. DistribusiRegorafenib undergo…
Klirens-
Genetik -
Regramostim DB05386
biotech | CAS: 127757-91-9

Regramostim (GM-CSF) is a differentially glycosylated factor produced mainly by activated T cells and macrophages. Endothelial cells and fibroblasts can also produce GM-CSF after exposure to TNF-?, IL-1, IL-2 and IFN-?. GM-CSF is found associated with extrace…

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsCarbohydrates +10
Target Protein:
Granulocyte-macrophage colony-stimulating factor receptor subunit alphaGM-CSF receptor alpha subunit
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Serine/threonine-protein kinase Chk1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Relacorilant DB14976
small molecule | CAS: 1496510-51-0

Relacorilant is under investigation in clinical trial NCT02804750 (Study to Evaluate CORT125134 in Patients With Cushing's Syndrome).

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Glucocorticoid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Relamorelin DB12678
small molecule | CAS: 661472-41-9

Relamorelin has been investigated for the treatment and basic science of Gastroparesis, Gastric Motility, Diabetes Mellitus, Parkinson's Disease, and Chronic Constipation, among others.

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Relatlimab Approved DB14851
biotech | CAS: 1673516-98-7

Relatlimab is a human IgG4 monoclonal antibody and novel immune checkpoint inhibitor that targets lymphocyte activation gene-3 (LAG-3).[A246165,L41265] It was the first commercially developed anti-LAG-3 antibody, entering clinical trials in 2013,[A246155] and…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +12
Target Protein:
Lymphocyte activation gene 3 protein
Waktu ParuhThe geometric mean …
Vol. DistribusiThe geometric mean …
KlirensAt steady-state, th…
Genetik -
Reldesemtiv DB15256
small molecule | CAS: 1345410-31-2

Reldesemtiv is under investigation in clinical trial NCT03160898 (A Study to Evaluate Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS)).

Target Protein:
Troponin C, skeletal muscle
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Relebactam Approved DB12377
small molecule | CAS: 1174018-99-5

Relebactam is a diazabicyclooctane beta-lactamase inhibitor, similar in structure to [avibactam].[A181195,A181207] It includes a piperidine ring which reduces export from bacterial cells by producing a positive charge.[A181207] It is currently available in a …

Kategori:
Antibacterials for Systemic UseAntiinfectives for Systemic UseAza Compounds +6
Target Protein:
Beta-lactamaseBeta-lactamase TEMBeta-lactamase SHV-1 +3
Waktu ParuhRelebactam has a ha…
Vol. DistribusiRelebactam has a vo…
KlirensRelebactam has a re…
Genetik -
Relenopride DB12798
small molecule | CAS: 1221416-43-8

Relenopride has been used in trials studying the treatment of Chronic Idiopathic Constipation.

Kategori:
Acids, AcyclicAcids, CarbocyclicAmides +2
Target Protein:
5-hydroxytryptamine receptor 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Remacemide DB06458
small molecule | CAS: 128298-28-2

Deskripsi belum tersedia.

Kategori:
AcetatesAcids, AcyclicAmides +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Remdesivir Approved DB14761
small molecule | CAS: 1809249-37-3

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-…

Kategori:
Adenine NucleotidesAmino AcidsAmino Acids, Peptides, and Proteins +37
Target Protein:
Replicase polyprotein 1abReplicase polyprotein 1abReplicase polyprotein 1ab +1
Waktu ParuhRemdesivir has an e…
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
Remestemcel-L Approved DB13973
biotech

Remestemcel-L is a third-party, off-the-shelf suspension of ex-vivo cultured adult human mesenchymal stem cells intended for intravenous infusion. The mesenchymal stem cells are derived from the bone marrow of unrelated and human leukocyte antigen (HLA)–unmat…

Kategori:
Anti-Infective AgentsAnti-Inflammatory AgentsAntiviral Agents +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Remikiren DB00212
small molecule | CAS: 126222-34-2

Remikiren is an orally active, high specificity renin inhibitor.

Kategori:
Agents Acting on the Renin-Angiotensin SystemAntihypertensive AgentsCardiovascular Agents +3
Target Protein:
Renin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Remimazolam Approved DB12404
small molecule | CAS: 308242-62-8

Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures.[L14647] Recent trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these…

Kategori:
BenzazepinesBenzodiazepine hypnotics and sedativesBenzodiazepines and benzodiazepine derivatives +8
Target Protein:
Gamma-aminobutyric acid receptor subunit gamma-3GABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu ParuhFollowing intraveno…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of re…
Genetik -
small molecule | CAS: 442201-24-3

Remogliflozin etabonate has been used in trials studying the treatment and basic science of Type 2 Diabetes Mellitus and Diabetes Mellitus, Type 2.

Kategori:
Blood Glucose Lowering AgentsCarbohydratesGlycosides +1
Target Protein:
Sodium/glucose cotransporter 2Probable glucose sensor protein SLC5A4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Remoxipride Approved DB00409
small molecule | CAS: 80125-14-0

Remoxipride is an atypical antipsychotic agent that is specific for dopamine D<sub>2</sub> receptors.[A215422] It gained approval in the UK in 1989 but was withdrawn in 1993 after it was found to be associated with an increased incidence of aplastic anemia.[A…

Kategori:
Acids, CarbocyclicAmidesAntipsychotic Agents +21
Target Protein:
D(2) dopamine receptorD(4) dopamine receptorD(3) dopamine receptor +2
Waktu ParuhThe half life of re…
Vol. DistribusiThe volume of distr…
KlirensThe renal clearance…
Genetik -
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