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15718

Total database: 17430
Struktur (SMILES)
10762 (68.5%)
Target
7957 (50.6%)
Genomik
112 (0.7%)
Referensi
15718 (100.0%)

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Hasil Pencarian (15718)

Halaman 50 / 315
ALM201 DB17206
biotech

ALM201 is an anti-angiogenic synthetic peptide identified from the endogenous human protein, FKBPL. It is being investigated in the treatment of various cancers.[A254556]

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Almasilate Approved DB13595
small molecule | CAS: 71205-22-6

Almasilate is a buffering antacid that has been used in peptic ulcers and dyspepsia. It is a crystalline polyhydrate of aluminium/magnesium silicate and mediates its buffering activity by binding hydrogen ions within the polymer. However its therapeutic effic…

Kategori:
Alimentary Tract and MetabolismAluminum and magnesium containing antacidsAntacids +6
Waktu ParuhReadily accessible …
Vol. DistribusiThe distribution of…
KlirensReadily accessible …
Genetik -
ALMB-0166 DB17937
biotech

ALMB-0166 is a umanized connexin 43 (Cx43) monoclonal antibody being investigated for the treatment of acute spinal cord injury. It was granted FDA orphan designation in November 2018.[L47067]

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ALMB-0168 DB16926
biotech

ALMB-0168 is a humanized connexin 43 (Cx43) monoclonal antibody being investigated for osteosarcoma.

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Alminoprofen DB13314
small molecule | CAS: 39718-89-3

Alminoprofen is a non-steroidal anti-inflammatory drug (NSAID) whose physiochemical characteristics make it a member of the phenylpropionic acid class of chemical substances.

Kategori:
Acids, AcyclicAgents causing hyperkalemiaAgents that produce hypertension +16
Waktu Paruh-
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Almitrine Approved DB01430
small molecule | CAS: 27469-53-0

Almitrine is a respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. It is used in the treatment of chronic obstructive pulmonary disease. It is also reported to have a potentially …

Kategori:
AlkaloidsCentral Nervous System AgentsCompounds used in a research, industrial, or household setting +12
Target Protein:
Sodium/potassium-transporting ATPase subunit alpha-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Almond Approved DB10500
biotech

Almond allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Almonertinib DB16640
small molecule | CAS: 1899921-05-1

Almonertinib is a third-generation EGFR tyrosine kinase inhibitor targeting EGFR-sensitizing and T790M resistance mutations.[A231859, A231864, A231869] It is being investigated against advanced or metastatic EGFR-mutated non-small cell lung cancer (NSCLC).[A2…

Kategori:
Acids, AcyclicAcrylatesAmides +1
Target Protein:
Epidermal growth factor receptorReceptor protein-tyrosine kinase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Almorexant DB06673
small molecule | CAS: 871224-64-5

Deskripsi belum tersedia.

Kategori:
AcetatesAcids, AcyclicAmides +1
Target Protein:
Orexin/Hypocretin receptor type 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Almotriptan Approved DB00918
small molecule | CAS: 154323-57-6

Almotriptan is a triptan drug for the treatment of migraine headaches. Almotriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain,…

Kategori:
Agents that produce hypertensionAminesAnalgesics +30
Target Protein:
5-hydroxytryptamine receptor 1D5-hydroxytryptamine receptor 1B
Gen Terkait:
GNB3
Waktu Paruh3-4 hours
Vol. Distribusi* 180 to 200 L
Klirens* 57 L/h [healthy] …
Genetik 1 Varian
Alnuctamab DB17194
biotech | CAS: 2296827-07-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Alnus glutinosa DB15904
biotech

Deskripsi belum tersedia.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Alnus incana subsp. rugosa pollen is the pollen of the Alnus incana subsp. rugosa plant. Alnus incana subsp. rugosa pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
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Alnus rhombifolia pollen Approved DB10722
biotech

Alnus rhombifolia pollen is the pollen of the Alnus rhombifolia plant. Alnus rhombifolia pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
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Klirens-
Genetik -
Alnus rubra pollen Approved DB10721
biotech

Alnus rubra pollen is the pollen of the Alnus rubra plant. Alnus rubra pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Alnus serrulata pollen Approved DB15509
biotech

Alnus serrulata pollen allergenic extract is used in allergenic testing.

Waktu Paruh-
Vol. Distribusi-
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Alobresib DB14970
small molecule | CAS: 1637771-14-2

Alobresib is under investigation in clinical trial NCT02607228 (Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GS-5829 as a Single Agent and In Combination With Enzalutamide in Participants With Metastatic Castrate-Resistant Prostate Cancer).

Waktu Paruh-
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Aloe ferox leaf Approved DB14257
biotech

Aloe ferox leaf is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

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Aloe vera flower Approved DB14254
biotech

Aloe vera flower is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
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Aloe vera leaf DB13906
biotech | CAS: 8001-97-6

Aloe describes a genus including over 500 species of flowering succulent plants that grow in the Southern peninsula and various islands. Aloe vera, or _Aloe barbadensis miller_, is the most common species of Aloe that is cultivated for agricultural and medica…

Target Protein:
Free radicals
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Alogabat DB18708
small molecule | CAS: 2230009-48-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Alogliptin Approved DB06203
small molecule | CAS: 850649-61-5

Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conve…

Kategori:
Agents causing angioedemaAlimentary Tract and MetabolismBlood Glucose Lowering Agents +15
Target Protein:
Dipeptidyl peptidase 4
Waktu ParuhTerminal half-life …
Vol. DistribusiFollowing a single,…
KlirensRenal clearance = 9…
Genetik -
Aloglutamol DB13650
small molecule | CAS: 13755-41-4

Aloglutamol is an antacid salt of aluminium, gluconic acid, and tris. Proprietary names include Altris, Pyreses, Tasto and Sabro.

Kategori:
AlcoholsAlimentary Tract and MetabolismAlkalies +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Alomfilimab DB16681
biotech | CAS: 2378692-24-9

Alomfilimab is under investigation in clinical trial NCT03829501 (Safety and Efficacy of KY1044 and Atezolizumab in Advanced Cancer).

Waktu Paruh-
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Alosetron Approved DB00969
small molecule | CAS: 122852-42-0

Alosetron is a 5-HT3 antagonist used only for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women. Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal (GI) pro…

Kategori:
Alimentary Tract and MetabolismAntidepressive AgentsAntiemetic Serotonin 5-HT3 Receptor Antagonists +23
Target Protein:
5-hydroxytryptamine receptor 3A
Waktu Paruh1.5 hours
Vol. Distribusi* 65 to 95 L
Klirens* 600 mL/min
Genetik -
Alovudine DB06198
small molecule | CAS: 25526-93-6

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsAntiviral AgentsDeoxyribonucleosides +3
Target Protein:
Gag-Pol polyproteinReverse transcriptase/RNaseH
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Alovudine F-18 DB14930
small molecule | CAS: 287114-80-1

Alovudine F-18 is under investigation in clinical trial NCT02819024 (Dexamethasone Effects in Patients With Refractory Non-Small Cell Lung Cancer Using FLT Positron Emission Tomography).

Kategori:
Anti-Infective AgentsAntiviral AgentsDeoxyribonucleosides +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aloxiprin DB13509
small molecule | CAS: 9014-67-9

Deskripsi belum tersedia.

Kategori:
AnalgesicsBenzene DerivativesBlood and Blood Forming Organs +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aloxistatin DB18145
small molecule | CAS: 88321-09-9

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, Branched-ChainAmino Acids, Essential +6
Target Protein:
Calpain-2 catalytic subunitCathepsin G
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Alpelisib Approved DB12015
small molecule | CAS: 1217486-61-7

Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110? [A179203], which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological proce…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 Inhibitors +32
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Waktu ParuhThe mean half life …
Vol. DistribusiThe apparent volume…
KlirensThe mean apparent o…
Genetik -
small molecule | CAS: 514-12-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 71018-10-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 7292-42-4

Deskripsi belum tersedia.

Kategori:
Adenine NucleotidesAntineoplastic AgentsHeterocyclic Compounds, Fused-Ring +5
Target Protein:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinasePantothenate synthetaseNH(3)-dependent NAD(+) synthetase +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Alpha-1-proteinase inhibitor Approved DB00058
biotech | CAS: 9041-92-3

Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation.

Kategori:
Acute-Phase ProteinsAlpha-GlobulinsAmino Acids, Peptides, and Proteins +21
Target Protein:
Neutrophil elastase
Waktu Paruh-
Vol. Distribusi* 5632 ± 2006 mL [A…
Klirens* 940 +/- 275 mL/da…
Genetik -
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
alpha-Amyl cinnamaldehyde Approved DB14175
small molecule | CAS: 122-40-7

alpha-Amyl cinnamaldehyde has a jasmine-like odor and is a widely used synthetic fragrance & suspected allergen. It is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleasePerfume +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
alpha-Arbutin Approved DB14109
small molecule | CAS: 84380-01-8

Deskripsi belum tersedia.

Target Protein:
Lysosomal alpha-glucosidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
alpha-Carotene DB15909
small molecule | CAS: 7488-99-5

Deskripsi belum tersedia.

Kategori:
AlkenesBiological FactorsCyclohexanes +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 467428-30-4

Deskripsi belum tersedia.

Kategori:
Biological FactorsComplex MixturesMarine Toxins +3
Target Protein:
Neuronal acetylcholine receptor subunit alpha-10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 10016-20-3

Deskripsi belum tersedia.

Target Protein:
Cyclomaltodextrin glucanotransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 37388-49-1

Deskripsi belum tersedia.

Target Protein:
Ribokinase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 6189-71-5

Deskripsi belum tersedia.

Target Protein:
LactotransferrinL-arabinose-binding periplasmic protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 2255-14-3

Deskripsi belum tersedia.

Target Protein:
Beta-phosphoglucomutase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 6294-16-2

The ?-anomer of D-galacturonic acid.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 58825-13-1

Deskripsi belum tersedia.

Target Protein:
Glycogen phosphorylase, muscle form
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 10139-18-1

Deskripsi belum tersedia.

Target Protein:
Beta-phosphoglucomutasePhosphoglucomutase-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 15209-11-7

Deskripsi belum tersedia.

Target Protein:
Aldo-keto reductase family 1 member B1Glycogen phosphorylase, muscle formGlutamine--fructose-6-phosphate aminotransferase [isomerizing] +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 59-56-3

Deskripsi belum tersedia.

Kategori:
CarbohydratesHexosephosphatesSugar Phosphates
Target Protein:
Glycogen phosphorylase, muscle formPhosphomannomutase/phosphoglucomutaseMaltodextrin phosphorylase +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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