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208

Total database: 17430
Struktur (SMILES)
175 (84.1%)
Target
165 (79.3%)
Genomik
10 (4.8%)
Referensi
208 (100.0%)

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Hasil Pencarian (208)

Halaman 5 / 5
Umifenovir DB13609
small molecule | CAS: 131707-25-0

Umifenovir is an indole-based, hydrophobic, dual-acting direct antiviral/host-targeting agent used for the treatment and prophylaxis of influenza and other respiratory infections.[A191475] It has been in use in Russia for approximately 25 years and in China s…

Kategori:
AnionsAntiinfectives for Systemic UseAntiviral Agents +19
Waktu ParuhThe half-life of um…
Vol. DistribusiData regarding the …
KlirensIn a study involvin…
Genetik -
Uridine triacetate Approved DB09144
small molecule | CAS: 4105-38-8

Uridine triacetate, formerly known as vistonuridine, is an orally active prodrug of the naturally occurring nucleoside uridine. It is used for the treatment of hereditary orotic aciduria (Xuriden), or for the emergency treatment of fluorouracil or capecitabin…

Kategori:
Acids, AcyclicAlimentary Tract and MetabolismFatty Acids +9
Waktu Paruh2 to 2.5 hours
Vol. DistribusiCirculating uridine…
Klirens-
Genetik -
Valsartan Approved DB00177
small molecule | CAS: 137862-53-4

Valsartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes [telmisartan], [candesartan], [losartan], [olmesartan], and [irbesartan]. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiote…

Kategori:
Agents Acting on the Renin-Angiotensin SystemAgents causing angioedemaAgents causing hyperkalemia +22
Target Protein:
Type-1 angiotensin II receptor
Waktu ParuhAfter intravenous (…
Vol. DistribusiThe steady-state vo…
KlirensFollowing intraveno…
Genetik -
Vardenafil Approved DB00862
small molecule | CAS: 224785-90-4

Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from n…

Kategori:
Cardiovascular AgentsCytochrome P-450 CYP2C19 InhibitorsCytochrome P-450 CYP2C19 Inhibitors (weak) +30
Target Protein:
cGMP-specific 3',5'-cyclic phosphodiesteraseRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaRetinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Waktu ParuhVardenafil and its …
Vol. DistribusiVardenafil has a st…
KlirensVardenafil has a to…
Genetik -
Vericiguat Approved DB15456
small molecule | CAS: 1350653-20-1

Vericiguat is a direct stimulator of soluble guanylate cyclase (sGC) used in the management of systolic heart failure to reduce mortality and hospitalizations.[L31153] A key component of the NO-sGC-cGMP signaling pathway that helps to regulate the cardiovascu…

Kategori:
BCRP/ABCG2 SubstratesCardiac TherapyGuanylate Cyclase Stimulators +8
Target Protein:
Retinal guanylyl cyclase 1Guanylate cyclase soluble subunit beta-1
Waktu ParuhIn patients with he…
Vol. DistribusiIn healthy subjects…
KlirensVericiguat is a low…
Genetik -
Viomycin Approved DB06827
small molecule | CAS: 32988-50-4

Viomycin is a tuberactinomycin antibiotic that was used to treat Mycobacterium tuberculosis until it was replaced by the less toxic capreomycin. These drugs bind RNA in bacterial ribosomes and inhibit protein synthesis. Viomycin was derived from the actinomyc…

Kategori:
Agents that produce neuromuscular block (indirect)Amino Acids, Peptides, and ProteinsAnti-Bacterial Agents +8
Target Protein:
16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Warfarin Approved DB00682
small molecule | CAS: 81-81-2

Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in Nort…

Kategori:
4-HydroxycoumarinsAgrochemicalsAnticoagulants +38
Target Protein:
Vitamin K epoxide reductase complex subunit 1Nuclear receptor subfamily 1 group I member 2
Gen Terkait:
CYP2C9 VKORC1 CYP4F2 +2
Waktu ParuhR-warfarin is clear…
Vol. DistribusiVd of 0.14 L/kg.[la…
KlirensClearance of warfar…
Genetik 5 Varian
Zinc Approved DB01593
small molecule | CAS: 7440-66-6

A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with…

Kategori:
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical UseDiet, Food, and NutritionElements +12
Target Protein:
B1 bradykinin receptorMethylated-DNA--protein-cysteine methyltransferaseFructose-bisphosphate aldolase A +121
Waktu ParuhThe half-life of zi…
Vol. DistribusiA pharmacokinetic s…
KlirensIn one study of hea…
Genetik -
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