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506

Total database: 17430
Struktur (SMILES)
477 (94.3%)
Target
400 (79.1%)
Genomik
2 (0.4%)
Referensi
506 (100.0%)

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Hasil Pencarian (506)

Halaman 5 / 11
Clodronic acid Approved DB00720
small molecule | CAS: 10596-23-3

Clodronic acid is a first generation bisphosphonate similar to [etidronic acid] and [tiludronic acid].[A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification.[A1923] clodronate’s use has decr…

Kategori:
BisphosphonatesBone Density Conservation AgentsDrugs Affecting Bone Structure and Mineralization +4
Target Protein:
HydroxylapatiteADP/ATP translocase 1ADP/ATP translocase 2 +1
Waktu ParuhThe mean plasma hal…
Vol. Distribusi-
KlirensThe renal clearance…
Genetik -
Cocarboxylase Approved DB01987
small molecule | CAS: 136-08-3

The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.

Kategori:
CoenzymesEnzymes and CoenzymesMicronutrients +5
Target Protein:
RNAAcetolactate synthase, catabolicPyruvate dehydrogenase E1 component +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 73-04-1

Deskripsi belum tersedia.

Kategori:
Adenine NucleotidesDeoxyribonucleotidesHeterocyclic Compounds, Fused-Ring +4
Target Protein:
Poly(A) polymerase alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Coumaphos DB11390
small molecule | CAS: 56-72-4

This drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a _dip_ or _wash_. Coumaphos is widely used for both farm and domestic animals to control ticks, …

Kategori:
AgrochemicalsAnthelminticsAnti-Infective Agents +22
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 6453-60-7

Deskripsi belum tersedia.

Kategori:
DeoxyribonucleotidesNucleic Acids, Nucleotides, and NucleosidesNucleotides +3
Target Protein:
5'(3')-deoxyribonucleotidase, mitochondrial
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 60-92-4

Cyclic adenosine monophosphate (cAMP, cyclic AMP or 3'-5'-cyclic adenosine monophosphate) is a molecule that is important in many biological processes; it is derived from adenosine triphosphate (ATP).

Kategori:
Adenine NucleotidesCyclic AMPHeterocyclic Compounds, Fused-Ring +8
Target Protein:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2cAMP-dependent protein kinase type I-alpha regulatory subunitcAMP-dependent protein kinase type II-beta regulatory subunit +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cyclic GMP DB02315
small molecule | CAS: 7665-99-8

Cyclic guanosine monophosphate (Cyclic GMP) is a guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger…

Kategori:
Guanine NucleotidesHeterocyclic Compounds, Fused-RingNucleic Acids, Nucleotides, and Nucleosides +5
Target Protein:
cGMP-dependent 3',5'-cyclic phosphodiesterasePotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2cAMP-dependent protein kinase type I-alpha regulatory subunit
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cythioate DB11392
small molecule | CAS: 115-93-5

Cythioate is a member of the organothiophosphate compounds that is used as an insecticide and anthelmintic. It is mainly used in veterinary as a treatment for fleas.

Kategori:
AgrochemicalsCompounds used in a research, industrial, or household settingInsecticides +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 84-52-6

Deskripsi belum tersedia.

Kategori:
Cytosine NucleotidesNucleic Acids, Nucleotides, and NucleosidesNucleotides +3
Target Protein:
Ribonuclease pancreatic
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 63-38-7

Cytidine 5'-(trihydrogen diphosphate). A cytosine nucleotide containing two phosphate groups esterified to the sugar moiety. Synonyms: CRPP; cytidine pyrophosphate. [PubChem]

Target Protein:
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase3-deoxy-manno-octulosonate cytidylyltransferase2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 63-37-6

A pyrimidine ribonucleoside 5'-monophosphate having cytosine as the nucleobase.

Kategori:
Cytosine NucleotidesNucleic Acids, Nucleotides, and NucleosidesNucleotides +3
Target Protein:
Uridine-cytidine kinase 23-deoxy-manno-octulosonate cytidylyltransferase2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

A nucleoside monophosphate sugar which donates N-acetylneuraminic acid to the terminal sugar of a ganglioside or glycoprotein. [PubChem]

Target Protein:
N-acylneuraminate cytidylyltransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 65-47-4

Cytidine 5'-(tetrahydrogen triphosphate). A cytosine nucleotide containing three phosphate groups esterified to the sugar moiety. [PubChem]

Target Protein:
P2Y purinoceptor 43-deoxy-manno-octulosonate cytidylyltransferaseUridine-cytidine kinase 2 +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 585-18-2

Deskripsi belum tersedia.

Target Protein:
2-dehydro-3-deoxyphosphooctonate aldolaseGlucose-6-phosphate isomerasePhospho-2-dehydro-3-deoxyheptonate aldolase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 20479-58-7

Deskripsi belum tersedia.

Kategori:
CarbohydratesSugar Phosphates
Target Protein:
Glucose-6-phosphate isomerase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 591-57-1

An aldotriose which is an important intermediate in glycolysis and in tryptophan biosynthesis.

Target Protein:
Glyceraldehyde-3-phosphate dehydrogenase AGlyceraldehyde-3-phosphate dehydrogenaseNADP-dependent glyceraldehyde-3-phosphate dehydrogenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Phosphoheptose isomerase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 27251-84-9

Deskripsi belum tersedia.

Kategori:
CarbohydratesHexosephosphatesSugar Phosphates
Target Protein:
Phosphomannomutase/phosphoglucomutase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 47055-78-7

Deskripsi belum tersedia.

Target Protein:
Type II inositol 1,4,5-trisphosphate 5-phosphatase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 2226-71-3

Deskripsi belum tersedia.

Kategori:
Sulfhydryl CompoundsSulfur Compounds
Target Protein:
Phosphopantetheine adenylyltransferasePhosphopantetheine adenylyltransferasePhosphopantetheine adenylyltransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
2,2-dialkylglycine decarboxylaseAlanine racemaseUDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
dATP DB03222
small molecule | CAS: 1927-31-7

Deskripsi belum tersedia.

Kategori:
Adenine NucleotidesDeoxyribonucleotidesHeterocyclic Compounds, Fused-Ring +4
Target Protein:
P2Y purinoceptor 11Anaerobic ribonucleoside-triphosphate reductaseProtein RecA +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 964-26-1

Deskripsi belum tersedia.

Kategori:
DeoxyribonucleotidesNucleic Acids, Nucleotides, and NucleosidesNucleotides +3
Target Protein:
Thymidylate synthaseDeoxyuridine 5'-triphosphate nucleotidohydrolaseThymidylate synthase +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrialDeoxyuridine 5'-triphosphate nucleotidohydrolaseDeoxyuridine 5'-triphosphate nucleotidohydrolase +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Septum formation protein MafPol polyproteinDeoxycytidine triphosphate deaminase +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 94087-98-6

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dexamethasone acetate Approved DB14649
small molecule | CAS: 1177-87-3

Commonly known as decadron, dexamethasone acetate is a glucocorticosteroid previously marketed in the USA for the treatment of inflammatory respiratory, allergic, autoimmune, and other conditions.[T797,L10695,L14348] Developed in 1957, dexamethasone is struct…

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsBCRP/ABCG2 Inhibitors +38
Target Protein:
Glucocorticoid receptorAnnexin A1Nitric oxide synthase, inducible +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dexfosfoserine DB04522
small molecule | CAS: 407-41-0

The phosphoric acid ester of serine.

Kategori:
Amino AcidsAmino Acids, NeutralAmino Acids, Peptides, and Proteins +1
Target Protein:
3-phosphoinositide-dependent protein kinase 1Glycogen phosphorylase, muscle formProtein kinase C theta type +18
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dichlorvos DB11397
small molecule | CAS: 62-73-7

Dichlorvos or 2,2-dichlorovinyl dimethyl phosphate is a drug of the _organophosphate_ class, frequently used as an insecticide for the control of indoor pests and for the protection of stored products from insect infestations. The compound has been available…

Kategori:
AgrochemicalsAnthelminticsAnti-Infective Agents +13
Target Protein:
SerotransferrinCholinesterase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Didanosine Approved DB00900
small molecule | CAS: 69655-05-6

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a…

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +24
Target Protein:
Reverse transcriptase/RNaseHGag-Pol polyproteinPurine nucleoside phosphorylase
Waktu Paruh30 minutes in plasm…
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Phosphotriesterase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
mRNA-capping enzyme
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 29505-79-1

Deskripsi belum tersedia.

Target Protein:
L-xylulose reductasePhosphate-binding protein PstS
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 96-26-4

A ketotriose compound. Its addition to blood preservation solutions results in better maintenance of 2,3-diphosphoglycerate levels during storage. It is readily phosphorylated to dihydroxyacetone phosphate by triokinase in erythrocytes. In combination with na…

Kategori:
CarbohydratesKetosesMonosaccharides +1
Target Protein:
Dihydroxyacetone kinase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 57-04-5

Dihydroxyacetone phosphate is an important intermediate in lipid biosynthesis and in glycolysis. Dihydroxyacetone phosphate has been investigated for the treatment of Lymphoma, Large-Cell, Diffuse.

Kategori:
CarbohydratesSugar Phosphates
Target Protein:
Fructose-bisphosphate aldolase ATriosephosphate isomeraseFructose-bisphosphate aldolase B +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Phosphotriesterase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 358-72-5

Deskripsi belum tersedia.

Kategori:
Terpenes
Target Protein:
Farnesyl pyrophosphate synthaseIsopentenyl-diphosphate Delta-isomerase 14-hydroxy-3-methylbut-2-enyl diphosphate reductase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Adenylate dimethylallyltransferasetRNA dimethylallyltransferaseFarnesyl diphosphate synthase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dipotassium phosphate Approved DB09414
small molecule | CAS: 7758-11-4

Dipotassium phosphate (K2HPO4) is a highly water-soluble salt often used as a fertilizer and food additive as a source of phosphorus and potassium as well as a buffering agent.

Kategori:
AcidsAcids, NoncarboxylicAnions +14
Waktu ParuhIn healthy children…
Vol. DistribusiDistribution is lar…
KlirensPhosphates are rapi…
Genetik -
Erlotinib Approved DB00530
small molecule | CAS: 183321-74-6

Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. E…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 Inhibitors +33
Target Protein:
Nuclear receptor subfamily 1 group I member 2Epidermal growth factor receptor
Gen Terkait:
EGFR EGFR EGFR
Waktu ParuhMedian half-life of…
Vol. DistribusiApparent volume of …
KlirensSmokers have a 24% …
Genetik 3 Varian
Estramustine Approved DB01196
small molecule | CAS: 2998-57-4

A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.

Kategori:
Alkylating ActivityAlkylating DrugsAntineoplastic Agents +18
Target Protein:
Estrogen receptor betaEstrogen receptorMicrotubule-associated protein 2 +1
Waktu Paruh20 hours
Vol. Distribusi-
Klirens-
Genetik -
Estramustine phosphate Approved DB14674
small molecule | CAS: 4891-15-0

A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.

Kategori:
Alkylating DrugsAntineoplastic AgentsAntineoplastic Agents, Alkylating +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1623-14-9

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicAnions +7
Target Protein:
CholinesteraseParathion hydrolase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
Cholinesterase Inhibitors
Target Protein:
Cholinesterase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etidronic acid Approved DB01077
small molecule | CAS: 2809-21-4

Etidronic acid is a first generation bisphosphonate similar to [clodronic acid] and [tiludronic acid].[A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification.[A1923] Etidronate’s use has decr…

Kategori:
BisphosphonatesBone Density Conservation AgentsDrugs Affecting Bone Structure and Mineralization +4
Target Protein:
HydroxylapatiteReceptor-type tyrosine-protein phosphatase SV-type proton ATPase catalytic subunit A +3
Waktu ParuhThe half life of et…
Vol. DistribusiEtidronic acid has …
KlirensEtidronic acid has …
Genetik -
Etrasimod Approved DB14766
small molecule | CAS: 1206123-37-6

Etrasimod is a synthetic next-generation selective Sphingosine 1-phosphate (S1P) receptor modulator that targets the S1P<sub>1,4,5</sub> with no detectable activity on S1P<sub>2</sub> and S1P<sub>3</sub> receptors. S1P receptors are membrane-derived lysophosp…

Kategori:
Acids, AcyclicAntineoplastic and Immunomodulating AgentsCytochrome P-450 CYP2C19 Substrates +11
Target Protein:
Sphingosine 1-phosphate receptor 1Sphingosine 1-phosphate receptor 4Sphingosine 1-phosphate receptor 5
Waktu ParuhThe mean plasma eli…
Vol. DistribusiThe mean apparent v…
KlirensThe apparent steady…
Genetik -
Evofosfamide DB06091
small molecule | CAS: 918633-87-1

TH-302 is a novel cancer therapeutic specifically activated under the low oxygen or "hypoxic" conditions typical of solid tumor cancer cells. TH-302 is a nitroimidazole-linked prodrug of a brominated derivative of an isophosphoramide mustard previously used i…

Kategori:
Hydrocarbons, HalogenatedImidazolesMustard Compounds +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Famphur DB11408
small molecule | CAS: 52-85-7

Deskripsi belum tersedia.

Kategori:
AgrochemicalsCompounds used in a research, industrial, or household settingInsecticides +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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