Digital Pharmacy - Dashboard Peneliti

Mezigdomide DB17584

small molecule | CAS: 2259648-80-9

Mezigdomide is under investigation in clinical trial NCT05372354 (A Study to Evaluate Safety, Drug Levels and Effectiveness of CC-92480 (BMS-986348) in Combination With Other Treatments in Participants With Relapsed or Refractory Multiple Myeloma).

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Mirdametinib DB07101

small molecule | CAS: 391210-10-9

PD-0325901 has been used in trials studying the treatment and basic science of Melanoma, Solid Tumour, Solid Tumors, Advanced Cancer, and Breast Neoplasms, among others.

Kategori:

Acids, CarbocyclicAmidesAmines +3

Target Protein:

Dual specificity mitogen-activated protein kinase kinase 1

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Monoctanoin DB06801

small molecule | CAS: 502-54-5

Monoctanoin is used to dissolve cholesterol gallstones.

Kategori:

Acids, AcyclicFatty AcidsLipids +1

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

N(2)-carbamimidoyl-N-{2-[4-(3-{4-[(5-carboxyfuran-2-yl)methoxy]-2,3-dichlorophenyl}-1-methyl-1H-pyrazol-5-yl)piperidin-1-yl]-2-oxoethyl}-D-leucinamide DB02581

small molecule

Deskripsi belum tersedia.

Target Protein:

Interleukin-2

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

N-(2,3-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE DB07742

small molecule

Deskripsi belum tersedia.

Target Protein:

Carbonic anhydrase 2

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

N-(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)GLYCINE DB07653

small molecule

Deskripsi belum tersedia.

Target Protein:

Serine/threonine-protein kinase Chk1

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE DB07929

small molecule

Deskripsi belum tersedia.

Target Protein:

Oxysterols receptor LXR-alphaRetinoic acid receptor RXR-beta

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

N-[(2R)-5-(aminosulfonyl)-2,3-dihydro-1H-inden-2-yl]-2-propylpentanamide DB07048

small molecule

Deskripsi belum tersedia.

Target Protein:

Carbonic anhydrase 2

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

N-[(E)-3-[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitrobenzamide DB03907

small molecule

Deskripsi belum tersedia.

Target Protein:

Catechol O-methyltransferase

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide DB07738

small molecule

Deskripsi belum tersedia.

Target Protein:

Beta-secretase 1

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

N-[2-(2,4-diaminopyrido[2,3-d]pyrimidin-7-yl)-2-methylpropyl]-4-phenoxybenzamide DB07041

small molecule

Deskripsi belum tersedia.

Target Protein:

DNA ligaseDNA ligase

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine DB07584

small molecule

Deskripsi belum tersedia.

Target Protein:

RAC-alpha serine/threonine-protein kinaseGlycogen synthase kinase-3 beta

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOTHIAZIN-4-YL]ETHYL}ACETAMIDE DB06899

small molecule

Deskripsi belum tersedia.

Target Protein:

Renin

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL]ETHYL}ACETAMIDE DB07059

small molecule

Deskripsi belum tersedia.

Target Protein:

Renin

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

N6-(2,5-Dimethoxy-Benzyl)-N6-Methyl-Pyrido[2,3-D]Pyrimidine-2,4,6-Triamine DB02583

small molecule | CAS: 175354-76-4

Deskripsi belum tersedia.

Target Protein:

Dihydrofolate reductase

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Narazaciclib DB19038

small molecule | CAS: 1357470-29-1

Narazaciclib is under investigation in clinical trial NCT06351644 (On 123300 (Narazaciclib) and Dexamethasone in Patients With Relapsed And/or Refractory Multiple Myeloma).

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Navoximod DB15439

small molecule | CAS: 1402837-78-8

Navoximod is under investigation in clinical trial NCT02048709 (Indoleamine 2,3-Dioxygenase (IDO) Inhibitor in Advanced Solid Tumors).

Kategori:

Heterocyclic Compounds, Fused-Ring

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Nemtabrutinib DB18866

small molecule | CAS: 2095393-15-8

Nemtabrutinib is under investigation in clinical trial NCT05624554 (A Study of Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated Chronic Lymphocytic Leukemia/small Lymphocytic Lymphoma (CLL/SLL) Without TP53 Aberrations (MK-1026-0…

Target Protein:

Tyrosine-protein kinase BTK

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Nintedanib Approved DB09079

small molecule | CAS: 656247-17-5

Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 20…

Kategori:

Antifibrotic AgentsAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +14

Target Protein:

Vascular endothelial growth factor receptor 1Vascular endothelial growth factor receptor 2Vascular endothelial growth factor receptor 3 +9

Waktu ParuhThe terminal elimin…

Vol. DistribusiNintedanib appears …

KlirensNintedanib is has a…

Genetik -

Nitrazepam Approved DB01595

small molecule | CAS: 146-22-5

A benzodiazepine derivative used as an anticonvulsant and hypnotic.

Kategori:

Anti-Anxiety AgentsAnticonvulsantsBenzazepines +22

Target Protein:

Gamma-aminobutyric acid receptor subunit alpha-1GABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site +1

Waktu Paruh15-38 hours (mean e…

Vol. Distribusi-

Klirens-

Genetik -

N~3~-(3-PYRIDIN-3-YLBENZYL)PYRIDINE-2,3-DIAMINE DB07284

small molecule

Deskripsi belum tersedia.

Target Protein:

Beta-secretase 1

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

N~3~-BENZYLPYRIDINE-2,3-DIAMINE DB07281

small molecule

Deskripsi belum tersedia.

Target Protein:

Beta-secretase 1

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

N~3~-[3-(1H-INDOL-6-YL)BENZYL]PYRIDINE-2,3-DIAMINE DB07993

small molecule

Deskripsi belum tersedia.

Target Protein:

Beta-secretase 1

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

N~3~-[3-(5-METHOXYPYRIDIN-3-YL)BENZYL]PYRIDINE-2,3-DIAMINE DB07303

small molecule

Deskripsi belum tersedia.

Target Protein:

Beta-secretase 1

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

N~3~-[5-(1H-INDOL-6-YL)-2-(PYRIDIN-2-YLMETHOXY)BENZYL]PYRIDINE-2,3-DIAMINE DB07994

small molecule

Deskripsi belum tersedia.

Target Protein:

Beta-secretase 1

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Ofloxacin Approved DB01165

small molecule | CAS: 82419-36-1

A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

Kategori:

4-QuinolonesAgents Causing Muscle ToxicityAnti-Bacterial Agents +22

Target Protein:

DNA gyrase subunit ADNA gyrase subunit BDNA gyrase subunit A +2

Waktu Paruh9 hours

Vol. Distribusi-

Klirens-

Genetik -

Olafertinib DB17179

small molecule

Deskripsi belum tersedia.

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

ONO-5334 DB19206

small molecule | CAS: 620614-15-5

ONO-5334 is under investigation in clinical trial NCT00532337 (Controlled Study of ONO-5334 in Postmenopausal Women With Osteopenia or Osteoporosis).

Kategori:

Osteoporosis, Postmenopausal, drug therapySulfur CompoundsThiazoles

Target Protein:

Cathepsin K

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Orforglipron DB18964

small molecule | CAS: 2212020-52-3

Orforglipron is under investigation in clinical trial NCT06010004 (A Long-term Safety Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes).

Kategori:

Oxazoles

Target Protein:

Glucagon-like peptide 1 receptor

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Osugacestat DB12006

small molecule | CAS: 1401066-79-2

Osugacestat (BMS-906024) has been used in trials studying the treatment of Cancer, Lymphoblastic Leukemia, Acute T-cell, and Precursor T-Cell Lymphoblastic Lymphoma.

Kategori:

BenzazepinesHeterocyclic Compounds, Fused-Ring

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Palbociclib Approved DB09073

small molecule | CAS: 571190-30-2

Palbociclib is a piperazine pyridopyrimidine[A176792] that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor[A176798] selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceuti…

Kategori:

Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 Inhibitors +21

Target Protein:

Cyclin-dependent kinase 4Cyclin-dependent kinase 6

Waktu ParuhThe mean plasma eli…

Vol. DistribusiThe mean apparent d…

KlirensThe mean apparent o…

Genetik -

Palopegteriparatide Approved DB18676

biotech | CAS: 2222514-07-8

Palopegteriparatide is a parathyroid hormone (PTH) analog. Palopegteriparatide is a prodrug consisting of PTH(1-34) conjugated to a methoxy polyethylene glycol carrier (mPEG) via a proprietary TransCon Linker.[L51134] PTH(1-34) contains the N-terminal part of…

Kategori:

Calcium HomeostasisParathyroid Hormones and AnaloguesSystemic Hormonal Preparations, Excl. Sex Hormones and Insulins +1

Target Protein:

Parathyroid hormone/parathyroid hormone-related peptide receptor

Waktu ParuhThe apparent half-l…

Vol. DistribusiThe estimated appar…

KlirensThe estimated clear…

Genetik -

Pamapimod DB19169

small molecule | CAS: 449811-01-2

Pamapimod is under investigation in clinical trial NCT05659459 (The KIN-FAST Trial (KIN001 for Accelerated Symptoms Termination) in Non Hospitalized Patients Infected With Sars-cov-2).

Kategori:

p38 Mitogen-Activated Protein Kinases, antagonists & inhibitorsPyridines

Target Protein:

Mitogen-activated protein kinase 14

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

PD173955 DB02567

small molecule

Deskripsi belum tersedia.

Kategori:

PyridinesTyrosine Kinase Inhibitors

Target Protein:

Platelet-derived growth factor receptor alphaTyrosine-protein kinase LckProto-oncogene tyrosine-protein kinase Src +3

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Phenyldehydroalanine DB04584

small molecule | CAS: 7060-39-1

Deskripsi belum tersedia.

Kategori:

Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +1

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Phytochlorin DB19265

small molecule | CAS: 19660-77-6

Phytochlorin is under investigation in clinical trial NCT06311890 (Study to Evaluate the Efficacy, Safety and Tolerability of Photodynamic Therapy(pdt) With Chlorin-e6 in Treating Moderate to Severe Acne).

Kategori:

ChlorophyllHeterocyclic Compounds, Fused-RingRadiation-Sensitizing Agents

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Pimasertib DB14904

small molecule | CAS: 1236699-92-5

Pimasertib is under investigation in clinical trial NCT01378377 (Combination Trial of Pimasertib (MSC1936369B) With Temsirolimus).

Kategori:

Nicotinic AcidsProtein Kinase InhibitorsPyridines

Target Protein:

Mitogen-activated protein kinase kinase (MAPKK)

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Piperacillin Approved DB00319

small molecule | CAS: 66258-76-2

Semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. It is also used in combination with other antibiotics.

Kategori:

Agents that produce neuromuscular block (indirect)AmidesAnti-Bacterial Agents +15

Target Protein:

Penicillin-binding protein 3Penicillin-binding protein 2BPenicillin-binding protein 2a +1

Waktu Paruh36-72 minutes

Vol. Distribusi* 101 mL/kg [intrav…

Klirens* 32 - 41 mL/min/1.…

Genetik -

Pirepemat DB19165

small molecule | CAS: 1227638-29-0

Pirepemat is under investigation in clinical trial NCT05258071 (A Clinical Study Evaluating Efficacy of Pirepemat on Falls Frequency in Patients With Parkinson's Disease (PD)).

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Propylthiouracil Approved DB00550

small molecule | CAS: 51-52-5

A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)

Kategori:

Agents Causing Muscle ToxicityAntimetabolitesAntithyroid agents +14

Target Protein:

Type I iodothyronine deiodinaseThyroid peroxidase

Waktu Paruh2 hours

Vol. Distribusi-

Klirens-

Genetik -

Propyphenazone DB13524

small molecule | CAS: 479-92-5

Deskripsi belum tersedia.

Kategori:

Agents causing hyperkalemiaAgents that produce hypertensionAnalgesics +11

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

PRX-08066 DB05607

small molecule

Deskripsi belum tersedia.

Kategori:

Antidepressive AgentsCentral Nervous System DepressantsSerotonin 5-HT2 Receptor Antagonists +3

Target Protein:

5-hydroxytryptamine receptor 2B

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Rezvilutamide DB19133

small molecule | CAS: 1572045-62-5

Rezvilutamide is under investigation in clinical trial NCT05956639 (Comparing a 6-month vs Long-term Course of Rezvilutamide With ADT Plus Chemotherapy in Mhspc).

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Ritlecitinib Approved DB14924

small molecule | CAS: 1792180-81-4

Ritlecitinib (PF-06651600) is a highly selective inhibitor of Janus kinase 3 (JAK3) and the tyrosine kinase expressed in hepatocellular carcinoma (TEC) kinase family. In June 2023, it was approved by the FDA for the treatment of severe alopecia areata in adul…

Kategori:

Antineoplastic and Immunomodulating AgentsCytochrome P-450 CYP1A2 InhibitorsCytochrome P-450 CYP1A2 Inhibitors (strength unknown) +16

Target Protein:

Tyrosine-protein kinase JAK3Tyrosine-protein kinase TecTyrosine-protein kinase ITK/TSK +3

Waktu ParuhRitlecitinib has a …

Vol. DistribusiRitlecitinib is pre…

KlirensRitlecitinib is pre…

Genetik -

Salvianolic acid B DB19313

small molecule | CAS: 121521-90-2

Deskripsi belum tersedia.

Kategori:

Acids, CarbocyclicAldehyde ReductaseAldehyde Reductase, antagonists & inhibitors +6

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Sepantronium DB17062

small molecule | CAS: 753440-91-4

Sepantronium is a compound that suppresses survivin expression in a dose and time-dependent manner, and causes broad-range apoptosis.[A253167]

Kategori:

NaphthalenesQuinones

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

sn-glycerol 3-phosphate DB02515

small molecule | CAS: 17989-41-2

Deskripsi belum tersedia.

Target Protein:

Fructose-bisphosphate aldolase BPyridoxine 5'-phosphate synthaseTriosephosphate isomerase +1

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Soraprazan DB17856

small molecule | CAS: 261944-46-1

Deskripsi belum tersedia.

Kategori:

Heterocyclic Compounds, Fused-Ring

Target Protein:

Potassium-transporting ATPase alpha chain 1Potassium-transporting ATPase subunit beta

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Sotorasib Approved DB15569

small molecule | CAS: 2252403-56-6

Sotorasib, also known as AMG-510, is an acrylamide-derived KRAS inhibitor developed by Amgen.[A187547,A187556] It is indicated in the treatment of adult patients with KRAS G12C mutant non-small cell lung cancer.[L34288] This mutation makes up >50% of all KRAS…

Kategori:

Antineoplastic AgentsAntineoplastic Agents, ImmunologicalAntineoplastic and Immunomodulating Agents +13

Target Protein:

GTPase KRas

Waktu ParuhSotorasib has a ter…

Vol. DistribusiThe volume of distr…

KlirensSotorasib has an ap…

Genetik -

SP2456 DB03957

small molecule

Deskripsi belum tersedia.

Target Protein:

Interleukin-2

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Hasil Filter

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (269)