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14494

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14494 (100.0%)

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Halaman 49 / 290
Anethole trithione Approved DB13853
small molecule | CAS: 532-11-6

Anethole trithione (ATT) appears to have a broad range of unique functions, from increasing salivary secretion to help treat xerostomia [A27165, A32618, A32620, A32621], to demonstrating an ability to inhibit carcinogenesis by increasing the activity of elect…

Kategori:
Alimentary Tract and MetabolismAnisolesBenzene Derivatives +10
Target Protein:
Protein-glutamine gamma-glutamyltransferase 2
Waktu ParuhDespite the medicat…
Vol. DistribusiDespite the medicat…
KlirensDespite the medicat…
Genetik -
biotech | CAS: 1375258-01-7

Anetumab ravtansine is under investigation in clinical trial NCT03455556 (Anetumab Ravtansine and Atezolizumab in Treating Participants With Advanced Non-small Cell Lung Cancer).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibody-drug Conjugates +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Anfibatide DB15094
biotech | CAS: 1622134-89-7

Anfibatide is under investigation in clinical trial NCT01585259 (Anfibatide Phase Ib-IIa Clinical Trial).

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsComplex Mixtures +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Angelica archangelica root Approved DB14283
biotech

Angelica archangelica root is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Angelica dahurica root is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Angelica sinensis root is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
AngelicaAngiospermsApiaceae +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Angiotensin 1-7 DB11720
small molecule | CAS: 51833-78-4

TXA127 has been investigated for the treatment of Miscellaneous Peripheral Blood Cell Abnormalities.

Kategori:
Amino Acids, Peptides, and ProteinsAngiotensinsAntihypertensive Agents +13
Target Protein:
Proto-oncogene Mas
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Angiotensin II Approved DB11842
biotech | CAS: 4474-91-3

Angiotensin II is under investigation for the treatment of Sepsis, Septic Shock, Diabetes Mellitus, and Acute Renal Failure. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and I…

Kategori:
Amino Acids, Peptides, and ProteinsAngiotensin II, antagonists & inhibitorsAngiotensins +16
Target Protein:
Type-2 angiotensin II receptorType-1 angiotensin II receptor
Waktu ParuhThe plasma half-lif…
Vol. DistribusiThe official prescr…
KlirensThe official prescr…
Genetik -
small molecule | CAS: 38390-45-3

Anhydrovinblastine has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Anidulafungin Approved DB00362
biotech | CAS: 166663-25-8

Anidulafungin or Eraxis is an anti-fungal drug manufactured by Pfizer that gained approval by the Food and Drug Administration (FDA) in February 21, 2006; it was previously known as LY303366. There is preliminary evidence that it has a similar safety profile …

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAntifungal Agents +6
Target Protein:
1,3-beta-glucan synthase component FKS11,3-beta-glucan synthase component GSC2
Waktu Paruh40-50 hours
Vol. Distribusi* 30 to 50 L
Klirens* 1 L/h
Genetik -
Anifrolumab Approved DB11976
biotech | CAS: 1326232-46-5

Anifrolumab, or MEDI-546, is a type 1 interferon receptor (IFNAR) inhibiting IgG1? monoclonal antibody indicated in the treatment of adults with moderate to severe systemic lupus erythematosus.[A237074,L34929] The standard therapy for systemic lupus erythemat…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +10
Target Protein:
Interferon alpha/beta receptor 1
Waktu ParuhThe serum eliminati…
Vol. DistribusiBased on population…
KlirensFollowing the admin…
Genetik -
Anileridine Approved DB00913
small molecule | CAS: 144-14-9

Anileridine is a synthetic opioid and strong analgesic medication. It is a narcotic pain reliever used to treat moderate to severe pain. Narcotic analgesics act in the central nervous system (CNS) to relieve pain. Some of their side effects are also caused by…

Kategori:
AnestheticsAnesthetics, GeneralNervous System +2
Target Protein:
Mu-type opioid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aniline DB06728
small molecule | CAS: 62-53-3

Aniline, phenylamine or aminobenzene is an organic compound with the formula C6H5NH2. Consisting of an amine attached to a benzene ring, aniline is the prototypical aromatic amine. Being a precursor to many industrial chemicals, its main use is in the manufac…

Kategori:
AminesCarcinogensCytochrome P-450 CYP2E1 Substrates +3
Target Protein:
Kallikrein-1Albumin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aniracetam DB04599
small molecule | CAS: 72432-10-1

Compound with anti-depressive properties used as a mental performance enhancer.

Kategori:
Antidepressive AgentsCentral Nervous System AgentsCentral Nervous System Depressants +6
Target Protein:
D(2) dopamine receptor5-hydroxytryptamine receptor 2AGlutamate receptor 2 +1
Waktu Paruh1-2.5 hours
Vol. Distribusi-
Klirens-
Genetik -
Anise oil DB15776
biotech | CAS: 8007-70-3

Deskripsi belum tersedia.

Kategori:
AngiospermsApiaceaeBiological Products +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Anisindione Approved DB01125
small molecule | CAS: 117-37-3

Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoa…

Kategori:
IndansIndenes
Target Protein:
Vitamin K-dependent gamma-carboxylaseProthrombin
Waktu ParuhNot Known
Vol. Distribusi-
Klirens-
Genetik -
Anisomycin DB07374
small molecule | CAS: 22862-76-6

Anisomycin (sometimes known as flagecidin), is an antibiotic retrieved from the bacteria _Streptomyces griseolus_. This drug acts to inhibit bacterial protein and DNA synthesis.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntiparasitic Agents +5
Target Protein:
Ribosomal protein uL16-likeLarge ribosomal subunit protein uL13Large ribosomal subunit protein uL14 +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Anisotropine methylbromide Approved DB00517
small molecule | CAS: 80-50-2

Anisotropine methylbromide is a quaternary ammonium compound. Its use as treatment adjunct in peptic ulcer has been replaced by the use of more effective agents. Depending on the dose, anisotropine methylbromide may reduce the motility and secretory activity …

Kategori:
Agents producing tachycardiaAlkaloidsAnticholinergic Agents +5
Target Protein:
Muscarinic acetylcholine receptor M5Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M2 +1
Waktu ParuhNot Known
Vol. Distribusi-
Klirens-
Genetik -
Anistreplase Approved DB00029
biotech | CAS: 81669-57-0

Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a c…

Kategori:
Agents causing angioedemaAmino Acids, Peptides, and ProteinsAnticoagulants +15
Target Protein:
PlasminogenFibrinogen alpha chainPlasminogen activator inhibitor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Anivamersen DB16089
biotech | CAS: 959716-29-1

Anivamersen is under investigation in clinical trial NCT01848106 (A Study to Determine the Efficacy and Safety of REG1 Compared to Bivalirudin in Patients Undergoing PCI).

Kategori:
CoagulantsNucleic Acids, Nucleotides, and NucleosidesNucleotides +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Anlotinib DB11885
small molecule | CAS: 1058156-90-3

Anlotinib has been investigated for the treatment of Non-small Cell Lung Cancer and Metastatic Colorectal Cancer.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Annamycin DB06420
small molecule | CAS: 92689-49-1

Deskripsi belum tersedia.

Kategori:
AnthracyclinesAntibiotics, AntineoplasticAntineoplastic Agents +4
Target Protein:
DNA topoisomerase 2-alphaDNA
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Anpocogin DB06552
biotech

Recombinant nematode anticoagulant protein c2 (rNAPc2) is a specific inhibitor of tissue factor (TF)/factor VIIa complex with novel antithrombotic activity. [A175642]

Target Protein:
Coagulation factor VIITissue factorCoagulation factor X
Waktu ParuhOver 50 hours
Vol. Distribusi-
Klirens-
Genetik -
Anrukinzumab DB12294
biotech | CAS: 910649-32-0

Anrukinzumab has been used in trials studying the diagnostic of Asthma.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Anselamimab DB17492
biotech | CAS: 2414866-63-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Anser anser feather Approved DB10422
biotech

Anser anser feather is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ansofaxine DB15052
small molecule | CAS: 916918-80-4

Ansofaxine is under investigation in clinical trial NCT02271412 (Multiple Ascending Dose Study in Healthy Subjects to Evaluate the Safety, Tolerability, and Pharmacokinetics of LY03005).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ansuvimab Approved DB16385
biotech | CAS: 2375952-29-5

Infection with pathogenic filoviruses, such as _Zaire ebolavirus_ (Ebola virus, EBOV), can cause severe hemorrhagic fever in humans, resulting in frequent outbreaks with case fatality rates as high as 90%.[A225933, A225938] Virtually all steps of the EBOV lif…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAntibodies +13
Target Protein:
Envelope glycoprotein
Waktu ParuhThe half-life of an…
Vol. DistribusiThe steady-state vo…
KlirensThe clearance of an…
Genetik -
Antazoline Approved DB08799
small molecule | CAS: 91-75-8

Antazoline is a 1st generation antihistamine with anticholinergic activity. It is used to relieve nasal congestion. It is also formulated as eye drops with naphazoline to relieve allergic conjunctivitis.

Kategori:
Anti-Allergic AgentsAntiallergic Agents, Excl. CorticosteroidsAntihistamines for Systemic Use +8
Target Protein:
Histamine H1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Anthoxanthum odoratum Approved DB14163
biotech

Anthoxanthum odoratum allergenic extract is used in allergenic testing.

Kategori:
Allergenic ExtractsNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Anthoxanthum odoratum pollen Approved DB10404
biotech

Anthoxanthum odoratum pollen is the pollen of the Anthoxanthum odoratum plant. Anthoxanthum odoratum pollen is mainly used in allergenic testing.

Kategori:
Allergenic ExtractsCell-mediated ImmunityGrass Pollen Allergen Extracts +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Anthralin Approved DB11157
small molecule | CAS: 1143-38-0

Anthralin (1,8?dihydroxy?9anthrone, dithranol) is an older anti-psoriatic agent that was first synthesized as a derivative of chrysarobin, obtained from the araroba tree in Brazil over 100 years ago. Adverse effects of anthralin include irritation and discolo…

Kategori:
AnthracenesAntipsoriaticsAntipsoriatics for Topical Use +2
Target Protein:
Keratin, type II cytoskeletal 2 epidermalKeratin, type I cytoskeletal 12C-Jun-amino-terminal kinase-interacting protein 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 118-92-3

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAminobenzoatesBenzene Derivatives +2
Target Protein:
L-amino-acid oxidaseD-amino-acid oxidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Anthrax immune globulin is a human antibody given with antibiotics for the treatment of anthrax. It is derived from the plasma of humans immunized with BioThrax (adsorbed anthrax vaccine), which is then further purified. Available as the product Anthrasil (FD…

Kategori:
Amino Acids, Peptides, and ProteinsBlood ProteinsHuman Immunoglobulin +5
Target Protein:
Protective antigen
Waktu Paruh24.3 days
Vol. Distribusi5714.8 mL
Klirens174.2 mL/day
Genetik -
Anthrax vaccine Approved DB11003
biotech

Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtra…

Kategori:
Actively Acquired ImmunityAnthrax VaccinesBacterial Vaccines +6
Waktu ParuhLimited information…
Vol. DistribusiLimited information…
KlirensLimited information…
Genetik -
biotech

Integrins are important adhesion molecules that regulate tumor and endothelial cell survival, proliferation and migration. The integrin alpha5beta1 has been shown to play a critical role during angiogenesis. anti-alpha5beta1 integrin antibody inhibits angioge…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Anti-GD2 monoclonal antibody 3F8 is under investigation in clinical trial NCT00089258 (Biological Therapy in Treating Patients With Neuroblastoma That Has Not Responded to Previous Treatment).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Anti-inhibitor coagulant complex, also known as FEIBA (factor eight inhibitor bypassing activity), contains several proteins involved in the prothrombinase complex. It is used to control bleeding in hemophilia A and B patients with inhibitors.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood and Blood Forming Organs +7
Target Protein:
Coagulation factor XProthrombinFibrinogen alpha chain +5
Waktu ParuhPlasma half lives o…
Vol. Distribusi-
Klirens-
Genetik -
biotech

A macrocyclic peptide (BMS-986189) with activity in binding and functional assays comparable to a PD-L1 antibody.

Kategori:
Immune Checkpoint Inhibitors
Target Protein:
Programmed cell death 1 ligand 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Anti-SARS-CoV-2 equine immunoglobulin fragments, also known as INOSARS, is a polyvalent passive immunization being tested in the clinical trial NCT04514302 (Safety and Efficacy of Anti-SARS-CoV-2 Equine Antibody Fragments (INOSARS) for Hospitalized Patients W…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Anti-SARS-CoV-2 IgY are chicken egg antibodies to SARS-CoV-2 which have the potential to provide temporary protection against the virus when administered as intranasal drops.[L27381] To create these antibodies, chickens are injected in the chest with the spik…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Hyperimmune immunoglobulin to SARS-CoV-2 (hIVIG) is obtained from the plasma of patients who recover from COVID-19 and develop neutralizing antibodies.[L27521] Anti-coronavirus immunoglobulin is derived from [COVID-19 convalescent plasma](https://go.drugbank.…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Anti-SARS-COV-2 REGN-COV2 is a combination of novel antibodies designed by Regeneron for both the prevention and treatment of SARS-COV-2, the virus that causes COVID-19. This drug is a combination of the antibodies REGN10933 and REGN10987, derived from human…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAntibodies +10
Target Protein:
Spike glycoprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 1628187-15-4

Antihemophilic Factor (Recombinant), PEGylated, was approved by the FDA in December 2016 as the product _Adynovate_ [FDA label]. Antihemophilic Factor (Recombinant), PEGylated, is a recombinant full-length human coagulation factor VIII (2,332 amino acids w…

Kategori:
AlcoholsAmino Acids, Peptides, and ProteinsBiological Factors +14
Target Protein:
von Willebrand factor
Waktu Paruh14.69 ± 3.79h for a…
Vol. DistribusiAt steady state: 0.…
Klirens2.27 ± 0.84 for adu…
Genetik -
Antihemophilic factor human Approved DB13192
biotech

Antihemophilic factor human, also known as Coagulation Factor VIII or Anti-Hemophilic Factor (AHF), is a non-recombinant, lyophilized concentrate of coagulation factor VIII, an endogenous protein and essential component of the coagulation cascade. Antihemophi…

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood and Blood Forming Organs +11
Target Protein:
Coagulation factor IXCoagulation factor X
Waktu ParuhThe mean half-life …
Vol. DistribusiThe pharmacokinetic…
KlirensThe reported cleara…
Genetik -
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