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11793

Total database: 17430
Struktur (SMILES)
8607 (73.0%)
Target
6418 (54.4%)
Genomik
102 (0.9%)
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11793 (100.0%)

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Halaman 49 / 236
AZD-7268 DB19203
small molecule | CAS: 1018988-00-5

AZD-7268 is under investigation in clinical trial NCT01020799 (AZD7268 Safety and Tolerability Study).

Kategori:
Heterocyclic Compounds, Fused-RingReceptors, Opioid, delta, agonists
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AZD-7295 DB12724
small molecule | CAS: 929890-64-2

AZD7295 has been investigated for the treatment of Hepatitis C.

Target Protein:
Genome polyprotein
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AZD-7325 DB13994
small molecule | CAS: 942437-37-8

AZD7325 is a high affinity, selective modulator of the GABAA receptor system. [L2936]

Kategori:
GABA ModulatorsHeterocyclic Compounds, Fused-Ring
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-3Gamma-aminobutyric acid receptor subunit alpha-2
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AZD-7648 DB16834
small molecule | CAS: 2230820-11-6

Deskripsi belum tersedia.

Kategori:
Enzyme InhibitorsHeterocyclic Compounds, Fused-RingProtein Kinase Inhibitors
Target Protein:
DNA-dependent protein kinase catalytic subunit
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AZD-7687 DB14949
small molecule | CAS: 1166827-44-6

AZD-7687 is under investigation in clinical trial NCT01119352 (AZD7687 Multiple Ascending Dose Study).

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +1
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AZD-7762 DB12242
small molecule | CAS: 860352-01-8

AZD7762 has been investigated for the treatment of Cancer, Solid Tumors, and Advanced Solid Malignancies.

Kategori:
AmidesSulfur Compounds
Target Protein:
Serine/threonine-protein kinase Chk1
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AZD-8165 DB15132
small molecule | CAS: 1201686-72-7

AZD-8165 is under investigation in clinical trial NCT01150812 (Oral AZD8165 After Single Oral Ascending Doses in Healthy Male Subjects).

Target Protein:
Prothrombin
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AZD-8186 DB15029
small molecule | CAS: 1627494-13-6

AZD-8186 is under investigation in clinical trial NCT03218826 (PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery).

Kategori:
AminesBenzopyransHeterocyclic Compounds, Fused-Ring +1
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
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AZD-8330 DB06061
small molecule | CAS: 869357-68-6

AZD-8330 is a potent, selective, orally active MEK inhibitor that blocks signal transduction pathways implicated in cancer cell proliferation and survival. AZD-8330 has shown tumor suppressive activity in multiple preclinical models of human cancer including …

Kategori:
Protein Kinase InhibitorsPyridines
Target Protein:
Mitogen-activated protein kinase kinase kinase 1
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AZD-8848 DB14868
small molecule | CAS: 866269-28-5

AZD-8848 is under investigation in clinical trial NCT01818869 (To Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses AZD8848 in Healthy Subjects).

Kategori:
Acids, CarbocyclicHeterocyclic Compounds, Fused-RingNucleic Acids, Nucleotides, and Nucleosides +4
Target Protein:
Toll-like receptor 7
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AZD-9056 DB12594
small molecule | CAS: 345304-65-6

AZD9056 has been used in trials studying the basic science and treatment of Rheumatoid Arthritis.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +3
Target Protein:
P2X purinoceptor 7
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AZD-9164 DB12115
small molecule | CAS: 1034978-04-5

AZD9164 has been used in trials studying the basic science and treatment of Chronic Obstructive Pulmonary Disease.

Kategori:
Receptor, Muscarinic M3, antagonists & inhibitors
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AZD-9496 DB15138
small molecule | CAS: 1639042-08-2

AZD-9496 is under investigation in clinical trial NCT02248090 (AZD9496 First Time in Patients Ascending Dose Study).

Kategori:
Acids, CarbocyclicHeterocyclic Compounds, Fused-Ring
Target Protein:
Estrogen receptor
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AZD-9684 DB05712
small molecule

AZD-9684 is the first member of a new anti-thrombotic class (CPU inhibitors). It is being developed by AstraZeneca.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +1
Target Protein:
Carboxypeptidase B2
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AZD-9977 DB15418
small molecule | CAS: 1850385-64-6

AZD-9977 is under investigation in clinical trial NCT03843060 (A Phase 1 Study to Assess the Pharmacokinetics of AZD9977 Administered Alone and in Combination With Itraconazole in Healthy Volunteers).

Kategori:
Acids, CarbocyclicBenzene Derivatives
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AZD2066 DB17078
small molecule | CAS: 934282-55-0

Deskripsi belum tersedia.

Kategori:
Gastrointestinal AgentsReceptor, Metabotropic Glutamate 5, antagonists & inhibitors
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AZD2315 DB06540
biotech | CAS: 457937-78-9

The drug AZD2315, an immunosuppressant developed by AstraZeneca, was in Phase 1 clinical trials for the treatment of rheumatoid arthritis but was discontinued during this phase

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AZD7442 DB15787
biotech

AZD7442 is a combination of SARS-CoV-2 antibodies (AZD8895 + AZD1061) currently undergoing phase I clinical trials for the prevention and treatment of COVID-19.[L15596] It was developed by AstraZeneca with the goal of conferring at least 6 months of protecti…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAntibodies +9
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AZD8529 DB16073
small molecule | CAS: 1092453-15-0

AZD8529 is under investigation in clinical trial NCT00921804 (Study to Assess the Efficacy, Safety, and Tolerability of AZD8529 in Adult Schizophrenia Patients).

Kategori:
Heterocyclic Compounds, Fused-RingOxazoles
Target Protein:
Metabotropic glutamate receptor 1
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AZD8630 DB19397
biotech

AZD8630 is an experimental drug under investigation, as described in the Phase I clinical study titled "Randomised, Blinded, Placebo-controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics (NCT05110976)

Target Protein:
Thymic stromal lymphopoietin
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Azelaprag DB19329
small molecule | CAS: 2049980-18-7

Azelaprag is under investigation in clinical trial NCT06515418 (Efficacy and Safety of Oral Azelaprag Plus Once Weekly Tirzepatide Compared With Tirzepatide Alone in Participants With Obesity Aged 55 Years and Over).

Target Protein:
Apelin receptor
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Azelastine Approved DB00972
small molecule | CAS: 58581-89-8

Azelastine, a phthalazine derivative, is an antihistamine available as an intranasal spray for the treatment of allergic and vasomotor rhinitis and as an ophthalmic solution for the treatment of allergic conjunctivitis.[L8240,L8270] It is a racemic mixture, t…

Kategori:
Anti-Allergic AgentsAntiallergic Agents, Excl. CorticosteroidsAntihistamines for Systemic Use +41
Target Protein:
Histamine H1 receptorHistamine H2 receptorPhospholipase A2 +1
Waktu ParuhBased on intravenou…
Vol. DistribusiAfter intravenous a…
KlirensBased on intravenou…
Genetik -
Azeliragon DB12689
small molecule | CAS: 603148-36-3

Azeliragon has been used in trials studying the treatment of Alzheimer's Disease.

Target Protein:
Advanced glycosylation end product-specific receptor
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Azemiglitazone DB16028
small molecule | CAS: 1133819-87-0

Azemiglitazone is under investigation in clinical trial NCT01280695 (A Randomized, Double-blind, Comparator- and Placebo-controlled, Multiple-dose Study to Evaluate the Safety, Tolerability and Efficacy of Three Dose Levels of MSDC-0602 in Type 2 Diabetic Pat…

Kategori:
KetonesSulfur CompoundsThiazoles
Target Protein:
Insulin receptor
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Azenosertib DB18028
small molecule | CAS: 2376146-48-2

Deskripsi belum tersedia.

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Azficel-T Approved DB11051
biotech

Azficel-T is an autologous cellular product composed of fibroblasts indicated for improvement of the appearance of moderate to severe nasolabial fold wrinkles in adults. Dermal fibroblasts are collected from the post-auricular biopsy tissue and aseptically ex…

Kategori:
Autologous Cultured Cell
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Azidocillin DB08795
small molecule | CAS: 17243-38-8

Azidocillin is a penicillin antibiotic similir to ampicillin.

Kategori:
AmidesAnti-Bacterial AgentsAntibacterials for Systemic Use +8
Target Protein:
Penicillin-binding protein 2aPenicillin-binding protein 1bPenicillin-binding protein 3 +2
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Azilsartan medoxomil Approved DB08822
small molecule | CAS: 863031-21-4

Azilsartan medoxomil is a prodrug that is broken down to azilsartan, which belongs in the angiotensin-receptor blocking (ARB) drug class. It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed…

Kategori:
Agents Acting on the Renin-Angiotensin SystemAgents causing angioedemaAgents causing hyperkalemia +18
Target Protein:
Type-1 angiotensin II receptor
Waktu ParuhThe elimination hal…
Vol. DistribusiThe volume of distr…
KlirensRenal clearance of …
Genetik -
Azintamide DB13992
small molecule | CAS: 1830-32-6

Deskripsi belum tersedia.

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biotech | CAS: 1826819-58-2

Azintuxizumab vedotin is under investigation in clinical trial NCT02951117 (A Study of Venetoclax and ABBV-838 Combination Therapy With Dexamethasone in Participants With Multiple Myeloma Whose Cancer Has Come Back or Had No Response to Recent Cancer Treatmen…

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Azithromycin Approved DB00207
small molecule | CAS: 83905-01-5

Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration [A174172]. It was initially approved by the FDA in 1991 [A174175]. It is primarily used for the treatment of respiratory, enteric and genito…

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntibacterials for Systemic Use +22
Target Protein:
23S ribosomal RNAProtein-arginine deiminase type-4
Waktu ParuhTerminal eliminatio…
Vol. DistribusiAfter oral administ…
KlirensMean apparent plasm…
Genetik -
Azlocillin Approved DB01061
small molecule | CAS: 37091-66-0

Azlocillin is a semisynthetic ampicillin-derived acylureido penicillin.

Kategori:
Agents that reduce seizure thresholdAmidesAnti-Bacterial Agents +11
Target Protein:
Penicillin-binding protein 1A
Waktu ParuhMean elimination ha…
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small molecule | CAS: 123-77-3

Deskripsi belum tersedia.

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +3
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Azosemide DB08961
small molecule | CAS: 27589-33-9

Azosemide is a loop diuretic used to treat hypertension, edema, and ascites.

Kategori:
AmidesAminesAniline Compounds +7
Waktu ParuhTerminal half life …
Vol. DistribusiPoor affinity for h…
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Genetik -
small molecule | CAS: 892497-01-7

Azoximer bromide is under investigation in clinical trial NCT04381377 (Efficacy and Safety of Polyoxidonium® in Hospitalized Patients With Coronavirus Disease COVID-19).

Kategori:
Macromolecular Substances
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Azoxystrobin DB07401
small molecule | CAS: 131860-33-8

Azoxystrobin is a methoxyacrylate analog and a strobilurin fungicide.

Kategori:
Acids, AcyclicAcrylatesElectron Transport Complex III +2
Target Protein:
Cytochrome c1, heme protein, mitochondrialCytochrome bCytochrome b-c1 complex subunit 1, mitochondrial +7
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Azurin-p28 DB17241
biotech | CAS: 897026-25-4

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsBacterial ProteinsMetalloproteins +2
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Azvudine DB16407
small molecule | CAS: 1011529-10-4

Azvudine is under investigation in clinical trial NCT04668235 (Study on Safety and Clinical Efficacy of AZVUDINE in COVID-19 Patients (Sars-cov-2 Infected)).

Kategori:
DeoxyribonucleosidesExperimental Unapproved Treatments for COVID-19Nitrogen Compounds +4
Target Protein:
Broad substrate specificity ATP-binding cassette transporter ABCG2ATP-binding cassette sub-family C member 2ATP-dependent translocase ABCB1
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AZX-100 DB06323
biotech | CAS: 1217194-46-1

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsHeat-Shock ProteinsMolecular Chaperones +1
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small molecule | CAS: 69984-73-2

Deskripsi belum tersedia.

Target Protein:
Pancreatic triacylglycerol lipaseCytochrome c oxidase subunit 1Cytochrome c oxidase subunit 2 +11
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B27PD DB16289
biotech | CAS: 160387-12-2

B27PD is under investigation in clinical trial NCT01195948 (Optiquel® as Corticosteroid-sparing Therapy for Chronic Noninfectious Uveitis).

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biotech

Deskripsi belum tersedia.

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BA-2664 DB01479
small molecule | CAS: 641-82-7

Deskripsi belum tersedia.

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Bacampicillin Approved DB01602
small molecule | CAS: 50972-17-3

Bacampicillin is a prodrug of ampicillin and is microbiologically inactive. It is absorbed following oral administration. During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. It is microbi…

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +10
Target Protein:
Penicillin-binding protein
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biotech

Deskripsi belum tersedia.

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biotech

BCG SSI has been used in trials studying Tuberculosis.

Kategori:
Live Attenuated Bacillus Calmette-Guerin VaccineLive vaccinesVaccines
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biotech

Bacillus Calmette-Guerin (BCG) substrain Russian BCG-I is a live BCG vaccine administered directly into the bladder for the adjuvant treatment of papillary urothelial cell carcinoma of the bladder. Live BCG vaccines administered intravesically have been a gol…

Kategori:
Antineoplastic AgentsLive vaccinesVaccines
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biotech

Bacillus calmette-guerin substrain tokyo 172-1 live antigen is under investigation in clinical trial NCT03091660 (S1602: Different Strains of BCG With or Without Vaccine in High Grade Non- Muscle Invasive Bladder Cancer).

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Bacillus cereus DB19245
biotech | CAS: 68038-62-0

Deskripsi belum tersedia.

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biotech

Deskripsi belum tersedia.

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