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14063

Total database: 17430
Struktur (SMILES)
10481 (74.5%)
Target
8038 (57.2%)
Genomik
107 (0.8%)
Referensi
14063 (100.0%)

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Hasil Pencarian (14063)

Halaman 49 / 282
Acetylcholine Approved DB03128
small molecule | CAS: 51-84-3

A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is gen…

Kategori:
AminesAntiglaucoma Preparations and MioticsBiogenic Amines +12
Target Protein:
Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M2Muscarinic acetylcholine receptor M3 +2
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Acetylcysteine Approved DB06151
small molecule | CAS: 616-91-1

Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of [acetaminophen] overdose.[L31378,L31383,L31388,L31478] Acetylcysteine has also been studied for a wide variety of off-label indications with mixed re…

Kategori:
Amino AcidsAmino Acids, NeutralAmino Acids, Peptides, and Proteins +19
Target Protein:
Glutathione synthetaseCystine/glutamate transporterNAPQI (N-acetyl-p-benzoquinone imine) +8
Waktu ParuhThe mean terminal h…
Vol. DistribusiThe volume of distr…
KlirensAcetylcysteine has …
Genetik -
small molecule | CAS: 38520-57-9

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsAmino Acids, Sulfur +2
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Genetik -
small molecule | CAS: 2736440-65-4

Deskripsi belum tersedia.

Kategori:
Experimental Unapproved Treatments for COVID-19
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small molecule | CAS: 3861-72-1

Deskripsi belum tersedia.

Kategori:
Cough and Cold PreparationsOpium Alkaloids and Derivatives
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Acetyldinaline DB16142
small molecule | CAS: 58338-59-3

Acetyldinaline is under investigation in clinical trial NCT00005624 (CI-994 in Treating Patients With Advanced Myeloma).

Kategori:
Acids, CarbocyclicAmidesAmines +8
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Acetylene Approved DB15906
small molecule | CAS: 74-86-2

Deskripsi belum tersedia.

Kategori:
AlkynesHydrocarbons, Acyclic
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small molecule | CAS: 17427-14-4

Deskripsi belum tersedia.

Kategori:
Central Nervous System DepressantsHypnotics and SedativesNervous System +1
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Acetylleucine DB13226
small molecule | CAS: 99-15-0

Used for treating vestibular-related imbalance and vertigo.

Kategori:
Amino AcidsAmino Acids, Branched-ChainAmino Acids, Peptides, and Proteins +2
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small molecule | CAS: 110044-82-1

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsCysteine Proteinase InhibitorsEnzyme Inhibitors +4
Target Protein:
Proteasome subunit alpha type-7
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Acetylphosphate DB02897
small molecule

Deskripsi belum tersedia.

Target Protein:
GDP-L-fucose synthasePhosphate acetyltransferase
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Acetylsalicylic acid Approved DB00945
small molecule | CAS: 50-78-2

Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and i…

Kategori:
Acids, CarbocyclicAgents causing angioedemaAgents causing hyperkalemia +38
Target Protein:
Prostaglandin G/H synthase 13-hydroxy-3-methylglutaryl-coenzyme A reductaseProstaglandin G/H synthase 2 +17
Gen Terkait:
CYP2C9 ITGB3 LTC4S
Waktu ParuhThe half-life of AS…
Vol. DistribusiThis drug is distri…
KlirensThe clearance rate …
Genetik 3 Varian
small molecule | CAS: 68957-71-1

Deskripsi belum tersedia.

Kategori:
ArylsulfonatesArylsulfonic AcidsBenzene Derivatives +3
Target Protein:
Bifunctional purine biosynthesis protein ATIC
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Acimtamig DB18674
biotech | CAS: 2738880-26-5

Acimtamig is a tetravalent bispecific chimeric anti-human CD30 x anti-human CD16A recombinant antibody construct.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
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Acipimox Approved DB09055
small molecule | CAS: 51037-30-0

Acipimox is a niacin derivative used as a hypolipidemic agent. It is used in low doses and may have less marked adverse effects, although it is unclear whether the recommended dose is as effective as are standard doses of nicotinic acid. Acipimox inhibits the…

Kategori:
Agents Causing Muscle ToxicityHypolipidemic AgentsLipid Modifying Agents +3
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Acitretin Approved DB00459
small molecule | CAS: 55079-83-9

An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.

Kategori:
AlkenesAntipsoriaticsAntipsoriatics for Systemic Use +17
Target Protein:
Retinoic acid receptor RXR-alphaSignal transducer and activator of transcription 3Retinoic acid receptor alpha +6
Waktu Paruh49 hours (range 33 …
Vol. Distribusi-
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Aclerastide DB12631
small molecule | CAS: 227803-63-6

Aclerastide has been investigated for the treatment of Diabetic Foot, Diabetic Foot Ulcers, and Foot Ulcer, Diabetic.

Kategori:
Amino Acids, Peptides, and ProteinsAngiotensinsAutacoids +10
Target Protein:
Proto-oncogene Mas
Waktu Paruh-
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Aclidinium Approved DB08897
small molecule | CAS: 727649-81-2

Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012.

Kategori:
Adrenergics, InhalantsAgents producing tachycardiaAgents to Treat Airway Disease +9
Target Protein:
Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M2Muscarinic acetylcholine receptor M3 +2
Waktu ParuhPlasma half-life = …
Vol. DistribusiFollowing IV admini…
KlirensTotal clearance, IV…
Genetik -
Aclimostat DB16079
small molecule | CAS: 2082752-83-6

Aclimostat is under investigation in clinical trial NCT03254368 (Study to Assess the Effects and Safety of ZGN-1061 in Overweight and Obese Participants With Type 2 Diabetes).

Kategori:
Anti-Obesity AgentsAzetinesEnzyme Inhibitors +1
Target Protein:
Methionine aminopeptidase 2
Waktu Paruh-
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Acolbifene DB16080
small molecule | CAS: 182167-02-8

Acolbifene is under investigation in clinical trial NCT01452373 (Dehydroepiandrosterone (DHEA) + Acolbifene Against Vasomotor Symptoms (Hot Flushes) in Postmenopausal Women).

Target Protein:
Estrogen receptor
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Genetik -
Acoltremon DB19202
small molecule | CAS: 68489-09-8

Acoltremon is under investigation in clinical trial NCT05493111 (A Long-term Safety Study Evaluating the Safety and Systemic Exposure of AR-15512).

Kategori:
AlcoholsAmidesAmines +10
Target Protein:
Transient receptor potential cation channel subfamily M member 8
Waktu Paruh-
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Aconiazide DB17731
small molecule | CAS: 13410-86-1

Deskripsi belum tersedia.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsDrugs for Treatment of Tuberculosis +3
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Genetik -
biotech

Acorus calamus root is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

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Acotiamide DB12482
small molecule | CAS: 185106-16-5

Acotiamide has been used in trials studying the treatment of Dyspepsia and Functional Dyspepsia.

Kategori:
Acids, CarbocyclicAlimentary Tract and MetabolismAmides +10
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Acoziborole DB13086
small molecule | CAS: 1266084-51-8

SCYX-7158 has been used in trials studying the treatment of Trypanosomiasis, Parasitic Diseases, Protozoan Infections, and Trypanosomiasis, African.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +1
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ACP-015 DB17824
biotech

Deskripsi belum tersedia.

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ACR325 DB05196
small molecule

ACR325 is developed for the treatment of Parkinson’s disease and psychoses, including bipolar disorder, for which disease existing therapies have only limited effect and considerable adverse side effects. ACR325 is a dopaminergic stabiliser, which has demonst…

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Acremonium strictum Approved DB10423
biotech

Acremonium strictum is a fungus which can provoke allergic reactions. Acremonium strictum extract is used in allergenic testing.

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small molecule | CAS: 89459-25-6

Acridine Carboxamide has been used in trials studying the treatment of Lung Cancer and Brain and Central Nervous System Tumors.

Kategori:
Antineoplastic AgentsEnzyme InhibitorsHeterocyclic Compounds, Fused-Ring +2
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Acrivastine Approved DB09488
small molecule | CAS: 87848-99-5

Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histami…

Kategori:
Antihistamines for Systemic UseDrugs that are Mainly Renally ExcretedHistamine Agents +7
Target Protein:
Histamine H1 receptor
Waktu ParuhThe mean terminal h…
Vol. Distribusi0.46 ± 0.05 L/kg
Klirens2.9 ± 0.7 mL/min/kg
Genetik -
Acrizanib DB16081
small molecule | CAS: 1229453-99-9

Acrizanib is under investigation in clinical trial NCT02355028 (LHA510 Proof-of-concept Study as a Maintenance Therapy for Patients With Wet Age-related Macular Degeneration).

Kategori:
Compounds used in a research, industrial, or household settingEnzyme InhibitorsHeterocyclic Compounds, Fused-Ring +5
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Acrylic Acid DB02579
small molecule | CAS: 79-10-7

A ?,?-unsaturated monocarboxylic acid that is ethene substituted by a carboxy group.

Kategori:
Acids, AcyclicCompounds used in a research, industrial, or household settingEquipment and Supplies +3
Target Protein:
Beta-lactamase SHV-1
Waktu Paruh-
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ACT-1 peptide DB18201
biotech

Deskripsi belum tersedia.

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Acteoside DB12996
small molecule | CAS: 61276-17-3

Acteoside is under investigation in clinical trial NCT02662283 (Validity and Security of Reh-acteoside Therapy for Patients of IgA Nephropathy).

Kategori:
Anti-Infective AgentsAntineoplastic AgentsAntineoplastic Agents, Phytogenic +13
Target Protein:
Protein kinase C alpha type
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Actinium DB12860
small molecule | CAS: 7440-34-8

Actinium has been investigated for the treatment of Breast Cancer and Pulmonary Disease, Chronic Obstructive.

Kategori:
Actinoid Series ElementsElementsElements, Radioactive +4
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Activated charcoal Approved DB09278
small molecule | CAS: 64365-11-3

Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from incomplete combustion of carbonaceous organic matter. It is activated by an oxidizing gas flow at high temperature passed over its surface to make a fine network of pores, p…

Kategori:
AdsorptionAlimentary Tract and MetabolismAnions +14
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Genetik -
biotech

Deskripsi belum tersedia.

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Actoxumab DB16376
biotech | CAS: 1245634-25-6

Actoxumab is under investigation in clinical trial NCT01241552 (A Study of MK-3415, MK-6072, and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-001)).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Neutralizing +6
Waktu Paruh-
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ACTX-401 DB18504
biotech

ACTX-401 is a single-stranded, non-replicating recombinant adeno-associated viral vector serotype 9 containing the human immunoglobulin u-binding protein 2 cDNA.

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Acumapimod DB15448
small molecule | CAS: 836683-15-9

Acumapimod is under investigation in clinical trial NCT02926326 (The Effect of Azithromycin on BCT197 Exposure in Healthy Male Volunteers).

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +3
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ACV tripeptide DB02025
small molecule | CAS: 32467-88-2

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
Waktu Paruh-
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Acyclovir Approved DB00787
small molecule | CAS: 59277-89-3

Acyclovir is a deoxynucleoside analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster, herpes labialis, and acute herpetic keratitis.[L7303,L7315,L7318,L7321,L7324,L7327] Acyclovir is generally used first line in the treatment of the…

Kategori:
Acyclovir and prodrugAnti-Infective AgentsAntiinfectives for Systemic Use +28
Target Protein:
DNA polymerase catalytic subunitDNA polymerase catalytic subunit
Waktu ParuhThe clearance of ac…
Vol. DistribusiThe volume of distr…
KlirensThe renal clearance…
Genetik -
AD 337 DB05725
small molecule

AD 337 was under investigation in clinical trial NCT00377039 (A Multicentre Trial to Determine the Efficacy and Safety of AD-337 in the Treatment of Fibromyalgia). The drug was created by Sosei pharmaceuticals to treat Fibromyalgia in female patients.

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AD-114 DB18285
biotech

Deskripsi belum tersedia.

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AD-214 DB18412
biotech

Deskripsi belum tersedia.

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Ad-CEA vaccine DB17581
biotech

Ad-CEA vaccine is a cancer immunotherapy composed of carcinoembryonic antigen (CEA). Ad-CEA vaccine is under investigation in clinical trial NCT03050814 (Standard of Care Alone or in Combination With Ad-cea Vaccine and Avelumab in People With Previously Untre…

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Ad-RTS-hIL-12 DB17177
biotech

Deskripsi belum tersedia.

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Ad5-nCoV DB15655
biotech

Ad5-nCoV is a recombinant adenovirus type-5 vector (Ad5) vaccine currently being investigated for prophylaxis against SARS-CoV-2.[L12675,L12678] It is being developed by CanSino Biologics Inc., in partnership with the Beijing Institute of Biotechnology, who i…

Kategori:
Experimental Unapproved Treatments for COVID-19
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Adafosbuvir DB14906
small molecule | CAS: 1613589-09-5

Adafosbuvir is under investigation in clinical trial NCT02894905 (A Study to Evaluate the Effect of Renal Impairment on the Pharmacokinetics of AL-335).

Kategori:
AcidsAcids, NoncarboxylicAmino Acids +13
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biotech | CAS: 1458687-85-8

Adagloxad simolenin is under investigation in clinical trial NCT03562637 (Study of Adagloxad Simolenin (OBI-822)/OBI-821 in the Adjuvant Treatment of Patients With Globo H Positive TNBC).

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