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3253

Total database: 17430
Struktur (SMILES)
2451 (75.3%)
Target
1833 (56.3%)
Genomik
35 (1.1%)
Referensi
3253 (100.0%)

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Hasil Pencarian (3253)

Halaman 47 / 66
PF-00446687 DB12517
small molecule | CAS: 862281-92-3

PF-00446687 has been investigated for the treatment of Erectile Dysfunction.

Kategori:
Receptor, Melanocortin, Type 4, agonists
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-03382792 DB12949
small molecule | CAS: 1400811-63-3

Pf 03382792 is under investigation in clinical trial NCT01045863 (To Evaluate Safety, Tolerability, Plasma Drug Levels And Other Biological Effects In Healthy Volunteers).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-03635659 DB12408
small molecule | CAS: 931409-24-4

Pf03635659 has been used in trials studying the treatment of Chronic Obstructive Pulmonary Disease.

Kategori:
Acids, CarbocyclicAzetinesPhenylacetates +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-03654746 DB12201
small molecule | CAS: 935840-31-6

PF-03654746 has been investigated for the treatment of Narcolepsy, Schizophrenia, Tourette's Syndrome, and Excessive Daytime Sleepiness.

Kategori:
CycloparaffinsHistamine H3 Antagonists
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-03654764 DB12360
small molecule | CAS: 935840-35-0

PF-03654764 has been used in trials studying the basic science and treatment of Allergic Rhinitis.

Kategori:
CycloparaffinsHistamine H3 Antagonists
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-03715455 DB12138
small molecule | CAS: 1056164-52-3

PF-03715455 has been used in trials studying the treatment of Asthma, Pulmonary Disease, Chronic Obstructive, and Chronic Obstructive Pulmonary Disease (COPD).

Kategori:
AmidesAnionsAza Compounds +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-04217903 DB12848
small molecule | CAS: 956905-27-4

PF-04217903 has been used in trials studying the treatment of Neoplasms.

Target Protein:
Hepatocyte growth factor receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-04418948 DB12024
small molecule | CAS: 1078166-57-0

Pf 04418948 is under investigation in clinical trial NCT01002963 (A Study To Investigate The Safety And Toleration Of A Single Dose Of PF-04418948 In Healthy Volunteers).

Kategori:
AzetinesReceptors, Prostaglandin E, EP2 Subtype
Target Protein:
Prostaglandin E2 receptor EP2 subtype
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-04457845 DB12012
small molecule | CAS: 1020315-31-4

PF-04457845 is under investigation in Fear Conditioning. PF-04457845 has been investigated for the treatment of Tourette Syndrome and Cannabis Dependence.

Kategori:
Amides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pf-04531083 DB12468
small molecule | CAS: 1079400-07-9

Pf-04531083 has been investigated for the treatment of Pain and Chronic Pain.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-04634817 DB14955
small molecule | CAS: 1228111-63-4

PF-04634817 is under investigation in clinical trial NCT01140672 (A Multiple Dose Study To Determine Safety, Tolerability, and Pharmacokinetics Of PF-04634817 In Healthy Adult Subjects).

Kategori:
Aza Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-04937319 DB15009
small molecule | CAS: 1245603-92-2

PF-04937319 is under investigation in clinical trial NCT01513928 (A Study To Compare The Pharmacokinetics Of Different Formulations Of PF-04937319 In Healthy Subjects).

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Hexokinase-4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-04958242 DB11843
small molecule | CAS: 1258963-59-5

PF-04958242 has been used in trials studying the basic science and treatment of Schizophrenia and Hearing Loss, Sensorineural.

Kategori:
AmidesSulfonesSulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-04991532 DB11765
small molecule | CAS: 1215197-37-7

PF-04991532 has been used in trials studying the basic science of Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2, and Glucose Metabolism Disorders.

Kategori:
Enzyme InhibitorsGlucokinase, antagonists & inhibitorsPyridines
Target Protein:
Hexokinase-4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-04995274 DB12675
small molecule | CAS: 1331782-27-4

Pf 04995274 is under investigation in clinical trial NCT01193062 (Study In Healthy Subjects To Evaluate The Changes In The Protein sAPP-Alpha In Cerebrospinal Fluid Following A Single Oral Dose Of PF-04995274).

Target Protein:
5-hydroxytryptamine receptor 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-05089771 DB14856
small molecule | CAS: 1235403-62-9

PF-05089771 is under investigation in clinical trial NCT01529671 (A Safety And Tolerability Study Of PF-05089771 In Healthy Subjects And In Subjects With Otseoarthritis Of The Knee).

Kategori:
AmidesBenzene DerivativesEthers +4
Target Protein:
Sodium channel protein type 9 subunit alphaSolute carrier family 22 member 12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-05175157 DB12096
small molecule | CAS: 1301214-47-0

PF-05175157 has been used in trials studying the basic science and treatment of Acne Vulgaris, Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes Mellitus Type 2, and Diabetes Mellitus, Type 2, among others.

Target Protein:
Acetyl-CoA carboxylase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-05212377 DB16044
small molecule | CAS: 1226793-34-5

PF-05212377 is under investigation in clinical trial NCT01712074 (Study Evaluating Thesafety and Efficacy of PF-05212377 or Placebo in Subjects With Alzheimer's Disease With Existing Neuropsychiatric Symptoms on Donepezil).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-05241328 DB15124
small molecule | CAS: 1387633-03-5

PF-05241328 is under investigation in clinical trial NCT01165736 (To Calculate the Pharmacokinetics (Concentration of Compound in and Rate of Excretion From the Blood) Following a Very Low Dose of Compound Which Will Not Have Any Pharmacological Activity).

Target Protein:
Sodium channel protein type 9 subunit alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-06260414 DB15221
small molecule | CAS: 1612755-71-1

PF-06260414 is under investigation in clinical trial NCT02070939 (Study To Evaluate Safety And Tolerability Of Single And Multiple Ascending Doses Of PF- 06260414 In Healthy Western And Japanese Male Subjects).

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Androgen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-06273340 DB12269
small molecule | CAS: 1402438-74-7

Pf 06273340 is under investigation in clinical trial NCT01934738 (A Study to Evaluate Safety, Toleration and Time Course of Plasma Concentration of Multiple Oral Doses of PF-06273340 in Healthy Subjects of Two AgeGroups, Aged 18-55 Years (Group 1) and Aged 56…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-06291874 DB15065
small molecule | CAS: 1393124-08-7

PF-06291874 is under investigation in clinical trial NCT02175121 (Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Study of PF-06291874 as Oral Monotherapy To Treat Adults With Type 2 Diabetes Mellitus).

Kategori:
AlanineAmino AcidsAmino Acids, Peptides, and Proteins
Target Protein:
Glucagon receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-06305591 DB12106
small molecule | CAS: 1449473-97-5

Pf 06305591 is under investigation in clinical trial NCT01776619 (Safety and Tolerability Study of Multiple Doses of PF-06305591).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-06751979 DB15105
small molecule | CAS: 1818339-66-0

PF-06751979 is under investigation in clinical trial NCT03126721 (The Study is to Evaluate the Effect of Multiple Doses PF-06751979 on the Pharmacokinetics of Midazolam in Healthy Adults).

Kategori:
Sulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-07038124 DB19143
small molecule | CAS: 2415085-44-6

PF-07038124 is under investigation in clinical trial NCT05298033 (Study of Efficacy, Safety and Tolerability of Crisaborole and PF-07038124 With and Without NBUVB in Vitiligo).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-07059013 DB18122
small molecule | CAS: 2435610-93-6

Deskripsi belum tersedia.

Target Protein:
Hemoglobin subunit beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-07304814 DB16514
small molecule

PF-07304814 is a small molecule prodrug that targets the 3CL<sup>pro</sup> protease (M<sup>pro)</sup>, which is used by viruses like SARS-CoV-2 to assemble and multiply[L31718]. Once administered through intravenous infusion, the compound is cleaved into PF-0…

Kategori:
Amino AcidsAmino Acids, Branched-ChainAmino Acids, Essential +4
Target Protein:
Replicase polyprotein 1ab
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-4136309 DB17200
small molecule | CAS: 1341224-83-6

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-477736 DB12611
small molecule | CAS: 952021-60-2

PF-00477736 has been used in trials studying the treatment of Neoplasms.

Kategori:
BenzazepinesEnzyme InhibitorsHeterocyclic Compounds, Fused-Ring +1
Target Protein:
Serine/threonine-protein kinase Chk1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-5212372 DB19212
small molecule | CAS: 916136-25-9

PF-5212372 is under investigation in clinical trial NCT02795832 (A Study to Determine the Safety & Efficacy of ZPL-5212372 in Healthy Subjects and in Subjects With Atopic Dermatitis).

Kategori:
Acids, CarbocyclicAmidesEnzyme Inhibitors +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PG-701 DB12252
small molecule | CAS: 583028-68-6

Hydroxytriptolide has been investigated for the treatment of Rheumatoid Arthritis.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PHA-793887 DB12686
small molecule | CAS: 718630-59-2

PHA-793887 has been used in trials studying the treatment of Advanced/Metastatic Solid Tumors.

Kategori:
Cyclin-Dependent Kinases, antagonists & inhibitors
Target Protein:
Cyclin-dependent kinase 2Cyclin-dependent kinase 4Cyclin-dependent kinase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Phanquinone DB13469
small molecule | CAS: 84-12-8

Deskripsi belum tersedia.

Kategori:
Antiparasitic Products, Insecticides and RepellentsAntiprotozoalsHeterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PHE885 DB18123
biotech

PHE885 is an investigational, autologous B-cell Maturation Antigen (BCMA)-directed chimeric antigen receptor (CAR)-T cell therapy.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Phenacemide Approved DB01121
small molecule | CAS: 63-98-9

Phenacemide is used to control certain seizures in the treatment of epilepsy. This medicine acts on the central nervous system (CNS) to reduce the number and severity of seizures.

Kategori:
AcetamidesAmidesAnticonvulsants +3
Target Protein:
Sodium channel protein type 1 subunit alpha
Waktu Paruh22-25 hours.
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 2257-09-2

Phenethyl Isothiocyanate has been used in trials studying the prevention and treatment of Leukemia, Lung Cancer, Tobacco Use Disorder, and Lymphoproliferative Disorders.

Kategori:
Aldehyde Dehydrogenase, antagonists & inhibitorsAnticarcinogenic AgentsAntineoplastic Agents +8
Target Protein:
Actin, aortic smooth muscleActin, cytoplasmic 1ATP synthase subunit beta, mitochondrial +42
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Phenindione Approved DB00498
small molecule | CAS: 83-12-5

An indandione that has been used as an anticoagulant. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)

Kategori:
AnticoagulantsBlood and Blood Forming OrgansHematologic Agents +4
Target Protein:
Vitamin K epoxide reductase complex subunit 1
Waktu Paruh5-10 hours
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 143-74-8

Phenolsulfonphthalein or otherwise called phenol red is a pH indicator commonly used in cell biology laboratories. Phenolsulfonphthalein is being investigated for use clinically due to its weak estrogen mimicking actions [A174964].

Kategori:
Benzene DerivativesColoring AgentsCompounds used in a research, industrial, or household setting +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Phenoxyethanol Approved DB11304
small molecule | CAS: 122-99-6

Phenoxyethanol is a colorless liquid with a pleasant odor. It is a glycol ether used as a perfume fixative, insect repellent, antiseptic, solvent, preservative, and also as an anesthetic in fish aquaculture. Phenoxyethanol is an ether alcohol with aromatic pr…

Kategori:
AlcoholsAnestheticsAnti-Infective Agents +5
Waktu Paruh-
Vol. DistribusiA pharmacokinetic s…
Klirens-
Genetik -
Phenserine DB04892
small molecule | CAS: 101246-66-6

Phenserine is under development by Axonyx, a US biopharmaceutical company that focuses on treatments for dementia. Phenserine is a next generation acetylcholinesterase (AChE) inhibitor indicated for the treatment of AD. Unlike currently marketed AChE inhibito…

Kategori:
Acids, AcyclicAlkaloidsCarbamates +11
Target Protein:
AcetylcholinesteraseCholinesteraseAmyloid-beta precursor protein
Waktu Paruh8 to 10 hours
Vol. Distribusi-
Klirens-
Genetik -
Phentermine Approved DB00191
small molecule | CAS: 122-09-8

Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine.[A174370] Phe…

Kategori:
Adrenergic AgentsAgents producing tachycardiaAgents that produce hypertension +22
Target Protein:
Sodium-dependent noradrenaline transporterSodium-dependent serotonin transporterSodium-dependent dopamine transporter +3
Waktu ParuhThe mean terminal h…
Vol. DistribusiThe reported volume…
KlirensThe reported cleara…
Genetik -
small molecule | CAS: 122-78-1

Deskripsi belum tersedia.

Kategori:
AldehydesOils, Volatile
Target Protein:
Primary amine oxidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Phenylalanine Approved DB00120
small molecule | CAS: 63-91-2

Phenylalanine is an essential aromatic amino acid that is a precursor of melanin, [dopamine], [noradrenalin] (norepinephrine), and [thyroxine].

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +7
Target Protein:
Tyrosine 3-monooxygenaseTyrosine aminotransferaseLarge neutral amino acids transporter small subunit 2 +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Carboxypeptidase A1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Phenylbutazone Approved DB00812
small molecule | CAS: 50-33-9

A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter&#39;s syndrome (investigational indication). Although phenylb…

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAnalgesics +28
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2Prostacyclin synthase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Phenylbutyric acid Approved DB06819
small molecule | CAS: 1821-12-1

Phenylbutyric acid is a fatty acid and a derivative of [butyric acid] naturally produced by colonic bacteria fermentation. It demonstrates a number of cellular and biological effects, such as relieving inflammation and acting as a chemical chaperone.[A249035]…

Kategori:
Acids, CarbocyclicAlimentary Tract and MetabolismAmmonium Ion Binding Activity +8
Target Protein:
Histone deacetylase 1Protein kinase C alpha typeAromatic-amino-acid aminotransferase +1
Waktu ParuhFollowing oral admi…
Vol. Distribusi-
Klirens-
Genetik -
Phenylephrine Approved DB00388
small molecule | CAS: 59-42-7

Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil,[L9413] and induce local vasoconstriction.[A187370] The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s…

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-1 Receptor Agonists +38
Target Protein:
Alpha-1A adrenergic receptorD(2) dopamine receptorAlpha-1B adrenergic receptor +1
Waktu ParuhIntravenous phenyle…
Vol. DistribusiThe volume of distr…
KlirensPhenylephrine has a…
Genetik -
small molecule | CAS: 60-12-8

An antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.

Kategori:
AlcoholsAnti-Infective AgentsAnti-Infective Agents, Local +5
Target Protein:
Parathion hydrolase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Phenylethyl resorcinol Approved DB14120
small molecule | CAS: 85-27-8

A tyrosinase inhibitor with skin-lightening activity.

Kategori:
Benzene DerivativesPhenols
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Phenyltoloxamine Approved DB11160
small molecule | CAS: 92-12-6

Phenyltoloxamine is an antihistamine drug with sedative and analgesic effects. It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. It is available in combination products that also contain other analgesics and antitu…

Kategori:
Benzene Derivatives
Target Protein:
D(2) dopamine receptorD(1B) dopamine receptorD(1A) dopamine receptor +2
Waktu ParuhReadily accessible …
Vol. DistribusiReadily accessible …
KlirensReadily accessible …
Genetik -
Menampilkan 2301–2350 dari 3253
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