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14494

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14494 (100.0%)

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Halaman 46 / 290
Ambrosia chamissonis pollen Approved DB10948
biotech

Ambrosia chamissonis pollen is the pollen of the Ambrosia chamissonis plant. Ambrosia chamissonis pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Pollen Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Ambrosia confertiflora pollen is the pollen of the Ambrosia confertiflora plant. Ambrosia confertiflora pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ambrosia deltoidea pollen Approved DB10765
biotech

Ambrosia deltoidea pollen is the pollen of the Ambrosia deltoidea plant. Ambrosia deltoidea pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Pollen Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ambrosia dumosa pollen Approved DB10871
biotech

Ambrosia dumosa pollen is the pollen of the Ambrosia dumosa plant. Ambrosia dumosa pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Pollen Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ambrosia psilostachya pollen Approved DB10387
biotech

Ambrosia psilostachya pollen is the pollen of the Ambrosia psilostachya plant. Ambrosia psilostachya pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Pollen Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ambrosia tenuifolia pollen Approved DB10490
biotech

Ambrosia tenuifolia pollen is the pollen of the Ambrosia tenuifolia plant. Ambrosia tenuifolia pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Pollen Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ambrosia trifida pollen Approved DB10386
biotech

Ambrosia trifida pollen is the pollen of the Ambrosia trifida plant. Ambrosia trifida pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Pollen Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ambroxol Approved DB06742
small molecule | CAS: 18683-91-5

Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosolvan, Lasolvan or Mucoangin. The substance is a mucoactive drug with several properties including se…

Kategori:
Adrenergics for Systemic UseAminesAnesthetics +13
Waktu Paruh7-12 hours
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 96989-76-3

Deskripsi belum tersedia.

Kategori:
AlkaloidsAminesAniline Compounds +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Amcasertib DB14866
small molecule | CAS: 1129403-56-0

Amcasertib is under investigation in clinical trial NCT02483247 (A Study of BBI503 in Combination With Selected Anti-Cancer Therapeutics in Adult Patients With Advanced Cancer).

Target Protein:
Platelet-derived growth factor receptor alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Amcinonide Approved DB00288
small molecule | CAS: 51022-69-6

Amcinonide is a corticosteroid.

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroid Hormone Receptor Agonists +24
Target Protein:
Steroid hormone receptor ERR1Steroid hormone receptor ERR2Estrogen-related receptor gamma +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Amcipatricin DB12333
small molecule | CAS: 143483-67-4

Amcipatricin has been used in trials studying the treatment of Cryptococcosis or Aspergillosis Infections. Amcipatricin (as amcipatricin diascorbate; SPK-843) is a water-soluble partricin derivative patented by SPA Societa Prodotti Antibiotici S.p.A. and deve…

Kategori:
AlkenesHydrocarbons, Acyclic
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Amdinocillin DB01163
small molecule | CAS: 32887-01-7

Amidinopenicillanic acid derivative with broad spectrum antibacterial action. It is poorly absorbed if given orally and is used in urinary infections and typhus. Amdinocillin is not available in the United States.

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +10
Target Protein:
Penicillin-binding protein 2aPenicillin-binding protein 2Penicillin-binding protein 3 +3
Waktu ParuhApproximately 1 hou…
Vol. Distribusi-
Klirens-
Genetik -
AME-527 DB05879
biotech

AME-527 is a humanized monoclonal antibody that recognizes human TNF-alpha (hTNF-alpha) with high affinity and specificity. AME-527 was generated by protein engineering and identified from a library of antibody variants based on its improved binding propertie…

Target Protein:
Tumor necrosis factor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Amedalin DB09188
small molecule | CAS: 22136-26-1

Amedalin is a selective norepinephrine reuptake inhibitor developed in the 1970s. It has no significant effect on reuptake of serotonin and dopamine and no antihistamine or anticholinergic properties. This drug was never marketed.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Amediplase DB06679
biotech | CAS: 151912-11-7

Amediplase is a recombinant chimeric plasminogen activator, consisting of the kringle 2 domain from the A-chain of tissue plasminogen activator (t-PA) and the carboxy terminal region of pro-urokinase. [MeSH]

Kategori:
Agents causing angioedemaAmino Acids, Peptides, and ProteinsAnticoagulants +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Amelubant DB06248
small molecule | CAS: 346735-24-8

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicReceptors, Leukotriene B4, antagonists & inhibitors
Target Protein:
Leukotriene B4 receptor 1Leukotriene B4 receptor 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
American chestnut Approved DB10686
biotech

American chestnut allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
American hazelnut Approved DB15612
biotech

American hazelnut allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Amfecloral DB08924
small molecule | CAS: 5581-35-1

Amfecloral is a stimulant drug of the phenethylamine and amphetamine chemical classes. For a short period of time, it was available under the brand Acutran and indicated as an appetite suppressant, but this product no longer exists. It acts as a prodrug which…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Amfenac DB15911
small molecule | CAS: 51579-82-9

Deskripsi belum tersedia.

Kategori:
Acids, Carbocyclic
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AMG 108 DB05545
biotech | CAS: 877879-38-4

AMG 108 was investigated for use as an antirheumatic agent.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AMG 424 DB17357
biotech

AMG 424 is a novel, humanized, anti-CD3/CD38 bispecific monoclonal antibody being investigated for multiple myeloma.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AMG-119 DB17363
biotech

AMG-119 are CAR-T cells targeting delta-like ligand 3 (DLL3).[A254811]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AMG-131 DB05490
small molecule | CAS: 315224-26-1

AMG-131 (T131), an orally-administered therapy, is expected to lower blood glucose in type II diabetic patients by improving the body’s ability to respond to insulin. T131 is a selective modulator of PPARg (peroxisome proliferator activated receptor gamma), a…

Kategori:
AmidesHeterocyclic Compounds, Fused-RingPPAR gamma, agonists +2
Target Protein:
Peroxisome proliferator-activated receptor gamma
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AMG-208 DB08079
small molecule | CAS: 1002304-34-8

AMG-208 has been used in trials studying the treatment of Cancer, Tumors, Oncology, Prostate Cancer, and Oncology Patients, among others.

Target Protein:
Hepatocyte growth factor receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AMG-337 DB15639
small molecule | CAS: 1173699-31-4

AMG-337 is under investigation in clinical trial NCT03147976 (QUILT-3.036: AMG 337 in Subjects With Advanced or Metastatic Solid Tumors).

Kategori:
Antineoplastic AgentsPyridines
Target Protein:
Hepatocyte growth factor receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AMG-553 DB18346
biotech

AMG-553 is an adoptive, anti-FLT3 chimeric antigen receptor T-cell therapy generated through transduction of autologous T-cells with a self-inactivating human immunodeficiency virus-1 based lentiviral vector.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AMGN-0007 DB06511
biotech

Recombinant osteoprotegerin (AMGN-0007) is a recombinant OPG construct developed as a potential therapeutic agent in the treatment of bone disease.

Kategori:
Amino Acids, Peptides, and ProteinsMembrane ProteinsProteins +1
Target Protein:
Tumor necrosis factor ligand superfamily member 11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Amibegron DB05395
small molecule | CAS: 121524-08-1

Amibegron is an agonist for atypical beta3-adrenoceptors which inhibits intestinal motility.

Kategori:
Acids, AcyclicAdrenergic AgentsAdrenergic Agonists +11
Target Protein:
Beta-3 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Tryptase beta-2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Amifampridine Approved DB11640
small molecule | CAS: 54-96-6

Amifampridine, or 3,4-diaminopyridine (3,4-DAP), is a quaternary ammonium compound that blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations [A33863]. It was first discovered in…

Kategori:
AminesAminopyridinesMembrane Transport Modulators +7
Target Protein:
Potassium voltage-gated channel subfamily A member 1
Waktu ParuhThe average elimina…
Vol. DistribusiIn healthy voluntee…
KlirensOverall clearance o…
Genetik -
Amifostine Approved DB01143
small molecule | CAS: 20537-88-6

A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.

Kategori:
Compounds used in a research, industrial, or household settingCytoprotective AgentDetoxifying Agents for Antineoplastic Treatment +9
Target Protein:
Alkaline phosphatase, germ cell type
Waktu Paruh8 minutes
Vol. Distribusi-
Klirens-
Genetik -
Amikacin Approved DB00479
small molecule | CAS: 37517-28-5

Amikacin is a semi-synthetic aminoglycoside antibiotic that is derived from kanamycin A.[FDA label] Amikacin is synthesized by acylation with the l-(-)-?-amino-?-hydroxybutyryl side chain at the C-1 amino group of the deoxystreptamine moiety of kanamycin A.[A…

Kategori:
Aminoglycoside AntibacterialsAnti-Bacterial AgentsAnti-Infective Agents +7
Target Protein:
30S ribosomal protein S12
Waktu ParuhThe plasma eliminat…
Vol. Distribusi* 24 L (28% of body…
KlirensThe mean serum clea…
Genetik -
Amiloride Approved DB00594
small molecule | CAS: 2609-46-3

A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negati…

Kategori:
Acid Sensing Ion Channel BlockersAgents causing hyperkalemiaCardiovascular Agents +11
Target Protein:
Amiloride-sensitive sodium channel subunit alphaAmiloride-sensitive sodium channel subunit betaAmiloride-sensitive sodium channel subunit gamma +6
Waktu ParuhPlasma half-life va…
Vol. Distribusi-
Klirens-
Genetik -
Amiloxate Approved DB11207
small molecule | CAS: 71617-10-2

Amiloxate is an EMA-approved chemical UV-filter found in over-the-counter sunscreen products at concentrations up to 10%m [F35]. It is often referred to as isoamyl 4-methoxycinnamate or isoamyl p-methoxycinnamate. Amiloxate is a cinnamic acid derivative with …

Kategori:
Acids, CarbocyclicSunscreen Agents
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Aminacrine DB11561
small molecule | CAS: 90-45-9

A highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH indicator.

Kategori:
Acridine DerivativesAcridinesAminoacridines +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aminaphthone DB13039
small molecule | CAS: 14748-94-8

Aminaftone has been investigated for the treatment of Cockett Syndrome, May-Thurner Syndrome, and Iliac Vein Obstruction.

Kategori:
Acids, CarbocyclicAminobenzoatesBenzene Derivatives +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Amineptine DB04836
small molecule | CAS: 57574-09-1

The Food and Drug Administration suspended the marketing authorisation for Survector in 1999 and France withdrew it from the market, however several developing countries continued to produce it up until 2005.

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAntidepressive Agents +11
Target Protein:
Sodium-dependent dopamine transporterSodium-dependent noradrenaline transporterSodium-dependent serotonin transporter
Waktu Paruh48 minutes for the …
Vol. Distribusi-
Klirens-
Genetik -
Amino acids DB09393
small molecule | CAS: 65072-01-7

Mixture of amino acids ; used for parenteral nutrition in infants.

Kategori:
Amino Acid Hypertonic SolutionAmino AcidsAmino Acids, Peptides, and Proteins +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aminoanthracene DB01976
small molecule | CAS: 62813-37-0

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aminobenzoic acid Approved DB02362
small molecule | CAS: 150-13-0

A member of the vitamin B complex. It used to be common in sunscreening agents until found to also be a sensitizer. The potassium salt is used therapeutically in fibrotic skin disorders.

Kategori:
4-Aminobenzoic AcidAcids, CarbocyclicAminobenzoates +10
Target Protein:
p-hydroxybenzoate hydroxylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aminocandin DB05128
small molecule | CAS: 227472-48-2

Aminocandin is a new representative of the echinocandins that could potentially affect the cellular morphology and metabolic status of Candida albicans cells within biofilms.

Kategori:
Amino Acids, Peptides, and ProteinsEchinocandin AntifungalLipids +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aminocaproic acid Approved DB00513
small molecule | CAS: 60-32-2

An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.

Kategori:
Acids, AcyclicAmino AcidsAmino Acids, Peptides, and Proteins +9
Target Protein:
PlasminogenTissue-type plasminogen activatorApolipoprotein(a)
Waktu ParuhThe terminal elimin…
Vol. Distribusi* 23.1 ± 6.6 L
Klirens* 169 mL/min
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Carbonic anhydrase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aminoflavone DB19077
small molecule | CAS: 165179-35-1

Aminoflavone is under investigation in clinical trial NCT01015521 (Efficacy Study of Aminoflavone Prodrug to Treat Breast Cancer).

Kategori:
BenzopyransChromonesHeterocyclic Compounds, Fused-Ring +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aminoglutethimide Approved DB00357
small molecule | CAS: 125-84-8

An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate c…

Kategori:
Antineoplastic AgentsAntineoplastic Agents, HormonalAntineoplastic and Immunomodulating Agents +17
Target Protein:
Cholesterol side-chain cleavage enzyme, mitochondrialAromatase
Waktu Paruh12.5 ± 1.6 h…
Vol. Distribusi-
Klirens-
Genetik -
Aminohippuric acid Approved DB00345
small molecule | CAS: 61-78-9

The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity. [PubChem]

Kategori:
Acids, CarbocyclicAmidesAminobenzoates +17
Target Protein:
Organic anion transporter 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 360-97-4

Deskripsi belum tersedia.

Kategori:
Imidazoles
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aminolevulinic acid Approved DB00855
small molecule | CAS: 106-60-5

A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem]

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsAntineoplastic Agents +18
Target Protein:
Protoporphyrinogen oxidaseDelta-aminolevulinic acid dehydratase
Waktu ParuhThe mean ± SD elimi…
Vol. DistribusiIn healthy voluntee…
Klirens-
Genetik -
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