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2279

Total database: 17430
Struktur (SMILES)
866 (38.0%)
Target
1100 (48.3%)
Genomik
31 (1.4%)
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2279 (100.0%)

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Halaman 46 / 46
Zanolimumab DB17376
biotech | CAS: 652153-01-0

Zanolimumab is a fully human monoclonal antibody directed against CD4.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Zanubrutinib Approved DB15035
small molecule | CAS: 1691249-45-2

Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy.[L10163] Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lym…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBruton's tyrosine kinase (BTK) inhibitors +19
Target Protein:
Tyrosine-protein kinase BTKEpidermal growth factor receptorReceptor tyrosine-protein kinase erbB-2 +12
Waktu ParuhFollowing administr…
Vol. DistribusiThe geometric mean …
KlirensThe mean (%CV) appa…
Genetik -
Zeaxanthin Approved DB11176
small molecule | CAS: 144-68-3

Zeaxanthin is a most common carotenoid alcohols found in nature that is involved in the xanthophyll cycle. As a coexistent isomer of lutein, zeaxanthin is synthesized in plants and some micro-organisms. It gives the distinct yellow color to many vegetables an…

Kategori:
AlkenesBiological FactorsCarotenoids +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Zelpultide alfa DB18587
biotech | CAS: 2245003-06-7

Zelpultide alfa is a recombinant human surfactant protein D.

Waktu Paruh-
Vol. Distribusi-
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Zeluvalimab DB18868
biotech | CAS: 2315361-37-4

Zeluvalimab is under investigation in clinical trial NCT04631601 (Safety and Efficacy of Therapies for Metastatic Castration-resistant Prostate Cancer (Mcrpc)).

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Zenocutuzumab Approved DB15559
biotech | CAS: 1969309-56-5

Zenocutuzumab is under investigation in clinical trial NCT03321981 (MCLA-128 With Trastuzumab/chemotherapy in HER2+ and With Endocrine Therapy in ER+ and Low HER2 Breast Cancer).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +8
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Ziconotide Approved DB06283
biotech | CAS: 107452-89-1

Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown effica…

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAntiarrhythmic agents +22
Target Protein:
Voltage-dependent N-type calcium channel subunit alpha-1BVoltage-dependent P/Q-type calcium channel subunit alpha-1A
Waktu ParuhIn patients adminis…
Vol. DistribusiIn patients adminis…
KlirensZiconotide CSF clea…
Genetik -
Zifibancimig DB19332
biotech | CAS: 2517939-46-5

Zifibancimig is under investigation in clinical trial NCT04567303, focusing on participants with neovascular age-related macular degeneration.

Waktu Paruh-
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Zilovertamab DB18403
biotech | CAS: 2485779-13-1

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ziltivekimab DB18836
biotech | CAS: 2226654-05-1

Ziltivekimab is under investigation in clinical trial NCT06200207 (A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Zimberelimab DB17505
biotech | CAS: 2259860-24-5

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Zimelidine Approved DB04832
small molecule | CAS: 56775-88-3

Zimelidine has been banned worldwide due to serious, sometimes fatal, cases of central and/or peripheral neuropathy known as Guillain-Barré syndrome and due to a peculiar hypersensitivity reaction involving many organs including skin exanthema, flu-like sympt…

Kategori:
Antidepressive AgentsCentral Nervous System DepressantsCytochrome P-450 CYP3A Inhibitors +16
Target Protein:
Sodium-dependent serotonin transporterAmine oxidase [flavin-containing] BAmine oxidase [flavin-containing] A
Waktu Paruh8.4 +/- 2.0 hours f…
Vol. Distribusi-
Klirens-
Genetik -
Zinc Approved DB01593
small molecule | CAS: 7440-66-6

A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with…

Kategori:
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical UseDiet, Food, and NutritionElements +12
Target Protein:
B1 bradykinin receptorMethylated-DNA--protein-cysteine methyltransferaseFructose-bisphosphate aldolase A +121
Waktu ParuhThe half-life of zi…
Vol. DistribusiA pharmacokinetic s…
KlirensIn one study of hea…
Genetik -
Zinc gluconate Approved DB11248
small molecule | CAS: 4468-02-4

Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA [L2081]. It is available as a trace mineral supplement and over the cou…

Kategori:
Acids, AcyclicAgents for Treatment of Hemorrhoids and Anal Fissures for Topical UseAlimentary Tract and Metabolism +8
Waktu Paruh280 days [L2091]
Vol. DistribusiStored primarily in…
KlirensPlease refer to Dru…
Genetik -
Zinc oxide Approved DB09321
small molecule | CAS: 1314-13-2

Zinc oxide is an inorganic compound used in a number of manufacturing processes. It can be found in rubbers, plastics, ceramics, glass, cement, lubricants, paints, ointments, adhesives, sealants, pigments, foods, batteries, ferrites, fire retardants, and firs…

Kategori:
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical UseBasic Ointments and ProtectantsBasic Powders and Demulcents +12
Waktu ParuhIntended for local …
Vol. DistribusiIntended for local …
KlirensIntended for local …
Genetik -
Zinlirvimab DB18867
biotech | CAS: 2417213-75-1

Zinlirvimab is under investigation in clinical trial NCT03707977 (Dual Bnab Treatment in Children).

Waktu Paruh-
Vol. Distribusi-
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Genetik -
biotech | CAS: 1387453-03-3

Zinpentraxin alfa is a recombinant form of PTX-2, a naturally circulating human protein. It is under investigation in clinical trial NCT01981850 (A Phase 2 Study Of PRM-151 In Subjects With Myelofibrosis).

Kategori:
Acute-Phase ProteinsAmino Acids, Peptides, and ProteinsAmyloid +7
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Ziprasidone Approved DB00246
small molecule | CAS: 146939-27-7

Disorders such as schizophrenia and bipolar disorder can significantly impair mood, cognition, and behavior.[A190525] These mental illnesses can often be accompanied by comorbidities such as depression and substance abuse, and can significantly impact the qua…

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +45
Target Protein:
D(2) dopamine receptorNeuronal acetylcholine receptor subunit alpha-75-hydroxytryptamine receptor 2A +24
Waktu ParuhThe half life of zi…
Vol. DistribusiThe mean apparent v…
KlirensThe mean apparent s…
Genetik -
biotech | CAS: 2377668-38-5

Deskripsi belum tersedia.

Waktu Paruh-
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ZM-39923 DB17064
small molecule | CAS: 273727-89-2

ZM-39923 is a small molecule that inhibits Janus kinase and human tissue transglutaminase (TGM2).[A253177]

Target Protein:
Tyrosine-protein kinase JAK1Tyrosine-protein kinase JAK3
Waktu Paruh-
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Genetik -
Zofin DB16519
biotech

Zofin, previously known as Organicell Flow, is a nanoparticle-based therapeutic derived from perinatal sources which is manufactured in a way that retains the naturally occurring microRNAs without the addition of other substances[L31323].

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Zolbetuximab Approved DB15118
biotech | CAS: 1496553-00-4

Zolbetuximab is under investigation in clinical trial NCT01630083 (Efficacy and Safety of IMAB362 in Combination With the EOX Regimen for CLDN18.2-positive Gastric Cancer).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Target Protein:
Claudin-18
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Zolpidem Approved DB00425
small molecule | CAS: 82626-48-0

Zolpidem, also known as _Ambien_, is a hypnotic drug that was initially approved by the FDA in 1992 [FDA label]. Zolpidem improves sleep in patients with insomnia. It is aimed for use in patients with difficulties initiating sleep. This drug decreases the ti…

Kategori:
Benzodiazepine hypnotics and sedativesCentral Nervous System AgentsCentral Nervous System Depressants +21
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Gamma-aminobutyric acid receptor subunit gamma-3Gamma-aminobutyric acid receptor subunit alpha-2 +2
Waktu ParuhThe average zolpide…
Vol. Distribusi0.54 to 0.68 L/kg (…
KlirensIn a clinical trial…
Genetik -
Zomepirac DB04828
small molecule | CAS: 33369-31-2

Zomepirac, formerly marketed as Zomax tablets, was associated with fatal and near-fatal anaphylactoid reactions. The manufacturer voluntarily removed Zomax tablets from the Canadian, US, and UK markets in March 1983.

Kategori:
Acetic Acid Derivatives and Related SubstancesAgents causing hyperkalemiaAgents that produce hypertension +15
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2Prostaglandin D2 receptor 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Zotepine Approved DB09225
small molecule | CAS: 26615-21-4

Zotepine, with the formula (2-chloro-11-(2-dimethyl-amino-ethoxy)-dibenzo thiepin, is a neuroleptic drug. It was designed and synthesized by Fujisawa Pharmaceutical Co Ltd.[A31855] It has been used as an antipsychotic in Japan, India and some places in Europe…

Kategori:
Antidepressive AgentsAntipsychotic AgentsAntipsychotic Agents (Second Generation [Atypical]) +21
Target Protein:
D(1) dopamine receptorD(2) dopamine receptor5-hydroxytryptamine receptor 2A +4
Waktu ParuhThe half-life of zo…
Vol. DistribusiThe apparent volume…
KlirensThe apparent oral c…
Genetik -
ZUBERITAMAB DB19443
biotech | CAS: 2251143-19-6

Zuberitamab is under investigation in clinical trial NCT06642909 (A Phase II Study of Zuberitamab Injection in Patients With Primary Membranous Nephropathy).

Waktu Paruh-
Vol. Distribusi-
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Zucapsaicin Approved DB09120
small molecule | CAS: 25775-90-0

Zucapsaicin, the cis-isomer of capsaicin, is a topical analgesic used to treat osteoarthritis of the knee and other neuropathic pain. It is a modulator of transient receptor potential cation channel subfamily V member 1 (TRPV-1), also known as the vanilloid o…

Kategori:
AlkaloidsAlkenesAlkynes +25
Target Protein:
Transient receptor potential cation channel subfamily V member 1
Waktu ParuhIn rats, the elimin…
Vol. Distribusi-
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Genetik -
ZVS101e DB18424
biotech

ZVS101e is a recombinant adeno-associated virus vector carrying human CYP4V2 gene.

Waktu Paruh-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Xanthan lyase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
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