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3253

Total database: 17430
Struktur (SMILES)
2451 (75.3%)
Target
1833 (56.3%)
Genomik
35 (1.1%)
Referensi
3253 (100.0%)

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Hasil Pencarian (3253)

Halaman 46 / 66
Patupilone DB03010
small molecule | CAS: 152044-54-7

Epothilone B is a 16-membered macrolide that mimics the biological effects of taxol.

Kategori:
Anti-Bacterial AgentsAntimitotic AgentsAntineoplastic Agents +9
Target Protein:
Tubulin beta chainTubulin beta-1 chainTubulin beta-4B chain +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pazufloxacin DB11774
small molecule | CAS: 127045-41-4

Pazufloxacin is under investigation in clinical trial NCT02592096 (Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol).

Kategori:
4-QuinolonesAnti-Bacterial AgentsAnti-Infective Agents +15
Target Protein:
DNA gyrase subunit ADNA gyrase subunit BDNA topoisomerase 4 subunit A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PB127 DB06208
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PBT-434 Approved DB16965
small molecule | CAS: 1232840-87-7

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingQuinazolines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PCI-27483 DB13000
small molecule | CAS: 871266-63-6

PCI-27483 has been used in trials studying the treatment of Pancreatic Cancer, Ductal Adrenocarcinoma, and Exocrine Pancreatic Cancer.

Kategori:
AmidesAmidinesAmino Acids +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PCLX-001 DB15567
small molecule | CAS: 1215011-08-7

PCLX-001 is a first-in-kind N-Myristoyltransferase (NMT) inhibitor being developed by [Pacylex Pharmaceuticals](https://pacylex.com). Current studies have shown that PCLX-001 works differently than other known cancer drugs and has high activity and positive r…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PCS-499 DB15122
small molecule | CAS: 1268605-91-9

PCS-499 is under investigation in clinical trial NCT01487109 (A Phase 2 Study to Evaluate the Safety and Efficacy of CTP-499 in Type 2 Diabetic Nephropathy Patients).

Kategori:
DeuteriumHeterocyclic Compounds, Fused-RingPurines +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PD-169316 DB17040
small molecule | CAS: 152121-53-4

PD-169316 is a p38 MAP kinase inhibitor.[A253062]

Kategori:
Enzyme Inhibitors
Target Protein:
Polyunsaturated fatty acid 5-lipoxygenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PD-217014 DB12493
small molecule | CAS: 444088-20-4

PD-217,014 has been used in trials studying the treatment of Pain and Irritable Bowel Syndrome.

Kategori:
Acids, AcyclicAmino AcidsAmino Acids, Peptides, and Proteins +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 2408734-39-2

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector Therapies
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pefcalcitol DB11786
small molecule | CAS: 381212-03-9

Pefcalcitol has been investigated for the basic science of Psoriasis.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Peg-100 stearate Approved DB11225
small molecule | CAS: 9004-99-3

Deskripsi belum tersedia.

Kategori:
Pegylated agents
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pegadricase DB15129
biotech | CAS: 1040753-26-1

Pegadricase is under investigation in clinical trial NCT01021241 (Safety and Efficacy Study of Intravenous Uricase-PEG 20).

Waktu Paruh-
Vol. Distribusi-
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Pegamotecan DB12842
small molecule | CAS: 581079-18-7

Pegamotecan has been used in trials studying the treatment of Cancer of Stomach, Sarcoma, Soft Tissue, and Gastroesophageal Cancer.

Kategori:
AlcoholsAlkaloidsCompounds used in a research, industrial, or household setting +5
Target Protein:
DNA topoisomerase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pegargiminase DB06592
small molecule | CAS: 1394129-74-8

Pegargiminase is an anticancer agent.

Kategori:
AlcoholsCompounds used in a research, industrial, or household settingEnzymes +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pegaspargase Approved DB00059
biotech | CAS: 130167-69-0

Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia.[L44667] Asparagine is an amino acid that is vital f…

Kategori:
AlcoholsAmidohydrolasesAntineoplastic Agents +15
Target Protein:
L-asparagine
Waktu ParuhThe mean eliminatio…
Vol. DistribusiBased on a non-comp…
KlirensFor a single intram…
Genetik -
Pegcantratinib DB16280
small molecule | CAS: 1233363-33-1

Pegcantratinib is under investigation in clinical trial NCT03448081 (Safety, Tolerability and Efficacy of SNA-120 for Treatment of Pruritus and Psoriasis in Subjects Treated With Calcipotriene).

Kategori:
Heterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pegilodecakin DB15162
biotech | CAS: 1966111-35-2

Pegilodecakin is under investigation in clinical trial NCT03382912 (Study of Pegilodecakin (LY3500518) With Nivolumab Compared to Nivolumab Alone Second-line Tx in Participants With Metastatic Non-Small Cell Lung Cancer).

Kategori:
AlcoholsAmino Acids, Peptides, and ProteinsBiological Factors +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Peginesatide Approved DB08894
biotech | CAS: 913976-27-9

Peginesatide is a synthetic peptide attached to polyethylene glycol for the treatment of anemia. The polyethylene glycol moiety helps make the drug less immunogenic and prolongs its plasma half-life. Chemically, peginesatide is designed to mimic the pharmacol…

Kategori:
AlcoholsAmino Acids, Peptides, and ProteinsAntianemic Preparations +10
Target Protein:
Erythropoietin receptor
Waktu ParuhIV dose, healthy su…
Vol. DistribusiIV dose, dialysis p…
KlirensSystemic clearance,…
Genetik -
Peginterferon beta-1a Approved DB09122
biotech | CAS: 1211327-92-2

Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms…

Kategori:
Adjuvants, ImmunologicAmino Acids, Peptides, and ProteinsAntineoplastic and Immunomodulating Agents +13
Target Protein:
Interferon alpha/beta receptor 1
Waktu ParuhThe mean half life …
Vol. DistribusiThe volume of distr…
KlirensThe average steady …
Genetik -
Pegvaliase Approved DB12839
biotech | CAS: 1585984-95-7

Pegvaliase is a recombinant phenylalanine ammonia lyase (PAL) enzyme derived from _Anabaena variabilis_ that converts phenylalanine to ammonia and _trans_-cinnamic acid [A33284]. Both the U.S. Food and Drug Administration and European Medicines Agency approve…

Kategori:
Alimentary Tract and MetabolismAmino Acids, Peptides, and ProteinsAmmonia-Lyases +7
Target Protein:
Phenylalanine-4-hydroxylase
Waktu ParuhFollowing once-dail…
Vol. DistribusiThe mean ± SD (rang…
KlirensAt steady state fol…
Genetik -
biotech | CAS: 1620390-06-8

Pegvorhyaluronidase alfa is under investigation in clinical trial NCT02241187 (Two Stage Study Of Single Dose PEGPH20 And Cetuximab In Patients With Pancreatic Adenocarcinoma Prior To Surgical Resection).

Kategori:
Carbon-Oxygen LyasesEnzymesEnzymes and Coenzymes +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 1417412-83-9

PEGylated Recombinant Factor VIII is under investigation in clinical trial NCT02585960 (BAX 855 Pk-guided Dosing).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1380087-89-7

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Bromodomain-containing protein 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pelacarsen DB16284
biotech | CAS: 1637637-70-7

Pelacarsen is under investigation in clinical trial NCT03070782 (Phase 2 Study of ISIS 681257 (Akcea-apo(a)-lrx) in Participants With Hyperlipoproteinemia(a) and Cardiovascular Disease).

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleotidesPolynucleotides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pelcitoclax DB16285
small molecule | CAS: 1619923-36-2

Pelcitoclax is under investigation in clinical trial NCT04210037 (Study of Combination APG-1252 Plus Paclitaxel in Patients With Relapsed/refractory Small Cell Lung Cancer).

Kategori:
Amines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pelitrexol DB12757
small molecule | CAS: 446022-33-9

Pelitrexol has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.

Kategori:
Sulfur Compounds
Target Protein:
Trifunctional purine biosynthetic protein adenosine-3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pelubiprofen DB12150
small molecule | CAS: 69956-77-0

Pelubiprofen has been investigated for the treatment of Chronic Back Pain.

Kategori:
Acids, Carbocyclic
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pemafibrate DB15212
small molecule | CAS: 848259-27-8

Pemafibrate is under investigation in clinical trial NCT03350165 (A Study of Pemafibrate in Patients With Nonalcoholic Fatty Liver Disease (NAFLD)).

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +6
Target Protein:
Peroxisome proliferator-activated receptor alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pemoline Approved DB01230
small molecule | CAS: 2152-34-3

In 2005, the Food and Drug Administration (FDA) withdrew approval for pemoline. In March 2005, Abbott Laboratories (Cylert marketer) had discontinued the production of Cylert arguing economic reasons.

Kategori:
Central Nervous System AgentsCentral Nervous System StimulantsCentrally Acting Sympathomimetics +4
Waktu ParuhThe serum half-life…
Vol. Distribusi-
Klirens-
Genetik -
Penclomedine DB12987
small molecule | CAS: 108030-77-9

Penclomedine has been used in trials studying the treatment of Lymphoma and Unspecified Adult Solid Tumor, Protocol Specific.

Kategori:
Antineoplastic AgentsPyridines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Penicillamine Approved DB00859
small molecule | CAS: 52-67-5

Penicillamine is a pharmaceutical of the chelator class. The pharmaceutical form is D-penicillamine, as L-penicillamine is toxic (it inhibits the action of pyridoxine). It is an ?-amino acid metabolite of penicillin, although it has no antibiotic properties.

Kategori:
Agents Causing Muscle ToxicityAmino AcidsAmino Acids, Peptides, and Proteins +16
Target Protein:
Copper
Waktu Paruh1 hour
Vol. Distribusi-
Klirens-
Genetik -
Penicillium roqueforti Approved DB10812
biotech

Penicillium roqueforti is a fungus which can provoke allergic reactions. Penicillium roqueforti extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pentaerythritol tetranitrate Approved DB06154
small molecule | CAS: 78-11-5

Pentaerythritol tetranitrate is the nitrate ester of pentaerythritol that possesses explosive properties. When mixed with a plasticizer, this chemical forms a plastic explosive. It is recognized by the FDA to be a coronary vasodilator in the treatment of hear…

Kategori:
AlcoholsAntianginal AgentsCarbohydrates +11
Target Protein:
Hemoglobin subunit alphaHemoglobin subunit betaFree radicals
Waktu ParuhThe elimination hal…
Vol. DistribusiThe steady-state vo…
KlirensIn a pharmacokineti…
Genetik -
Pentetreotide Approved DB12602
small molecule | CAS: 138661-02-6

Pentetreotide has been used in trials studying the diagnosis of Cushing's syndrome.

Kategori:
AcetatesAcids, AcyclicAmines +20
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pentobarbital Approved DB00312
small molecule | CAS: 76-74-4

A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness…

Kategori:
Adjuvants, AnesthesiaAnticholinergic AgentsAnticonvulsants +23
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Gamma-aminobutyric acid receptor subunit alpha-2Gamma-aminobutyric acid receptor subunit alpha-3 +10
Waktu Paruh5 to 50 hours (dose…
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 123583-37-9

Peptide YY (3-36), a synthetic human PYY 3-36, is a compound being evaluated for the treatment of obesity. It reduces appetite and increases satiety in obese patients.

Kategori:
Amino Acids, Peptides, and ProteinsGastrointestinal HormonesHormones +3
Target Protein:
Neuropeptide Y receptor type 2Neuropeptide Y receptor type 1Neuropeptide Y receptor type 5 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perampanel Approved DB08883
small molecule | CAS: 380917-97-5

Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizu…

Kategori:
AMPA Receptor AntagonistsAnticonvulsantsCentral Nervous System Depressants +23
Target Protein:
Glutamate receptor 2Glutamate receptor 3Glutamate receptor 4 +1
Waktu ParuhPerampanel has a lo…
Vol. DistribusiThe volume of distr…
KlirensIn healthy patients…
Genetik -
Perazine Approved DB12710
small molecule | CAS: 84-97-9

Perazine has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.

Kategori:
Antipsychotic AgentsCentral Nervous System AgentsCentral Nervous System Depressants +12
Target Protein:
D(2) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perflubutane Approved DB12821
small molecule | CAS: 355-25-9

Perflubutane has been used in trials studying the diagnostic of Liver Mass, Liver Diseases, Liver Metastasis, Portal Hypertension, and Peripheral Artery Disease. It is a cardiovascular drug designed to enable ultrasound to compete more effectively with nuclea…

Kategori:
AnionsCompounds used in a research, industrial, or household settingContrast Media +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 84808-64-0

Oxycyte has been used in trials studying the treatment of Traumatic Brain Injury.

Kategori:
Hydrocarbons, FluorinatedHydrocarbons, Halogenated
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perfosfamide DB12727
small molecule | CAS: 62435-42-1

Perfosfamide has been used in trials studying the treatment of Lymphoma, Neuroblastoma, and Multiple Myeloma and Plasma Cell Neoplasm.

Kategori:
Hydrocarbons, HalogenatedMustard CompoundsNitrogen Mustard Compounds +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pertuzumab Approved DB06366
biotech | CAS: 380610-27-5

Pertuzumab is a recombinant humanized monoclonal antibody that targets the extracellular dimerization domain (subdomain II) of the human epidermal growth factor receptor 2 protein (HER2). It consists of two heavy chains and two lights chains that have 448 and…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +19
Target Protein:
Receptor tyrosine-protein kinase erbB-2
Waktu ParuhThe median half-lif…
Vol. DistribusiThe average steady-…
KlirensThe median clearanc…
Genetik -
Perzinfotel DB12365
small molecule | CAS: 144912-63-0

Perzinfotel has been used in trials studying the treatment of Diabetes Mellitus and Diabetic Neuropathy, Painful.

Kategori:
Aza CompoundsOrganophosphorus Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Petesicatib DB15297
small molecule | CAS: 1252637-35-6

Petesicatib is under investigation in clinical trial NCT02295332 (A Study of RG7625 in Healthy Volunteers).

Kategori:
Enzyme Inhibitors
Target Protein:
Cathepsin S
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pexacerfont DB12572
small molecule | CAS: 459856-18-9

Pexacerfont has been investigated for the treatment of Alcoholism, Anxiety Disorder, Alcohol Dependence, and Alcohol-Related Disorders.

Target Protein:
Corticotropin-releasing factor receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 1058624-46-6

Pexastimogene devacirepvec is under investigation in clinical trial NCT00429312 (A Study of Recombinant Vaccinia Virus to Treat Malignant Melanoma).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pexidartinib Approved DB12978
small molecule | CAS: 1029044-16-3

Pexidartinib is a selective tyrosine kinase inhibitor that works by inhibiting the colony-stimulating factor (CSF1)/CSF1 receptor pathway. Pexidartinib was originally developed by Daiichi Sankyo, Inc. and it was approved by the FDA in August 2019 as the first…

Kategori:
AminesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +34
Target Protein:
Macrophage colony-stimulating factor 1 receptorMast/stem cell growth factor receptor KitReceptor-type tyrosine-protein kinase FLT3 +1
Waktu ParuhThe elimination hal…
Vol. DistribusiThe apparent volume…
KlirensThe apparent cleara…
Genetik -
Pexmetinib DB16294
small molecule | CAS: 945614-12-0

Pexmetinib is under investigation in clinical trial NCT04074967 (Study of ARRY-614 Plus Either Nivolumab or Ipilimumab).

Kategori:
AmidesHeterocyclic Compounds, Fused-RingPyrazoles
Target Protein:
Angiopoietin-1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-00217830 DB12998
small molecule | CAS: 846032-02-8

PF-00217830 has been used in trials studying the treatment of Schizophrenia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
D(2) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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