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3253

Total database: 17430
Struktur (SMILES)
2451 (75.3%)
Target
1833 (56.3%)
Genomik
35 (1.1%)
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3253 (100.0%)

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Halaman 45 / 66
Ozanezumab DB12891
biotech | CAS: 1310680-64-8

Ozanezumab has been used in trials studying the treatment of Multiple Sclerosis, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis, Relapsing-Remitting.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ozanimod Approved DB12612
small molecule | CAS: 1306760-87-1

Ozanimod is a once-daily sphingosine 1-phosphate receptor modulator for the treatment of relapsing Multiple Sclerosis (MS) and inflammatory bowel disease. It was developed by Celgene (now acquired by Bristol-Myers Squibb) [L11025] and was approved by the FDA …

Kategori:
Antineoplastic and Immunomodulating AgentsBCRP/ABCG2 SubstratesCytochrome P-450 CYP2C8 Substrates +13
Target Protein:
Sphingosine 1-phosphate receptor 1Sphingosine 1-phosphate receptor 5
Waktu ParuhThe half-life of oz…
Vol. DistribusiThe average volume …
KlirensThe mean apparent o…
Genetik -
Ozarelix DB12581
small molecule | CAS: 295350-45-7

Ozarelix has been used in trials studying the treatment of Prostate Cancer, Benign Prostatic Hypertrophy, and Benign Prostatic Hyperplasia (BPH).

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
Target Protein:
Gonadotropin-releasing hormone receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ozenoxacin Approved DB12924
small molecule | CAS: 245765-41-7

To date, ozenoxacin has been used in trials studying the treatment of impetigo. As of December 11, 2017 the FDA approved Ferrer Internacional S.A.'s Xepi (ozenoxacin 1%) as a topically applied cream indicated for the treatment of impetigo caused by *Staphy…

Kategori:
AminesAnti-Bacterial AgentsAnti-Infective Agents +9
Target Protein:
DNA gyrase subunit ADNA topoisomerase 4 subunit ADNA gyrase subunit B +1
Waktu Paruh-
Vol. DistribusiOzenoxacin undergoe…
KlirensOzenoxacin undergoe…
Genetik -
Ozone DB12510
small molecule | CAS: 10028-15-6

Ozone has been used in trials studying the treatment of Mild Asthma and Primary Apical Periodontite.

Kategori:
Compounds used in a research, industrial, or household settingGasesNoxae +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ozoralizumab DB12014
biotech | CAS: 1167985-17-2

Ozoralizumab has been used in trials studying the treatment of Rheumatoid Arthritis and Active Rheumatoid Arthritis.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
P-113D DB04987
biotech | CAS: 190673-60-0

P-113D is a novel 12 amino-acid antimicrobial peptide drug derived from histatins, which are compounds found naturally in human saliva. It is being pursued as a potential treatment for cystic fibrosis by Demegen, Inc.

Kategori:
Amino Acids, Peptides, and ProteinsAntimicrobial Cationic PeptidesAntimicrobial Peptides +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
P-2045 Re-188 DB17204
biotech | CAS: 934712-65-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
p-Aminophenol DB14144
small molecule | CAS: 123-30-8

Deskripsi belum tersedia.

Kategori:
AminesAniline CompoundsBenzene Derivatives +4
Target Protein:
Carbonic anhydrase 14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 123-08-0

Deskripsi belum tersedia.

Kategori:
Aldehydes
Target Protein:
4-aminobutyrate aminotransferase, mitochondrialAmine oxidase [flavin-containing] B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1126-48-3

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicBenzene DerivativesBenzoates +9
Target Protein:
Carbonic anhydrase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
P-nitrobiphenyl Approved DB12300
small molecule | CAS: 92-93-3

Pnb has been used in trials studying the treatment of Pelvic Organ Prolapse.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
p-Quaterphenyl DB12794
small molecule | CAS: 135-70-6

p-Quaterphenyl has been used in trials studying the treatment of Malaria.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 104-15-4

Deskripsi belum tersedia.

Kategori:
ArylsulfonatesArylsulfonic AcidsBenzene Derivatives +3
Target Protein:
Lysozyme CPro-cathepsin H
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PAC-113 DB05756
small molecule

PAC-113 an anti-fungal, for the treatment of oral candidiasis infections. It is a 12 amino-acid antimicrobial peptide derived from a naturally occurring histatin protein found in saliva. In vitro studies demonstrate that it has potent anti-fungal activity aga…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PAC-14028 DB12428
small molecule | CAS: 1005168-10-4

PAC-14028 has been used in trials studying the treatment of Skin Pruritus, Papulopustular Rosacea, and Erythematotelangiectatic Rosacea.

Kategori:
Acids, AcyclicAcrylatesAmides +1
Target Protein:
Transient receptor potential cation channel subfamily V member 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Paclitaxel Approved DB01229
small molecule | CAS: 33069-62-4

Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic…

Kategori:
Agents Causing Muscle ToxicityAlbuminsAmino Acids, Peptides, and Proteins +42
Target Protein:
Tubulin beta-1 chainApoptosis regulator Bcl-2Nuclear receptor subfamily 1 group I member 2
Waktu ParuhWhen a 24 hour infu…
Vol. Distribusi* 227 to 688 L/m^2 …
Klirens* 21.7 L/h/m2 [Dose…
Genetik -
Pactimibe DB12971
small molecule | CAS: 189198-30-9

Pactimibe has been used in trials studying the treatment of Atherosclerosis and Coronary Heart Disease.

Kategori:
Heterocyclic Compounds, Fused-RingIndolesSterol O-Acyltransferase, antagonists & inhibitors
Target Protein:
Liver carboxylesterase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Padimate A DB11229
small molecule

Padimate A is an ester derivative of PABA and an ingredient in some sunscreens. It absorbs ultraviolet rays thereby preventing sunburn, however, its chemical structure and behaviour is similar to an industrial free radical generator. In Europe this chemical w…

Kategori:
Acids, CarbocyclicAminobenzoatesBenzene Derivatives +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Padimate O Approved DB11570
small molecule | CAS: 21245-02-3

Padimate O is an active sunscreen agent in cosmetics and over-the-counter sunscreen drug products in concentrations up to 8%, as regulated by the FDA [L2153]. It is a structurally-related compound to [DB02362] that absorbs UV-B rays to prevent photodamage. It…

Kategori:
Acids, CarbocyclicAminobenzoatesBenzene Derivatives +7
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Padsevonil DB14977
small molecule | CAS: 1294000-61-5

Padsevonil is under investigation in clinical trial NCT03695094 (A Study in Participants With Epilepsy, to Evaluate the Pharmacokinetics, Safety and Tolerability of Oxcarbazepine on Padsevonil).

Kategori:
AnticonvulsantsCentral Nervous System AgentsCentral Nervous System Depressants +3
Target Protein:
Synaptic vesicle glycoprotein 2A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Palazestrant DB18971
small molecule | CAS: 2092925-89-6

Palazestrant is under investigation in clinical trial NCT06016738 (OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Paliperidone Approved DB01267
small molecule | CAS: 144598-75-4

Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a com…

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +37
Target Protein:
5-hydroxytryptamine receptor 2AD(2) dopamine receptorD(4) dopamine receptor +12
Waktu ParuhThe terminal elimin…
Vol. Distribusi* 487 L
Klirens-
Genetik -
small molecule | CAS: 14967-68-1

Palladium Pd-103 is under investigation in clinical trial NCT00247312 (Pd-103 Dose De-Escalation for Early Stage Prostate Cancer: A Prospective Randomized Trial).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 147732-56-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 221227-05-0

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Palomid 529 DB12812
small molecule | CAS: 914913-88-5

Palomid 529 has been used in trials studying the treatment of Age-Related Macular Degeneration.

Kategori:
Heterocyclic Compounds, Fused-RingPyrans
Target Protein:
Target of rapamycin complex 2 subunit MAPKAP1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Palopegteriparatide Approved DB18676
biotech | CAS: 2222514-07-8

Palopegteriparatide is a parathyroid hormone (PTH) analog. Palopegteriparatide is a prodrug consisting of PTH(1-34) conjugated to a methoxy polyethylene glycol carrier (mPEG) via a proprietary TransCon Linker.[L51134] PTH(1-34) contains the N-terminal part of…

Kategori:
Calcium HomeostasisParathyroid Hormones and AnaloguesSystemic Hormonal Preparations, Excl. Sex Hormones and Insulins +1
Target Protein:
Parathyroid hormone/parathyroid hormone-related peptide receptor
Waktu ParuhThe apparent half-l…
Vol. DistribusiThe estimated appar…
KlirensThe estimated clear…
Genetik -
Paltusotine DB16277
small molecule | CAS: 2172870-89-0

Paltusotine is under investigation in clinical trial NCT04261712 (A Study to Evaluate the Long-term Safety and Efficacy of Paltusotine for the Treatment of Acromegaly (ACROBAT Advance)).

Target Protein:
Somatostatin receptor type 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 59763-91-6

Pancreatic Polypeptide has been investigated for the treatment of Diabetes Mellitus, Type 1.

Kategori:
Amino Acids, Peptides, and ProteinsGastrointestinal AgentsHormones +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pancrelipase Approved DB00085
biotech | CAS: 53608-75-6

Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands.[L2509] The pancrelipase mixture was developed by Ortho-McNeil-Janssen Pharmace…

Kategori:
Alimentary Tract and MetabolismCarboxylic Ester HydrolasesComplex Mixtures +10
Target Protein:
Dietary fatDietary proteinDietary starch
Waktu ParuhPancrelipase acts l…
Vol. DistribusiPancrelipase acts l…
KlirensPancrelipase acts l…
Genetik -
Pancrelipase amylase Approved DB11065
biotech | CAS: 9000-90-2

Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands.[L2509] The amylases are enzymes that help in the chemical process of digestion…

Kategori:
AmylasesAmylases, antagonists & inhibitorsEnzymes +3
Target Protein:
Dietary starch
Waktu ParuhPlease refer to [DB…
Vol. DistribusiPlease refer to [DB…
KlirensPlease refer to [DB…
Genetik -
Pancrelipase lipase Approved DB13147
biotech | CAS: 9001-62-1

Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands.[L2509] The pancrelipase lipase is an enzyme secreted by the pancreas that is r…

Kategori:
Carboxylic Ester HydrolasesEnzymesEnzymes and Coenzymes +4
Target Protein:
Dietary fat
Waktu ParuhPlease refer to [DB…
Vol. DistribusiPlease refer to [DB…
KlirensPlease refer to [DB…
Genetik -
Pancrelipase protease Approved DB11066
biotech | CAS: 9001-94-9

Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands.[L2509] The pancrelipase protease is a mix of enzymes, formed by trypsin and ch…

Kategori:
EnzymesEnzymes and CoenzymesHydrolases +1
Target Protein:
Dietary protein
Waktu ParuhPlease refer to [DB…
Vol. DistribusiPlease refer to [DB…
KlirensPlease refer to [DB…
Genetik -
Panitumumab Approved DB01269
biotech | CAS: 339177-26-3

Panitumumab (ABX-EGF) is a recombinant human IgG2 monoclonal antibody that binds specifically to the human epidermal growth factor receptor (EGFR). This drug is an antineoplastic agent. Panitumumab was granted FDA approval on 27 September 2006.[L17663]

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +16
Target Protein:
Epidermal growth factor receptor
Waktu Paruh7.5 days (range: 4-…
Vol. Distribusi-
Klirens* 4.9+/- 1.4 mL/kg/…
Genetik -
Panthenol Approved DB11204
small molecule | CAS: 16485-10-2

Panthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Panthenol exists as a racemic mixture containing both the dextrorotatory form (dexpanthenol) and the…

Kategori:
AlanineAmino AcidsAmino Acids, Peptides, and Proteins +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pantoprazole Approved DB00213
small molecule | CAS: 102625-70-7

Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatmen…

Kategori:
2-PyridinylmethylsulfinylbenzimidazolesAcid ReducersAlimentary Tract and Metabolism +27
Target Protein:
Potassium-transporting ATPase alpha chain 1Potassium-transporting ATPase subunit betaN(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Waktu ParuhAbout 1 hour[F3202]
Vol. DistribusiThe apparent volume…
Klirens**Adults**: With in…
Genetik -
Paraldehyde Approved DB09117
small molecule | CAS: 123-63-7

Paraldehyde was initially introduced into medical practice in the United Kingdom in 1882 by the Italian physician Vincenzo Cervello. It is classified as a central nervous system (CNS) depressant and has also been found to be an effective anticonvulsant, hypno…

Kategori:
AcetaldehydeAnticonvulsantsCentral Nervous System Agents +4
Waktu ParuhThe mean half life …
Vol. Distribusi-
Klirens-
Genetik -
Parasorbic acid DB14121
small molecule | CAS: 10048-32-5

Sole constituent of "Vogelbeerol" oil obtained by steam distillation of the acidified juice of the ripe berries of the mountain ash.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pardoprunox DB12061
small molecule | CAS: 269718-84-5

Pardoprunox has been used in trials studying the treatment of Early Stage Parkinson's Disease and Advanced Stage Parkinson's Disease. Pardoprunox is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
D(2) dopamine receptorD(3) dopamine receptorD(4) dopamine receptor +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Paritaprevir Approved DB09297
small molecule | CAS: 1216941-48-8

Paritaprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into ni…

Kategori:
AmidesAmino AcidsAmino Acids, Cyclic +27
Target Protein:
Genome polyproteinGag-Pol polyprotein
Waktu Paruh5.5 hr [FDA Label]
Vol. DistribusiVolume of distribut…
Klirens-
Genetik -
Paroxetine Approved DB00715
small molecule | CAS: 61869-08-7

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others.[T653]…

Kategori:
Agents producing tachycardiaAnticholinergic AgentsAntidepressive Agents +39
Target Protein:
Sodium-dependent serotonin transporterSodium-dependent noradrenaline transporter5-hydroxytryptamine receptor 2A +9
Gen Terkait:
ABCB1 CYP2D6 CYP2D6 +4
Waktu ParuhThe mean eliminatio…
Vol. DistribusiParoxetine has a la…
KlirensThe apparent oral c…
Genetik 7 Varian
Parsaclisib DB14867
small molecule | CAS: 1426698-88-5

Parsaclisib is under investigation in clinical trial NCT03126019 (An Open-Label Study of Parsaclisib in Relapsed or Refractory Follicular Lymphoma (CITADEL-203)).

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsPhosphatidylinositol-3-kinase (Pi3K) inhibitors +1
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Parsatuzumab DB14897
biotech | CAS: 1312797-14-0

Parsatuzumab is under investigation in clinical trial NCT01366131 (Study Evaluating the Safety and Efficacy of MEGF0444A in Combination With Carboplatin, Paclitaxel and Bevacizumab in Patients With Advanced or Recurrent Non-Squamous Non-Small Cell Lung Cancer…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pascolizumab DB06560
biotech | CAS: 331243-22-2

Pascolizumab (SB 240683) is a humanized anti-interleukin-4 antibody with therapeutic potential in asthma.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +4
Target Protein:
Interleukin-4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PAT-1251 DB16735
small molecule | CAS: 2098884-52-5

PAT-1251 is under investigation in clinical trial NCT04054245 (PAT-1251 in Treating Patients With Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, or Post-essential Thrombocytosis Myelofibrosis).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pateclizumab DB14997
biotech | CAS: 1202526-59-7

Pateclizumab is under investigation in clinical trial NCT01225393 (A Study to Evaluate the Efficacy and Safety of MLTA3698A in Combination With a Disease-Modifying Anti-Rheumatic Drug (DMARD) Compared With Adalimumab in Combination With a DMARD in Patients Wi…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Patidegib DB12655
small molecule | CAS: 1037210-93-7

Patidegib has been investigated for the treatment of Conventional Chondrosarcoma.

Kategori:
Alkaloids
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Patiromer Approved DB09263
small molecule | CAS: 1260643-52-4

Patiromer is a powder for suspension in water for oral administration, approved in the U.S. as Veltassa in October, 2015. Patiromer is supplied as patiromer sorbitex calcium which consists of the active moiety, patiromer, a non-absorbed potassium-binding poly…

Kategori:
Cation Exchange ResinsCompounds used in a research, industrial, or household settingMacromolecular Substances +3
Target Protein:
Potassium
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Patritumab DB12090
biotech | CAS: 1262787-83-6

Patritumab has been used in trials studying the treatment of LUNG CANCER, Solid Tumors, Neoplasms by Site, Head and Neck Neoplasms, and Non-small Cell Lung Cancer, among others.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 2201–2250 dari 3253
Sebelumnya Halaman 45 / 66 Berikutnya