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6694

Total database: 17430
Struktur (SMILES)
4518 (67.5%)
Target
3751 (56.0%)
Genomik
81 (1.2%)
Referensi
6694 (100.0%)

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Hasil Pencarian (6694)

Halaman 43 / 134
small molecule | CAS: 541-02-6

Cyclomethicone 5 is member of cyclomethicone, which are a group of liquid methyl siloxanes that have low viscosity and high volatility. Cyclomethicones are cyclic in structure with a monomer backbone of one silicon and two oxygen atoms bonded together. Cyclom…

Kategori:
Macromolecular SubstancesOrganosilicon CompoundsPolymers +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cyclopenthiazide Approved DB13532
small molecule | CAS: 742-20-1

Cyclopenthiazide is a thiazide diuretic with antihypertensive properties. In a double blind, randomized crossover study, cyclopenthiazide was effective in reducing diastolic blood pressure in mildly hypertensive non-insulin dependent diabetic patients [A27180…

Kategori:
Antihypertensive AgentsBenzothiadiazinesCardiovascular Agents +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cyclopentolate Approved DB00979
small molecule | CAS: 512-15-2

A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia.

Kategori:
Acids, CarbocyclicAnticholinergic AgentsAutonomic Agents +11
Target Protein:
Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cyclophosphamide Approved DB00531
small molecule | CAS: 50-18-0

Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used…

Kategori:
Alkylating ActivityAlkylating DrugsAntineoplastic Agents +47
Target Protein:
DNANuclear receptor subfamily 1 group I member 2
Gen Terkait:
CYP3A4 CYP2B6
Waktu Paruh3-12 hours
Vol. Distribusi30-50 L
KlirensTotal body clearanc…
Genetik 2 Varian
Cyclopropane DB13984
small molecule | CAS: 75-19-4

Cyclopropane was initially investigated because it was thought to be the toxic element in ethylene. Instead, it turned out to be an excellent anesthetic with very rapid onset and recovery while maintaining stable hemodynamics. Its use was ultimately limited b…

Kategori:
AnestheticsCentral Nervous System AgentsCentral Nervous System Depressants +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cycloserine Approved DB00260
small molecule | CAS: 68-41-7

Antibiotic substance produced by Streptomyces garyphalus.

Kategori:
Amino AcidsAmino Acids, NeutralAmino Acids, Peptides, and Proteins +14
Target Protein:
Glutamate receptor ionotropic, NMDA 1D-alanine--D-alanine ligase AAlanine racemase
Waktu ParuhHalf-life in patien…
Vol. Distribusi-
Klirens-
Genetik -
Cyclosporine Approved DB00091
small molecule | CAS: 59865-13-3

Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_.[A174049] Initially manufactur…

Kategori:
Agents causing hyperkalemiaAgents Causing Muscle ToxicityAgents that produce hypertension +45
Target Protein:
Guided entry of tail-anchored proteins factor CAMLGProtein phosphatase 3 catalytic subunit alphaCalcineurin subunit B type 2 +2
Waktu ParuhThe half-life of cy…
Vol. DistribusiThe distribution of…
KlirensCyclosporin shows a…
Genetik -
Cyclothiazide Approved DB00606
small molecule | CAS: 2259-96-3

As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like cyclothiazide also inhibit sodium ion transport…

Kategori:
Antihypertensive AgentsCardiovascular AgentsDiuretics +11
Target Protein:
Sodium/potassium-transporting ATPase subunit gammaCarbonic anhydraseCarbonic anhydrase 2 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cycrimine Approved DB00942
small molecule | CAS: 77-39-4

Cycrimine is a drug used to reduce levels of acetylcholine to return a balance with dopamine in the treatment and management of Parkinson's disease.

Kategori:
Agents producing tachycardiaAnticholinergic AgentsMuscarinic Antagonists
Target Protein:
Muscarinic acetylcholine receptor M1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cynodon dactylon pollen Approved DB10351
biotech

Cynodon dactylon pollen, also known as bermuda grass pollen, is a standardized grass pollen extracts used for the diagnosis and treatment of allergic disease to grass pollen. It can be cutaneously, intradermally and subcutaneously administered to initiate an …

Kategori:
Allergenic ExtractsCell-mediated ImmunityGrass Pollen Allergen Extracts +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CYP-001 DB15739
biotech

CYP-001 is a mesenchymoangioblast (MCA)-derived mesenchymal stem cell (MSC) therapy that originates from the mesoderm. When activated with fibroblast growth factor-2 (FGF-2), MCAs create colonies with specific phenotypes. These cells are then able to differen…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cyproheptadine Approved DB00434
small molecule | CAS: 129-03-3

Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors.[L32474] It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation[L32519] and its off-label use in the tr…

Kategori:
Agents producing tachycardiaAgents that reduce seizure thresholdAnti-Allergic Agents +28
Target Protein:
Histamine H1 receptor5-hydroxytryptamine receptor 2A5-hydroxytryptamine receptor 2C +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cyproterone acetate Approved DB04839
small molecule | CAS: 427-51-0

An anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of …

Kategori:
Adrenal Cortex HormonesAntiandrogensAntiandrogens and Estrogens +27
Target Protein:
Androgen receptorProstate-specific antigen
Waktu ParuhElimination Followi…
Vol. Distribusi-
Klirens-
Genetik -
Cysteamine Approved DB00847
small molecule | CAS: 60-23-1

Cystinosis is a rare disease caused by mutations in the CTNS gene that encodes for cystinosin, a protein responsible for transporting cystine out of the cell lysosome. A defect in cystinosin function is followed by cystine accumulation throughout the body, es…

Kategori:
Alimentary Tract and MetabolismAminesAmino Acids and Derivatives +11
Target Protein:
SomatostatinCystineNeuropeptide Y receptor type 2
Waktu ParuhThe half-life of cy…
Vol. DistribusiCysteamine has a vo…
KlirensThe plasma clearanc…
Genetik -
Cysteine Approved DB00151
small molecule | CAS: 52-90-4

A thiol-containing non-essential amino acid that is oxidized to form cystine.

Kategori:
Amino AcidsAmino Acids, NeutralAmino Acids, Peptides, and Proteins +9
Target Protein:
Glutamate--cysteine ligase regulatory subunitGlutamate--cysteine ligase catalytic subunitAspartate aminotransferase, cytoplasmic +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cystine Approved DB00138
small molecule | CAS: 56-89-3

A covalently linked dimeric nonessential amino acid formed by the oxidation of cysteine. Two molecules of cysteine are joined together by a disulfide bridge to form cystine.

Kategori:
Amino AcidsAmino Acids, DiaminoAmino Acids, Dicarboxylic +12
Target Protein:
Cystine/glutamate transporterCystinosin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CYT006-AngQb DB05739
biotech

CYT006-AngQb is a therapeutic vaccine in development for treatment of hypertension. It is designed to instruct the patient’s immune system to produce an antibody response against angiotensin II, a small peptide that causes blood vessels to narrow and results…

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
Target Protein:
Type-1 angiotensin II receptorType-2 angiotensin II receptor
Waktu Paruh4 months
Vol. Distribusi-
Klirens-
Genetik -
CYT007-TNFQb DB05758
biotech

CYT007-TNFQb is an active immunization therapy that aims at providing a novel treatment to people suffering from RA or psoriasis. The vaccine should allow for administration of low amounts of drug to individual patients (in the microgram range) and for conv…

Target Protein:
Tumor necrosis factor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cytarabine Approved DB00987
small molecule | CAS: 147-94-4

A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of …

Kategori:
Agents Causing Muscle ToxicityAnti-Infective AgentsAntimetabolites +23
Target Protein:
DNA polymerase betaDNA polymerase catalytic subunitDNA
Waktu Paruh10 minutes
Vol. Distribusi-
Klirens-
Genetik -
Cythioate DB11392
small molecule | CAS: 115-93-5

Cythioate is a member of the organothiophosphate compounds that is used as an insecticide and anthelmintic. It is mainly used in veterinary as a treatment for fleas.

Kategori:
AgrochemicalsCompounds used in a research, industrial, or household settingInsecticides +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cytidine DB02097
small molecule | CAS: 65-46-3

Deskripsi belum tersedia.

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleosidesPyrimidine Nucleosides +2
Target Protein:
Uridine-cytidine kinase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 84-52-6

Deskripsi belum tersedia.

Kategori:
Cytosine NucleotidesNucleic Acids, Nucleotides, and NucleosidesNucleotides +3
Target Protein:
Ribonuclease pancreatic
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 63-37-6

A pyrimidine ribonucleoside 5'-monophosphate having cytosine as the nucleobase.

Kategori:
Cytosine NucleotidesNucleic Acids, Nucleotides, and NucleosidesNucleotides +3
Target Protein:
Uridine-cytidine kinase 23-deoxy-manno-octulosonate cytidylyltransferase2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

A nucleoside monophosphate sugar which donates N-acetylneuraminic acid to the terminal sugar of a ganglioside or glycoprotein. [PubChem]

Target Protein:
N-acylneuraminate cytidylyltransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cytisine DB09028
small molecule | CAS: 485-35-8

Cytisine is an alkaloid naturally derived from the Fabaceae family of plants including the genera Laburnum and Cytisus. Recent studies have shown it to be a more effective and significantly more affordable smoking cessation treatment than nicotine replacement…

Kategori:
AlkaloidsDrugs Used in Addictive DisordersDrugs Used in Nicotine Dependence +5
Target Protein:
Neuronal acetylcholine receptor subunit alpha-2Neuronal acetylcholine receptor subunit beta-4Neuronal acetylcholine receptor subunit alpha-4 +4
Waktu Paruh4.8 hours.
Vol. DistribusiOral: 6.2 l/kg Oral…
KlirensRenal: 43 mL/min.
Genetik -
CZEN 002 DB05479
small molecule

CZEN-002 is a novel, non-azole anti-fungal synthetic octapeptide, derived from alpha-Melanocyte-Stimulating Hormone (a-MSH). CZEN-002 modulates inflammatory and immune responses. It has also been shown to kill Candida albicans (C. albicans), a single-celled f…

Target Protein:
Melanocyte-stimulating hormone receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

A reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols. [PubChem]

Target Protein:
6,7-dimethyl-8-ribityllumazine synthase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Chymotrypsinogen B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Chymotrypsinogen B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-3082-L DB17440
biotech | CAS: 2170657-73-3

D-3082-L is one of the components of the human papilloma virus (HPV) type 16 E6/E7 synthetic long peptide (SLP) vaccine ISA101b.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 22818-40-2

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsCarnitine O-Palmitoyltransferase, antagonists & inhibitors +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Alanine DB01786
small molecule | CAS: 338-69-2

The D-enantiomer of alanine.

Target Protein:
ThermolysinD-alanyl-D-alanine carboxypeptidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-alpha-Tocopherol acetate Approved DB14002
small molecule | CAS: 58-95-7

Alpha-tocopherol is the primary form of vitamin E that is preferentially used by the human body to meet appropriate dietary requirements. In particular, the RRR-alpha-tocopherol (or sometimes called the d-alpha-tocopherol stereoisomer) stereoisomer is conside…

Kategori:
AntioxidantsBenzopyransBiological Factors +12
Target Protein:
SEC14-like protein 3SEC14-like protein 2Nuclear receptor subfamily 1 group I member 2 +3
Waktu Paruh_In addition to any…
Vol. Distribusi_In addition to any…
Klirens_In addition to any…
Genetik -
D-arginine DB04027
small molecule | CAS: 157-06-2

A D-?-amino acid that is the D-isomer of arginine (only the L-form is physiologically active).

Target Protein:
Creatine kinase M-type
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Asparagine DB03943
small molecule | CAS: 2058-58-4

A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd …

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Aspartic Acid DB02655
small molecule | CAS: 1783-96-6

The D-isomer of aspartic acid. [PubChem]

Kategori:
Amino AcidsAmino Acids, AcidicAmino Acids, Dicarboxylic +1
Target Protein:
Glutamate receptor ionotropic, NMDA 2BGlutamate receptor ionotropic, NMDA 2AGlutamate receptor ionotropic, NMDA 1 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Cysteine DB03201
small molecule | CAS: 921-01-7

A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.

Target Protein:
Carboxypeptidase A1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Eritadenine DB03769
small molecule | CAS: 23918-98-1

Deskripsi belum tersedia.

Kategori:
Enzyme InhibitorsHeterocyclic Compounds, Fused-RingPurines
Target Protein:
Adenosylhomocysteinase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 25023-78-3

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 20479-58-7

Deskripsi belum tersedia.

Kategori:
CarbohydratesSugar Phosphates
Target Protein:
Glucose-6-phosphate isomerase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-glucose Approved DB01914
small molecule | CAS: 50-99-7

Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants. It is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms (glycogenolysis). It circulates in human cir…

Kategori:
CarbohydratesCompounds used in a research, industrial, or household settingDiet, Food, and Nutrition +11
Waktu ParuhThe approximate hal…
Vol. DistribusiThe mean volume of …
KlirensThe mean metabolic …
Genetik -
D-Glutamic Acid DB02517
small molecule | CAS: 6893-26-1

Glutamic acid is the most common excitatory neurotransmitter in the central nervous system.

Target Protein:
Thermolysin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Glutamine DB02174
small molecule | CAS: 5959-95-5

A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from glutamic acid and ammonia. It is the principal carrier of nitrogen in the body and is an important energy source for many cel…

Kategori:
Amino AcidsAmino Acids, BasicAmino Acids, Diamino +3
Target Protein:
Glutamate racemase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Lactic acid DB03066
small molecule | CAS: 10326-41-7

A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)

Kategori:
Hydroxy AcidsLactates
Target Protein:
(S)-2-haloacid dehalogenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Leucine DB01746
small molecule | CAS: 328-38-1

An essential branched-chain amino acid important for hemoglobin formation. [PubChem]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Levofloxacin DB03034
small molecule | CAS: 100986-86-5

A synthetic fluoroquinolone (FLUOROQUINOLONES) antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.

Target Protein:
Autolysin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Lysine DB03252
small molecule | CAS: 923-27-3

An essential amino acid. It is often added to animal feed. [PubChem]

Target Protein:
Alanine racemase, catabolicDiaminopimelate decarboxylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Malic acid DB03499
small molecule | CAS: 636-61-3

Deskripsi belum tersedia.

Target Protein:
NAD-dependent malic enzyme, mitochondrialCitrate synthase, mitochondrialCircadian clock protein KaiB +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1986-14-7

Deskripsi belum tersedia.

Target Protein:
AlgQ1AlgQ2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Subtilisin Carlsberg
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 2101–2150 dari 6694
Sebelumnya Halaman 43 / 134 Berikutnya