Hasil Filter

3253

Total database: 17430
Struktur (SMILES)
2451 (75.3%)
Target
1833 (56.3%)
Genomik
35 (1.1%)
Referensi
3253 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (3253)

Halaman 41 / 66
small molecule

Deskripsi belum tersedia.

Target Protein:
Egl nine homolog 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Cathepsin BPro-cathepsin H
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Bifunctional cytochrome P450/NADPH--P450 reductase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Cell division protein ZipACell division protein ZipA
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Matrilysin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Prothrombin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nadide DB14128
small molecule | CAS: 53-84-9

A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately o…

Kategori:
Adenine NucleotidesCoenzymesEnzymes and Coenzymes +6
Target Protein:
17-beta-hydroxysteroid dehydrogenase type 1Lysosomal alpha-glucosidaseNeutral alpha-glucosidase AB +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nadifloxacin DB12447
small molecule | CAS: 124858-35-1

Nadifloxacin has been used in trials studying the treatment of Acne Vulgaris.

Kategori:
4-QuinolonesAnti-Acne PreparationsAnti-Acne Preparations for Topical Use +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nadofaragene firadenovec Approved DB17381
biotech | CAS: 1823059-12-6

Nadofaragene firadenovec (nadofaragene firadenovec-vncg) is a recombinant non-replicating adenovirus serotype 5 vector containing a transgene encoding human interferon alfa-2b (IFN?2b).[L44381] It was approved by the FDA on December 2022 for the treatment of …

Kategori:
Adeno-associated Viral Vector TherapiesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nadolol Approved DB01203
small molecule | CAS: 42200-33-9

Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor b…

Kategori:
Adrenergic AgentsAdrenergic AntagonistsAdrenergic beta-Antagonists +30
Target Protein:
Beta-1 adrenergic receptorBeta-2 adrenergic receptor
Waktu ParuhThe half life of na…
Vol. DistribusiIn healthy subjects…
KlirensIn healthy subjects…
Genetik -
Nafamostat DB12598
small molecule | CAS: 81525-10-2

Nafamostat is a synthetic serine protease inhibitor that is commonly formulated with hydrochloric acid due to its basic properties. It has been used in trials studying the prevention of Liver Transplantation and Postreperfusion Syndrome. The use of nafamostat…

Kategori:
AmidinesAnalgesicsAnalgesics, Non-Narcotic +16
Target Protein:
Tumor necrosis factorProthrombinCoagulation factor X +4
Waktu ParuhApproximately 8 min…
Vol. Distribusi-
Klirens-
Genetik -
Nafithromycin DB16246
small molecule | CAS: 1691240-78-4

Nafithromycin is under investigation in clinical trial NCT02903836 (Phase II Study of Oral Nafithromycin in CABP).

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsEnzyme Inhibitors +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Naftopidil DB12092
small molecule | CAS: 57149-07-2

Naftopidil has been investigated for the treatment of Disorder of Urinary Stent.

Kategori:
Adrenergic AgentsAdrenergic alpha-AntagonistsAdrenergic Antagonists +16
Target Protein:
Alpha-1A adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nagrestipen DB12075
biotech | CAS: 166089-33-4

Nagrestipen has been used in trials studying the treatment of CANCER, Neoplasm, Metastasis, Radiation Oncology, and Neoplasm Metastasis.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsChemokines +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
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Naloxegol Approved DB09049
small molecule | CAS: 854601-70-0

Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non?…

Kategori:
AlcoholsAlimentary Tract and MetabolismAlkaloids +24
Target Protein:
Mu-type opioid receptor
Waktu Paruh6-11 hours.
Vol. Distribusi968 to 2140 L.
KlirensFeces (68%), urine …
Genetik -
Naloxone Approved DB01183
small molecule | CAS: 465-65-6

Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide.[A234594] More specifically, naloxone has a high …

Kategori:
Alimentary Tract and MetabolismAlkaloidsAnalgesics +27
Target Protein:
Mu-type opioid receptorDelta-type opioid receptorKappa-type opioid receptor +4
Waktu ParuhThe mean half life …
Vol. DistribusiThe volume of distr…
KlirensThe clearance of na…
Genetik -
Namilumab DB13037
biotech | CAS: 1206681-39-1

Namilumab has been used in trials studying the treatment of Plaque Psoriasis and Rheumatoid Arthritis.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Namitecan DB12124
small molecule | CAS: 372105-27-6

Namitecan has been used in trials studying the treatment of Solid Tumors.

Kategori:
AlkaloidsAntineoplastic AgentsAntineoplastic Agents, Phytogenic
Target Protein:
DNA topoisomerase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Namodenoson DB12885
small molecule | CAS: 163042-96-4

Namodenoson has been used in trials studying the treatment of Chronic Hepatitis C and Hepatocellular Carcinoma.

Kategori:
Heterocyclic Compounds, Fused-RingNeurotransmitter AgentsNucleic Acids, Nucleotides, and Nucleosides +7
Target Protein:
Adenosine receptor A3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nanatinostat DB15419
small molecule | CAS: 1256448-47-1

Nanatinostat is under investigation in clinical trial NCT00697879 (Safety Study of the Histone Deacetylase Inhibitor, CHR-3996, in Patients With Advanced Solid Tumours).

Kategori:
Antineoplastic AgentsAza CompoundsHistone Deacetylase Inhibitors
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Napabucasin DB12155
small molecule | CAS: 83280-65-3

Napabucasin has been investigated for the treatment of Colorectal Carcinoma.

Kategori:
Heterocyclic Compounds, Fused-RingNaphthalenesQuinones
Target Protein:
Signal transducer and activator of transcription 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Naproxen Approved DB00788
small molecule | CAS: 22204-53-1

Naproxen is classified as a nonsteroidal anti-inflammatory dug (NSAID) and was initially approved for prescription use in 1976 and then for over-the-counter (OTC) use in 1994.[A178975] It can effectively manage acute pain as well as pain related to rheumatic …

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAnalgesics +41
Target Protein:
Pancreatic triacylglycerol lipaseProstaglandin G/H synthase 1Prostaglandin G/H synthase 2 +1
Waktu ParuhThe elimination hal…
Vol. DistribusiNaproxen has a volu…
KlirensNaproxen is cleared…
Genetik -
small molecule | CAS: 385800-16-8

Naproxen etemesil has been used in trials studying the treatment of Osteoarthritis.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 676258-98-3

Naptumomab Estafenatox has been used in trials studying the treatment of Pancreatic Cancer, Renal Cell Carcinoma, and Non-Small-Cell Lung Carcinoma.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBiological Factors +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Naquotinib DB12036
small molecule | CAS: 1448232-80-1

Naquotinib has been used in trials studying the treatment of Solid Tumors, Non-small Cell Lung Cancer, Non-Small-Cell Lung Cancer (NSCLC), Epidermal Growth Factor Receptor Mutations, and Epidermal Growth Factor Receptor (EGFR) Mutations, among others.

Kategori:
Antineoplastic AgentsEnzyme InhibitorsProtein Kinase Inhibitors
Target Protein:
Epidermal growth factor receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Naratriptan Approved DB00952
small molecule | CAS: 121679-13-8

Naratriptan is a triptan drug that is selective for the 5-hydroxytryptamine1 receptor subtype. It is typically used for the treatment of migraine headaches.

Kategori:
Agents that produce hypertensionAminesAnalgesics +23
Target Protein:
5-hydroxytryptamine receptor 1A5-hydroxytryptamine receptor 1D5-hydroxytryptamine receptor 1B +1
Gen Terkait:
GNB3
Waktu Paruh5-8 hours
Vol. Distribusi* 170 L
Klirens* 6.6 mL/min/kg
Genetik 1 Varian
Narazaciclib DB19038
small molecule | CAS: 1357470-29-1

Narazaciclib is under investigation in clinical trial NCT06351644 (On 123300 (Narazaciclib) and Dexamethasone in Patients With Relapsed And/or Refractory Multiple Myeloma).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Naronapride DB05542
small molecule | CAS: 860174-12-5

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAmidesAntidepressive Agents +7
Target Protein:
5-hydroxytryptamine receptor 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
NAV 1800 DB05437
biotech

RIGScan CR49, a 125I-labelled CR monoclonal antibody directed against the tumour-associated antigen TAG-72, is undergoing development with Neoprobe for the intraoperative detection of metastatic colorectal cancer.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Navafenterol DB19195
small molecule | CAS: 1435519-06-4

Navafenterol is under investigation in clinical trial NCT02971293 (Efficacy, Pharmacokinetics (PK), Safety and Tolerability Study of Inhaled AZD8871).

Kategori:
Heterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Naveglitazar DB12662
small molecule | CAS: 476436-68-7

Naveglitazar has been used in trials studying the treatment of Diabetes Mellitus, Non-Insulin-Dependent.

Kategori:
Acids, CarbocyclicPPAR alpha, agonistsPPAR gamma, agonists
Target Protein:
Peroxisome proliferator-activated receptor gammaPeroxisome proliferator-activated receptor alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Navicixizumab DB12634
biotech | CAS: 1638338-43-8

Navicixizumab is under investigation in clinical trial NCT02298387 (A Phase 1 Study of Navicixizumab in Subjects With Solid Tumors).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Navitoclax DB12340
small molecule | CAS: 923564-51-6

Navitoclax has been used in trials studying the treatment and basic science of Solid Tumors, Non-Hodgkin's Lymphoma, EGFR Activating Mutation, Chronic Lymphoid Leukemia, and Hematological Malignancies, among others. Navitoclax is an orally bioavailable sma…

Kategori:
AmidesAminesAntineoplastic Agents +3
Target Protein:
Bcl-2-like protein 1G1/S-specific cyclin-D1Apoptosis regulator Bcl-2 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
NB-001 DB12716
small molecule | CAS: 686301-48-4

NB-001 has been investigated for the treatment of Recurrent Herpes Labialis.

Kategori:
Adenine NucleotidesAdenylyl Cyclase InhibitorsEnzyme Inhibitors +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
NB-124 sulfate DB16951
small molecule | CAS: 1375073-96-3

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
NC-6300 DB17341
small molecule

NC-6300, also known as K-912, is a novel [epirubicin] drug-conjugated polymeric micelle.

Kategori:
Amino Acids, Peptides, and ProteinsAminoglycoside AntibacterialsAnthracyclines +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ND1251 DB05132
small molecule

ND1251 is an orally active phosphodiesterase-4 (PDE4) inhibitor, a mechanism clinically proven to play a role in alleviating symptoms of depression. ND1251 is a very potent compound with a large safety margin. ND1251 may also have applications in other disord…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
NDI-5001 DB17609
small molecule | CAS: 1365571-66-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
NE-180 DB05619
small molecule

NE-180 was under investigation in a clinical trial conducted in the European Union.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nebicapone DB14849
small molecule | CAS: 274925-86-9

Nebicapone is under investigation in clinical trial NCT03097211 (Effect of BIA 6-512 at Steady-state on the Levodopa Pharmacokinetics With a Single-dose of Levodopa/Benserazide 200/50 mg or With a Single-dose of Levodopa/Benserazide 200/50 mg Plus a Single-do…

Kategori:
COMT InhibitorsKetones
Target Protein:
Catechol O-methyltransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Necuparanib DB16251
small molecule | CAS: 1415139-34-2

Necuparanib is under investigation in clinical trial NCT01621243 (M402 in Combination With Nab-paclitaxel and Gemcitabine in Pancreatic Cancer).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nefopam Approved DB12293
small molecule | CAS: 13669-70-0

Nefopam is under investigation for the prevention of Cholecystitis and Post Anaesthetic Shivering. Nefopam has been investigated for the prevention of Kidney Transplantation.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAzocines +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1239309-58-0

Neladenoson bialanate has been investigated for the treatment of Heart Failure.

Kategori:
Amino Acids, Peptides, and ProteinsOligopeptidesPeptides
Target Protein:
Adenosine receptor A1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nelarabine Approved DB01280
small molecule | CAS: 121032-29-9

Nelarabine is an antineoplastic agent that is typically used to treat acute T-cell lymphoblastic leukemia, particularly T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL), in both adult and pediatric patients whose disease h…

Kategori:
AntimetabolitesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +8
Target Protein:
DNADNA polymerase alpha catalytic subunitDNA ligase 1 +2
Waktu ParuhNelarabine and ara-…
Vol. DistribusiNelarabine and ara-…
KlirensRenal clearance ave…
Genetik -
Nelipepimut-S DB06226
biotech | CAS: 160212-35-1

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntigensAntigens, Surface +25
Target Protein:
Receptor tyrosine-protein kinase erbB-2HLA class I histocompatibility antigen, A-3 alpha chain
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nelistotug DB19334
biotech | CAS: 2645437-82-5

Nelistotug is under investigation in clinical trial NCT06062420 (A Platform Study of Novel Immunotherapy Combinations as First-line Treatment in Participants With PD-L1 Positive Recurrent/metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-2…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nelivaptan DB12643
small molecule | CAS: 439687-69-1

Nelivaptan has been used in trials studying the treatment of Anxiety Disorders, Depressive Disorder, and Major Depressive Disorder.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Vasopressin V1b receptorVasopressin V2 receptorOxytocin receptor +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nelonicline DB19040
small molecule | CAS: 1026134-63-3

Nelonicline is under investigation in clinical trial NCT01678755 (A Phase 2 Study to Evaluate ABT-126 for the Treatment of Cognitive Deficits in Schizophrenia).

Kategori:
Sulfur CompoundsThiazoles
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nelotanserin DB12555
small molecule | CAS: 839713-36-9

Nelotanserin has been used in trials studying the treatment of Lewy Body Dementia, Visual Hallucinations, Dementia With Lewy Bodies, and REM Sleep Behavior Disorder. It is a highly selective antagonist at the 5-HT2A serotonin receptor. It increases non-REM sl…

Kategori:
AmidesBenzene Derivatives
Target Protein:
5-hydroxytryptamine receptor 2A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Nemiralisib DB16253
small molecule | CAS: 1254036-71-9

Nemiralisib is under investigation in clinical trial NCT03345407 (Dose Finding Study of Nemiralisib (GSK2269557) in Subjects With an Acute Moderate or Severe Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)).

Kategori:
Enzyme InhibitorsHeterocyclic Compounds, Fused-RingProtein Kinase Inhibitors +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 2001–2050 dari 3253
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