Hasil Filter

3253

Total database: 17430
Struktur (SMILES)
2451 (75.3%)
Target
1833 (56.3%)
Genomik
35 (1.1%)
Referensi
3253 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (3253)

Halaman 40 / 66
Modithromycin DB16238
small molecule | CAS: 736992-12-4

Modithromycin is under investigation in clinical trial NCT00270517 (Comparative Study of EDP-420 Versus Another Antibiotic in the Treatment of Community Acquired Pneumonia).

Kategori:
LactonesPolyketides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Modufolin DB12676
small molecule | CAS: 31690-11-6

Modufolin is under investigation for the treatment of Osteosarcoma.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mogamulizumab Approved DB12498
biotech | CAS: 1159266-37-1

Mogamulizumab is a humanized monoclonal antibody (mAb) directed against CC chemokine receptor 4 (CCR4) for the treatment of Mycosis Fungoides (MF) and Sézary Syndrome (SS), the most common subtypes of cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occu…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +15
Target Protein:
C-C chemokine receptor type 4
Waktu ParuhThe terminal half-l…
Vol. DistribusiThe central volume …
KlirensClearance is 12 mL/…
Genetik -
MOL-4239 DB16051
small molecule | CAS: 1204306-34-2

MOL-4239 is under investigation in clinical trial NCT01826201 (Paired Psoriasis Lesion, Comparative, Study to Evaluate MOL4239 in Psoriasis).

Target Protein:
Signal transducer and activator of transcription 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Molgramostim DB12525
biotech | CAS: 99283-10-0

Molgramostim has been used in trials studying the treatment of Bronchiectasis, Cystic Fibrosis, Pulmonary Alveolar Proteinosis, Acute Respiratory Distress Syndrome, and Autoimmune Pulmonary Alveolar Proteinosis.

Kategori:
Adjuvants, ImmunologicAmino Acids, Peptides, and ProteinsAntineoplastic Agents +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Molibresib DB16239
small molecule | CAS: 1260907-17-2

Molibresib is under investigation in clinical trial NCT01943851 (A Dose Escalation Study to Investigate the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD) and Clinical Activity of GSK525762 in Subjects With Relapsed, Refractory Hematologic Malignancies).

Kategori:
BenzazepinesHeterocyclic Compounds, Fused-Ring
Target Protein:
Bromodomain-containing protein 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mometasone furoate Approved DB14512
small molecule | CAS: 83919-23-7

Mometasone furoate is a corticosteroid drug that can be used for the treatment of asthma, rhinitis, and certain skin conditions[FDA Label][F4292,F4295]. It has a glucocorticoid receptor binding affinity 22 times stronger than [dexamethasone] and higher than m…

Kategori:
Adrenal Cortex HormonesAdrenalsAdrenergics, Inhalants +28
Target Protein:
Glucocorticoid receptorProgesterone receptor
Waktu ParuhThe terminal half l…
Vol. DistribusiSteady state volume…
KlirensThe clearance rate …
Genetik -
Monalizumab DB12824
biotech | CAS: 1228763-95-8

Monalizumab has been used in trials studying the treatment of Gynecologic Cancer, Chronic Lymphocytic Leukemia, and Squamous Cell Carcinoma of the Oral Cavity.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Monteplase DB12726
biotech | CAS: 156616-23-8

Monteplase has been used in trials studying the treatment of Pulmonary Embolism.

Kategori:
Amino Acids, Peptides, and ProteinsAnticoagulantsBlood Proteins +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Morphine Approved DB00295
small molecule | CAS: 57-27-2

Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805.[A176035] It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse.[A176050] Morphine is still routinely used today, though there …

Kategori:
AlkaloidsAnalgesicsAnesthetics +25
Target Protein:
Mu-type opioid receptorKappa-type opioid receptorDelta-type opioid receptor +1
Gen Terkait:
ABCB1 OPRM1
Waktu ParuhMorphine has a half…
Vol. DistribusiThe volume of distr…
KlirensThe apparent cleara…
Genetik 2 Varian
Mosapride DB11675
small molecule | CAS: 112885-41-3

Mosapride is under investigation for the treatment and prevention of Postoperative Ileus and Gastric Peroral Endoscopic Pyloromyotomy (G-POEM). Mosapride has been investigated for the treatment and diagnostic of Constipation, Type 2 Diabetes, Functional Dyspe…

Kategori:
Acids, CarbocyclicAlimentary Tract and MetabolismAmides +13
Target Protein:
5-hydroxytryptamine receptor 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mosedipimod DB12592
small molecule | CAS: 221139-79-3

Mosedipimod has been used in trials studying the supportive care and treatment of Chemotherapy-induced Neutropenia.

Kategori:
Experimental Unapproved Treatments for COVID-19Lipids
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Motolimod DB12303
small molecule | CAS: 926927-61-9

Motolimod has been used in trials studying the treatment of Lymphoma, Tongue Cancer, Ovarian Cancer, Adult Solid Neoplasm, and Fallopian Tube Cancer, among others.

Kategori:
Heterocyclic Compounds, Fused-RingToll-Like Receptor 8, agonists
Target Protein:
Toll-like receptor 8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Moxaverine DB12251
small molecule | CAS: 10539-19-2

Moxaverine has been investigated for the treatment of Retina, Ocular Physiology, and Regional Blood Flow.

Kategori:
Alimentary Tract and MetabolismAlkaloidsAutonomic Agents +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Moxetumomab pasudotox Approved DB12688
biotech | CAS: 1020748-57-5

CD22 is a lineage-restricted B-cell antigen that is expressed solely in on B-chronic lymphocytic leukemia, hairy cell leukemia, acute lymphocytic leukemiathe and Burkitt's lymphoma. The predecessor of Moxetumab pasudotox (MxP), named BL22, was first created b…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +18
Target Protein:
B-cell receptor CD22Elongation factor 2
Waktu ParuhMxP presents a shor…
Vol. DistribusiThe mean volume of …
KlirensThe mean systemic c…
Genetik -
Moxifloxacin Approved DB00218
small molecule | CAS: 151096-09-2

Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment.

Kategori:
4-QuinolonesAnti-Bacterial AgentsAnti-Infective Agents +18
Target Protein:
DNA gyrase subunit ADNA gyrase subunit BDNA gyrase subunit A +3
Waktu Paruh11.5-15.6 hours (si…
Vol. Distribusi* 1.7 to 2.7 L/kg
Klirens* 12 +/- 2 L/hr
Genetik -
MPT0B640 DB16512
small molecule

MPT0B640 was under investigation in clinical trials NCT04526717 for COVID-19 infection and NCT04294875 for locally advanced or metastatic solid malignancies.

Kategori:
Experimental Unapproved Treatments for COVID-19
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MRX-I DB12796
small molecule | CAS: 1112968-42-9

MRX-I has been used in trials studying the treatment of Bacterial Infections.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MSX-122 DB12715
small molecule | CAS: 897657-95-3

MSX-122 has been used in trials studying the treatment of Solid Tumors.

Kategori:
Receptors, CXCR4, antagonists & inhibitors
Target Protein:
C-X-C chemokine receptor type 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mubritinib DB12682
small molecule | CAS: 366017-09-6

Mubritinib has been used in trials studying the treatment of Lung Neoplasm, Renal Neoplasm, Breast Neoplasm, Ovarian Neoplasm, and Pancreatic Neoplasm.

Target Protein:
Epidermal growth factor receptorReceptor tyrosine-protein kinase erbB-2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Mucor circinelloides f. circinelloides allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mufemilast DB18075
small molecule | CAS: 1255909-03-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mupirocin Approved DB00410
small molecule | CAS: 12650-69-0

Mupirocin, formerly termed pseudomonic acid A,[A178531] is a novel antibacterial agent with a unique chemical structure and mode of action apart from other antibiotic agents. Produced by fermentation using the organism _Pseudomonas fluorescens_, mupirocin is …

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntibiotics for Topical Use +12
Target Protein:
Isoleucine--tRNA ligase
Waktu ParuhIn healthy male vol…
Vol. DistribusiNo information avai…
KlirensNo information avai…
Genetik -
Muplestim DB12431
biotech | CAS: 148641-02-5

Muplestim is under investigation in clinical trial NCT00002258 (A Phase I, Open Label Trial to Evaluate the Safety, Tolerance and Biological Effects of SDZ ILE-964 (Recombinant Human Interleukin-3, RhIL-3) in HIV Infected Patients With Cytopenia).

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsCarbohydrates +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mus musculus skin Approved DB10412
biotech

Mus musculus skin or pelt is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Muscimol DB12458
small molecule | CAS: 2763-96-4

Muscimol has been used in trials studying the treatment of Epilepsy and Parkinson's Disease.

Kategori:
Biological FactorsGABA AgentsGABA Agonists +5
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Gamma-aminobutyric acid receptor subunit beta-3Gamma-aminobutyric acid receptor subunit gamma-2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MVR-T3011 DB17378
biotech

MVR-T3011 is a genetically modified oncolytic Herpes Simplex Virus (HSV-1) with 2 exogenous genes encoding the active heterodimer human interleukin 12 (IL-12) and the Fab fragment of an anti-human PD-1 antibody.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mycophenolate mofetil Approved DB00688
small molecule | CAS: 128794-94-5

Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH).[A180805] This drug is an immunosuppressant combined with drugs such as [Cyclospor…

Kategori:
Agents Causing Muscle ToxicityAnti-Bacterial AgentsAnti-Infective Agents +23
Target Protein:
Prostaglandin E2 receptor EP2 subtypeInosine-5'-monophosphate dehydrogenase 1Inosine-5'-monophosphate dehydrogenase 2 +1
Waktu ParuhThe average apparen…
Vol. DistribusiThe volume of distr…
KlirensPlasma clearance of…
Genetik -
Myrtecaine DB15785
small molecule | CAS: 7712-50-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 86303-23-3

Deskripsi belum tersedia.

Target Protein:
Peroxisome proliferator-activated receptor alphaInsulin-like growth factor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 68-12-2

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicAmidesCytochrome P-450 CYP2E1 Substrates +3
Target Protein:
ReninChymotrypsin-like elastase family member 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Enoyl-[acyl-carrier-protein] reductase [NADH]
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Coagulation factor XI
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
N-6022 DB12206
small molecule | CAS: 1208315-24-5

N6022 has been used in trials studying the treatment of Asthma and Cystic Fibrosis.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +1
Target Protein:
Carbonyl reductase [NADPH] 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
N-Acetylglucosamine Approved DB00141
small molecule | CAS: 7512-17-6

The N-acetyl derivative of glucosamine.

Kategori:
Amino SugarsCarbohydratesDietary Supplements +2
Target Protein:
Beta-1,4-galactosyltransferase 1Beta-1,4-galactosyltransferase 4N-acetyl-D-glucosamine kinase +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 3615-17-6

N-acetylmannosamine is under investigation for the other of GNE Myopathy.

Kategori:
Amino SugarsCarbohydrates
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1210-83-9

Deskripsi belum tersedia.

Kategori:
AminesAutacoidsBiogenic Amines +6
Target Protein:
Melatonin receptor type 1ASepiapterin reductase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 121-60-8

ASC has been investigated for the screening of Patients Undergoing Screening or Surveillance Colonoscopy.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 68391-01-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

N-alkyl ethylbenzyl dimethyl ammonium (c12-c14) is a quaternary ammonium compound with surfactant properties. It is found in sanitizing solutions or soaps as an active ingredient due to its antimicrobial properties. Employed in a great variety of cleaning …

Waktu ParuhReadily accessible …
Vol. DistribusiReadily accessible …
KlirensReadily accessible …
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Serine protease 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 128-53-0

A sulfhydryl reagent that is widely used in experimental biochemical studies. [PubChem]

Kategori:
Acids, AcyclicCompounds used in a research, industrial, or household settingDicarboxylic Acids +7
Target Protein:
Galectin-10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Cyclin-dependent kinase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Cyclin-dependent kinase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
E3 ubiquitin-protein ligase XIAP
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Ferrochelatase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 50903-99-6

L-NAME has been investigated for the treatment of Hypotension and Spinal Cord Injury.

Kategori:
Amino AcidsAmino Acids, BasicAmino Acids, Diamino +3
Target Protein:
Nitric oxide synthase 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

N-sulfoglucosamine sulfohydrolase recombinant is under investigation for the treatment of Mucopolysaccharidosis III and Sanfilippo Syndrome Type A (MPS IIIA).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
RAC-beta serine/threonine-protein kinaseGlycogen synthase kinase-3 beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 1951–2000 dari 3253
Sebelumnya Halaman 40 / 66 Berikutnya