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3253

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2451 (75.3%)
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1833 (56.3%)
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35 (1.1%)
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3253 (100.0%)

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Halaman 39 / 66
Miltefosine Approved DB09031
small molecule | CAS: 58066-85-6

Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid drug that was originally developed in the 1980s as an anti-cancer agent. It is currently the only recognized oral agent used to treat visceral, cutaneous, and mucosal forms of leish…

Kategori:
Agents Against Leishmaniasis and TrypanosomiasisAminesAnti-Infective Agents +9
Target Protein:
Phospholipase A2ATP-dependent translocase ABCB1
Waktu ParuhThe primary elimina…
Vol. DistribusiRadioactivity studi…
KlirensPlasma clearance is…
Genetik -
Minigastrin DB19196
biotech | CAS: 101212-63-9

Minigastrin is under investigation in clinical trial NCT06155994 (68ga-dota-mgs5 PET/CT in Patients With Advanced Neuroendocrine Tumours).

Kategori:
Amino Acids, Peptides, and ProteinsGastrointestinal HormonesHormones +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Minnelide DB17309
small molecule | CAS: 1254702-87-8

Deskripsi belum tersedia.

Kategori:
Alkylating DrugsAntineoplastic AgentsAntineoplastic Agents, Alkylating +6
Target Protein:
Heat shock 70 kDa protein 1BHeat shock 70 kDa protein 1A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1254885-39-6

Deskripsi belum tersedia.

Kategori:
Alkylating DrugsAntineoplastic AgentsAntineoplastic Agents, Alkylating +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Minocycline Approved DB01017
small molecule | CAS: 10118-90-8

Minocycline was first described in the literacture in 1966.[A190681] It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria.[A190723] Like other semisynthetic tetracyclines, minocycline has modificati…

Kategori:
Agents Causing Muscle ToxicityAgents that produce neuromuscular block (indirect)Alimentary Tract and Metabolism +16
Target Protein:
30S ribosomal protein S930S ribosomal protein S416S ribosomal RNA +9
Waktu ParuhThe half life of mi…
Vol. DistribusiThe volume of distr…
KlirensIntravenous minocyc…
Genetik -
MIP-1095 I-123 DB12994
small molecule | CAS: 949575-25-1

123 I Mip 1095 is under investigation in clinical trial NCT00712829 (Study to Evaluate the Safety, Pharmacokinetics, Tissue Distribution, Metabolism and Dosimetry of Two Prostate Cancer Imaging Agents).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MIP-1095 I-131 DB14978
small molecule | CAS: 1258980-67-4

MIP-1095 I-131 is under investigation in clinical trial NCT03030885 (Use of an Experimental Radiopharmaceutical (131I-MIP-1095) in Men With Metastatic Castration-Resistant Prostate Cancer (mCRPC)).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mipomersen Approved DB05528
biotech | CAS: 1000120-98-8

Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (ap…

Kategori:
Anticholesteremic AgentsAntisense Elements (Genetics)Antisense Oligonucleotides +20
Target Protein:
Apolipoprotein B-100mRNA of ApoB-100
Waktu ParuhMipomersem has a ve…
Vol. DistribusiThe volume of distr…
KlirensClearance of mipome…
Genetik -
Mipsagargin DB11813
small molecule | CAS: 1245732-48-2

Mipsagargin has been used in trials studying the treatment of Prostate Cancer, Prostatic Neoplasms, Advanced Solid Tumors, Glioblastoma Multiforme, and Hepatocellular Carcinoma, among others.

Target Protein:
Glutamate carboxypeptidase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mirabegron Approved DB08893
small molecule | CAS: 223673-61-8

Mirabegron is a sympathomimetic beta-3 adrenergic receptor agonist used to relax the smooth muscle of the bladder in the treatment of urinary frequency and incontinence. It is unique amongst overactive bladder treatment options in that, unlike other treatment…

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic beta-3 Receptor Agonists +32
Target Protein:
Beta-3 adrenergic receptorBeta-1 adrenergic receptor
Waktu ParuhThe mean terminal e…
Vol. DistribusiFollowing intraveno…
KlirensTotal plasma cleara…
Genetik -
Miravirsen DB12851
biotech | CAS: 1072874-90-8

Miravirsen has been investigated for the treatment of Hepatitis C and Hepatitis C, Chronic.

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleotidesPolynucleotides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mirdametinib DB07101
small molecule | CAS: 391210-10-9

PD-0325901 has been used in trials studying the treatment and basic science of Melanoma, Solid Tumour, Solid Tumors, Advanced Cancer, and Breast Neoplasms, among others.

Kategori:
Acids, CarbocyclicAmidesAmines +3
Target Protein:
Dual specificity mitogen-activated protein kinase kinase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mirvetuximab soravtansine Approved DB12489
biotech | CAS: 1453084-37-1

Mirvetuximab soravtansine-gynx (IMGN853) is an antibody-drug conjugate (ADC) formed by a monoclonal antibody (M9346A) that targets folate receptor alpha (FR?), covalently joined by a cleavable disulfide linker to the genotoxic compound DM4 (also known as sora…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +19
Target Protein:
Folate receptor alpha
Waktu ParuhAfter the first dos…
Vol. DistribusiMirvetuximab soravt…
KlirensThe total plasma cl…
Genetik -
Misoprostol Approved DB00929
small molecule | CAS: 59122-46-2

Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions.[L7616,L7619,A181589,A181583,A181697] The stimulation of prostaglandin receptors…

Kategori:
Abortifacient AgentsAbortifacient Agents, NonsteroidalAlimentary Tract and Metabolism +24
Target Protein:
Prostacyclin receptorProstaglandin E2 receptor EP3 subtypeProstaglandin E2 receptor EP2 subtype +2
Waktu ParuhThe half life of an…
Vol. DistribusiData regarding the …
KlirensBecause of the rapi…
Genetik -
Mitapivat Approved DB16236
small molecule | CAS: 1260075-17-9

Mitapivat is a novel, first-in-class pyruvate kinase activator. It works to increase the activity of erythrocyte pyruvate kinase, a key enzyme involved in the survival of red blood cells. Defects in the pyruvate kinase enzyme in various red blood cells disord…

Kategori:
Anemia, Hemolytic, Congenital, drug therapyBlood and Blood Forming OrgansCytochrome P-450 CYP1A2 Substrates +27
Target Protein:
Pyruvate kinase PKLRAromatase
Waktu ParuhIn patients with py…
Vol. DistribusiThe mean volume of …
KlirensPopulation pharmaco…
Genetik -
Mitiglinide DB01252
small molecule | CAS: 145375-43-5

Mitiglinide is a drug for the treatment of type 2 diabetes. It may stimulate insulin secretion in beta-cells by closing off ATP dependant potassium ion channels.

Kategori:
Alimentary Tract and MetabolismBlood Glucose Lowering AgentsDrugs Used in Diabetes +4
Target Protein:
ATP-binding cassette sub-family C member 8ATP-sensitive inward rectifier potassium channel 10Peroxisome proliferator-activated receptor gamma
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mitoguazone DB12967
small molecule | CAS: 459-86-9

Mitoguazone has been used in trials studying the treatment of Lymphoma, HIV Infections, and Lymphoma, Non-Hodgkin.

Kategori:
AmidinesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +2
Target Protein:
S-adenosylmethionine decarboxylase proenzyme
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mitolactol DB12916
small molecule | CAS: 10318-26-0

Mitolactol has been used in trials studying the treatment of Brain and Central Nervous System Tumors.

Kategori:
AlcoholsAlkylating DrugsAntineoplastic Agents +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mitometh DB12117
small molecule | CAS: 107465-03-2

Mitometh is under investigation for the treatment of Adenocarcinoma, Oropharyngeal Neoplasms, Nasopharyngeal Carcinoma, Non-small Cell Lung Cancer, and Stage IV Non-small Cell Lung Cancer, among others. Mitometh has been investigated for the treatment of Lung…

Kategori:
Hydrocarbons, ChlorinatedHydrocarbons, Halogenated
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mitomycin Approved DB00305
small molecule | CAS: 50-07-7

Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protei…

Kategori:
Alkylating ActivityAlkylating DrugsAntibiotics, Antineoplastic +19
Target Protein:
DNA
Waktu Paruh8-48 min
Vol. Distribusi-
Klirens-
Genetik -
Mitoxantrone Approved DB01204
small molecule | CAS: 65271-80-9

An anthracenedione-derived antineoplastic agent.

Kategori:
AnalgesicsAnthracenesAnthracyclines and Related Substances +30
Target Protein:
DNA topoisomerase 2-betaDNADNA topoisomerase 2-alpha
Waktu Paruh75 hours
Vol. Distribusi* 1000 L/m2
Klirens* 21.3 L/hr/m2 [Eld…
Genetik -
Mivacurium Approved DB01226
small molecule | CAS: 133814-19-4

Mivacurium is a bisbenzylisoquinolinium based neuromuscular blocker or muscle relaxant. It binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in a block of neuromuscular transmission.

Kategori:
Agents producing tachycardiaAnticholinergic AgentsCentral Nervous System Depressants +13
Target Protein:
Neuronal acetylcholine receptor subunit alpha-2Muscarinic acetylcholine receptor M2Muscarinic acetylcholine receptor M3 +1
Waktu ParuhThe mean eliminatio…
Vol. Distribusi-
Klirens-
Genetik -
Mivavotinib DB16849
small molecule | CAS: 1312691-33-0

Deskripsi belum tersedia.

Target Protein:
Receptor-type tyrosine-protein kinase FLT3Tyrosine-protein kinase SYK
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mivelsiran DB19003
biotech | CAS: 2572991-83-2

Mivelsiran is under investigation in clinical trial NCT06393712 (A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mizolastine Approved DB12523
small molecule | CAS: 108612-45-9

Mizolastine is under investigation in clinical trial NCT01928316 (A Bioequivalence Study of Domestic (Made in China) and Imported Mizolastine Tablets in Healthy Volunteers).

Kategori:
Antihistamines for Systemic UseCytochrome P-450 CYP2D6 InhibitorsCytochrome P-450 CYP2D6 Inhibitors (strength unknown) +9
Target Protein:
Histamine H1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mizoribine DB12617
small molecule | CAS: 50924-49-7

Mizoribine has been investigated for the treatment of Rheumatoid Arthritis.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Infective Agents +15
Target Protein:
Inosine-5'-monophosphate dehydrogenase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0557 DB12168
small molecule | CAS: 328232-95-7

MK0557 has been investigated for the treatment of Schizophrenia and Paranoid Schizophrenia.

Kategori:
Cycloparaffins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0686 DB12563
small molecule | CAS: 578727-68-1

MK0686 has been used in trials studying the treatment of Osteoarthritis, Pain, Postoperative, and Neuralgia, Postherpetic.

Kategori:
AcetatesAcids, AcyclicAcids, Carbocyclic +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0752 DB12852
small molecule | CAS: 471905-41-6

Mk 0752 is under investigation in clinical trial NCT00572182 (MK0752 in Treating Young Patients With Recurrent or Refractory CNS Cancer).

Kategori:
Acids, AcyclicAmyloid Precursor Protein Secretases, antagonists & inhibitorsEnzyme Inhibitors +5
Target Protein:
Gamma-secretase subunit PEN-2NicastrinGamma-secretase subunit APH-1B +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0767 DB12055
small molecule | CAS: 934017-32-0

MK0767 has been used in trials studying the treatment of Dyslipidemia, Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2, and Diabetes Mellitus, Type II, among others.

Kategori:
Sulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0777 DB12238
small molecule | CAS: 252977-51-8

MK-0777 has been used in trials studying the treatment of Schizophrenia, Anxiety Disorder, and Generalized Anxiety Disorder.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0812 DB11990
small molecule | CAS: 624733-88-6

MK0812 has been used in trials studying the treatment of Relapsing-Remitting Multiple Sclerosis.

Target Protein:
C-C chemokine receptor type 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-0893 DB12044
small molecule

MK0893 has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Diabetes Mellitus, Type 2.

Kategori:
AlanineAmino AcidsAmino Acids, Peptides, and Proteins +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-1064 DB15028
small molecule | CAS: 1207253-08-4

MK-1064 is under investigation in clinical trial NCT02549014 (A Single Dose Study of the Safety, Pharmacokinetics and Pharmacodynamics of MK-1064 (MK-1064-001)).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-1496 DB12763
small molecule | CAS: 1037254-47-9

MK-1496 has been used in trials studying the treatment of Neoplasms and Malignant.

Target Protein:
Serine/threonine-protein kinase PLK1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-212 DB12111
small molecule | CAS: 64022-27-1

MK-212 has been used in trials studying the treatment of Alcoholism.

Kategori:
Antidepressive AgentsCentral Nervous System DepressantsNeurotransmitter Agents +3
Target Protein:
5-hydroxytryptamine receptor 2C
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-3207 DB12424
small molecule | CAS: 957118-49-9

Mk3207 has been used in trials studying the treatment of Migraine and Migraine Disorders.

Kategori:
Receptors, Calcitonin Gene-Related Peptide, antagonists & inhibitors
Target Protein:
Calcitonin gene-related peptide type 1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-3577 DB14957
small molecule | CAS: 1019112-29-8

MK-3577 is under investigation in clinical trial NCT00868790 (A Study of the Safety and Efficacy of MK-3577 in Participants With Type 2 Diabetes Mellitus (MK-3577-009)).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-5108 DB12556
small molecule | CAS: 1010085-13-8

MK-5108 has been used in trials studying the treatment of Cancer, Neoplasms, Tumors.

Kategori:
Acids, CarbocyclicCyclohexanesCycloparaffins +2
Target Protein:
Aurora kinase BAurora kinase A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-6186 DB12999
small molecule | CAS: 1034474-19-5

MK6186 has been used in trials studying the treatment of HIV-1 Infection.

Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-6325 DB15249
small molecule | CAS: 1263814-52-3

MK-6325 is under investigation in clinical trial NCT01329913 (Safety, Pharmacokinetics, and Pharmacodynamics of MK-6325 in Hepatitis C Virus (HCV) Infections (MK-6325-003)).

Target Protein:
Genome polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-7145 DB11968
small molecule | CAS: 1255204-84-2

MK-7145 has been used in trials studying the treatment of Hypertension and Renal Insufficiency.

Kategori:
Heterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-7622 DB12897
small molecule | CAS: 1227923-29-6

MK-7622 has been used in trials studying the treatment of Alzheimer's Disease.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MK-8245 DB13024
small molecule | CAS: 1030612-90-8

MK-8245 has been used in trials studying the treatment of Type 2 Diabetes Mellitus.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MKC-1 DB05608
small molecule | CAS: 125313-92-0

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingProtein Kinase Inhibitors
Target Protein:
Cyclin-dependent kinase 4Cyclin-dependent kinase 2Cyclin-dependent kinase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MLN-977 DB05431
small molecule | CAS: 175212-04-1

MLN-977 is a small molecule compound that inhibits the production of leukotrienes, especially 5-lipoxygenase. It is developed by PharmaEngine to treat asthma and chronic obstructive pulmonary disease.

Target Protein:
Polyunsaturated fatty acid 5-lipoxygenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MM-093 DB05512
biotech

MM-093 is a recombinant version of human alpha-fetoprotein (hAFP), an immunomodulatory serum protein normally produced at very high levels by the fetus and present in low levels in the blood of adults and children. Research on AFP suggests that it may play a …

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
MM3122 DB16737
small molecule

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsExperimental Unapproved Treatments for COVID-19Heterocyclic Compounds, Fused-Ring +2
Target Protein:
Transmembrane protease serine 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Moderna COVID-19 Vaccine Approved DB15654
biotech

The Moderna COVID-19 Vaccine (mRNA-1273) is a novel mRNA-based vaccine encapsulated in a lipid nanoparticle that encodes for a full-length pre-fusion stabilized spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus dis…

Kategori:
Biological ProductsCOVID-19 VaccinesExperimental Unapproved Treatments for COVID-19 +5
Waktu ParuhThere is limited ph…
Vol. DistribusiThere is limited ph…
KlirensThere is limited ph…
Genetik -
Modipafant DB16237
small molecule | CAS: 122957-06-6

Modipafant is under investigation in clinical trial NCT02569827 (Celgosivir or Modipafant as Treatment for Adult Participants With Uncomplicated Dengue Fever in Singapore).

Kategori:
Pyridines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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