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12560

Total database: 17430
Struktur (SMILES)
9109 (72.5%)
Target
6912 (55.0%)
Genomik
109 (0.9%)
Referensi
12560 (100.0%)

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Hasil Pencarian (12560)

Halaman 37 / 252
Acemannan DB19224
small molecule | CAS: 110042-95-0

Acemannan is under investigation in clinical trial NCT03250923 (Celagace™ Orarinse Solution for Treatment of Candidiasis).

Kategori:
Adjuvants, ImmunologicAnti-Infective AgentsAntineoplastic Agents +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acemetacin Approved DB13783
small molecule | CAS: 53164-05-9

Acemetacin is a carboxymethyl ester of indometacin. It is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is thought to be mainly through its active metabolite indomethacin.[A31352] In clinical trials, aceme…

Kategori:
Acetic Acid Derivatives and Related SubstancesAgents causing hyperkalemiaAgents that produce hypertension +16
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2
Waktu ParuhThe elimination hal…
Vol. DistribusiThe apparent volume…
KlirensIntravenous adminis…
Genetik -
Acenocoumarol Approved DB01418
small molecule | CAS: 152-72-7

Acenocoumarol is a coumarin derivative used as an anticoagulant. Coumarin derivatives inhibit the reduction of vitamin K by vitamin K reductase. This prevents carboxylation of vitamin K-dependent clotting factors, II, VII, IX and X, and interferes with coagul…

Kategori:
4-HydroxycoumarinsAnticoagulantsBenzopyrans +19
Target Protein:
Vitamin K epoxide reductase complex subunit 1
Gen Terkait:
CYP2C9 CYP2C9 CYP2C9 +2
Waktu Paruh8 to 11 hours.
Vol. DistribusiThe volume of distr…
Klirens-
Genetik 5 Varian
Aceprometazine DB01615
small molecule | CAS: 13461-01-3

Aceprometazine is a is a drug with neuroleptic and anti-histamine properties. Although not widely prescribed, it is used in combination with meprobamate for the treatment of sleep disorders in France under the trade name Mepronizine.

Kategori:
Antipsychotic AgentsCentral Nervous System AgentsCentral Nervous System Depressants +13
Target Protein:
Histamine H1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acer negundo pollen Approved DB10354
biotech

Acer negundo pollen is the pollen of the Acer negundo plant. Acer negundo pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acer rubrum pollen Approved DB10475
biotech

Acer rubrum pollen is the pollen of the Acer rubrum plant. Acer rubrum pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acer saccharinum pollen Approved DB10735
biotech

Acer saccharinum pollen is the pollen of the Acer saccharinum plant. Acer saccharinum pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acesulfame DB16868
small molecule | CAS: 33665-90-6

Deskripsi belum tersedia.

Kategori:
Sulfur CompoundsSweetening Agents
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetamide DB02736
small molecule | CAS: 60-35-5

Deskripsi belum tersedia.

Kategori:
AcetatesAcids, AcyclicAmides
Target Protein:
Aliphatic amidase expression-regulating protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetaminophen Approved DB00316
small molecule | CAS: 103-90-2

Acetaminophen (paracetamol), also commonly known as _Tylenol_, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO).[A176318] It is also used for its antipyretic effe…

Kategori:
Acetaminophen and ProdrugsAmidesAmines +31
Target Protein:
Prostaglandin G/H synthase 2Sodium-dependent serotonin transporterSodium-dependent noradrenaline transporter +3
Waktu ParuhThe half-life for a…
Vol. DistribusiVolume of distribut…
KlirensAdults: 0.27 L/h/kg…
Genetik -
Acetate DB14511
small molecule | CAS: 71-50-1

Deskripsi belum tersedia.

Kategori:
AcetatesAcids, AcyclicFatty Acids +2
Target Protein:
Macrophage metalloelastaseCalmodulin-1Superoxide dismutase [Cu-Zn] +19
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetazolamide Approved DB00819
small molecule | CAS: 59-66-5

One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacer…

Kategori:
AnticonvulsantsAntiglaucoma AgentsAntiglaucoma Preparations and Miotics +22
Target Protein:
Carbonic anhydrase 1Carbonic anhydrase 2Carbonic anhydrase 4 +5
Waktu Paruh3 to 9 hours
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 78887-71-5

Acetic acid C-11 is under investigation in clinical trial NCT01953965 (Look at Way the Heart Functions in People With Pulmonary Hypertension (PH) Who Have Near Normal Right Ventricle (RV) Function and People With Pulmonary Hypertension Who Have Impaired RV Fu…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 541-50-4

Deskripsi belum tersedia.

Kategori:
Keto AcidsKetone BodiesKetones
Target Protein:
Fumarylacetoacetase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetoacetyl-CoA DB03059
small molecule | CAS: 1420-36-6

Deskripsi belum tersedia.

Kategori:
Adenine NucleotidesCoenzymesEnzymes and Coenzymes +7
Target Protein:
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrialAcetyl-CoA acetyltransferaseShort-chain specific acyl-CoA dehydrogenase, mitochondrial +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetohydroxamic acid Approved DB00551
small molecule | CAS: 546-88-3

Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not a…

Kategori:
AminesEnzyme InhibitorsGenito Urinary System and Sex Hormones +5
Target Protein:
Urease subunit alphaMacrophage metalloelastase
Waktu Paruh5-10 hours in patie…
Vol. Distribusi-
Klirens-
Genetik -
Acetomenaphthone Approved DB19387
small molecule | CAS: 573-20-6

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 75-86-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetophenazine Approved DB01063
small molecule | CAS: 2751-68-0

Acetophenazine is an antipsychotic drug of moderate-potency. It is used in the treatment of disorganized and psychotic thinking. It is also used to help treat false perceptions (e.g. hallucinations or delusions). It primarily targets the dopamine D2 receptor.

Kategori:
Antipsychotic AgentsCentral Nervous System DepressantsDopamine Antagonists +8
Target Protein:
D(2) dopamine receptorAndrogen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetorphine DB01469
small molecule | CAS: 25333-77-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetrizoic acid DB09347
small molecule | CAS: 85-36-9

Acetrizoic acid presents the molecular formula of 3-acetamidol-2,4,6-triiodobenzoic acid[L1702] and it is the first monomeric ionic compound used as an X-ray contrast agent.[A32135] It was first synthesized by Wallingford in 1953[A32136] and it was filled in …

Kategori:
Acids, CarbocyclicAminobenzoatesBenzene Derivatives +9
Waktu ParuhWhen water-soluble …
Vol. Distribusi-
Klirens-
Genetik -
Acetyl chloride DB14623
small molecule | CAS: 75-36-5

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicAnionsChlorine Compounds +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 145576-25-6

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 543-24-8

Deskripsi belum tersedia.

Target Protein:
Glycine oxidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetylcholine Approved DB03128
small molecule | CAS: 51-84-3

A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is gen…

Kategori:
AminesAntiglaucoma Preparations and MioticsBiogenic Amines +12
Target Protein:
Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M2Muscarinic acetylcholine receptor M3 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetylcysteine Approved DB06151
small molecule | CAS: 616-91-1

Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of [acetaminophen] overdose.[L31378,L31383,L31388,L31478] Acetylcysteine has also been studied for a wide variety of off-label indications with mixed re…

Kategori:
Amino AcidsAmino Acids, NeutralAmino Acids, Peptides, and Proteins +19
Target Protein:
Glutathione synthetaseCystine/glutamate transporterNAPQI (N-acetyl-p-benzoquinone imine) +8
Waktu ParuhThe mean terminal h…
Vol. DistribusiThe volume of distr…
KlirensAcetylcysteine has …
Genetik -
small molecule | CAS: 38520-57-9

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsAmino Acids, Sulfur +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 2736440-65-4

Deskripsi belum tersedia.

Kategori:
Experimental Unapproved Treatments for COVID-19
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetyldigitoxin Approved DB00511
small molecule | CAS: 1111-39-3

Cardioactive derivative of lanatoside A or of digitoxin used for fast digitalization in congestive heart failure.

Kategori:
Antiarrhythmic agentsCarbohydratesCardanolides +12
Target Protein:
Sodium/potassium-transporting ATPase subunit alpha-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetyldigoxin DB13691
small molecule | CAS: 5511-98-8

Deskripsi belum tersedia.

Kategori:
Antiarrhythmic agentsCarbohydratesCardanolides +15
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 3861-72-1

Deskripsi belum tersedia.

Kategori:
Cough and Cold PreparationsOpium Alkaloids and Derivatives
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetyldinaline DB16142
small molecule | CAS: 58338-59-3

Acetyldinaline is under investigation in clinical trial NCT00005624 (CI-994 in Treating Patients With Advanced Myeloma).

Kategori:
Acids, CarbocyclicAmidesAmines +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetylene Approved DB15906
small molecule | CAS: 74-86-2

Deskripsi belum tersedia.

Kategori:
AlkynesHydrocarbons, Acyclic
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetyleneurea DB03533
small molecule | CAS: 496-46-8

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingImidazoles
Target Protein:
Streptavidin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetylleucine DB13226
small molecule | CAS: 99-15-0

Used for treating vestibular-related imbalance and vertigo.

Kategori:
Amino AcidsAmino Acids, Branched-ChainAmino Acids, Peptides, and Proteins +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 110044-82-1

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsCysteine Proteinase InhibitorsEnzyme Inhibitors +4
Target Protein:
Proteasome subunit alpha type-7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetylsalicylic acid Approved DB00945
small molecule | CAS: 50-78-2

Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and i…

Kategori:
Acids, CarbocyclicAgents causing angioedemaAgents causing hyperkalemia +38
Target Protein:
Prostaglandin G/H synthase 13-hydroxy-3-methylglutaryl-coenzyme A reductaseProstaglandin G/H synthase 2 +17
Gen Terkait:
CYP2C9 ITGB3 LTC4S
Waktu ParuhThe half-life of AS…
Vol. DistribusiThis drug is distri…
KlirensThe clearance rate …
Genetik 3 Varian
ACG-801 DB17659
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 68957-71-1

Deskripsi belum tersedia.

Kategori:
ArylsulfonatesArylsulfonic AcidsBenzene Derivatives +3
Target Protein:
Bifunctional purine biosynthesis protein ATIC
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acifluorfen DB07338
small molecule | CAS: 50594-66-6

Acifluorfen is a protoporphyrinogen oxidase inhibitor.

Kategori:
Acids, CarbocyclicAgrochemicalsBenzene Derivatives +6
Target Protein:
Protoporphyrinogen oxidaseProtoporphyrinogen oxidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acimtamig DB18674
biotech | CAS: 2738880-26-5

Acimtamig is a tetravalent bispecific chimeric anti-human CD30 x anti-human CD16A recombinant antibody construct.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acipimox Approved DB09055
small molecule | CAS: 51037-30-0

Acipimox is a niacin derivative used as a hypolipidemic agent. It is used in low doses and may have less marked adverse effects, although it is unclear whether the recommended dose is as effective as are standard doses of nicotinic acid. Acipimox inhibits the…

Kategori:
Agents Causing Muscle ToxicityHypolipidemic AgentsLipid Modifying Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acitretin Approved DB00459
small molecule | CAS: 55079-83-9

An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.

Kategori:
AlkenesAntipsoriaticsAntipsoriatics for Systemic Use +17
Target Protein:
Retinoic acid receptor RXR-alphaSignal transducer and activator of transcription 3Retinoic acid receptor alpha +6
Waktu Paruh49 hours (range 33 …
Vol. Distribusi-
Klirens-
Genetik -
Aclarubicin DB11617
small molecule | CAS: 57576-44-0

Deskripsi belum tersedia.

Kategori:
AnthracyclinesAnthracyclines and Related SubstancesAntibiotics, Antineoplastic +9
Target Protein:
DNA topoisomerase 2-alphaDNA topoisomerase 2-beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aclerastide DB12631
small molecule | CAS: 227803-63-6

Aclerastide has been investigated for the treatment of Diabetic Foot, Diabetic Foot Ulcers, and Foot Ulcer, Diabetic.

Kategori:
Amino Acids, Peptides, and ProteinsAngiotensinsAutacoids +10
Target Protein:
Proto-oncogene Mas
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aclimostat DB16079
small molecule | CAS: 2082752-83-6

Aclimostat is under investigation in clinical trial NCT03254368 (Study to Assess the Effects and Safety of ZGN-1061 in Overweight and Obese Participants With Type 2 Diabetes).

Kategori:
Anti-Obesity AgentsAzetinesEnzyme Inhibitors +1
Target Protein:
Methionine aminopeptidase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acolbifene DB16080
small molecule | CAS: 182167-02-8

Acolbifene is under investigation in clinical trial NCT01452373 (Dehydroepiandrosterone (DHEA) + Acolbifene Against Vasomotor Symptoms (Hot Flushes) in Postmenopausal Women).

Target Protein:
Estrogen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acoltremon DB19202
small molecule | CAS: 68489-09-8

Acoltremon is under investigation in clinical trial NCT05493111 (A Long-term Safety Study Evaluating the Safety and Systemic Exposure of AR-15512).

Kategori:
AlcoholsAmidesAmines +10
Target Protein:
Transient receptor potential cation channel subfamily M member 8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aconitate Ion DB04351
small molecule

Deskripsi belum tersedia.

Target Protein:
Aconitate hydratase, mitochondrialAconitate hydratase B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acoramidis DB17999
small molecule | CAS: 1446711-81-4

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAmyloidosis, prevention & controlBenzene Derivatives
Target Protein:
Transthyretin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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