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3253

Total database: 17430
Struktur (SMILES)
2451 (75.3%)
Target
1833 (56.3%)
Genomik
35 (1.1%)
Referensi
3253 (100.0%)

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Hasil Pencarian (3253)

Halaman 36 / 66
Loxoprofen Approved DB09212
small molecule | CAS: 68767-14-6

Loxoprofen is a propionic acid derivative non-steroidal anti-inflammatory drug. It is marketed under the trade name Loxonin in Brazil, Mexico and Japan by Sankyo, as Loxomac in India, and as Oxeno in Argentina. A transdermal preparation was approved for use i…

Kategori:
Acids, CarbocyclicAgents causing hyperkalemiaAgents that produce hypertension +13
Target Protein:
Prostaglandin G/H synthase 2Prostaglandin G/H synthase 1
Waktu ParuhThe elimination hal…
Vol. DistribusiLoxoprofen has a vo…
KlirensMost of the drug as…
Genetik -
Loxoribine DB17589
small molecule | CAS: 121288-39-9

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingNucleic Acids, Nucleotides, and NucleosidesNucleosides +3
Target Protein:
Toll-like receptor 7
Waktu Paruh-
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LP-284 DB18006
small molecule | CAS: 2412580-47-1

Deskripsi belum tersedia.

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LPT-99 DB17142
small molecule | CAS: 1263477-83-3

Deskripsi belum tersedia.

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LTX-109 DB12711
small molecule | CAS: 1166254-80-3

LTX-109 has been investigated for the treatment of Atopic Dermatitis, Mild Eczema/Dermatoses, and Gram-positive, Skin Infections.

Kategori:
Amino Acids, Peptides, and ProteinsPeptidesPeptidomimetics
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LTX-315 DB12748
small molecule | CAS: 1345407-05-7

LTX-315 has been used in trials studying the treatment of Cancer, Lymphoma, Melanoma, Carcinoma, and Breast Cancer, among others.

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
Waktu Paruh-
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Lucatumumab DB06360
biotech | CAS: 903512-50-5

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Target Protein:
Tumor necrosis factor receptor superfamily member 5
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Lucerastat DB14872
small molecule | CAS: 141206-42-0

Lucerastat is under investigation in clinical trial NCT03425539 (Efficacy and Safety of Lucerastat Oral Monotherapy in Adult Subjects With Fabry Disease).

Kategori:
AlkaloidsCarbohydratesImines +3
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Lucinactant Approved DB04897
biotech | CAS: 825600-90-6

Lucinactant is a new synthetic peptide-containing surfactant for intratracheal use. It contains sinapultide, a novel, hydrophobic, 21-amino acid peptide (leucine and lysine repeating units, KL4 peptide) designed to mimic human surfactant protein-B (SB-P). Mor…

Kategori:
AlcoholsAmino Acids, Peptides, and ProteinsBiological Factors +11
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Lumefantrine co-artemether Approved DB13085
small molecule | CAS: 141204-94-6

Lumefantrine Co-Artemether (Riamet) has been investigated for the treatment of Malaria, Malaria, Falciparum, Malaria in Pregnancy, Uncomplicated Malaria, and Uncomplicated Knowlesi Malaria. Lumefantrine Co-Artemether is a tablet formulation of artemether and …

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Lumiracoxib Approved DB01283
small molecule | CAS: 220991-20-8

Lumiracoxib is a COX-2 selective non-steroidal anti-inflammatory drug (NSAID). On August 11, 2007, Australia's Therapeutic Goods Administration (TGA, the Australian equivalent of the FDA) cancelled the registration of lumiracoxib in Australia due to concerns …

Kategori:
Acids, CarbocyclicAgents causing hyperkalemiaAgents that produce hypertension +21
Target Protein:
Prostaglandin G/H synthase 2Prostaglandin G/H synthase 1
Waktu ParuhTerminal half-life …
Vol. Distribusi-
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Lumretuzumab DB12683
biotech | CAS: 1448327-63-6

Lumretuzumab has been used in trials studying the treatment of Neoplasms, Breast Cancer, Squamous Non-Small Cell Lung Cancer, and Non-Squamous Non-Small Cell Lung Cancer.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
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Lupeol DB12622
small molecule | CAS: 545-47-1

Lupeol has been investigated for the treatment of Acne.

Kategori:
Anti-Inflammatory AgentsPentacyclic TriterpenesTerpenes +1
Target Protein:
DNA topoisomerase 2-alphaDNA topoisomerase 2-betaNeutrophil elastase
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Lurbinectedin Approved DB12674
small molecule | CAS: 497871-47-3

Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma,[A214325] chronic lymphocytic leukemia (CLL),[A214328] breast cancer,[A214322] and small-cell lung cancer (SCLC).[A214310] It i…

Kategori:
Alkylating DrugsAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +12
Target Protein:
DNA
Waktu ParuhThe terminal half-l…
Vol. DistribusiThe steady-state vo…
KlirensThe total plasma cl…
Genetik -
Lurtotecan DB12222
small molecule | CAS: 149882-10-0

Lurtotecan is under investigation in clinical trial NCT00022594 (Liposomal Lurtotecan in Treating Patients With Metastatic or Locally Recurrent Head and Neck Cancer).

Kategori:
AlkaloidsAntineoplastic Agents
Target Protein:
DNA topoisomerase 1
Waktu Paruh-
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Luseogliflozin DB12214
small molecule | CAS: 898537-18-3

Luseogliflozin has been used in trials studying the treatment of Diabetes Melltius, Type 2.

Kategori:
AlcoholsAlimentary Tract and MetabolismBlood Glucose Lowering Agents +5
Waktu Paruh-
Vol. Distribusi-
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Luspatercept Approved DB12281
biotech | CAS: 1373715-00-4

Luspatercept is a recombinant fusion protein comprised of a modified extracellular domain of activin receptor type IIB fused to the FC domain of human IgG1.[A187829,L42455] It was first approved for use in the United States in November 2019 under the brand na…

Kategori:
Activin ReceptorsAmino Acids, Peptides, and ProteinsAntianemia Drugs +25
Waktu ParuhThe average half-li…
Vol. DistribusiThe average apparen…
KlirensThe total apparent …
Genetik -
Lusutrombopag Approved DB13125
small molecule | CAS: 1110766-97-6

Lusutrombopag is an orally bioavailable thrombopoietin receptor (TPOR) agonist developed by Shionogi & Company (Osaka, Japan). TPOR is a regulatory target site for endogenous thrombopoietin, which acts as a primary cytokine to promote megakaryocyte proliferat…

Kategori:
Acids, CarbocyclicBCRP/ABCG2 SubstratesBlood and Blood Forming Organs +4
Target Protein:
Thrombopoietin receptor
Waktu ParuhIn healthy adult su…
Vol. DistribusiThe mean (%CV) lusu…
KlirensThe approximate mea…
Genetik -
Lutein Approved DB00137
small molecule | CAS: 127-40-2

Lutein is an xanthophyll and one of 600 known naturally occurring carotenoids. Lutein is synthesized only by plants and like other xanthophylls is found in high quantities in green leafy vegetables such as spinach, kale and yellow carrots. In green plants, xa…

Kategori:
AlkenesBiological FactorsCarotenoids +10
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biotech | CAS: 1703749-62-5

Lutetium Lu-177 vipivotide tetraxetan is a radioligand therapeutic agent. It consists of a radionuclide, [lutetium Lu-177], linked to a moiety that binds to PSMA, a transmembrane protein that is expressed in prostate cancer.[L41280] Lutetium Lu-177 vipivot…

Kategori:
Compounds used in a research, industrial, or household settingDiagnostic Uses of ChemicalsRadioactive Therapeutic Agent +6
Target Protein:
Prostate-specific antigen
Waktu ParuhThe terminal elimin…
Vol. DistribusiThe mean volume of …
KlirensThe mean clearance …
Genetik -
Lutikizumab DB16224
biotech | CAS: 1791411-57-8

Lutikizumab is under investigation in clinical trial NCT02087904 (A Study Evaluating the Safety, Efficacy, and Pharmacodynamic Effects of ABT-981 in Patients With Knee Osteoarthritis).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +6
Waktu Paruh-
Vol. Distribusi-
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Lutropin alfa Approved DB00044
biotech | CAS: 152923-57-4

Lutropin alfa is a recombinant human luteinizing hormone produced in yeast with 2 subunits, alpha = 92 residues, beta = 121 residues. It is a heterodimeric glycoprotein made up of monomeric units. Lutropin alfa was the first and only recombinant human form of…

Kategori:
Genito Urinary System and Sex HormonesGonadotropinsGonadotropins and Antigonadotropins +1
Target Protein:
Lutropin-choriogonadotropic hormone receptor
Waktu ParuhBiphasic; terminal …
Vol. DistribusiThe steady state vo…
Klirens* 2 – 3 L/h [health…
Genetik -
LY-2334737 DB12906
small molecule | CAS: 892128-60-8

LY2334737 has been used in trials studying the treatment of Solid Tumor, Metastatic Tumor, and Malignant Solid Tumor.

Kategori:
DeoxyribonucleosidesNucleic Acids, Nucleotides, and NucleosidesNucleosides +2
Target Protein:
Ribonucleoside-diphosphate reductase subunit M2
Waktu Paruh-
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LY-2452473 DB12573
small molecule | CAS: 1029692-15-6

Ly2452473 is under investigation for the supportive care of Prostate Cancer. Ly2452473 has been investigated for the treatment of Erectile Dysfunction.

Kategori:
Acids, Acyclic
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LY-2584702 DB12690
small molecule | CAS: 1082949-67-4

LY2584702 has been used in trials studying the treatment of Cancer, Advanced Cancer, Renal Cell Carcinoma, Metastases, Neoplasm, and Neuroendocrine Tumors, among others.

Kategori:
Ribosomal Protein S6 Kinases, 70-kDa, antagonists & inhibitors
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LY-2608204 DB12284
small molecule | CAS: 1234703-40-2

LY2608204 has been used in trials studying the treatment of Diabetes Mellitus, Type 2.

Kategori:
Enzyme ActivatorsSulfur Compounds
Target Protein:
Hexokinase-4Serine/threonine-protein kinase Chk1
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LY-2624803 DB15092
small molecule | CAS: 879409-35-5

LY-2624803 is under investigation in clinical trial NCT01236105 (Effect of Activated Charcoal and Time of Dose on the Pharmacokinetics of LY2624803 in Healthy Subject).

Target Protein:
Histamine H1 receptor
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LY-2874455 DB13022
small molecule | CAS: 1254473-64-7

LY2874455 has been used in trials studying the treatment of Advanced Cancer.

Kategori:
Heterocyclic Compounds, Fused-RingPyrazolesReceptors, Fibroblast Growth Factor, antagonists & inhibitors
Target Protein:
Fibroblast growth factor receptor 2
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LY-2881835 DB15046
small molecule | CAS: 1292290-38-0

LY-2881835 is under investigation in clinical trial NCT01358981 (A Study of LY2881835 in Healthy People and People With Diabetes).

Target Protein:
Free fatty acid receptor 1
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LY-2886721 DB12547
small molecule | CAS: 1262036-50-9

LY2886721 has been used in trials studying the basic science of Alzheimer's Disease.

Kategori:
Heterocyclic Compounds, Fused-RingPyridines
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LY-295501 DB12574
small molecule | CAS: 150869-74-2

ILX-295501 has been used in trials studying the treatment of Ovarian Cancer, Metastatic Cancer, Fallopian Tube Cancer, and Primary Peritoneal Cavity Cancer.

Kategori:
AmidesBenzene DerivativesHeterocyclic Compounds, Fused-Ring
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LY-3023414 DB12167
small molecule | CAS: 1386874-06-1

LY3023414 has been used in trials studying the treatment of Neoplasm, Solid Tumor, COLON CANCER, BREAST CANCER, and Advanced Cancer, among others.

Kategori:
Heterocyclic Compounds, Fused-RingQuinolines
Target Protein:
Serine/threonine-protein kinase mTORPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Waktu Paruh-
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LY-3039478 DB12050
small molecule | CAS: 1421438-81-4

LY3039478 has been used in trials studying the treatment and basic science of LYMPHOMA, Neoplasms, Solid Tumor, COLON CANCER, and BREAST CANCER, among others.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Neurogenic locus notch homolog protein 4Neurogenic locus notch homolog protein 1
Waktu Paruh-
Vol. Distribusi-
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LY-377604 DB12858
small molecule | CAS: 204592-94-9

Ly377604 has been used in trials studying the treatment of Obesity.

Target Protein:
Beta-3 adrenergic receptor
Waktu Paruh-
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LY-517717 DB05713
small molecule | CAS: 313489-71-3

LY517717 is an investigational oral direct inhibitor of activated Factor Xa. It is believed to be Lilly's PMD-3112 (licensed from Amgen).

Kategori:
Amino AcidsAmino Acids, Peptides, and Proteins
Target Protein:
Coagulation factor X
Waktu Paruh-
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LY-518674 DB12988
small molecule | CAS: 425671-29-0

LY518674 has been used in trials studying the treatment of Metabolic Syndrome X.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +1
Target Protein:
Peroxisome proliferator-activated receptor alpha
Waktu Paruh-
Vol. Distribusi-
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LY2828360 DB16074
small molecule | CAS: 1231220-79-3

LY2828360 is under investigation in clinical trial NCT01319929 (A Study of LY2828360 in Patients With Osteoarthritic Knee Pain).

Kategori:
Cannabinoid Receptor AgonistsCannabinoids and similarsHeterocyclic Compounds, Fused-Ring +3
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Lycopene Approved DB11231
small molecule | CAS: 502-65-8

Lycopene is a naturally occurring red carotenoid pigment that is responsible for red to pink colors seen in tomatoes, pink grapefruit, and other foods [A27242]. Having a chemical formula of C40H56, lycopene is a tetraterpene assembled from eight isoprene unit…

Kategori:
AlkenesAnti-Inflammatory AgentsAnticarcinogenic Agents +13
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Lymecycline Approved DB00256
small molecule | CAS: 992-21-2

Lymecycline is a broad-spectrum second-generation tetracycline antibiotic used for the treatment of acne and other susceptible bacterial infections.[L13880,L13883] It has been proven a cost-effective alternative to treatment with [minocycline] with comparable…

Kategori:
Agents that produce neuromuscular block (indirect)Anti-Bacterial AgentsAnti-Infective Agents +4
Target Protein:
30S ribosomal protein S4
Waktu ParuhThe half-life of ly…
Vol. DistribusiLymecycline is lipo…
KlirensLymecycline is part…
Genetik -
Lynestrenol Approved DB12474
small molecule | CAS: 52-76-6

Lynestrenol is a progestin and prodrug of [norethisterone].

Kategori:
Adrenal Cortex HormonesCombination Contraceptives (with Estrogen and derivatives)Contraceptive Agents, Female +25
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Lysine Approved DB00123
small molecule | CAS: 56-87-1

Lysine (abbreviated as Lys or K) is an ?-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and his…

Kategori:
Amino AcidsAmino Acids, BasicAmino Acids, Diamino +10
Target Protein:
High affinity cationic amino acid transporter 1Cationic amino acid transporter 4Cationic amino acid transporter 3 +2
Waktu Paruh-
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Lysozyme DB13260
biotech | CAS: 12650-88-3

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsAntiinfectives for Systemic UseDermatologicals +6
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Vol. Distribusi-
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Genetik -
small molecule | CAS: 156021-12-4

Deskripsi belum tersedia.

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small molecule | CAS: 6640-24-0

m-Chlorophenylpiperazine has been used in trials studying the treatment of Alcoholism.

Kategori:
Antidepressive AgentsCentral Nervous System DepressantsNeurotransmitter Agents +7
Target Protein:
5-hydroxytryptamine receptor 1E5-hydroxytryptamine receptor 75-hydroxytryptamine receptor 6 +4
Waktu Paruh-
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M012 DB18243
biotech

Deskripsi belum tersedia.

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Macelignan DB14129
small molecule | CAS: 107534-93-0

Macelignan is an NSAID with antioxidant, free radical scavenging, and neuroprotective activities.

Kategori:
Benzene DerivativesBenzyl Compounds
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Macimorelin Approved DB13074
small molecule | CAS: 381231-18-1

Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH sec…

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +11
Target Protein:
Growth hormone secretagogue receptor type 1
Waktu ParuhThe mean terminal h…
Vol. DistribusiFollowing a single …
KlirensFollowing a single …
Genetik -
Mafosfamide DB12083
small molecule | CAS: 88859-04-5

Mafosfamide has been used in trials studying the treatment of Lymphoma, Leukemia, Meningeal Neoplasm, and Brain and Central Nervous System Tumors.

Kategori:
Adjuvants, ImmunologicAntineoplastic AgentsHydrocarbons, Halogenated +6
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Magnesium Approved DB14513
small molecule | CAS: 7439-95-4

Magnesium is classified as an alkaline earth metal and has 2 hydration shells.[A19349] The element can be found in abundance in the hydrosphere and in mineral salts such as dolomite and magnesium carbonate.[A19349] Common dietary sources of magnesium incl…

Kategori:
ElementsLaxativesMagnesium Compounds +6
Waktu ParuhMagnesiums biologic…
Vol. DistribusiAccording to a phar…
Klirens-
Genetik -
Magnesium Aluminum Silicate Approved DB11230
small molecule | CAS: 1327-43-1

Magnesium aluminum silicate is a naturally occurring mineral obtained from silicate ores of the montmorillonite group [A32782]. It is refined to a powder for use in cosmetic and pharmaceutical applications as an absorbent, anticaking agent, opacifying agent, …

Kategori:
Agents that produce neuromuscular block (indirect)MineralsPharmaceutic Aids +1
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Menampilkan 1751–1800 dari 3253
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