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12560

Total database: 17430
Struktur (SMILES)
9109 (72.5%)
Target
6912 (55.0%)
Genomik
109 (0.9%)
Referensi
12560 (100.0%)

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Hasil Pencarian (12560)

Halaman 35 / 252
small molecule | CAS: 91421-43-1

Aminocamptothecin has been used in trials studying the treatment of Lymphoma, Gastric Cancer, Ovarian Cancer, Esophageal Cancer, and Ovarian Neoplasms, among others.

Kategori:
AlkaloidsAntineoplastic AgentsCytochrome P-450 CYP3A Substrates +3
Target Protein:
DNA topoisomerase 1
Waktu Paruh-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Purine nucleoside phosphorylase DeoD-type
Waktu Paruh-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Heat shock protein HSP 90-alpha
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Heat shock protein HSP 90-alpha
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Heat shock protein HSP 90-alpha
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small molecule

Deskripsi belum tersedia.

Target Protein:
Heat shock protein HSP 90-alphaHeat shock protein HSP 90-beta
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9-Deazaguanine DB04356
small molecule | CAS: 65996-58-9

Deskripsi belum tersedia.

Kategori:
Cytochrome P-450 CYP1A2 SubstratesCytochrome P-450 SubstratesHeterocyclic Compounds, Fused-Ring +3
Target Protein:
Hypoxanthine-guanine-xanthine phosphoribosyltransferaseHypoxanthine-guanine phosphoribosyltransferase
Waktu Paruh-
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Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingPurinesPurinones
Target Protein:
Purine nucleoside phosphorylasePurine nucleoside phosphorylase
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9-deazainosine DB02796
small molecule | CAS: 89458-19-5

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingNucleic Acids, Nucleotides, and NucleosidesNucleosides +3
Target Protein:
Purine nucleoside phosphorylase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Purine nucleoside phosphorylase
Waktu Paruh-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Group IIE secretory phospholipase A2
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9-Methylguanine DB02489
small molecule | CAS: 5502-78-3

Deskripsi belum tersedia.

Kategori:
Cytochrome P-450 CYP1A2 SubstratesCytochrome P-450 SubstratesHeterocyclic Compounds, Fused-Ring +3
Target Protein:
Dihydroneopterin aldolase
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99mTc-14 F7 Mab DB05867
biotech

99mTc 14F7 Mab has strong anti tumor activity against myeloma cells in vivo. Growth inhibition and prolonged survival of the myeloma tumor were obtained as evidences of anti tumor effect after treatment with 99mTc 14F7 Mab.

Target Protein:
Lactosylceramide alpha-2,3-sialyltransferase
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99mTc-glucarate DB05810
small molecule

99mTc-glucarate(GLA) is an agent for non-invasive detection of breast tumours.

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small molecule | CAS: 913556-61-3

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsOrganometallic CompoundsPeptides +1
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9CUAB30 DB12316
small molecule | CAS: 205252-57-9

9 Cuab30 has been used in trials studying the treatment and prevention of HER2/Neu Positive, HER2/Neu Negative, No Evidence of Disease, Estrogen Receptor Negative, and estrogen receptor positive, among others.

Kategori:
Fatty AcidsLipids
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small molecule | CAS: 101860-00-8

?-Methylacetylfentanyl is an analog of fentanyl with opioid analgesic properties. It was categorized under the Schedule I in the US and it was illegally sold in early 1980. ?-Methylacetylfentanyl synthesis process is very similar to ?-methylfentanyl with the …

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small molecule | CAS: 79704-88-4

?-Methylfentanyl is an analog of fentanyl with opioid analgesic properties.

Kategori:
Designer DrugsPiperidinesStreet Drugs
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small molecule | CAS: 79146-56-8

?-Methylfentanyl is an analgesic of the _opioid_ class. It is an analog of the potent opioid, fentanyl.

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?A?–Gas6 DB17069
biotech

?A?–Gas6 is a chimeric fusion protein being investigated in preclinical studies as an immunotherapeutic agent for Alzheimer's disease (AD). It is made of a single chain variable fragment (scFv) of an Amyloid ? (A?)-targeting monoclonal antibody fused with a t…

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A-16L DB18270
biotech | CAS: 410527-75-2

Deskripsi belum tersedia.

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A-674563 DB08568
small molecule | CAS: 552325-73-2

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingPyrazoles
Target Protein:
RAC-alpha serine/threonine-protein kinasecAMP-dependent protein kinase catalytic subunit alphacAMP-dependent protein kinase inhibitor alpha
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biotech | CAS: 1470038-56-2

A-dmDT390-bisFv(UCHT1) is under investigation in clinical trial NCT02943642 (Safety and Effectiveness of A-dmdt390-bisfv(ucht1) Fusion Protein in Subjects With Mycosis Fungoides).

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A166 DB17413
biotech

A166 is an antibody-drug conjugate composed of a novel cytotoxic drug (Duo-5, anti-microtubule agent) site-specifically conjugated to an anti-HER2 antibody (trastuzumab) via a stable protease-cleavable valine citrulline linker.

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AAV-AIPL DB17857
biotech

AAV-AIPL is an adenovirus-associated viral vector serotype 8 containing the human _AIPL1_ gene. Developed by MeiraGTx, it is being investigated for the treatment of inherited retinal dystrophy due to defects in _AIPL1_ gene.

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AAV-RPE65 DB18343
biotech

AAV-RPE65 is an adenovirus associated viral vector serotype 5 containing the human RPE65 gene

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AAV1-FS344 DB17855
biotech

AAV1-FS344 is an investigational gene therapy developed by Milo Biotechnology to deliver follistatin, a potent myostatin inhibitor. It is being investigated for the treatment of Duchenne Muscular Dystrophy, Becker Muscular Dystrophy, and inclusion body myosit…

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AB-001 DB18009
small molecule | CAS: 2663700-89-6

Deskripsi belum tersedia.

Kategori:
Bridged-Ring CompoundsCycloparaffinsHeterocyclic Compounds, Fused-Ring
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AB-201 DB18629
biotech

AB-201 is a CAR-NK cell therapy targeted against HER2.[L48340] It is under investigation for the treatment of HER2-positive cancers, including breast and gastric carcinomas.

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AB-8939 DB17115
small molecule | CAS: 1974336-09-8

Deskripsi belum tersedia.

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AB-G023 DB18576
biotech

AB-G023 is a solution stable glucagon analog

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Abacavir Approved DB01048
small molecule | CAS: 136470-78-5

Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring. In vivo, …

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +22
Target Protein:
Reverse transcriptase/RNaseHGag-Pol polyprotein
Gen Terkait:
HCP5
Waktu Paruh1.54 ± 0.63 hours
Vol. Distribusi* 0.86 ± 0.15 L/kg …
Klirens* 0.80 ± 0.24 L/hr/…
Genetik 1 Varian
Abafungin DB06395
small molecule | CAS: 129639-79-8

Deskripsi belum tersedia.

Kategori:
Antifungal AgentsAzole AntifungalsSulfur Compounds
Target Protein:
Lanosterol 14-alpha demethylase
Waktu Paruh-
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Abagovomab DB16077
biotech | CAS: 792921-10-9

Abagovomab is under investigation in clinical trial NCT00418574 (Efficacy Multicentre Trial of Immunotherapy Vaccination With Abagovomab to Treat Ovarian Cancer Patients).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +8
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Abaloparatide Approved DB05084
biotech | CAS: 247062-33-5

Abaloparatide is an N-terminal analog of parathyroid hormone-related protein (PTHrP) [A256778] and an agonist at the parathyroid hormone type 1 (PTH1) receptor.[L740] It is a synthetic 34 amino acid peptide with 41% homology to human parathyroid hormone 1-34 …

Kategori:
Amino Acids, Peptides, and ProteinsAnalogs/DerivativesBiological Factors +13
Target Protein:
Parathyroid hormone/parathyroid hormone-related peptide receptor
Waktu ParuhThe mean half-life …
Vol. DistribusiThe volume of distr…
KlirensThe mean apparent t…
Genetik -
Abametapir Approved DB11932
small molecule | CAS: 1762-34-1

Abametapir is a novel pediculicidal metalloproteinase inhibitor used to treat infestations of head lice.[L15153] The life cycle of head lice (_Pediculus capitis_) is approximately 30 days, seven to twelve of which are spent as eggs laid on hair shafts near th…

Kategori:
Antiparasitic Products, Insecticides and RepellentsCytochrome P-450 CYP1A2 InhibitorsCytochrome P-450 CYP1A2 Inhibitors (strength unknown) +13
Waktu ParuhThe elimination hal…
Vol. DistribusiData regarding the …
KlirensThe clearance and e…
Genetik -
Abarelix Approved DB00106
small molecule | CAS: 183552-38-7

Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market.

Kategori:
Amino Acids, Peptides, and ProteinsAntineoplastic and Immunomodulating AgentsEndocrine Therapy +4
Target Protein:
Gonadotropin-releasing hormone receptor
Waktu Paruh13.2 ± 3.2 d…
Vol. Distribusi-
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Abatacept Approved DB01281
biotech | CAS: 332348-12-6

Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1).[L20504,L42715] Structurally, …

Kategori:
Agents reducing cytokine levelsAmino Acids, Peptides, and ProteinsAntibodies +18
Target Protein:
T-lymphocyte activation antigen CD80T-lymphocyte activation antigen CD86Cytotoxic T-lymphocyte protein 4
Waktu Paruh16.7 (12-23) days i…
Vol. Distribusi* 0.07 L/kg [RA Pat…
Klirens* 0.23 mL/h/kg [Hea…
Genetik -
ABBV-514 DB17586
biotech

ABBV-514 is in development for the treatment of non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC) as a single agent and in combination with a PD-1 inhibitor.[L45464]

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ABBV-706 DB18710
biotech

ABBV-706 is an antibody-drug conjugate that is anti-SEZ6.[L49156,L49161]

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ABBV-744 DB19199
small molecule | CAS: 2138861-99-9

Deskripsi belum tersedia.

Target Protein:
Bromodomain-containing protein 3Bromodomain-containing protein 2Bromodomain-containing protein 4
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Abciximab Approved DB00054
biotech | CAS: 143653-53-6

Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, a…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +18
Target Protein:
Integrin beta-3Integrin alpha-IIbLow affinity immunoglobulin gamma Fc region receptor II-a +2
Waktu ParuhFollowing intraveno…
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Abediterol DB12100
small molecule | CAS: 915133-65-2

Abediterol has been used in trials studying the treatment of Asthma, Chronic Obstructive Pulmonary Disease (COPD), and Chronic Obstructive Pulmonary Disease (COPD) and Asthma.

Kategori:
Adrenergic AgonistsAdrenergic beta-2 Receptor AgonistsAdrenergic beta-Agonists +4
Target Protein:
Beta-2 adrenergic receptor
Waktu Paruh-
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Abelacimab DB16682
biotech | CAS: 2098724-83-3

Abelacimab is under investigation in clinical trial NCT04755283 (Safety and Tolerability of Abelacimab (MAA868) vs. Rivaroxaban in Patients With Atrial Fibrillation).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
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Abeprazan DB16078
small molecule | CAS: 1902954-60-2

Abeprazan is under investigation in clinical trial NCT04341454 (Study to Evaluate the Efficacy and Safety of DWP14012 in Patients With Acute or Chronic Gastritis).

Kategori:
Gastrointestinal Agents
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Abequolixron DB17146
small molecule | CAS: 610318-54-2

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicBenzene Derivatives
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Abequose DB02590
small molecule | CAS: 56816-60-5

Deskripsi belum tersedia.

Kategori:
CarbohydratesMonosaccharides
Target Protein:
Tail fiber protein
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Abexinostat DB12565
small molecule | CAS: 783355-60-2

Abexinostat has been used in trials studying the treatment of Sarcoma, Lymphoma, Leukemia, Lymphocytic, and Hodgkin Disease, among others. It is a novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplasti…

Kategori:
AminesAntineoplastic AgentsEnzyme Inhibitors +6
Target Protein:
Histone deacetylase 1Histone deacetylase
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ABG-023 DB18829
biotech

ABG-023 is a glucagon analog which is soluble and solution-stable.[L50778]

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ABH001 DB16177
small molecule | CAS: 502-97-6

ABH001 is under investigation in clinical trial NCT01749306 (A Study of the Efficacy and Safety of ABH001 in the Treatment of Patients With Epidermolysis Bullosa Who Have Wounds That Are Not Healing).

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Menampilkan 1701–1750 dari 12560
Sebelumnya Halaman 35 / 252 Berikutnya