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1977

Total database: 17430
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1977 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (1977)

Halaman 33 / 40
SM-1997 DB18670
biotech

SM-1997 is a protein-free solution derived from calf's blood comprising electrolytes, trace minerals, amino acids, peptides, nucleosides, and nucleotides.[A261816] It is under investigation for the treatment of cutaneous sulfur mustard-induced injury.

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Sodium aurothiomalate Approved DB09276
small molecule | CAS: 12244-57-4

Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in act…

Kategori:
Acids, AcyclicAntiinflammatory and Antirheumatic ProductsAntirheumatic Agents +13
Waktu Paruh12.5 days
Vol. DistribusiThe apparent volume…
Klirens7.0 ml/ kg/day
Genetik -
Sodium oxybate Approved DB09072
small molecule | CAS: 502-85-2

Sodium oxybate (Xyrem) is a central nervous system (CNS) depressant used to treat cataplexy or excessive daytime sleepiness associated with narcolepsy.[L30598] It is a sodium salt of [gamma-Hydroxybutyric acid], an endogenous cerebral inhibitory neurotransmit…

Kategori:
Acids, AcyclicAdjuvants, AnesthesiaAnesthetics +9
Target Protein:
GABA(B) ReceptorSolute carrier family 52, riboflavin transporter, member 2
Waktu ParuhGHB has an eliminat…
Vol. DistribusiThe apparent volume…
KlirensIn healthy GHB-naïv…
Genetik -
Sodium stibogluconate Approved DB05630
small molecule | CAS: 16037-91-5

Sodium stibogluconate is a medicine used to treat leishmaniasis and is only available for administration by injection. It belongs to the class of medicines known as the pentavalent antimonials. Sodium stibogluconate is sold in the UK as Pentostam (manufacture…

Kategori:
Acids, AcyclicAgents Against Leishmaniasis and TrypanosomiasisAnti-Infective Agents +10
Target Protein:
DNA topoisomerase 1
Waktu Paruh-
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Sodium sulfide Approved DB11159
small molecule | CAS: 1313-82-2

Sodium sulfide is a chemical compound with a chemical formula Na2S. Sodium sulfide is used in the pulp and paper industry, water treatment, textile industry, and various chemical manufacturing processes including the production of rubber chemicals, sulfur dye…

Kategori:
AnionsElectrolytesHydrogen Sulfide +2
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Sofosbuvir Approved DB08934
small molecule | CAS: 1190307-88-0

Sofosbuvir (tradename Sovaldi) is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is c…

Kategori:
Anti-Infective AgentsAntiinfectives for Systemic UseAntiviral Agents +18
Target Protein:
Genome polyproteinRNA-dependent RNA-polymerase
Waktu ParuhSofosbuvir has a te…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of so…
Genetik -
Sofpironium Approved DB19325
small molecule | CAS: 1628251-49-9

Sofpironium is a "soft" anticholinergic analog of [glycopyrronium] that has been modified with a readily hydrolyzable ester moiety.[L51109] Soft drugs are designed to reduce systemic toxicity while enhancing local efficacy by employing retrometabolic drug des…

Kategori:
Anticholinergic AgentsCytochrome P-450 CYP2D6 InhibitorsCytochrome P-450 CYP2D6 Inhibitors (strength unknown) +13
Target Protein:
Muscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor
Waktu ParuhThe _in vitro_ half…
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Solnatide DB12136
biotech | CAS: 259206-53-6

Solnatide has been used in trials studying the treatment of Acute Lung Injury.

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
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Solriamfetol Approved DB14754
small molecule | CAS: 178429-62-4

Solriamfetol marketed under the brand name Sunosi by Jazz Pharmaceuticals in the United States is a dopamine and norepinephrine reuptake inhibitor (DNRI) indicated in treating daytime sleepiness associated with narcolepsy or obstructive sleep apnea[FDA Label]…

Kategori:
Acids, AcyclicAdrenergic AgentsAdrenergic Uptake Inhibitors +22
Target Protein:
Sodium-dependent dopamine transporterSodium-dependent noradrenaline transporter
Waktu Paruh7.1 hours[FDA Label…
Vol. Distribusi199L[FDA Label]. Ot…
KlirensRenal clearance is …
Genetik -
Somatotropin Approved DB00052
biotech | CAS: 12629-01-5

Human growth hormone (HGH), also known as somatotropin, is a peptide hormone that is synthesized and secreted by the somatotropic cells of the anterior pituitary gland.[A228183] Growth hormone plays an essential role in growth regulation during childhood as w…

Kategori:
Agents Causing Muscle ToxicityAmino Acids, Peptides, and ProteinsAnterior Pituitary Lobe Hormones and Analogues +23
Target Protein:
Growth hormone receptorProlactin receptor
Waktu ParuhWhen somatotropin w…
Vol. DistribusiInformation is unav…
KlirensFollowing intraveno…
Genetik -
Somatrem Approved DB09098
biotech | CAS: 82030-87-3

Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate [A3…

Kategori:
Amino Acids, Peptides, and ProteinsAnterior Pituitary Lobe Hormones and AnaloguesGrowth Hormone +9
Target Protein:
Growth hormone receptorInsulin-like growth factor 1 receptor
Waktu ParuhThe mean terminal h…
Vol. DistribusiAnimal studies with…
KlirensThe clearance of so…
Genetik -
Somatrogon Approved DB14960
biotech | CAS: 1663481-09-1

Somatrogon is a long-acting recombinant human growth hormone. Growth hormone is a peptide hormone secreted by the pituitary gland that plays a crucial role in promoting longitudinal growth during childhood and adolescence and regulating metabolic function in …

Kategori:
Amino Acids, Peptides, and ProteinsAnterior Pituitary Lobe Hormones and AnaloguesGrowth Hormone +10
Target Protein:
Growth hormone receptor
Waktu ParuhFollowing subcutane…
Vol. DistribusiFollowing subcutane…
KlirensFollowing subcutane…
Genetik -
SOR-C13 DB15366
biotech | CAS: 1187852-48-7

SOR-C13 is under investigation in clinical trial NCT01578564 (Safety and Tolerability Study of SOR-C13 in Subjects With Advanced Cancers Commonly Known to Express the TRPV6 Channel).

Kategori:
Amino Acids, Peptides, and ProteinsAntiarrhythmic agentsAntineoplastic Agents +9
Target Protein:
Transient receptor potential cation channel subfamily V member 6
Waktu Paruh-
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Sorghum halepense pollen Approved DB10365
biotech

Sorghum halepense pollen is the pollen of the Sorghum halepense plant. Sorghum halepense pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityGrass Pollen Allergen ExtractsIncreased Histamine Release +2
Waktu Paruh-
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Sotalol Approved DB00489
small molecule | CAS: 3930-20-9

Sotalol is a methanesulfonanilide developed in 1960.[A178579] It was the first of the class III anti arrhythmic drugs.[A178579] Sotalol was first approved as an oral tablet on 30 October 1992.[L6334] A racemic mixture of sotalol is currently formulated as a t…

Kategori:
Adrenergic AgentsAdrenergic AntagonistsAdrenergic beta-Antagonists +23
Target Protein:
Beta-1 adrenergic receptorBeta-2 adrenergic receptorVoltage-gated inwardly rectifying potassium channel KCNH2
Waktu ParuhThe terminal elimin…
Vol. DistribusiThe apparent volume…
KlirensIn patients with a …
Genetik -
Sotevtamab DB19120
biotech | CAS: 2411526-47-9

Sotevtamab is under investigation in clinical trial NCT06225843 (Sotevtamab (AB-16B5) Combined With FOLFOX as Neoadjuvant Treatment Prior to Resection of Colorectal Cancer Liver Metastasis).

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Sotorasib Approved DB15569
small molecule | CAS: 2252403-56-6

Sotorasib, also known as AMG-510, is an acrylamide-derived KRAS inhibitor developed by Amgen.[A187547,A187556] It is indicated in the treatment of adult patients with KRAS G12C mutant non-small cell lung cancer.[L34288] This mutation makes up >50% of all KRAS…

Kategori:
Antineoplastic AgentsAntineoplastic Agents, ImmunologicalAntineoplastic and Immunomodulating Agents +13
Target Protein:
GTPase KRas
Waktu ParuhSotorasib has a ter…
Vol. DistribusiThe volume of distr…
KlirensSotorasib has an ap…
Genetik -
Soy sterol DB11325
biotech | CAS: 129311-52-0

Deskripsi belum tersedia.

Kategori:
Biological FactorsCholestanesFused-Ring Compounds +5
Waktu Paruh-
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Soybean oil Approved DB09422
biotech | CAS: 8001-22-7

Derived from soybeans, soybean oil is a common vegetable oil and a source of polyunsaturated and saturated fatty acids. It is a complex mixture of triglycerides where per 100 g, soybean oil has 16 g of saturated fat, 23 g of monounsaturated fat, and 58 g of p…

Kategori:
Biological ProductsCaloric AgentsComplex Mixtures +12
Target Protein:
Peroxisome proliferator-activated receptor alpha
Waktu Paruh-
Vol. DistribusiAfter triglycerides…
KlirensThe elimination rat…
Genetik -
SP-420 DB16069
small molecule | CAS: 911714-45-9

SP-420 is under investigation in clinical trial NCT03801889 (SP-420 in Subjects With Transfusion-dependent Beta-thalassemia or Other Rare Anemias).

Kategori:
CyclohexanesCycloparaffinsKetones +1
Waktu Paruh-
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Spaglumic acid DB08835
small molecule | CAS: 4910-46-7

Spaglumic acid is the ?-aspartyl isoform of N-Acetyl-l-aspartylglutamate (isospaglumic Acid is N-(N-Acetyl-l-?-aspartyl)-l-glutamic acid). In eye drops, spaglumic acid is either a magnesium or sodium salt of N-Acetyl-l-aspartylglutamate. Spaglumic acid is a m…

Kategori:
Antiallergic Agents, Excl. CorticosteroidsDecongestants and AntiallergicsMast Cell Stabilizers +3
Target Protein:
Glutamate carboxypeptidase 2
Waktu Paruh-
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Sphingosine DB03203
small molecule | CAS: 123-78-4

An amino alcohol with a long unsaturated hydrocarbon chain. Sphingosine and its derivative sphinganine are the major bases of the sphingolipids in mammals. (Dorland, 28th ed)

Kategori:
AlcoholsAminesAmino Alcohols +2
Target Protein:
Choline-phosphate cytidylyltransferase BGenome polyproteinGenome polyprotein +4
Waktu Paruh-
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Spironolactone Approved DB00421
small molecule | CAS: 52-01-7

Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists.[A178192] It promotes sodium and water excretion and potassium retention.[A11837] Spironolactone was originally developed purely f…

Kategori:
Agents causing hyperkalemiaAntihypertensive AgentsAntihypertensive Agents Indicated for Hypertension +19
Target Protein:
Mineralocorticoid receptorGlucocorticoid receptorAndrogen receptor +4
Waktu ParuhThe mean half-life …
Vol. Distribusi-
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Sporisorium cruentum Approved DB10873
biotech

Sporisorium cruentum is a fungus which can provoke allergic reactions. Sporisorium cruentum extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
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Sprifermin DB12616
biotech | CAS: 890058-52-3

Sprifermin has been used in trials studying the treatment of Osteoarthritis, Knee and Cartilage Injury of Knee.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsIntercellular Signaling Peptides and Proteins +2
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Squalene Approved DB11460
small molecule | CAS: 111-02-4

Squalene is originally obtained from shark liver oil. It is a natural 30-carbon isoprenoid compound and intermediate metabolite in the synthesis of cholesterol. It is not susceptible to lipid peroxidation and provides skin protection. It is ubiquitously distr…

Kategori:
AlkenesHydrocarbons, AcyclicPolyenes +2
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SS1(dsFv)-PE38 DB17579
biotech

SS1(dsFv)-PE38 is a recombinant anti-mesothelin immunotoxin. SS1(dsFv)-PE38 is under investigation in clinical trial NCT01051934 (A Phase I Trial of SS1 (Dsfv) PE38 With Paclitaxel, Carboplatin, and Bevacizumab in Subjects With Unresectable Non-small Cell Lun…

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St. John's Wort Approved DB01323
biotech | CAS: 84082-80-4

Deskripsi belum tersedia.

Kategori:
AngiospermsAntidepressive AgentsAntidepressive Agents Indicated for Depression +33
Waktu Paruh-
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Stannsoporfin DB04912
small molecule | CAS: 106344-20-1

Stannsoporfin is a competitive heme oxygenase (HO) inhibitor being developed by InfaCare, a subsidiary of WellSpring Pharmaceuticals, for the prevention of hyperbilirubinemia in infants at risk of developing jaundice.

Kategori:
Biological FactorsCoordination ComplexesEnzyme Inhibitors +4
Target Protein:
Heme oxygenase 1Heme oxygenase 2
Waktu Paruh3.8 hours following…
Vol. Distribusi-
Klirens-
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Stapokibart DB18990
biotech | CAS: 2734715-10-5

Stapokibart is under investigation in clinical trial NCT06424470 (Study on the Treatment of Prurigo Nodularis With Stapokibart Injection).

Waktu Paruh-
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STC3141 DB16475
small molecule

STC3141, was investigated in clinical trial NCT04880694 to evaluate its safety and effect in subjects with severe COVID-19 pneumonia.

Kategori:
Experimental Unapproved Treatments for COVID-19
Waktu Paruh-
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STG-001 DB16734
small molecule

STG-001 is under investigation in clinical trial NCT04489511 (Study of STG-001 in Subjects With Stargardt Disease).

Waktu Paruh-
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Stiripentol Approved DB09118
small molecule | CAS: 49763-96-4

Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's pote…

Kategori:
AnticonvulsantsBCRP/ABCG2 InhibitorsCentral Nervous System Agents +37
Target Protein:
GABA(A) ReceptorGamma-aminobutyric acid receptor subunit gamma-3L-lactate dehydrogenase A chain +1
Waktu ParuhThe elimination hal…
Vol. DistribusiThe average volume …
KlirensPlasma clearance de…
Genetik -
biotech

Streptococcus pneumoniae type 1 capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 1 of *Streptococcus pneumoniae*. It is an active immunization for intramuscular or subcutan…

Kategori:
Actively Acquired ImmunityInactivated Pneumococcal Vaccine
Waktu Paruh-
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biotech

Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of *Streptococcus pneumoniae* serotype 1 individually conjugated to the CRM197 protein,…

Kategori:
Actively Acquired ImmunityInactivated Pneumococcal Vaccine
Waktu Paruh-
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biotech

Streptococcus pneumoniae type 10a capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 10a of *Streptococcus pneumoniae*. It is an active immunization for intramuscular or subc…

Kategori:
Actively Acquired ImmunityInactivated Pneumococcal Vaccine
Waktu Paruh-
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biotech

Streptococcus pneumoniae type 10A capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of *Streptococcus pneumoniae* serotype 10A individually conjugated to the CRM197 prot…

Kategori:
Inactivated Pneumococcal Vaccine
Waktu Paruh-
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biotech

Streptococcus pneumoniae type 11a capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 11a of *Streptococcus pneumoniae*. It is an active immunization for intramuscular or subc…

Kategori:
Actively Acquired ImmunityInactivated Pneumococcal Vaccine
Waktu Paruh-
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biotech

Streptococcus pneumoniae type 11A capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of *Streptococcus pneumoniae* serotype 11A individually conjugated to the CRM197 prot…

Kategori:
Inactivated Pneumococcal Vaccine
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biotech

Streptococcus pneumoniae type 12f capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 12f of *Streptococcus pneumoniae*. It is an active immunization for intramuscular or subc…

Kategori:
Actively Acquired ImmunityInactivated Pneumococcal Vaccine
Waktu Paruh-
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biotech

Streptococcus pneumoniae type 12F capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of *Streptococcus pneumoniae* serotype 12F individually conjugated to the CRM197 prot…

Kategori:
Inactivated Pneumococcal Vaccine
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biotech

Streptococcus pneumoniae type 14 capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 14 of *Streptococcus pneumoniae*. It is an active immunization for intramuscular or subcut…

Kategori:
Actively Acquired ImmunityInactivated Pneumococcal Vaccine
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of *Streptococcus pneumoniae* serotype 14 individually conjugated to the CRM197 protei…

Kategori:
Actively Acquired ImmunityInactivated Pneumococcal Vaccine
Waktu Paruh-
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biotech

Streptococcus pneumoniae type 15A capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of _Streptococcus pneumoniae_ serotype 15A individually conjugated to the CRM197 prot…

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biotech

Streptococcus pneumoniae type 15b capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 15b of *Streptococcus pneumoniae*. It is an active immunization for intramuscular or subc…

Kategori:
Actively Acquired ImmunityInactivated Pneumococcal Vaccine
Waktu Paruh-
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biotech

Streptococcus pneumoniae type 15B capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of *Streptococcus pneumoniae* serotype 15B individually conjugated to the CRM197 prot…

Kategori:
Inactivated Pneumococcal Vaccine
Waktu Paruh-
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biotech

Streptococcus pneumoniae type 16F capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of _Streptococcus pneumoniae_ serotype 16F individually conjugated to the CRM197 prot…

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Genetik -
biotech

Streptococcus pneumoniae type 17f capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 17f of *Streptococcus pneumoniae*. It is an active immunization for intramuscular or subc…

Kategori:
Actively Acquired ImmunityInactivated Pneumococcal Vaccine
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Streptococcus pneumoniae type 17F capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of _Streptococcus pneumoniae_ serotype 17F individually conjugated to the CRM197 prot…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Streptococcus pneumoniae type 18c capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 18c of *Streptococcus pneumoniae*. It is an active immunization for intramuscular or subc…

Kategori:
Actively Acquired ImmunityInactivated Pneumococcal Vaccine
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Menampilkan 1601–1650 dari 1977
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