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11793

Total database: 17430
Struktur (SMILES)
8607 (73.0%)
Target
6418 (54.4%)
Genomik
102 (0.9%)
Referensi
11793 (100.0%)

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Hasil Pencarian (11793)

Halaman 32 / 236
Acetarsol Approved DB13268
small molecule | CAS: 97-44-9

Acetarsol, with the molecular formula N-acetyl-4-hydroxy-m-arsanilic acid, is a pentavalent arsenical compound with antiprotozoal and antihelmintic properties.[L2622] It was first discovered in 1921 by Ernest Fourneau at the Pasteur Institute. It was develope…

Kategori:
Agents Against Leishmaniasis and TrypanosomiasisAlimentary Tract and MetabolismAnti-Infective Agents +8
Waktu ParuhThis pharmacokineti…
Vol. DistribusiThis pharmacokineti…
KlirensThis pharmacokineti…
Genetik -
Acetazolamide Approved DB00819
small molecule | CAS: 59-66-5

One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacer…

Kategori:
AnticonvulsantsAntiglaucoma AgentsAntiglaucoma Preparations and Miotics +22
Target Protein:
Carbonic anhydrase 1Carbonic anhydrase 2Carbonic anhydrase 4 +5
Waktu Paruh3 to 9 hours
Vol. Distribusi-
Klirens-
Genetik -
Acetic acid Approved DB03166
small molecule | CAS: 64-19-7

Acetic acid is a product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed) Acetic acid otic (for the ear) is an antibiotic that …

Kategori:
AcetatesAcids, AcyclicAnti-Bacterial Agents +14
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 78887-71-5

Acetic acid C-11 is under investigation in clinical trial NCT01953965 (Look at Way the Heart Functions in People With Pulmonary Hypertension (PH) Who Have Near Normal Right Ventricle (RV) Function and People With Pulmonary Hypertension Who Have Impaired RV Fu…

Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Prostaglandin G/H synthase 1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 541-50-4

Deskripsi belum tersedia.

Kategori:
Keto AcidsKetone BodiesKetones
Target Protein:
Fumarylacetoacetase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetoacetyl-CoA DB03059
small molecule | CAS: 1420-36-6

Deskripsi belum tersedia.

Kategori:
Adenine NucleotidesCoenzymesEnzymes and Coenzymes +7
Target Protein:
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrialAcetyl-CoA acetyltransferaseShort-chain specific acyl-CoA dehydrogenase, mitochondrial +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetohexamide Approved DB00414
small molecule | CAS: 968-81-0

A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market.

Kategori:
Alimentary Tract and MetabolismAmidesBenzene Derivatives +13
Target Protein:
ATP-sensitive inward rectifier potassium channel 1ATP-binding cassette sub-family C member 8
Waktu ParuhElimination half-li…
Vol. Distribusi-
Klirens-
Genetik -
Acetohydroxamic acid Approved DB00551
small molecule | CAS: 546-88-3

Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not a…

Kategori:
AminesEnzyme InhibitorsGenito Urinary System and Sex Hormones +5
Target Protein:
Urease subunit alphaMacrophage metalloelastase
Waktu Paruh5-10 hours in patie…
Vol. Distribusi-
Klirens-
Genetik -
Acetomenaphthone Approved DB19387
small molecule | CAS: 573-20-6

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 75-86-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Acetophenazine Approved DB01063
small molecule | CAS: 2751-68-0

Acetophenazine is an antipsychotic drug of moderate-potency. It is used in the treatment of disorganized and psychotic thinking. It is also used to help treat false perceptions (e.g. hallucinations or delusions). It primarily targets the dopamine D2 receptor.

Kategori:
Antipsychotic AgentsCentral Nervous System DepressantsDopamine Antagonists +8
Target Protein:
D(2) dopamine receptorAndrogen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetophenone DB04619
small molecule | CAS: 98-86-2

Deskripsi belum tersedia.

Kategori:
DermatologicalsKetonesPhotosensitizing Agents +1
Target Protein:
R-specific alcohol dehydrogenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetorphine DB01469
small molecule | CAS: 25333-77-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetoxolone DB13640
small molecule | CAS: 6277-14-1

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismDrugs for Acid Related DisordersDrugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetrizoic acid DB09347
small molecule | CAS: 85-36-9

Acetrizoic acid presents the molecular formula of 3-acetamidol-2,4,6-triiodobenzoic acid[L1702] and it is the first monomeric ionic compound used as an X-ray contrast agent.[A32135] It was first synthesized by Wallingford in 1953[A32136] and it was filled in …

Kategori:
Acids, CarbocyclicAminobenzoatesBenzene Derivatives +9
Waktu ParuhWhen water-soluble …
Vol. Distribusi-
Klirens-
Genetik -
Acetyl chloride DB14623
small molecule | CAS: 75-36-5

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicAnionsChlorine Compounds +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 616204-22-9

Argireline has been used in trials studying the treatment of wrinkles.

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 145576-25-6

Deskripsi belum tersedia.

Waktu Paruh-
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Genetik -
Acetylcysteine Approved DB06151
small molecule | CAS: 616-91-1

Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of [acetaminophen] overdose.[L31378,L31383,L31388,L31478] Acetylcysteine has also been studied for a wide variety of off-label indications with mixed re…

Kategori:
Amino AcidsAmino Acids, NeutralAmino Acids, Peptides, and Proteins +19
Target Protein:
Glutathione synthetaseCystine/glutamate transporterNAPQI (N-acetyl-p-benzoquinone imine) +8
Waktu ParuhThe mean terminal h…
Vol. DistribusiThe volume of distr…
KlirensAcetylcysteine has …
Genetik -
small molecule | CAS: 36330-79-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 2736440-65-4

Deskripsi belum tersedia.

Kategori:
Experimental Unapproved Treatments for COVID-19
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetyldigoxin DB13691
small molecule | CAS: 5511-98-8

Deskripsi belum tersedia.

Kategori:
Antiarrhythmic agentsCarbohydratesCardanolides +15
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 3861-72-1

Deskripsi belum tersedia.

Kategori:
Cough and Cold PreparationsOpium Alkaloids and Derivatives
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Acetyldinaline DB16142
small molecule | CAS: 58338-59-3

Acetyldinaline is under investigation in clinical trial NCT00005624 (CI-994 in Treating Patients With Advanced Myeloma).

Kategori:
Acids, CarbocyclicAmidesAmines +8
Waktu Paruh-
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Genetik -
Acetylene Approved DB15906
small molecule | CAS: 74-86-2

Deskripsi belum tersedia.

Kategori:
AlkynesHydrocarbons, Acyclic
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetyleneurea DB03533
small molecule | CAS: 496-46-8

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingImidazoles
Target Protein:
Streptavidin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetylleucine DB13226
small molecule | CAS: 99-15-0

Used for treating vestibular-related imbalance and vertigo.

Kategori:
Amino AcidsAmino Acids, Branched-ChainAmino Acids, Peptides, and Proteins +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acetylsalicylic acid Approved DB00945
small molecule | CAS: 50-78-2

Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and i…

Kategori:
Acids, CarbocyclicAgents causing angioedemaAgents causing hyperkalemia +38
Target Protein:
Prostaglandin G/H synthase 13-hydroxy-3-methylglutaryl-coenzyme A reductaseProstaglandin G/H synthase 2 +17
Gen Terkait:
CYP2C9 ITGB3 LTC4S
Waktu ParuhThe half-life of AS…
Vol. DistribusiThis drug is distri…
KlirensThe clearance rate …
Genetik 3 Varian
ACG-801 DB17659
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acheta domesticus Approved DB10866
biotech

House cricket allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 68957-71-1

Deskripsi belum tersedia.

Kategori:
ArylsulfonatesArylsulfonic AcidsBenzene Derivatives +3
Target Protein:
Bifunctional purine biosynthesis protein ATIC
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acifluorfen DB07338
small molecule | CAS: 50594-66-6

Acifluorfen is a protoporphyrinogen oxidase inhibitor.

Kategori:
Acids, CarbocyclicAgrochemicalsBenzene Derivatives +6
Target Protein:
Protoporphyrinogen oxidaseProtoporphyrinogen oxidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acimtamig DB18674
biotech | CAS: 2738880-26-5

Acimtamig is a tetravalent bispecific chimeric anti-human CD30 x anti-human CD16A recombinant antibody construct.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acitretin Approved DB00459
small molecule | CAS: 55079-83-9

An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.

Kategori:
AlkenesAntipsoriaticsAntipsoriatics for Systemic Use +17
Target Protein:
Retinoic acid receptor RXR-alphaSignal transducer and activator of transcription 3Retinoic acid receptor alpha +6
Waktu Paruh49 hours (range 33 …
Vol. Distribusi-
Klirens-
Genetik -
Aclarubicin DB11617
small molecule | CAS: 57576-44-0

Deskripsi belum tersedia.

Kategori:
AnthracyclinesAnthracyclines and Related SubstancesAntibiotics, Antineoplastic +9
Target Protein:
DNA topoisomerase 2-alphaDNA topoisomerase 2-beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aclerastide DB12631
small molecule | CAS: 227803-63-6

Aclerastide has been investigated for the treatment of Diabetic Foot, Diabetic Foot Ulcers, and Foot Ulcer, Diabetic.

Kategori:
Amino Acids, Peptides, and ProteinsAngiotensinsAutacoids +10
Target Protein:
Proto-oncogene Mas
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aclidinium Approved DB08897
small molecule | CAS: 727649-81-2

Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012.

Kategori:
Adrenergics, InhalantsAgents producing tachycardiaAgents to Treat Airway Disease +9
Target Protein:
Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M2Muscarinic acetylcholine receptor M3 +2
Waktu ParuhPlasma half-life = …
Vol. DistribusiFollowing IV admini…
KlirensTotal clearance, IV…
Genetik -
Aclimostat DB16079
small molecule | CAS: 2082752-83-6

Aclimostat is under investigation in clinical trial NCT03254368 (Study to Assess the Effects and Safety of ZGN-1061 in Overweight and Obese Participants With Type 2 Diabetes).

Kategori:
Anti-Obesity AgentsAzetinesEnzyme Inhibitors +1
Target Protein:
Methionine aminopeptidase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acolbifene DB16080
small molecule | CAS: 182167-02-8

Acolbifene is under investigation in clinical trial NCT01452373 (Dehydroepiandrosterone (DHEA) + Acolbifene Against Vasomotor Symptoms (Hot Flushes) in Postmenopausal Women).

Target Protein:
Estrogen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acoltremon DB19202
small molecule | CAS: 68489-09-8

Acoltremon is under investigation in clinical trial NCT05493111 (A Long-term Safety Study Evaluating the Safety and Systemic Exposure of AR-15512).

Kategori:
AlcoholsAmidesAmines +10
Target Protein:
Transient receptor potential cation channel subfamily M member 8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aconiazide DB17731
small molecule | CAS: 13410-86-1

Deskripsi belum tersedia.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsDrugs for Treatment of Tuberculosis +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acoramidis DB17999
small molecule | CAS: 1446711-81-4

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAmyloidosis, prevention & controlBenzene Derivatives
Target Protein:
Transthyretin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acotiamide DB12482
small molecule | CAS: 185106-16-5

Acotiamide has been used in trials studying the treatment of Dyspepsia and Functional Dyspepsia.

Kategori:
Acids, CarbocyclicAlimentary Tract and MetabolismAmides +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acoziborole DB13086
small molecule | CAS: 1266084-51-8

SCYX-7158 has been used in trials studying the treatment of Trypanosomiasis, Parasitic Diseases, Protozoan Infections, and Trypanosomiasis, African.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ACR-16 DB05371
small molecule

ACR-16 is under investigation by NeuroSearch. ACR16 has been successfully investigated in a Phase II multi-centre, randomised and placebo-controlled trial in patients with Huntington’s disease as well as in three Phase Ib studies within Huntington’s disease, …

Waktu Paruh-
Vol. Distribusi-
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Genetik -
ACR325 DB05196
small molecule

ACR325 is developed for the treatment of Parkinson’s disease and psychoses, including bipolar disorder, for which disease existing therapies have only limited effect and considerable adverse side effects. ACR325 is a dopaminergic stabiliser, which has demonst…

Waktu Paruh-
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Genetik -
small molecule | CAS: 89459-25-6

Acridine Carboxamide has been used in trials studying the treatment of Lung Cancer and Brain and Central Nervous System Tumors.

Kategori:
Antineoplastic AgentsEnzyme InhibitorsHeterocyclic Compounds, Fused-Ring +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acriflavine DB13373
small molecule | CAS: 65589-70-0

Deskripsi belum tersedia.

Kategori:
AcridinesAminoacridinesAnti-Infective Agents +10
Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Acrivastine Approved DB09488
small molecule | CAS: 87848-99-5

Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histami…

Kategori:
Antihistamines for Systemic UseDrugs that are Mainly Renally ExcretedHistamine Agents +7
Target Protein:
Histamine H1 receptor
Waktu ParuhThe mean terminal h…
Vol. Distribusi0.46 ± 0.05 L/kg
Klirens2.9 ± 0.7 mL/min/kg
Genetik -
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