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16004

Total database: 17430
Struktur (SMILES)
12010 (75.0%)
Target
9041 (56.5%)
Genomik
112 (0.7%)
Referensi
16004 (100.0%)

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Hasil Pencarian (16004)

Halaman 301 / 321
Trelagliptin DB15323
small molecule | CAS: 865759-25-7

Trelagliptin is under investigation in clinical trial NCT03555591 (Specified Drug-Use Survey of Trelagliptin Tablets "Survey on Long-term Use in Patients With Type 2 Diabetes Mellitus").

Kategori:
PyrimidinesPyrimidinones
Target Protein:
Dipeptidyl peptidase 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trelanserin DB18793
small molecule | CAS: 189003-92-7

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
5-hydroxytryptamine receptor 2A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tremelimumab Approved DB11771
biotech | CAS: 745013-59-6

Tremelimumab, formerly known as ticilimumab, is a fully human IgG2 monoclonal antibody directed against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). CTLA-4 is a cell surface receptor expressed on activated T cells to act as a negative regulator for T…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +11
Target Protein:
Cytotoxic T-lymphocyte protein 4
Waktu ParuhThe geometric mean …
Vol. DistribusiThe geometric mean …
KlirensThe geometric mean …
Genetik -
biotech

Tremella fuciformis whole is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trenbolone DB11551
small molecule | CAS: 10161-33-8

Trenbolone, also known as trienolone or trienbolone, is a steroid used on livestock to increase muscle growth and appetite. To increase its effective half-life, trenbolone is administered as a prodrug as an ester conjugate such as [trenbolone acetate], trenbo…

Kategori:
Anabolic AgentsEstranesEstrenes +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 10161-34-9

Deskripsi belum tersedia.

Kategori:
Anabolic AgentsEstranesEstrenes +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Neutrophil gelatinase-associated lipocalin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trenonacog alfa DB13201
biotech | CAS: 1232401-60-3

Human coagulation factor IX (EC 3.4.21.22, Christmas factor, plasma thromboplastin component), produced in CHO cells.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood Coagulation Factors +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Treosulfan Approved DB11678
small molecule | CAS: 299-75-2

Treosulfan is under investigation in Allogeneic Haematopoietic Stem Cell Transplantation. Treosulfan has been investigated for the treatment of Lymphoblastic Leukemia, Acute, Childhood.

Kategori:
AlcoholsAlkanesAlkanesulfonates +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trepibutone DB13311
small molecule | CAS: 41826-92-0

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismDrugs for Functional Gastrointestinal Disorders
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Treprostinil Approved DB00374
small molecule | CAS: 81846-19-7

Treprostinil is a stable tricyclic analogue of prostacyclin[A248770] that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmona…

Kategori:
Antihypertensive AgentsAutacoidsBiological Factors +19
Target Protein:
Prostacyclin receptorProstaglandin E2 receptor EP2 subtypeProstaglandin D2 receptor +2
Waktu ParuhThe terminal elimin…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of tr…
Genetik -
small molecule | CAS: 1706528-83-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trestolone DB05830
small molecule | CAS: 3764-87-2

Trestolone (7?-methyl-19-nortestosterone) is a synthetic androgen developed by the Population Council as a potential candidate drug for use in hormonal male contraceptive methods. In males, regular administration of sufficient quantities of trestolone induces…

Kategori:
Adrenal Cortex HormonesContraceptive Agents, HormonalContraceptive Agents, Male +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 6157-87-5

Trestolone acetate is a synthetic and injected anabolic–androgenic steroid (AAS) and a derivative of nandrolone (19-nortestosterone) which was never marketed. It is an androgen ester – specifically, the C17 acetate ester of [DB05830].

Kategori:
EstranesEstrenesFused-Ring Compounds +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tretamine DB14031
small molecule | CAS: 51-18-3

Toxic alkylating agent used in industry; also as antineoplastic and research tool to produce chromosome aberrations and cancers.

Kategori:
Alkylating DrugsAntineoplastic AgentsAntineoplastic Agents, Alkylating +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tretazicar DB04253
small molecule | CAS: 21919-05-1

Tretazicar is under investigation in clinical trial NCT00746590 (Study of Anti-tumour Effects and Safety of Prolarix™ in Hepatocellular Carcinoma).

Kategori:
Antineoplastic AgentsAzirinesProdrugs +1
Target Protein:
Ribosyldihydronicotinamide dehydrogenase [quinone]Oxygen-insensitive NAD(P)H nitroreductase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tretinoin Approved DB00755
small molecule | CAS: 302-79-4

Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol).[A257474] It is an oxidation product in the physiological pathway of vitamin A metabolism.[A257689] In human circulation, tretinoin is normal…

Kategori:
Agents that produce hypertensionAlkenesAnti-Acne Preparations +37
Target Protein:
Retinoic acid receptor alphaRetinoic acid receptor betaRetinoic acid receptor gamma +13
Waktu ParuhThe terminal elimin…
Vol. DistribusiTretinoin is rapidl…
KlirensNo information is a…
Genetik -
Tretoquinol DB13692
small molecule | CAS: 30418-38-3

Deskripsi belum tersedia.

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic beta-Agonists +16
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trevogrumab DB15159
biotech | CAS: 1429201-24-0

Trevogrumab is under investigation in clinical trial NCT02943239 (Study of Safety, Tolerability, and Pharmacokinetics of REGN2477 Alone and in Combination With REGN1033 in Healthy Postmenopausal Women and Healthy Adult Men).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Triacetin DB16005
small molecule | CAS: 102-76-1

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsAntifungal AgentsCompounds used in a research, industrial, or household setting +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 13319-32-9

Deskripsi belum tersedia.

Target Protein:
Lysozyme C
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Triamcinolone Approved DB00620
small molecule | CAS: 124-94-7

Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis.[L8255] Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain,[L826…

Kategori:
Adrenal Cortex HormonesAdrenalsAgents Causing Muscle Toxicity +44
Target Protein:
Glucocorticoid receptor
Waktu ParuhThe half life of tr…
Vol. DistribusiThe apparent volume…
KlirensThe clearance of tr…
Genetik -
Triamterene Approved DB00384
small molecule | CAS: 396-01-0

Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the neph…

Kategori:
Agents causing hyperkalemiaCardiovascular AgentsCytochrome P-450 CYP1A2 Substrates +15
Target Protein:
Amiloride-sensitive sodium channel subunit gammaAmiloride-sensitive sodium channel subunit alphaAmiloride-sensitive sodium channel subunit beta +1
Waktu ParuhThe half-life of th…
Vol. DistribusiIn a pharmacolineti…
KlirensThe total plasma cl…
Genetik -
Triapine DB11940
small molecule | CAS: 143621-35-6

Triapine has been used in trials studying the treatment of Leukemia, Lung Cancer, Kidney Cancer, Prostate Cancer, and Pancreatic Cancer, among others.

Kategori:
SemicarbazidesSemicarbazonesSulfur Compounds
Target Protein:
Ribonucleoside-diphosphate reductase subunit M2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Triazavirin DB15622
small molecule | CAS: 123606-06-4

Triazavirin is a guanine nucleotide analog antiviral originally developed in Russia that has shown efficacy against influenza A and B, including the H5N1 strain.[A191709,A191625,A191916] It appears that Triazavirin has shown promise in reducing influenza dise…

Kategori:
Antiviral AgentsExperimental Unapproved Treatments for COVID-19Guanine Nucleotides
Waktu ParuhIn rabbits, intraga…
Vol. DistribusiIn rabbits, intraga…
KlirensIn rabbits, intraga…
Genetik -
Triaziquone DB13304
small molecule | CAS: 68-76-8

Deskripsi belum tersedia.

Kategori:
Alkylating DrugsAntineoplastic AgentsAntineoplastic Agents, Alkylating +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Triazolam Approved DB00897
small molecule | CAS: 28911-01-5

Withdrawn in the United Kingdom due to risk of psychiatric adverse drug reactions. This drug continues to be available in the U.S. Internationally, triazolam is a Schedule IV drug under the Convention on Psychotropic Substances.

Kategori:
Adjuvants, AnesthesiaAgents Causing Muscle ToxicityAnti-Anxiety Agents +24
Target Protein:
Translocator proteinGABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu Paruh1.5-5.5 hours
Vol. Distribusi-
Klirens-
Genetik -
Tribenoside DB13227
small molecule | CAS: 10310-32-4

Anti-inflammatory agent used in edema of extremities, varicose veins & phlebitis.

Kategori:
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical UseAnalgesicsAnalgesics, Non-Narcotic +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 101200-48-0

Deskripsi belum tersedia.

Kategori:
Arylsulfonic AcidsSulfonic AcidsSulfur Acids +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 4619-74-3

Deskripsi belum tersedia.

Kategori:
Antifungals for Dermatological UseAntifungals for Topical UseDermatologicals
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Tribulus terrestris is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Tribulus terrestris fruit is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
AngiospermsBiological ProductsComplex Mixtures +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Tribulus terrestris root is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tributyltin DB08601
small molecule | CAS: 688-73-3

Deskripsi belum tersedia.

Kategori:
Organometallic CompoundsOrganotin Compounds
Target Protein:
Retinoic acid receptor RXR-alphaNuclear receptor coactivator 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tributyrin DB12709
small molecule | CAS: 60-01-5

Tributyrin has been used in trials studying the treatment of Prostate Cancer and Unspecified Adult Solid Tumor, Protocol Specific.

Kategori:
GlyceridesLipids
Target Protein:
Caspase-3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tricaine DB11552
small molecule | CAS: 582-33-2

Tricaine (as tricaine methanesulfonate) is white powder used for anesthesia, sedation, or euthanasia of fish. It is also the only anesthetic licensed in the United States for use in fin fish that are intended for human consumption.

Kategori:
Acids, CarbocyclicAnestheticsBenzene Derivatives +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tricaprylin DB12176
small molecule | CAS: 538-23-8

Tricaprilin has been used in trials studying the supportive care and treatment of Alzheimer's Disease.

Kategori:
Acids, AcyclicAlzheimer Disease, drug therapyCompounds used in a research, industrial, or household setting +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 99-14-9

Deskripsi belum tersedia.

Kategori:
Acids, Acyclic
Target Protein:
Aconitate hydratase, mitochondrial
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Azurin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tricetin DB08230
small molecule | CAS: 520-31-0

Deskripsi belum tersedia.

Kategori:
AntioxidantsBenzopyransBiological Factors +9
Target Protein:
Serine/threonine-protein kinase pim-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trichlormethiazide Approved DB01021
small molecule | CAS: 133-67-5

A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830)

Kategori:
Antihypertensive AgentsBenzothiadiazinesCardiovascular Agents +13
Target Protein:
Solute carrier family 12 member 3Solute carrier family 12 member 1Sodium/potassium-transporting ATPase subunit alpha-1 +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 75-87-6

Deskripsi belum tersedia.

Kategori:
AlcoholsEthylene GlycolsGlycols
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trichloroacetate Approved DB11152
small molecule | CAS: 76-03-9

Trichloroacetate, or trichloroacetic acid, is a strong acid prepared by the reaction of chlorine with acetic acid in the presence of a suitable catalyst. In clinical chemistry and biochemistry, it is used as a precipitant of macromolecules including proteins,…

Kategori:
AcetatesAcids, AcyclicCaustics +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trichloroethylene Approved DB13323
small molecule | CAS: 79-01-6

Trichloroethylene is a halocarbon commonly used as an industrial solvent, not to be confused with the similar 1,1,1-trichloroethane, also known as chlorothene. It has been sold under a variety of trade names including Trimar and Trilene and used as a volatile…

Kategori:
Agents that produce hypertensionAnestheticsAnesthetics, General +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trichostatin A DB04297
small molecule | CAS: 58880-19-6

Deskripsi belum tersedia.

Kategori:
AminesAnti-Infective AgentsAntifungal Agents +9
Target Protein:
Histone deacetylase 7Histone deacetylase 8Acetoin utilization protein +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Triciribine DB12405
small molecule | CAS: 35943-35-2

Triciribine has been used in trials studying the treatment of Leukemia, Ovarian Cancer, HER2/Neu Negative, Breast Adenocarcinoma, and Stage IV Breast Cancer, among others.

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleosides
Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 61966-08-3

Deskripsi belum tersedia.

Kategori:
NaphthalenesNucleic Acids, Nucleotides, and NucleosidesNucleotides
Target Protein:
RAC-gamma serine/threonine-protein kinase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Triclabendazole Approved DB12245
small molecule | CAS: 68786-66-3

Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helmi…

Kategori:
AnthelminticsAnti-Infective AgentsAntihelminthic +34
Target Protein:
CruzipainExcretory Secretory (ES) proteins
Waktu ParuhThe plasma eliminat…
Vol. DistribusiThe apparent volume…
Klirens-
Genetik -
Triclocarban Approved DB11155
small molecule | CAS: 101-20-2

Triclocarban, with the chemical formula C13H9Cl3N2O [L2675] is an antibacterial agent that is particularly effective against Gram-positive bacteria such as *Staphylococcus aureus*. It is a bacteriostatic compound that has been found in antibacterial soaps and…

Kategori:
AmidesAminesAnilides +10
Target Protein:
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Waktu Paruh10 hours [L2680]
Vol. Distribusi-
KlirensAfter a pharmacokin…
Genetik -
Triclofos Approved DB06753
small molecule | CAS: 306-52-5

Deskripsi belum tersedia.

Kategori:
Central Nervous System DepressantsHypnotics and SedativesNervous System +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 15001–15050 dari 16004
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