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6694

Total database: 17430
Struktur (SMILES)
4518 (67.5%)
Target
3751 (56.0%)
Genomik
81 (1.2%)
Referensi
6694 (100.0%)

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Hasil Pencarian (6694)

Halaman 28 / 134
Benzalkonium Approved DB11105
small molecule

Benzalkonium is a quaternary ammonium compound used as a biocide, a cationic surfactant, and as a phase transfer agent [FDA Label]. Benzalkonium is more commonly contained in consumer products in its salt form, benzalkonium chloride [FDA Label]. This salt is …

Kategori:
AminesAnti-Infective AgentsAnti-Infective Agents, Local +18
Waktu Paruh-
Vol. DistribusiWhen applied as a t…
Klirens-
Genetik -
Benzatropine Approved DB00245
small molecule | CAS: 86-13-5

Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ethe…

Kategori:
Agents producing tachycardiaAlkaloidsAnti-Dyskinesia Agents +23
Target Protein:
Muscarinic acetylcholine receptor M1Sodium-dependent dopamine transporterHistamine H1 receptor +2
Waktu ParuhThe elimination hal…
Vol. DistribusiBenztropine is expe…
KlirensExtensive pharmacod…
Genetik -
Benzbromarone DB12319
small molecule | CAS: 3562-84-3

Benzbromarone has been used in trials studying the basic science and treatment of Heart Failure, Hyperuricemia, Chronic Kidney Disease, Abnormal Renal Function, and Gout and Asymptomatic Hyperuricemia.

Kategori:
Antigout PreparationsAntirheumatic AgentsBenzofurans +12
Target Protein:
Anoctamin-1Solute carrier family 22 member 12Multidrug resistance-associated protein 1 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 517-60-2

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicBenzene Derivatives
Target Protein:
Phosphoglycerate mutase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 618-41-7

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicSulfur Acids +1
Target Protein:
Oxysterols receptor LXR-beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzethonium Approved DB11125
small molecule | CAS: 10172-60-8

Benzethonium is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties. Its salt form, benzethonium chloride, is primarily used as a skin disinfectant at concentrations of 0.1-0.2 %, which are safe and ef…

Kategori:
AminesAnti-Infective AgentsAnti-Infective Agents, Local +7
Waktu ParuhPharmacokinetic stu…
Vol. DistribusiPharmacokinetic stu…
KlirensPharmacokinetic stu…
Genetik -
Benzgalantamine Approved DB19353
small molecule | CAS: 224169-27-1

Benzgalantamine is a prodrug of [galantamine]. Gastrointestinal adverse effects are the most frequently reported side effects in patients undergoing treatment with cholinesterase inhibitors, including galantamine, and are often a reason for treatment disconti…

Kategori:
AlkaloidsAlzheimer Disease, drug therapyAmaryllidaceae Alkaloids +11
Target Protein:
AcetylcholinesteraseCholinesteraseNeuronal acetylcholine receptor subunit alpha-7 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 495-18-1

Deskripsi belum tersedia.

Kategori:
AminesBenzoatesHydroxy Acids +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzocaine Approved DB01086
small molecule | CAS: 94-09-7

Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.[A231219] It is commonly used for local anesthesia in many over the counter products.[L32454,L32459,L32464] Benzocaine was first u…

Kategori:
Acids, CarbocyclicAgents for Treatment of Hemorrhoids and Anal Fissures for Topical UseAminobenzoates +29
Target Protein:
Sodium channel protein type 10 subunit alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzododecinium DB13282
small molecule | CAS: 10328-35-5

Benzododecinium is used as an antiseptic/disinfectant compound. It has been marketed as a tincture for antiseptic product for wounds in the Czech Republic.

Kategori:
AminesAnti-Infective AgentsAnti-Infective Agents, Local +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzoic acid Approved DB03793
small molecule | CAS: 65-85-0

A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid. As the sodium salt form, sodium benzoate is used as a treatment for urea cycle disorders due to its ability to bind amin…

Kategori:
Acids, CarbocyclicAlimentary Tract and MetabolismAmmonium Ion Binding Activity +18
Target Protein:
Ras-related protein Rab-9ASolute carrier family 15 member 1Cocaine esterase +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzoin resin Approved DB11222
biotech | CAS: 9000-05-9

Benzoin resin is a balsamic resin obtained from the bark of several species of trees in the genus _Styrax_. There are two common kinds of benzoin, benzoin Siam and benzoin Sumatra, that are obtained from different species of the _Styrax_ tree. While benzoin r…

Kategori:
AngiospermsAnti-Infective Agents, LocalBiological Products +11
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Benzonatate Approved DB00868
small molecule | CAS: 104-31-4

Benzonatate is an oral antitussive drug used in the relief and suppression of cough in patients older than ten years of age.[A5790] Currently, benzonatate is the only non-narcotic antitussive available as a prescription drug.[A189519] It works to reduce the a…

Kategori:
AlkanesAminesAntitussive Agents +8
Target Protein:
Sodium channel protein type 5 subunit alpha
Waktu ParuhThe half life of be…
Vol. DistribusiThere is limited in…
KlirensThere is limited in…
Genetik -
Benzoyl peroxide Approved DB09096
small molecule | CAS: 94-36-0

Benzoyl peroxide is a commonly used drug in topical treatments for acne.[L33249,L33264,L33269,L33299,L33314] It has been formulated as products with either a single active ingredient,[L33249,L33299] or with [erythromycin],[L33264] [clindamycin],[L33269] or [a…

Kategori:
Acids, CarbocyclicAnti-Acne PreparationsAnti-Acne Preparations for Topical Use +5
Target Protein:
CatalaseGlutathione peroxidaseAntizyme inhibitor 2 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzoylecgonine DB01515
small molecule | CAS: 519-09-5

Benzoylecgonine is the major metabolite of cocaine. It is formed by hydrolysis of cocaine in the liver, catalysed by carboxylesterases. It is excreted in the urine of cocaine users after processing in the liver. It is the main pharmaceutical ingredient in the…

Kategori:
AlkaloidsAza CompoundsAzabicyclo Compounds +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 611-73-4

Deskripsi belum tersedia.

Kategori:
Acids, AldehydicAcids, CarbocyclicHydroxy Acids
Target Protein:
2-Hydroxyacid oxidase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzoylpas DB19382
small molecule | CAS: 13898-58-3

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Beta-lactamaseBeta-lactamase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzthiazide Approved DB00562
small molecule | CAS: 91-33-8

Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium…

Kategori:
DiureticsGenito Urinary System and Sex HormonesGynecological Antiinfectives and Antiseptics +8
Target Protein:
Solute carrier family 12 member 3Carbonic anhydraseCarbonic anhydrase 2 +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzydamine Approved DB09084
small molecule | CAS: 642-72-8

Benzydamine (also known as Tantum Verde or Difflam), available as the hydrochloride salt, is a locally-acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties. It is used topically for pain relief and anti-inflammato…

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAlimentary Tract and Metabolism +18
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2
Waktu ParuhApproximately 13 h …
Vol. DistribusiThe volume of distr…
KlirensBenzydamine demonst…
Genetik -
Benzyl benzoate Approved DB00676
small molecule | CAS: 120-51-4

Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl b…

Kategori:
AcaricidesAcids, CarbocyclicAgrochemicals +8
Target Protein:
Hormone-sensitive lipase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 94-44-0

Deskripsi belum tersedia.

Kategori:
Pyridines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzylparaben Approved DB14176
small molecule | CAS: 94-18-8

Benzylparaben is used in allergenic testing.

Kategori:
Acids, CarbocyclicBenzene DerivativesBenzoates +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzylpenicillin Approved DB01053
small molecule | CAS: 61-33-6

Benzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorption. Penicillin G may al…

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +18
Target Protein:
Peptidoglycan synthase FtsIPenicillin-binding protein 1APenicillin-binding protein 1B +5
Waktu ParuhIn adults with norm…
Vol. Distribusi0.53–0.67 L/kg in a…
Klirens560ml/min in health…
Genetik -
Benzylpenicilloyl polylysine Approved DB00895
small molecule | CAS: 31855-75-1

Benzylpenicilloyl polylysine is used as a skin-testing reagent to detect immunoglobulin E antibodies in people with a history of penicillin allergy. The quantitation of in vitro IgE antibodies to the benzylpenicilloyl determinant is a useful tool for evaluati…

Kategori:
AcetamidesAmidesAnti-Bacterial Agents +9
Target Protein:
High affinity immunoglobulin epsilon receptor subunit gammaHigh affinity immunoglobulin epsilon receptor subunit alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 100-87-8

Deskripsi belum tersedia.

Kategori:
AlkanesAlkanesulfonatesAlkanesulfonic Acids +4
Target Protein:
ChymaseSubtilisin BPN'Sigma factor SigB regulation protein RsbQ +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 6336-50-1

Deskripsi belum tersedia.

Kategori:
Antithyroid agentsPyrimidinesPyrimidinones +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bepridil Approved DB01244
small molecule | CAS: 64706-54-3

A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a cal…

Kategori:
Agents causing hyperkalemiaAntiarrhythmic agentsAntihypertensive Agents +20
Target Protein:
Voltage-dependent P/Q-type calcium channel subunit alpha-1AVoltage-dependent T-type calcium channel subunit alpha-1HVoltage-dependent calcium channel subunit alpha-2/delta-2 +7
Waktu Paruh24-50 hours
Vol. Distribusi-
Klirens-
Genetik -
Beractant Approved DB06761
biotech | CAS: 108778-82-1

Beractant is a pulmonary surfactant used for the treatment of Respiratory Distress Syndrome (RDS) in premature infants. Considered a natural source of surfactant as it is made from bovine lung extract, beractant contains a mixture of phospholipids, neutral li…

Kategori:
Alveolar Surface Tension ReductionBradycardia-Causing AgentsComplex Mixtures +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1868138-66-2

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Berdazimer Approved DB18712
small molecule

Berdazimer is a polymeric substance consisting of a polysiloxane backbone (Si-O-Si bonds) with covalently bound N-diazeniumdiolate nitric oxide (NO) donors. It releases NO through exposure to proton donors like water, which will degrade the N-diazeniumdiolate…

Kategori:
Macromolecular SubstancesOrganosilicon CompoundsPolymers +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Beremagene geperpavec Approved DB17831
biotech | CAS: 2241888-62-8

Beremagene geperpavec is a live, replication-defective herpes simplex virus type 1 (HSV-1)-based vector therapy. Developed by Krystal Biotech, it was first approved by the FDA on May 19, 2023, for the treatment of wounds associated with dystrophic epidermolys…

Kategori:
Administration, TopicalCellular and Gene TherapyCicatrizants +2
Waktu ParuhThere is no informa…
Vol. DistribusiThere is no informa…
KlirensThere is no informa…
Genetik -
Bergamot oil DB14335
biotech | CAS: 8007-75-8

Bergamot oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
Biological ProductsComplex MixturesCompounds used in a research, industrial, or household setting +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Berotralstat Approved DB15982
small molecule | CAS: 1809010-50-1

Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE).[L26661] It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that pro…

Kategori:
BCRP/ABCG2 SubstratesBlood and Blood Forming OrgansCytochrome P-450 CYP2D6 Inhibitors +16
Target Protein:
Plasma kallikrein
Waktu ParuhFollowing a single …
Vol. DistribusiThe blood to plasma…
KlirensThere is no informa…
Genetik -
Bersiporocin DB18017
small molecule | CAS: 2241808-52-4

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Berubicin DB17149
small molecule | CAS: 677017-23-1

Deskripsi belum tersedia.

Kategori:
Aminoglycoside AntibacterialsAnti-Bacterial AgentsCarbohydrates +2
Target Protein:
DNA topoisomerase 2-alphaDNA topoisomerase 2-beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Besifloxacin Approved DB06771
small molecule | CAS: 141388-76-3

Besifloxacin is a fourth generation fluoroquinolone-type opthalmic antibiotic for the treatment of bacterial conjunctivitis. FDA approved on May 28, 2009.

Kategori:
4-QuinolonesAnti-Bacterial AgentsAnti-Infective Agents +16
Target Protein:
DNA topoisomerase 4 subunit ADNA gyrase subunit BDNA gyrase subunit A +3
Waktu ParuhThe average elimina…
Vol. DistribusiNot absorbed into t…
KlirensN/A
Genetik -
Beta carotene Approved DB06755
small molecule | CAS: 7235-40-7

Beta-carotene, with the molecular formula C40H56, belongs to the group of carotenoids consisting of isoprene units. The presence of long chains of conjugated double bonds donates beta-carotene with specific colors.[T162] It is the most abundant form of carote…

Kategori:
Alimentary Tract and MetabolismAlkenesBiological Factors +20
Target Protein:
Free radicals
Waktu ParuhThe apparent half-l…
Vol. DistribusiNo pharmacokinetic …
KlirensThe clearance rate …
Genetik -
beta-Alanine DB03107
small molecule | CAS: 107-95-9

beta-Alanine is an amino acid formed in vivo by the degradation of [dihydrouracil] and [carnosine]. Since neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may be a false transmitter replacing GAMMA-AMINOBU…

Kategori:
AlanineAmino AcidsAmino Acids, Peptides, and Proteins
Target Protein:
Sodium- and chloride-dependent GABA transporter 3Pantothenate synthetase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 18968-14-4

Deskripsi belum tersedia.

Target Protein:
AlgQ1AlgQ2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 15209-12-8

Deskripsi belum tersedia.

Target Protein:
Glucose-6-phosphate 1-dehydrogenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 23018-83-9

Deskripsi belum tersedia.

Kategori:
CarbohydratesHexosesMonosaccharides
Target Protein:
Hyaluronate lyaseChondroitinase-ACXylan alpha-1,2-glucuronidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
beta-Escin DB15774
small molecule | CAS: 26339-90-2

Deskripsi belum tersedia.

Kategori:
CarbohydratesCardiovascular AgentsGlycosides +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, AcidicAmino Acids, Dicarboxylic +2
Target Protein:
Beta-lactamase TEM
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 300-85-6

Beta-hydroxybutyrate is being studied in around 230 clinical trials, including NCT06351124 (recruiting for Crohn's disease), NCT05584371 (recruiting for safety and tolerability of exogenous ketosis), NCT04656236 (completed for type 1 diabetes), and NCT0558104…

Kategori:
Acids, AcyclicButyratesExperimental Unapproved Treatments for COVID-19 +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 625-08-1

beta-Hydroxyisovaleric acid is under investigation in clinical trial NCT03018496 (Investigating the Effects of Beta-Hydroxy-Beta-Methylbutyrate on Glucose Handling in Older and Younger Men.).

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, Branched-ChainAmino Acids, Peptides, and Proteins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
beta-Sitosterol DB14038
small molecule | CAS: 83-46-5

Active fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity.

Kategori:
Biological FactorsCholestanesCholestenes +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Betahistine Approved DB06698
small molecule | CAS: 5638-76-6

Ménière's disease is a progressive disease of the inner ear characterized by vertigo, tinnitus, and hearing loss. It has a significant impact on both the physical and social functioning of affected individuals.[A220318,L16408] Betahistine is a histamine-l…

Kategori:
Antivertigo PreparationsHistamine AgentsHistamine Agonists +7
Target Protein:
Histamine H1 receptorHistamine H3 receptor
Waktu ParuhThe half-life of be…
Vol. DistribusiIn a pharmacokineti…
Klirens-
Genetik -
Betaine Approved DB06756
small molecule | CAS: 107-43-7

Betaine is a methyl group donor that functions in the normal metabolic cycle of methionine. It is a naturally occurring choline derivative commonly ingested through diet, with a role in regulating cellular hydration and maintaining cell function.[A252235,A252…

Kategori:
Acid PreparationsAlimentary Tract and MetabolismAmines +12
Target Protein:
Betaine--homocysteine S-methyltransferase 1
Waktu ParuhIn healthy voluntee…
Vol. DistribusiBased on a study do…
KlirensBased on a study do…
Genetik -
Menampilkan 1351–1400 dari 6694
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