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3253

Total database: 17430
Struktur (SMILES)
2451 (75.3%)
Target
1833 (56.3%)
Genomik
35 (1.1%)
Referensi
3253 (100.0%)

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Hasil Pencarian (3253)

Halaman 28 / 66
Glucosamine Approved DB01296
small molecule | CAS: 3416-24-8

Osteoarthritis (OA) is a progressive and degenerative joint disease marked by loss of cartilage, bone changes, and synovial membrane inflammation.[A232289] Treatment with chondroprotective drugs, such as glucosamine sulfate may offer additional benefits to no…

Kategori:
Amino SugarsAntiinflammatory and Antirheumatic ProductsAntiinflammatory and Antirheumatic Products, Non-Steroids +3
Target Protein:
Interleukin-1 betaInterferon gammaTranscription factor p65
Waktu ParuhThe estimated half-…
Vol. DistribusiResults of a pharma…
Klirens-
Genetik -
Glucose oxidase DB12862
biotech | CAS: 9001-37-0

Glucose oxidase has been investigated for the treatment of Upper Respiratory Tract Infections.

Kategori:
Alcohol OxidoreductasesEnzymesEnzymes and Coenzymes +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 80143-57-3

Glutamine 2-n-15 is under investigation in clinical trial NCT01912235 (Arginine Synthesis in Healthy Adult Humans).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Glyburide Approved DB01016
small molecule | CAS: 10238-21-8

Glyburide is a second generation sulfonylurea used to treat patients with diabetes mellitus type II.[L8123] It is typically given to patients who cannot be managed with the standard first line therapy, [metformin].[L8123] Glyburide stimulates insulin secretio…

Kategori:
Alimentary Tract and MetabolismAmidesBCRP/ABCG2 Substrates +28
Target Protein:
ATP-binding cassette sub-family C member 8Sulfonylurea receptor 1, Kir6.2ATP-binding cassette sub-family C member 9 +6
Waktu ParuhElderly patients ha…
Vol. DistribusiElderly patients ha…
KlirensElderly patients ha…
Genetik -
biotech

Deskripsi belum tersedia.

Kategori:
Aldehyde OxidoreductasesEnzymesEnzymes and Coenzymes +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 31566-31-1

Glycerol monostearate, commonly known as GMS, is the glycerol ester of stearic acid . It is commonly used as an emulsifier in foods.

Kategori:
Lipids
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 2752-99-0

Glyceryl Trierucate has been investigated for the treatment of Adrenoleukodystrophy.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 122-32-7

Glyceryl Trioleate has been investigated for the treatment of Adrenoleukodystrophy.

Kategori:
FatsFats, UnsaturatedGlycerides +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 640-79-9

A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic. [PubChem]

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsBile Acids and Salts +12
Target Protein:
7-alpha-hydroxysteroid dehydrogenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Glycopyrronium Approved DB00986
small molecule | CAS: 740028-90-4

Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers.[L33110] They are both quaternary ammonium compounds and long acting muscarinic antagonists.[L33110] It is one of the most commonly prescribed anticholinergic medi…

Kategori:
Adjuvants, AnesthesiaAdrenergics, InhalantsAgents producing tachycardia +30
Target Protein:
Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor M2 +2
Waktu ParuhThe half life after…
Vol. DistribusiThe mean volume of …
KlirensA 6 µg/kg intraveno…
Genetik -
Glycovir DB13106
small molecule | CAS: 131262-82-3

Glycovir has been used in trials studying the treatment of HIV Infections.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +1
Target Protein:
Maltase-glucoamylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Glycyrrhiza glabra Approved DB14312
biotech | CAS: 84775-66-6

Glycyrrhiza glabra is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
AngiospermsBiological ProductsCell-mediated Immunity +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Glyoxylic acid DB04343
small molecule | CAS: 298-12-4

Deskripsi belum tersedia.

Kategori:
Acids, Aldehydic
Target Protein:
Malate synthase GIsocitrate lyaseMalate synthase G +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Go-6976 DB17029
small molecule | CAS: 136194-77-9

An inhibitor of calcium-dependent isoforms of protein kinase C.[A253002,A253007]

Kategori:
Enzyme InhibitorsHeterocyclic Compounds, Fused-RingIndoles +1
Target Protein:
Transcription factor RelBNuclear factor NF-kappa-B p105 subunitNuclear factor NF-kappa-B p100 subunit +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Golodirsen Approved DB15593
biotech | CAS: 1422959-91-8

Golodirsen is a morpholino antisense oligomer designed to treat about 8% of patients with Duchenne Muscular Dystrophy (DMD). This is an X-linked condition leading to progressive muscle degeneration that begins in early childhood, rendering many patients wheel…

Kategori:
Antisense Elements (Genetics)Antisense OligonucleotidesCompounds used in a research, industrial, or household setting +10
Target Protein:
Dystrophin
Waktu ParuhIn a pharmacokineti…
Vol. DistribusiThe volume of distr…
KlirensThis drug is rapidl…
Genetik -
Gontivimab DB16179
biotech | CAS: 1257358-38-5

Gontivimab is under investigation in clinical trial NCT03468829 (Efficacy and Safety of ALX-0171 in Adult Hematopoietic Stem Cell Transplant (HSCT) Recipients Who Present With Respiratory Syncytial Virus (RSV) Infection).

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAntiviral Agents +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Granaticin B DB17273
small molecule | CAS: 19879-03-9

Deskripsi belum tersedia.

Kategori:
BenzopyransBenzoquinonesChromans +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Granotapide DB12934
small molecule | CAS: 594842-13-4

Granotapide has been used in trials studying the treatment of Type II Diabetes Mellitus.

Kategori:
Acids, AcyclicAcids, CarbocyclicAmides +3
Target Protein:
Microsomal triglyceride transfer protein large subunit
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Grapiprant DB12836
small molecule | CAS: 415903-37-6

Grapiprant, also known as AT-001 and CJ-023, is a drug from the piprant class. These molecules were derived from acylsulfonamide and are characterized to be a novel series of para-N-acylaminomethylbenzoic acid known to be prostaglandin receptor antagonists.[A…

Kategori:
AmidesBenzene DerivativesP-glycoprotein substrates +3
Target Protein:
Prostaglandin E2 receptor EP4 subtype
Waktu ParuhThe reported elimin…
Vol. DistribusiThe reported volume…
KlirensThe reported cleara…
Genetik -
Grazoprevir Approved DB11575
small molecule | CAS: 1350514-68-9

Grazoprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nin…

Kategori:
Acids, AcyclicAmidesAnti-Infective Agents +24
Target Protein:
Genome polyprotein
Waktu ParuhThe geometric mean …
Vol. DistribusiGrazoprevir has an …
KlirensThe clearance of Gr…
Genetik -
Griseofulvin Approved DB00400
small molecule | CAS: 126-07-8

An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections.

Kategori:
Anti-Infective AgentsAntifungal AgentsAntifungals for Dermatological Use +14
Target Protein:
Tubulin beta chainKeratin, type I cytoskeletal 12
Waktu Paruh9-21 hours
Vol. Distribusi-
Klirens-
Genetik -
GS-441524 DB15686
small molecule | CAS: 1191237-69-0

GS-441524 is an adenosine nucleotide analog antiviral, similar to [remdesivir].[A203057,L13239] This molecule was patented in 2009.[L13775] _In vitro_ studies of GS-441524 have determined it has a higher EC<sub>50</sub> than remdesivir against a number of vir…

Kategori:
Adenine NucleotidesAnti-Infective AgentsAntiviral Agents +10
Target Protein:
Replicase polyprotein 1abRNA-directed RNA polymerase L
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GS-5745 DB12296
biotech | CAS: 1518996-49-0

GS-5745 has been used in trials studying the treatment of Tumors, Breast Cancer, Crohn's Disease, Colorectal Cancer, and Pancreatic Cancer, among others.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GS-9256 DB12876
small molecule | CAS: 1001094-46-7

GS-9256 has been used in trials studying the treatment of HCV Infection and Chronic Hepatitis C Infection.

Kategori:
AcidsAcids, NoncarboxylicAmino Acids, Peptides, and Proteins +4
Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSBR-1290 DB18551
small molecule

GSBR-1290 is a small molecule agonist of the GLP-1 receptor.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSI-136 DB12819
small molecule | CAS: 443989-01-3

GSI-136 has been used in trials studying the treatment of Alzheimer Disease.

Target Protein:
Gamma-secretase subunit APH-1BNicastrinGamma-secretase subunit APH-1A +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-1004723 DB12806
small molecule | CAS: 955359-72-5

Gsk1004723 has been investigated for the treatment of Allergic Rhinitis and Rhinitis, Allergic, Seasonal.

Kategori:
Histamine AntagonistsHistamine H1 AntagonistsPyridazines
Target Protein:
Histamine H3 receptorHistamine H1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-1292263 DB12627
small molecule | CAS: 1032823-75-8

GSK1292263 has been investigated for the treatment of DIABETES MELLITUS, TYPE 2.

Target Protein:
Glucose-dependent insulinotropic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-1521498 DB12886
small molecule | CAS: 1007573-18-3

GSK1521498 has been used in trials studying the treatment of Obesity and Alcoholism.

Kategori:
IndenesReceptors, Opioid, mu
Target Protein:
Mu-type opioid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-239512 DB15120
small molecule | CAS: 720691-69-0

GSK-239512 is under investigation in clinical trial NCT00474513 (An Imaging Study to Investigate the Distribution of GSK239512 in the Brain.).

Kategori:
Heterocyclic Compounds, Fused-RingHistamine Antagonists
Target Protein:
Histamine H3 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-256066 DB12137
small molecule | CAS: 801312-28-7

Gsk256066 has been used in trials studying the treatment and diagnostic of SAR, Asthma, Mild Asthma, Allergic Rhinitis, and Seasonal Allergic Rhinitis, among others.

Kategori:
Enzyme InhibitorsHeterocyclic Compounds, Fused-RingPhosphodiesterase 4 Inhibitors +3
Target Protein:
3',5'-cyclic-AMP phosphodiesterase 4A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-269962A DB17030
small molecule | CAS: 850664-21-0

GSK-269962A is a Rho kinase (ROCK) inhibitor with both ROCK1 and ROCK2 affinity.[A253012]

Kategori:
Oxazoles
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-2981278 DB16319
small molecule | CAS: 1474110-21-8

GSK-2981278 is under investigation in clinical trial NCT03004846 (A Study of GSK2981278 Ointment in Subjects With Plaque Psoriasis).

Kategori:
AmidesBenzene DerivativesSulfonamides +2
Target Protein:
Nuclear receptor ROR-gamma
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-356278 DB12542
small molecule | CAS: 720704-34-7

Gsk356278 has been used in trials studying the treatment and basic science of Anxiety Disorders, Huntington Disease, Depressive Disorder, Huntingtons Disease, and Depressive Disorder, Major, among others.

Kategori:
OxazolesSulfur Compounds
Target Protein:
3',5'-cyclic-AMP phosphodiesterase 4A3',5'-cyclic-AMP phosphodiesterase 4D3',5'-cyclic-AMP phosphodiesterase 4B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-376501 DB12654
small molecule | CAS: 1010412-80-2

GSK376501 has been used in trials studying the treatment and diagnostic of Type 2 Diabetes Mellitus.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-424887 DB12219
small molecule

Gsk424887 has been used in trials studying the basic science and treatment of Depressive Disorder and Anxiety Disorder.

Kategori:
AcetatesAcids, AcyclicAmides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK-690693 DB12745
small molecule | CAS: 937174-76-0

GSK690693 has been used in trials studying the treatment of Tumor, CANCER, and Lymphoma.

Kategori:
Oxazoles
Target Protein:
RAC-gamma serine/threonine-protein kinase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK2245035 DB16076
small molecule | CAS: 1207629-49-9

GSK2245035 is under investigation in clinical trial NCT02833974 (Effect of the GSK2245035 on the Allergen-induced Asthmatic Response).

Kategori:
Heterocyclic Compounds, Fused-RingPurines
Target Protein:
Toll-like receptor 7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GSK2256098 DB16106
small molecule | CAS: 1224887-10-8

GSK2256098 is under investigation in clinical trial NCT02523014 (Vismodegib and FAK Inhibitor GSK2256098 in Treating Patients With Progressive Meningiomas).

Kategori:
AminesHydroxy AcidsHydroxylamines +1
Target Protein:
Focal adhesion kinase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Guanfacine Approved DB01018
small molecule | CAS: 29110-47-2

Guanfacine, or BS 100-141,[A189838,A189841] is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension[L11274] but is now indicated as an extended release tablet for the treatment of ADHD.[L11277] Guanfacine was …

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-2 Receptor Agonists +26
Target Protein:
Alpha-2A adrenergic receptorAlpha-2B adrenergic receptor
Waktu ParuhGuanfacine has a ha…
Vol. DistribusiGuanfacine has a vo…
KlirensGuanfacine has a to…
Genetik -
Guanidine Approved DB00536
small molecule | CAS: 113-00-8

A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th…

Kategori:
Acetylcholine Releasing AgentAmidinesGuanidines +7
Target Protein:
Aldehyde dehydrogenase, mitochondrialRibonuclease pancreaticDNA +4
Waktu Paruh7-8 hours
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
ADP-ribosylation factor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gusperimus DB12692
small molecule | CAS: 98629-43-7

Gusperimus has been used in trials studying the treatment of Lupus Nephritis, Wegeners Granulomatosis, and Wegener's Granulomatosis.

Kategori:
AmidinesAntibiotics, AntineoplasticAntineoplastic Agents +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GW-274150 DB12237
small molecule | CAS: 210354-22-6

GW274150 has been used in trials studying the treatment and prevention of Asthma, Migraine, Migraine Disorders, and Arthritis, Rheumatoid.

Kategori:
AnionsElectrolytesHydrogen Sulfide +3
Target Protein:
Nitric oxide synthase, inducible
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GW-406381 DB12009
small molecule | CAS: 221148-46-5

GW-406381 has been used in trials studying the treatment of Pain, Trauma, Neurodynia, Dental Pain, and Hyperalgesia, among others.

Target Protein:
Prostaglandin G/H synthase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GW-493838 DB12760
small molecule | CAS: 253124-46-8

GW493838 has been used in trials studying the treatment of Neuropathic Pain.

Target Protein:
Adenosine receptor A1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GW-813893 DB07278
small molecule | CAS: 478644-12-1

Deskripsi belum tersedia.

Kategori:
AmidesAnticoagulantsAntithrombins +8
Target Protein:
Coagulation factor XProthrombin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GW-870086 DB12322
small molecule | CAS: 827319-43-7

GW870086X has been investigated for the treatment of ASTHMA.

Kategori:
Fused-Ring Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
H-89 DB07995
small molecule | CAS: 127243-85-0

Deskripsi belum tersedia.

Kategori:
AmidesEnzyme InhibitorsHeterocyclic Compounds, Fused-Ring +3
Target Protein:
cAMP-dependent protein kinase catalytic subunit alphacAMP-dependent protein kinase inhibitor alphaSerine/threonine-protein kinase haspin +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
H3B-8800 DB14017
small molecule | CAS: 1825302-42-8

H3B-8800 is a novel spliceosome inhibitor developed by H3 Biomedicine [L2551]. It offers the benefit of preferentially killing spliceosome-mutant cancer cells whereas other splicesome inhibitors, such as the pladienolide analogue E7107, show no such preferent…

Target Protein:
Splicing factor 3B subunit 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 1351–1400 dari 3253
Sebelumnya Halaman 28 / 66 Berikutnya