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17430

Total database: 17430
Struktur (SMILES)
12313 (70.6%)
Target
9368 (53.7%)
Genomik
112 (0.6%)
Referensi
17430 (100.0%)

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Hasil Pencarian (17430)

Halaman 272 / 349
Polyethylene glycol 400 Approved DB11077
small molecule | CAS: 25322-68-3

Polyethylene glycols (PEGs) are products made of condensed ethylene oxide and water that can contain various derivatives and have various functions. Because many PEG types are hydrophilic, they are favorably used as enhancers of penetration, and used heavily …

Kategori:
AlcoholsArtificial TearsCompounds used in a research, industrial, or household setting +8
Target Protein:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1Oxidoreductase HTATIP2
Waktu ParuhGreat than 24h [L17…
Vol. Distribusi-
KlirensIn mice, lease than…
Genetik -
Polygala senega root Approved DB14749
biotech

Deskripsi belum tersedia.

Kategori:
AngiospermsBiological ProductsComplex Mixtures +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Polygeline DB15879
biotech | CAS: 66455-30-9

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsBlood SubstitutesHematologic Agents +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 31961-54-3

Deskripsi belum tersedia.

Kategori:
AmidinesFlocculation
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Polymyxin B Approved DB00781
biotech | CAS: 1404-26-8

Polymyxin B was discovered in the 1940s[A176429]. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes[A176426]. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and …

Kategori:
Alimentary Tract and MetabolismAmino Acids, Peptides, and ProteinsAnti-Bacterial Agents +19
Target Protein:
Bacterial outer membraneDihydropteroate synthase
Waktu ParuhIn one study the ha…
Vol. Distribusi1 compartment model…
Klirens1 compartment model…
Genetik -
small molecule | CAS: 81859-24-7

Polyquaternium-10 is a quaternized hydroxyethyl cellulose and a polycationic polymer. It is commonly found in cosmetics and personal care products to mainly reduce static electricity and form films.

Waktu Paruh-
Vol. Distribusi-
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Polysilicone-15 Approved DB11271
small molecule | CAS: 207574-74-1

Polysilicone-15 is a silicone based UVB absorber [L2796, L2797, L2799, F87, F88, F89]. The compound is a colorless to pale yellow viscous liquid which is soluble in organic solvents of medium polarity and insoluble in water [L2796, L2797, L2799, F87, F88, F89…

Kategori:
Sunscreen Agents
Waktu ParuhPolysilicone-15 is …
Vol. DistribusiPolysilicone-15 is …
KlirensPolysilicone-15 is …
Genetik -
Polysorbate 20 Approved DB11178
small molecule | CAS: 9005-64-5

Polysorbate 20 is a polysorbate-type nonionic surfactant used in many commercial, household and pharmaceutical products. It is composed of 20 repeated units of polyethylene glycol via ethoxylation. Polysorbate 20 is a wetting agent in food products, as well a…

Kategori:
AlcoholsCompounds used in a research, industrial, or household settingEthylene Glycols +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Polysorbate 60 DB14153
small molecule | CAS: 9005-67-8

Deskripsi belum tersedia.

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Polysorbate 80 Approved DB11063
small molecule | CAS: 9005-65-6

Polysorbate, a substance formulated by the reaction of sorbitan fatty acid ester (a nonionic surfactant) with ethylene oxide, is used in many foreign countries, including the U.S. and the EU, where it acts as an emulsifier, a solubilizer in many foods, includ…

Kategori:
AlcoholsArtificial TearsCompounds used in a research, industrial, or household setting +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
CarbohydratesPolysaccharides
Waktu Paruh-
Vol. Distribusi-
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Polythiazide Approved DB01324
small molecule | CAS: 346-18-9

A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826)

Kategori:
AmidesAntihypertensive AgentsAntihypertensive Agents Indicated for Hypertension +18
Target Protein:
Solute carrier family 12 member 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Polyvalent antigen-KLH conjugate vaccine is a multivalent cancer vaccine comprised of the five tumor-associated antigens (TAAs) globo H, GM2 ganglioside, Tn-MUC1, TF, and sTn conjugated with the immunoadjuvant keyhole limpet hemocyanin (KLH). It is under inve…

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Polyvinyl alcohol Approved DB11060
small molecule | CAS: 9002-89-5

Polyvinyl alcohol is a water-soluble synthetic polymer obtained by polymerization of vinyl alcohol. It has varying roles in commercial and industrial applications such as papermaking, textiles, and printing. Polyvinyl alcohol is found in ophthalmic solutions …

Kategori:
AlcoholsAlkenesArtificial Tears +8
Waktu ParuhWhen injected intra…
Vol. DistribusiThis drug does not …
Klirens-
Genetik -
Pomalidomide Approved DB08910
small molecule | CAS: 19171-19-8

Pomalidomide, an analogue of thalidomide, is an immunomodulatory antineoplastic agent. FDA approved on February 8, 2013.

Kategori:
Acids, CarbocyclicAngiogenesis InhibitorsAngiogenesis Modulating Agents +29
Target Protein:
Protein cereblonTumor necrosis factorProstaglandin G/H synthase 2
Waktu ParuhHealthy subjects = …
Vol. DistribusiMean apparent volum…
KlirensTotal body clearanc…
Genetik -
Pomegranate DB14317
biotech

Pomegranate is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pomotrelvir DB18975
small molecule | CAS: 2713437-86-4

Pomotrelvir is under investigation in clinical trial NCT05543707 (PBI-0451 (Pomotrelvir) Phase 2 Study in Nonhospitalized Symptomatic Adults With COVID-19).

Waktu Paruh-
Vol. Distribusi-
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Ponatinib Approved DB08901
small molecule | CAS: 943319-70-8

Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012.

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBcr-Abl Tyrosine Kinase Inhibitors +23
Target Protein:
Tyrosine-protein kinase ABL1Breakpoint cluster region proteinMast/stem cell growth factor receptor Kit +12
Waktu ParuhAfter oral administ…
Vol. DistribusiAfter oral administ…
Klirens-
Genetik -
Ponazuril DB11452
small molecule | CAS: 69004-04-2

Ponazuril, sold by the Bayer Corporation under the trade name Marquis, is a drug currently approved for the treatment of equine protozoal myeloencephalitis in horses, caused by Sarcocystis neurona.

Waktu Paruh-
Vol. Distribusi-
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Ponesimod Approved DB12016
small molecule | CAS: 854107-55-4

Ponesimod is a selective sphingosine 1-phosphate receptor 1 modulator indicated in the treatment of relapsing forms of multiple sclerosis in adults.[A232079,L32709] Ponesimod was developed out of a need for a more selective modulator of sphingosine 1-phosphat…

Kategori:
Antineoplastic and Immunomodulating AgentsCytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 Substrates +13
Target Protein:
Sphingosine 1-phosphate receptor 1
Waktu ParuhPonesimod has an el…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of po…
Genetik -
Ponezumab DB15135
biotech | CAS: 1178862-65-1

Ponezumab is under investigation in clinical trial NCT00607308 (A Phase I, Single Dose Study Of PF-04360365 In Japanese Patients With Mild To Moderate Alzheimer's Disease).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ponsegromab DB18943
biotech | CAS: 2368950-15-4

Ponsegromab is under investigation in clinical trial NCT05492500 (A Study of Ponsegromab in People With Heart Failure).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Poppy seed Approved DB10681
biotech

Poppy seed allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Populus alba pollen Approved DB10383
biotech

Populus alba pollen is the pollen of the Populus alba plant. Populus alba pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Populus balsamifera subsp. trichocarpa pollen is the pollen of the Populus balsamifera subsp. trichocarpa plant. Populus balsamifera subsp. trichocarpa pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Populus deltoides pollen Approved DB10463
biotech

Populus deltoides pollen is the pollen of the Populus deltoides plant. Populus deltoides pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Populus deltoides subsp. monilifera pollen is the pollen of the Populus deltoides subsp. monilifera plant. Populus deltoides subsp. monilifera pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Populus fremontii pollen Approved DB10464
biotech

Populus fremontii pollen is the pollen of the Populus fremontii plant. Populus fremontii pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Populus nigra pollen Approved DB10750
biotech

Populus nigra pollen is the pollen of the Populus nigra plant. Populus nigra pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Populus tremuloides pollen Approved DB10456
biotech

Populus tremuloides pollen is the pollen of the Populus tremuloides plant. Populus tremuloides pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Poractant alfa Approved DB09113
biotech | CAS: 129069-19-8

Poractant alfa is a pulmonary surfactant marketed as Curosurf in the United States and Canada. It is used to treat Respiratory Distress Syndrome (RDS) in premature infants with an endogenous pulmonary surfactant deficiency. Poractant alfa is an extract of nat…

Kategori:
Alveolar Surface Tension ReductionBradycardia-Causing AgentsComplex Mixtures +6
Waktu ParuhThe half-life of po…
Vol. DistribusiNo studies on the d…
KlirensNo studies on clear…
Genetik -
Porfimer sodium Approved DB00707
small molecule | CAS: 87806-31-3

The purified component of hematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (hematoporphyrin photoradiation); to treat malignant lesions with visible light and experimentally as an antiviral agen…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBiological Factors +13
Target Protein:
Low-density lipoprotein receptorHigh affinity immunoglobulin gamma Fc receptor I
Waktu Paruh10-452 hours
Vol. Distribusi* 0.49 ± 0.28 L/kg …
Klirens* Renal cl=199.7 +/…
Genetik -
Porfiromycin DB06478
small molecule | CAS: 801-52-5

Porfiromycin is a substance that is being studied in the treatment of cancer. It belongs to the family of drugs called anticancer antibiotics.

Kategori:
Antibiotics, AntineoplasticAntineoplastic AgentsAzirines +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Porgaviximab DB17773
biotech | CAS: 1792982-55-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pork Approved DB10561
biotech

Pork allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pork collagen Approved DB14100
biotech

Pork Collagen is used within MACI® (autologous cultured chondrocytes on porcine collagen membrane) as an autologous cellularized scaffold product indicated for the repair of single or multiple symptomatic, full-thickness cartilage defects of the knee with or …

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Porphobilinogen DB02272
small molecule | CAS: 487-90-1

Porphobilinogen is a pyrrole involved in porphyrin metabolism. It is generated by the enzyme ALA dehydratase, and converted into hydroxymethyl bilane by the enzyme porphobilinogen deaminase.

Target Protein:
Delta-aminolevulinic acid dehydratase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Myoglobin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Posaconazole Approved DB01263
small molecule | CAS: 171228-49-2

Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.

Kategori:
14-alpha Demethylase InhibitorsAnti-Infective AgentsAntifungal Agents +23
Target Protein:
Lanosterol 14-alpha demethylase
Waktu ParuhPosaconazole is eli…
Vol. Distribusi* 1774 L
Klirens* 32 L/hr * 51 L/h…
Genetik -
Posdinemab DB18941
biotech | CAS: 2517973-04-3

Posdinemab is under investigation in clinical trial NCT04619420 (A Study of JNJ-63733657 in Participants With Early Alzheimer's Disease).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Poseltinib DB16299
small molecule | CAS: 1353552-97-2

Poseltinib is under investigation in clinical trial NCT02628028 (A Study of LY3337641 in Rheumatoid Arthritis).

Kategori:
Amines
Target Protein:
Tyrosine-protein kinase BTK
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Posiphen DB15317
small molecule | CAS: 116839-68-0

Posiphen is under investigation in clinical trial NCT02925650 (Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease).

Kategori:
Acids, AcyclicAlkaloidsCarbamates +11
Waktu Paruh-
Vol. Distribusi-
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Posizolid DB04850
small molecule | CAS: 252260-06-3

Posizolid (AZD2563) is an oxazolidinone antibiotic. In July 2002, after completion of phase I trials in December 2001, AstraZeneca announced that they were no longer pursuing the development of Posizolid, presumably due to negative trial results (though no r…

Kategori:
OATP1B1/SLCO1B1 InhibitorsOxazoles
Target Protein:
23S ribosomal RNAAmine oxidase [flavin-containing] A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Posoleucel DB17974
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
POT-4 DB06056
biotech

POT-4 is a peptide that specifically inhibits complement activation and is initially being developed for the treatment of age-related macular degeneration (AMD). The investigational drug was under investigation in clinical trial NCT00473928 (Safety of Intravi…

Target Protein:
Complement C3
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Potassium Approved DB14500
small molecule | CAS: 7440-09-7

Potassium is an essential nutrient, like [Calcium] and [Magnesium]. It was identified as a shortfall nutrient by the 2015-2020 Advisory Committee of Dietary Guidelines for Americans.[A186928] Many conditions and diseases interfere with normal body potassium b…

Kategori:
Agents causing hyperkalemiaDiureticsElements +8
Target Protein:
Sodium/potassium-transporting ATPase subunit alpha-1
Waktu ParuhIn one clinical stu…
Vol. DistribusiPotassium is presen…
KlirensPotassium is freely…
Genetik -
Potassium acetate Approved DB14498
small molecule | CAS: 127-08-2

Deskripsi belum tersedia.

Kategori:
AcetatesAcids, AcyclicAgents causing hyperkalemia +8
Target Protein:
Sodium/potassium-transporting ATPase subunit alpha-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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