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3253

Total database: 17430
Struktur (SMILES)
2451 (75.3%)
Target
1833 (56.3%)
Genomik
35 (1.1%)
Referensi
3253 (100.0%)

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Halaman 27 / 66
Gatifloxacin Approved DB01044
small molecule | CAS: 112811-59-3

Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin…

Kategori:
4-QuinolonesAnti-Bacterial AgentsAnti-Infective Agents +23
Target Protein:
DNA gyrase subunit ADNA gyrase subunit BDNA gyrase subunit A +3
Waktu Paruh7-14 hours
Vol. Distribusi-
Klirens-
Genetik -
Gatipotuzumab DB18861
biotech | CAS: 1264737-26-9

Gatipotuzumab is under investigation in clinical trial NCT01899599 (Pankomab-gex™ Versus Placebo as Maintenance Therapy in Advanced Ovarian Cancer).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gaxilose Approved DB12767
small molecule | CAS: 14087-31-1

Gaxilose has been used in trials studying the diagnostic of Lactose Intolerance.

Kategori:
CarbohydratesOligosaccharidesPolysaccharides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GB1211 DB17499
small molecule | CAS: 1978336-95-6

GB1211 is an orally active galectin-3 (Gal-3) inhibitor.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GBR-12783 DB17027
small molecule | CAS: 145428-33-7

A selective inhibitor of dopamine uptake.[A252997]

Kategori:
Dopamine AgentsDopamine AgonistsDopamine Uptake Inhibitors +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GBR-12879 DB17028
small molecule | CAS: 67469-43-6

Deskripsi belum tersedia.

Kategori:
Piperazines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GDC-0152 DB12380
small molecule | CAS: 873652-48-3

GDC-0152 has been used in trials studying the treatment of Solid Cancers.

Kategori:
Cycloparaffins
Target Protein:
E3 ubiquitin-protein ligase XIAP
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GDC-0349 DB13072
small molecule | CAS: 1207360-89-1

GDC-0349 has been used in trials studying the treatment of Non-Hodgkin's Lymphoma, Solid Tumor.

Kategori:
AmidesBenzene Derivatives
Target Protein:
Serine/threonine-protein kinase mTOR
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GDC-0810 DB12253
small molecule | CAS: 1365888-06-7

ARN-810 has been used in trials studying the basic science and treatment of Breast Cancer.

Kategori:
Acids, CarbocyclicHeterocyclic Compounds, Fused-RingPyrazoles
Target Protein:
Estrogen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GDC-0917 DB12336
small molecule | CAS: 1446182-94-0

CUDC-427 has been used in trials studying the treatment of LYMPHOMA and Solid Cancers.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GDX012 DB18448
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gebasaxturev DB17296
biotech | CAS: 2122169-83-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gefarnate DB12079
small molecule | CAS: 51-77-4

Gefarnate has been investigated for the treatment and prevention of Stomach Ulcer, Duodenal Ulcer, and Cardio-cerebrovascular Disease.

Kategori:
Alimentary Tract and MetabolismAnti-Ulcer AgentsDrugs for Acid Related Disorders +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gelatin Approved DB11242
small molecule | CAS: 9000-70-8

Gelatin is a multifunctional ingredient that is used in foods, pharmaceuticals, cosmetics, and photographic films as a gelling agent, stabilizer, thickener, emulsifier, as well as film former.[A32432] As a thermoreversible hydrocolloid with a small gap bet…

Kategori:
Amino Acids, Peptides, and ProteinsBlood and Blood Forming OrgansBlood and Related Products +4
Waktu ParuhHalf-life is about …
Vol. Distribusi-
KlirensA large percentage …
Genetik -
Gemcabene DB05123
small molecule | CAS: 183293-82-5

Gemcabene is a new drug that lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C).

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 210829-30-4

Gemcitabine elaidate has been used in trials studying the treatment of Solid Tumor, Lung Cancer, Non-small-cell Lung Cancer, and Metastatic Pancreatic Adenocarcinoma.

Kategori:
DeoxyribonucleosidesNucleic Acids, Nucleotides, and NucleosidesNucleosides +2
Target Protein:
Ribonucleoside-diphosphate reductase subunit M2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gemfibrozil Approved DB01241
small molecule | CAS: 25812-30-0

Gemfibrozil is a fibric acid agent, similar to [clofibrate], used to treat Type IIb, IV, and V hyperlipidemias.[A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not responded adequately to weight loss, diet, exer…

Kategori:
Acids, AcyclicAgents Causing Muscle ToxicityBenzene Derivatives +53
Target Protein:
Peroxisome proliferator-activated receptor alphaLipoprotein lipaseSolute carrier organic anion transporter family member 1B1 +3
Waktu ParuhGemfibrozil has a p…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of ge…
Genetik -
Gemigliptin DB12412
small molecule | CAS: 911637-19-9

Gemigliptin is under investigation in Type 2 Diabetes Mellitus. Gemigliptin has been investigated for the treatment of Cancer and Cisplatin Adverse Reaction.

Kategori:
Agents causing angioedemaAlimentary Tract and MetabolismBlood Glucose Lowering Agents +5
Target Protein:
Dipeptidyl peptidase 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Gemogenovatucel-T is a bi-shRNA furin/Granulocyte Macrophage Colony Stimulating Factor (GMCSF) Augmented autologous tumour cell vaccine. Furin is a convertase involved in the activation of TGF?-1 and TGF?-2.[A255163] Gemogenovatucel-T is being investigated in…

Kategori:
Biological ProductsComplex MixturesVaccines +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Genipin DB19124
small molecule | CAS: 6902-77-8

Genipin is under investigation in clinical trial NCT05755750 (Intratendinous Genipin Injection in Horses With Tendon Injuries).

Kategori:
AdhesivesCholagogues and CholereticsCycloparaffins +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gentamicin C1a DB04729
small molecule | CAS: 26098-04-4

Deskripsi belum tersedia.

Kategori:
Agents that produce neuromuscular block (indirect)Aminoglycoside AntibacterialsAnti-Bacterial Agents +6
Target Protein:
30S ribosomal protein S1216S ribosomal RNA
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gepirone Approved DB12184
small molecule | CAS: 83928-76-1

Gepirone, an azapirone, is a pharmacologic analog of [buspirone] that acts selectively on the pre- and post-synaptic 5HT<sub>1A</sub> receptors. Although earlier clinical trials showed promising results for gepirone, its formulation as an immediate-release ta…

Kategori:
Anti-Anxiety AgentsAntidepressive AgentsCentral Nervous System Agents +12
Target Protein:
5-hydroxytryptamine receptor 1A
Waktu ParuhThe mean terminal h…
Vol. DistribusiThe apparent volume…
KlirensAfter the administr…
Genetik -
Gepotidacin DB12134
small molecule | CAS: 1075236-89-3

Gepotidacin has been used in trials studying the treatment of Gonorrhea, Infections, Bacterial, and Infections, Respiratory Tract.

Kategori:
Antineoplastic AgentsEnzyme InhibitorsHeterocyclic Compounds, Fused-Ring +2
Target Protein:
DNA topoisomerase 2-alphaDNA topoisomerase 2-beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Geraniol Approved DB14183
small molecule | CAS: 106-24-1

Geraniol is a monoterpene that is found within many essential oils of fruits, vegetables, and herbs including rose oil, citronella, lemongrass, lavender, and other aromatic plants. It is emitted from the flowers of many species of plant and is commonly used b…

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseMonoterpenes +2
Target Protein:
Transient receptor potential cation channel subfamily M member 8
Waktu ParuhIn vitro measuremen…
Vol. Distribusi-
Klirens-
Genetik -
Gestonorone caproate Approved DB14677
small molecule | CAS: 1253-28-7

Deskripsi belum tersedia.

Kategori:
Fused-Ring CompoundsNorpregnanesNorpregnenes +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GET-73 DB12928
small molecule | CAS: 202402-01-5

Get 73 has been investigated for the treatment of Alcohol Dependence.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gevokizumab DB12119
biotech | CAS: 1129435-60-4

Gevokizumab has been used in trials studying the treatment of Acne Vulgaris, Osteoarthritis, Behcet's Uveitis, Pyoderma Gangrenosum, and Behcet's Disease Uveitis, among others. Gevokizumab acts as a modulator of cytokine imbalance in IL-1 mediated disease sta…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Target Protein:
Interleukin-1 beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GFH-925 DB17481
small molecule

GFH-925 is an irreversibly covalent inhibitor of KRAS G12C.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GI heptapeptide DB15070
biotech

GI heptapeptide is under investigation in clinical trial NCT01391208 (Esophageal Protocol for Detection of Neoplasia in the Digestive Tract).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GI-181771X DB12309
small molecule | CAS: 305366-98-7

Gski181771 X is under investigation in clinical trial NCT00600743 (Effect of a CCK-1R Agonist on Food Intake in Humans).

Kategori:
BenzazepinesHeterocyclic Compounds, Fused-RingReceptor, Cholecystokinin A, agonists
Target Protein:
Cholecystokinin receptor type A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GI-4000 DB05698
biotech

A vaccine containing a heat-killed recombinant <em>Saccharomyces cerevisiae</em> yeast transfected with mutated forms of Ras, an oncogene frequently found in solid tumors, with potential immunostimulant and antitumor activity. [L112]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gilteritinib Approved DB12141
small molecule | CAS: 1254053-43-4

Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group.[A40036] It is a pyrazinecarboxamide derivative that showed h…

Kategori:
AminesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +16
Target Protein:
Receptor-type tyrosine-protein kinase FLT3Tyrosine-protein kinase receptor UFOALK tyrosine kinase receptor +1
Waktu ParuhThe reported median…
Vol. DistribusiThe estimated appar…
KlirensThe estimated clear…
Genetik -
Gimatecan DB06721
small molecule | CAS: 292618-32-7

Gimatecan is an orally available 7-t-butoxyiminomethyl-substituted lipophilic camptothecin derivative.

Kategori:
AlkaloidsOATP1B1/SLCO1B1 Substrates
Target Protein:
DNA topoisomerase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ginsenoside Rd DB19256
small molecule | CAS: 52705-93-8

Ginsenoside Rd is under investigation in clinical trial NCT00815763 (Efficacy and Safety of Ginsenoside-rd for Acute Ischemic Stroke).

Kategori:
CarbohydratesGlycosidesPanax +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ginsenoside Rg3 DB19257
small molecule | CAS: 14197-60-5

Ginsenoside Rg3 is under investigation in clinical trial NCT01757366 (Safety and Efficacy of Ginsenoside Rg3 in Combination With First-line Chemotherapy in Advanced Gastric Cancer).

Kategori:
Antineoplastic AgentsAntineoplastic Agents, PhytogenicCarbohydrates +5
Target Protein:
Voltage-gated inwardly rectifying potassium channel KCNH2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Giredestrant DB19125
small molecule | CAS: 1953133-47-5

Giredestrant is under investigation in clinical trial NCT06065748 (A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With Er-positive, Her2-negative Advanced Breast Cancer Resistant to…

Kategori:
Heterocyclic Compounds, Fused-RingIndole AlkaloidsIndoles +1
Target Protein:
Estrogen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 1011710-99-8

Girentuximab I-124 is under investigation in clinical trial NCT01762592 (REDECT 2: REnal Masses: Pivotal Trial to DEteCT Clear Cell Renal Cell Carcinoma With PET/CT).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Givinostat Approved DB12645
small molecule | CAS: 497833-27-9

Givinostat is a small molecule histone deacetylase (HDAC) inhibitor. It has been investigated as a treatment for a variety of inflammatory diseases, like Crohn's disease and juvenile idiopathic arthritis, cancers like leukemia and lymphoma, as well as several…

Kategori:
Acids, AcyclicAminesAntineoplastic Agents +20
Target Protein:
Histone deacetylaseTyrosine-protein kinase JAK2Histone deacetylase 1
Waktu ParuhThe apparent plasma…
Vol. DistribusiAccording to popula…
KlirensAccording to popula…
Genetik -
Glecaprevir Approved DB13879
small molecule | CAS: 1365970-03-1

Glecaprevir is a direct acting antiviral agent and Hepatitis C virus (HCV) NS3/4A protease inhibitor that targets the the viral RNA replication. In combination with [DB13878], glecaprevir is a useful therapy for patients who experienced therapeutic failure fr…

Kategori:
Acids, AcyclicAmidesAmino Acids +37
Target Protein:
NS3 proteaseGenome polyprotein
Waktu ParuhThe elimination hal…
Vol. Distribusi-
Klirens-
Genetik -
Glesatinib DB06302
small molecule | CAS: 936694-12-1

Deskripsi belum tersedia.

Kategori:
AcetamidesAmidesBenzene Derivatives +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 195009-21-3

Glial growth factor 2 has been used in trials studying the treatment of Heart Failure.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Gliclazide Approved DB01120
small molecule | CAS: 21187-98-4

Gliclazide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It has been classified differently according to its drug properties in which based on its chemical structure, gliclazide is considered a f…

Kategori:
Alimentary Tract and MetabolismAmidesBenzene Derivatives +15
Target Protein:
ATP-binding cassette sub-family C member 8Vascular endothelial growth factor A, long form
Gen Terkait:
CYP2C19 CYP2C19
Waktu Paruh10.4 hours. Duratio…
Vol. Distribusi-
Klirens-
Genetik 2 Varian
Glipizide Approved DB01067
small molecule | CAS: 29094-61-9

Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 [A179491] and is available in various countries incl…

Kategori:
Alimentary Tract and MetabolismBlood Glucose Lowering AgentsBSEP/ABCB11 Substrates +11
Target Protein:
ATP-binding cassette sub-family C member 8ATP-sensitive inward rectifier potassium channel 10Peroxisome proliferator-activated receptor gamma
Gen Terkait:
CYP2C9
Waktu ParuhThe mean terminal e…
Vol. DistribusiThe mean volume of …
KlirensThe mean total body…
Genetik 1 Varian
Gliquidone Approved DB01251
small molecule | CAS: 33342-05-1

Gliquidone is a sulfonylurea drug used to treat diabetes mellitus type 2. It is an ATP-dependent K+ (KATP) channel blocker. This block causes a depolarization which leads to activation of voltage-dependent Ca channels and Ca2+ influx, and eventually increases…

Kategori:
Alimentary Tract and MetabolismAmidesBlood Glucose Lowering Agents +8
Target Protein:
ATP-binding cassette sub-family C member 8ATP-sensitive inward rectifier potassium channel 10ATP-sensitive inward rectifier potassium channel 8
Waktu ParuhThe mean terminal h…
Vol. Distribusi-
Klirens-
Genetik -
Glisoxepide DB01289
small molecule | CAS: 25046-79-1

Glisoxepide is one of the sulphonamide-derived oral antidiabetic drugs. It inhibits the uptake of bile acids into isolated rat hepatocytes. However it inhibits taurocholate uptake only in the absence of sodium ions. Glisoxepide uptake could be further inhibit…

Kategori:
Alimentary Tract and MetabolismAmidesBlood Glucose Lowering Agents +8
Target Protein:
ATP-sensitive inward rectifier potassium channel 10ATP-sensitive inward rectifier potassium channel 8Insulin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GLPG-0187 DB12297
small molecule | CAS: 1320346-97-1

GLPG0187 has been used in trials studying the treatment of Solid Tumors.

Kategori:
AmidesHeterocyclic Compounds, Fused-RingSulfones +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GLPG-0492 DB12461
small molecule | CAS: 1215085-92-9

Glpg0492 is under investigation in clinical trial NCT01130818 (First-in-Human Single Ascending Dose of GLPG0492).

Kategori:
AndrogensImidazolesImidazolidines
Target Protein:
Androgen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
GLPG-1205 DB15346
small molecule | CAS: 1445847-37-9

GLPG-1205 is under investigation in clinical trial NCT03725852 (A Clinical Study to Test How Effective and Safe GLPG1205 is for Patients With Idiopathic Pulmonary Fibrosis (IPF)).

Kategori:
Heterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 223460-79-5

Glucagon-like peptide II is under investigation for the basic science of Short Bowel Syndrome.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Glucarpidase Approved DB08898
biotech | CAS: 9074-87-7

Glucarpidase is a recombinant carboxypeptidase G2 produced by genetically modified _Escherichia coli_ bacteria. It is a 390-amino acid homodimer protein.[L39855] High-dose [methotrexate], an antifolate agent, has been widely and safely used for many decades i…

Kategori:
Amino Acids, Peptides, and ProteinsAntidotesCarboxypeptidases +8
Waktu ParuhFollowing intraveno…
Vol. DistribusiIn healthy adults w…
KlirensThe mean systemic c…
Genetik -
Menampilkan 1301–1350 dari 3253
Sebelumnya Halaman 27 / 66 Berikutnya