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17430

Total database: 17430
Struktur (SMILES)
12313 (70.6%)
Target
9368 (53.7%)
Genomik
112 (0.6%)
Referensi
17430 (100.0%)

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Hasil Pencarian (17430)

Halaman 268 / 1743
Abatacept Approved DB01281
biotech | CAS: 332348-12-6

Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1).[L20504,L42715] Structurally, …

Kategori:
Agents reducing cytokine levelsAmino Acids, Peptides, and ProteinsAntibodies +18
Target Protein:
T-lymphocyte activation antigen CD80T-lymphocyte activation antigen CD86Cytotoxic T-lymphocyte protein 4
Waktu Paruh16.7 (12-23) days i…
Vol. Distribusi* 0.07 L/kg [RA Pat…
Klirens* 0.23 mL/h/kg [Hea…
Genetik -
ABBV-011 DB18622
biotech

ABBV-011 is an antibody-drug conjugate of humanized, cysteine-engineered IgG1 monoclonal antibody targeting seizure-related 6 homolog conjugated to N-acetyl-gamma-calicheamicin.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ABBV-514 DB17586
biotech

ABBV-514 is in development for the treatment of non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC) as a single agent and in combination with a PD-1 inhibitor.[L45464]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ABBV-706 DB18710
biotech

ABBV-706 is an antibody-drug conjugate that is anti-SEZ6.[L49156,L49161]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ABBV-744 DB19199
small molecule | CAS: 2138861-99-9

Deskripsi belum tersedia.

Target Protein:
Bromodomain-containing protein 3Bromodomain-containing protein 2Bromodomain-containing protein 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ABBV-CLS-7262 DB18407
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Abciximab Approved DB00054
biotech | CAS: 143653-53-6

Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, a…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +18
Target Protein:
Integrin beta-3Integrin alpha-IIbLow affinity immunoglobulin gamma Fc region receptor II-a +2
Waktu ParuhFollowing intraveno…
Vol. Distribusi-
Klirens-
Genetik -
Abediterol DB12100
small molecule | CAS: 915133-65-2

Abediterol has been used in trials studying the treatment of Asthma, Chronic Obstructive Pulmonary Disease (COPD), and Chronic Obstructive Pulmonary Disease (COPD) and Asthma.

Kategori:
Adrenergic AgonistsAdrenergic beta-2 Receptor AgonistsAdrenergic beta-Agonists +4
Target Protein:
Beta-2 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Abelacimab DB16682
biotech | CAS: 2098724-83-3

Abelacimab is under investigation in clinical trial NCT04755283 (Safety and Tolerability of Abelacimab (MAA868) vs. Rivaroxaban in Patients With Atrial Fibrillation).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Abemaciclib Approved DB12001
small molecule | CAS: 1231929-97-7

Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abem…

Kategori:
AminesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +36
Target Protein:
Cyclin-dependent kinase 4Cyclin-dependent kinase 6
Waktu ParuhThe mean plasma eli…
Vol. DistribusiThe geometric mean …
KlirensThe geometric mean …
Genetik -
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