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14063

Total database: 17430
Struktur (SMILES)
10481 (74.5%)
Target
8038 (57.2%)
Genomik
107 (0.8%)
Referensi
14063 (100.0%)

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Hasil Pencarian (14063)

Halaman 267 / 282
Tryptophan Approved DB00150
small molecule | CAS: 73-22-3

An essential amino acid that is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of indole alkaloids in plants. It is a precursor of serotonin (hence its use as an antidepressant and sleep aid). It can be a precurso…

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +14
Target Protein:
Indoleamine 2,3-dioxygenase 1Tryptophan--tRNA ligase, cytoplasmicTryptophan--tRNA ligase +1
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Tryptophanamide DB04537
small molecule | CAS: 20696-57-5

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +1
Target Protein:
Tryptophan--tRNA ligase, cytoplasmicTryptophan--tRNA ligase
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TSHA-101 DB18280
biotech

Deskripsi belum tersedia.

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TSHA-102 DB18599
biotech

TSHA-102 is a recombinant serotype 9 adeno-associated virus encoding a codon-optimized human MECP2 gene.

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TSHA-104 DB18225
biotech

Deskripsi belum tersedia.

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TSHA-105 DB18328
biotech

TSHA-105 is an adeno-associated virus serotype 9 (AAV9) vector with an engineered transgene encoding the human SLC13A5 protein.

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TSHA-120 DB16985
biotech

Deskripsi belum tersedia.

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TSN-084 DB18306
small molecule | CAS: 2412309-60-3

Deskripsi belum tersedia.

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TT-232 DB12088
small molecule | CAS: 147159-51-1

Tln 232 is under investigation in clinical trial NCT00422786 (Phase II Study of CAP-232 in Patients With Refractory Metastatic Renal Cell Carcinoma).

Kategori:
Amino Acids, Peptides, and ProteinsHormonesHormones, Hormone Substitutes, and Hormone Antagonists +8
Target Protein:
Pyruvate kinase PKM
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TT-301 DB12899
small molecule | CAS: 886208-76-0

TT301 has been used in trials studying the treatment of Traumatic Brain Injury.

Target Protein:
Interleukin-1 beta
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TTAX01 DB17928
biotech

TTAX01 is a cryopreserved human umbilical cord product being developed by TissueTech.[L47246]

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TTI-101 DB17578
small molecule | CAS: 432001-19-9

Deskripsi belum tersedia.

Kategori:
AmidesBenzene DerivativesNaphthalenes +3
Target Protein:
Signal transducer and activator of transcription 3
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TTX-MC138 DB18628
biotech

TTX-MC138 is an antisense oligonucleotide targeting miR-10b.[L48335] It is under investigation for the treatment of various metastatic cancers.

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TU-100 DB12467
small molecule | CAS: 1310907-71-1

TU-100 has been used in trials studying the treatment of Abdominal Pain, Colonic Transit, Crohn's Disease, Rectal Sensation, and Gastric Emptying, among others.

Kategori:
DNA Topoisomerases, Type IINaphthalenesQuinones +1
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Tuaminoheptane DB13238
small molecule | CAS: 123-82-0

Deskripsi belum tersedia.

Kategori:
Nasal PreparationsSympathomimetics, Plain
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Tubercidin DB03172
small molecule | CAS: 69-33-0

An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic acids.

Kategori:
Antibiotics, AntineoplasticAntimetabolitesAntineoplastic Agents +8
Target Protein:
Purine nucleoside phosphorylase DeoD-type
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biotech | CAS: 92129-86-7

Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves t…

Kategori:
Amino Acids, Peptides, and ProteinsAntigensAntigens, Bacterial +12
Target Protein:
Toll-like receptor 2
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Tubocurarine Approved DB01199
small molecule | CAS: 57-95-4

Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid.[A216008] Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to coat the tips of hunting arrows and dart…

Kategori:
AlkaloidsAminesAnticholinergic Agents +23
Target Protein:
Neuronal acetylcholine receptor subunit alpha-25-hydroxytryptamine receptor 3AAcetylcholinesterase +1
Waktu Paruh1-2 hours
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Tucaresol DB13027
small molecule | CAS: 84290-27-7

Tucaresol has been used in trials studying the treatment of HIV Infections.

Kategori:
Acids, CarbocyclicAldehydesBenzene Derivatives
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Tucatinib Approved DB11652
small molecule | CAS: 937263-43-9

Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020.[L12951] Tucatinib is a…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 Substrates +18
Target Protein:
Receptor tyrosine-protein kinase erbB-2Receptor tyrosine-protein kinase erbB-3
Waktu ParuhA pharmacokinetic s…
Vol. DistribusiThe volume of distr…
KlirensThe apparent cleara…
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biotech | CAS: 339986-90-2

Tucotuzumab celmoleukin is under investigation in clinical trial NCT00016237 (Interleukin-2 Combined With Monoclonal Antibody Therapy in Treating Patients With Kidney, Bladder, or Lung Cancer That Has Not Responded to Previous Treatment).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +10
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Tulathromycin A DB11474
small molecule | CAS: 217500-96-4

Tulathromycin is a macrolide antibiotic used to treat bovine respiratory disease in cattle and swine respiratory disease in pigs. It is marketed by Pfizer Inc. under the tradename Draxxin.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsCarbohydrates +4
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Tulisokibart DB18719
biotech | CAS: 2648504-55-4

PRA023 is a humanized monoclonal antibody directed to vascular endothelial growth inhibitor, also known as tumour necrosis factor (TNF)-like ligand 1A (TL1A) and TNF superfamily member 15. It is being investigated for ulcerative colitis.

Target Protein:
Tumor necrosis factor ligand superfamily member 15
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Tulmimetostat DB19446
small molecule | CAS: 2567686-02-4

Tulmimetostat is under investigation in clinical trial NCT05467748 (EZH2 Inhibitor, Tulmimetostat, and PD-1 Blockade for Treatment of Advanced Non-small Cell Lung Cancer).

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Tulobuterol DB12248
small molecule | CAS: 41570-61-0

Tulobuterol has been used in trials studying the treatment of Chronic Obstructive Pulmonary Disease.

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic beta-Agonists +17
Target Protein:
Beta-2 adrenergic receptor
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Tulrampator DB16344
small molecule | CAS: 1038984-31-4

Tulrampator is under investigation in clinical trial NCT02626572 (Efficacy and Safety of 3 Doses of S47445 Versus Placebo in Patients With Alzheimer's Disease at Mild to Moderate Stages With Depressive Symptoms).

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TUM012 DB18652
biotech

TUM012 is a synthetic polymer PEG conjugated to a phospholipid anchor (2-dipalmitoyl-sn-glycerol-3-phosphatidylethanolamine)

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Tunicamycin DB13172
small molecule | CAS: 11089-65-9

Tunicamycin is a mixture of homologous nucleoside antibiotics that inhibits the UDP-HexNAc: polyprenol-P HexNAc-1-P family of enzymes. One member of this family is the enzyme GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-acetylglucosamine…

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsNucleic Acids, Nucleotides, and Nucleosides +3
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Tunlametinib DB18791
small molecule | CAS: 1801756-06-8

Deskripsi belum tersedia.

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Tuparstobart DB19118
biotech | CAS: 2649466-03-3

Tuparstobart is under investigation in clinical trial NCT05287113 (Study of Retinfanlimab in Combination With INCAGN02385 and INCAGN02390 as First-line Treatment in Participants With Pd-l1-positive (CPS ? 1) Recurrent/metastatic Squamous Cell Carcinoma of the…

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Turmeric Approved DB14276
biotech

Turmeric is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
AngiospermsAntioxidantsBiological Factors +16
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Turmeric oil Approved DB14692
biotech

Deskripsi belum tersedia.

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biotech

Turnera diffusa leaf is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

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Turnip Approved DB10652
biotech

Turnip allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract +1
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Turoctocog alfa Approved DB09109
biotech | CAS: 1192451-26-5

Turoctocog alfa is a recombinant factor VIII (rFVIII) with a truncated B-domain made from the sequence coding for 10 amino acids from the N-terminus and 11 amino acids from the C-terminus of the naturally occurring B-domain. Turoctocog alfa is produced in Chi…

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood Coagulation Factors +5
Target Protein:
Coagulation factor IXCoagulation factor XProthrombin
Waktu ParuhIn pre-clinical stu…
Vol. DistribusiIn pre-clinical stu…
KlirensIn pre-clinical stu…
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Turoctocog alfa pegol Approved DB14738
biotech | CAS: 1309086-46-1

Turoctocog alfa pegol is a pegylated version of [turoctocog alfa]. Novo Nordisk's brand name Esperoct (turoctocog alfa pegol, N8-GP) was approved by the US FDA on February 19, 2019. Fundamentally, the N8-GP moiety is identical to [turoctocog alfa], a recom…

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood Coagulation Factors +5
Target Protein:
Coagulation factor IXCoagulation factor XProthrombin +1
Waktu ParuhThe mean plasma hal…
Vol. DistribusiThe mean volume of …
KlirensThe mean clearance …
Genetik -
small molecule | CAS: 629664-81-9

Fxr 450 is under investigation in clinical trial NCT00509756 (Study Evaluating Turofexorate isopropyl in Healthy Japanese Men).

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Bile acid receptor
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Turpentine Approved DB11120
small molecule | CAS: 9005-90-7

Turpentine, also known as spirit of turpentine, oil of turpentine, and wood turpentine, is a liquid extracted from live trees, mainly pine, through distillation of resin. It is used as a solvent and base material in organic synthesis reactions. Turpentine is …

Kategori:
Biological ProductsComplex MixturesCompounds used in a research, industrial, or household setting +9
Target Protein:
Mitogen-activated protein kinase 1
Waktu ParuhEight male voluntee…
Vol. DistribusiTurpentine, as a li…
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biotech | CAS: 2254086-60-5

Tusamitamab ravtansine is an antibody-drug conjugate that targets carcinoembryonic antigen-related cell adhesion molecule-5 (CEACAM5).

Kategori:
Amino Acids, Peptides, and ProteinsBlood ProteinsGlobulins +4
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Tuspetinib DB15343
small molecule

Tuspetinib (HM-43239) is under investigation in clinical trial NCT03850574 (Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM43239 in Patients With Relapsed or Refractory Acute Myeloid Leukemia).

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Tuvirumab DB17752
biotech | CAS: 138660-97-6

Deskripsi belum tersedia.

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Tuvusertib DB18790
small molecule

Deskripsi belum tersedia.

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TVI-Brain-1 DB17227
biotech

Deskripsi belum tersedia.

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TVN-102 DB16990
biotech

Deskripsi belum tersedia.

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TW-37 DB17059
small molecule | CAS: 877877-35-5

TW-37 is a small-molecule inhibitor of Bcl-2 investigated for its anti-cancer properties.[A253157]

Target Protein:
Apoptosis regulator Bcl-2Induced myeloid leukemia cell differentiation protein Mcl-1
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TY027 DB16500
biotech

Deskripsi belum tersedia.

Kategori:
Experimental Unapproved Treatments for COVID-19
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Tyloxapol Approved DB06439
small molecule | CAS: 25301-02-4

Tyloxapol is a non-ionic detergent often used as a surfactant.

Kategori:
AlcoholsCompounds used in a research, industrial, or household settingCough and Cold Preparations +8
Target Protein:
Transcription factor RelBNuclear factor NF-kappa-B p105 subunitNuclear factor NF-kappa-B p100 subunit +3
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Tylvalosin DB11554
small molecule | CAS: 63409-12-1

Deskripsi belum tersedia.

Kategori:
Anti-Bacterial AgentsLactonesMacrolides
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Tymazoline DB08803
small molecule | CAS: 24243-97-8

Tymazoline is a nasal preparation.

Kategori:
Nasal PreparationsSympathomimetics, Plain
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Typhoid vaccine Approved DB14022
biotech

Deskripsi belum tersedia.

Kategori:
Bacterial VaccinesBiological ProductsComplex Mixtures +3
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Menampilkan 13301–13350 dari 14063
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