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13591

Total database: 17430
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10177 (74.9%)
Target
7625 (56.1%)
Genomik
104 (0.8%)
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13591 (100.0%)

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Hasil Pencarian (13591)

Halaman 262 / 272
biotech | CAS: 886584-10-7

Vanutide cridificar has been investigated for the treatment of Alzheimer Disease.

Kategori:
Amino Acids, Peptides, and ProteinsProteinsRecombinant Proteins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Vanzacaftor DB18373
small molecule | CAS: 2374124-49-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Vapitadine DB05738
small molecule | CAS: 793655-64-8

Vapitadine is an antihistamine that Barrier Therapeutics is developing as a treatment for allergic reactions of the skin, such as those associated with hives and for the itch associated with atopic dermatitis. An advantage of vapitadine over other antihistami…

Target Protein:
Histamine H1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Vapreotide DB04894
biotech | CAS: 103222-11-3

Vapreotide is a synthetic octapeptide somatostatin analog. It was being studied for the treatment of cancer.

Kategori:
Amino Acids, Peptides, and ProteinsAnalgesicsAntineoplastic Agents +20
Target Protein:
Somatostatin receptor type 2Somatostatin receptor type 5Substance-P receptor
Waktu Paruh30 minutes
Vol. Distribusi-
Klirens-
Genetik -
Vardenafil Approved DB00862
small molecule | CAS: 224785-90-4

Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from n…

Kategori:
Cardiovascular AgentsCytochrome P-450 CYP2C19 InhibitorsCytochrome P-450 CYP2C19 Inhibitors (weak) +30
Target Protein:
cGMP-specific 3',5'-cyclic phosphodiesteraseRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaRetinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Waktu ParuhVardenafil and its …
Vol. DistribusiVardenafil has a st…
KlirensVardenafil has a to…
Genetik -
Varenicline Approved DB01273
small molecule | CAS: 249296-44-4

Varenicline is a prescription medication used to treat smoking addiction. This medication is the first approved nicotinic receptor partial agonist. Specifically, varenicline is a partial agonist of the alpha4/beta2 subtype of the nicotinic acetylcholine recep…

Kategori:
BenzazepinesCholinergic AgentsCholinergic Agonists +17
Target Protein:
Neuronal acetylcholine receptor subunit alpha-4Neuronal acetylcholine receptor subunit alpha-7Neuronal acetylcholine receptor subunit alpha-3 +2
Waktu ParuhThe elimination hal…
Vol. Distribusi-
Klirens-
Genetik -
Varespladib DB11909
small molecule | CAS: 172732-68-2

Varespladib has been investigated for the treatment and prevention of Sickle Cell Disease, Vaso-occlusive Crisis, and Acute Coronary Syndrome.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +4
Target Protein:
Phospholipase A2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 172733-08-3

Varespladib methyl has been investigated for the treatment of Acute Coronary Syndrome. Studies showed that Varespladib methyl treatment resulted in significant positive changes on lipoproteins and inflammation.

Kategori:
Acids, AcyclicEnzyme InhibitorsFatty Acids +4
Target Protein:
Phospholipase A2, membrane associatedGroup 10 secretory phospholipase A2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Live attenuated zoster vaccine is available as two products: Zostavax for the prevention of shingles in immunocompetent people over the age of 50, and Varivax for the prevention of chickenpox in individuals 12 months of age and older. While the two vaccines c…

Kategori:
Actively Acquired ImmunityAntiinfectives for Systemic UseBiological Products +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Recombinant zoster vaccine, manufactured as the product Shingrix by GlaxoSmithKline, is an adjuvanted non-live recombinant vaccine indicated for prevention of shingles. First approved in October 2017 by the Food and Drug Administration, Shingrix is the prefer…

Kategori:
VaccinesVaricella Zoster Vaccines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Varlilumab DB11930
biotech | CAS: 1393344-72-3

Varlilumab has been used in trials studying the treatment of MELANOMA, Skin Ulcer, Burkett's Lymphoma, Mantle cell lymphoma, and Any T-cell Malignancy, among others.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 37221-79-7

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsCardiovascular AgentsCentral Nervous System Agents +13
Target Protein:
Vasoactive intestinal polypeptide receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Vasopressin Approved DB00067
biotech | CAS: 11000-17-2

Vasopressin (arginine-vasopressin or antidiuretic hormone) is a nonapeptide primarily produced in the hypothalamus that exhibits diverse physiological functions related to diuresis, hemodynamic modulation, and behaviour.[A110, A111, A112, A113, A228008] Vasop…

Kategori:
Amino Acids, Peptides, and ProteinsAntidiuretic AgentsArginine Vasopressin +22
Target Protein:
Vasopressin V2 receptorVasopressin V1a receptorVasopressin V1b receptor +1
Waktu ParuhVasopressin adminis…
Vol. Distribusi-
KlirensVasopressin has a c…
Genetik -
Vatalanib DB04879
small molecule | CAS: 212141-54-3

Vatalanib (PTK787/ZK-222584) is a new oral antiangiogenic molecule that inhibits all known vascular endothelial growth factor receptors. Vatalanib is under investigation for the treatment of solid tumors.

Kategori:
Enzyme InhibitorsProtein Kinase InhibitorsPyridazines +1
Target Protein:
Epidermal growth factor receptorVascular endothelial growth factor receptor 3Vascular endothelial growth factor receptor 2 +1
Waktu ParuhApproximately 6 hou…
Vol. Distribusi-
Klirens-
Genetik -
Vatelizumab DB12346
biotech | CAS: 1238217-55-4

Vatelizumab has been used in trials studying the treatment of Ulcerative Colitis.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Vatiquinone DB11917
small molecule | CAS: 1213269-98-7

Vatiquinone has been investigated for the treatment and prevention of Retinopathy, Rett Syndrome, Genetic Disease, Noise-induced Hearing Loss, and Methylmalonic Aciduria and Homocystinuria,Cblc Type.

Kategori:
BenzoquinonesCoenzymesEnzymes and Coenzymes +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 897936-89-9

Vatreptacog Alfa (Activated) has been used in trials studying the treatment of Haemophilia B, Haemophilia A, Congenital Bleeding Disorder, Haemophilia A With Inhibitors, and Haemophilia B With Inhibitors.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood Coagulation Factors +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Vayarin Approved DB09328
biotech

Vayarin is a prescription medical food for the clinical dietary management of certain lipid imbalances blamed to be associated with attention deficit hyperactivity disorder (ADHD) in children. Vayarin contains _Lipirinen_, a proprietary composition containing…

Kategori:
Cytochrome P-450 CYP2E1 InhibitorsCytochrome P-450 CYP2E1 Inhibitors (strength unknown)Cytochrome P-450 Enzyme Inhibitors
Waktu ParuhAbout 2h [L1507]
Vol. Distribusi-
KlirensMainly in the feces…
Genetik -
VB-201 DB15259
small molecule | CAS: 630112-41-3

VB-201 is under investigation in clinical trial NCT01001468 (Study to Assess VB-201 in Patients With Psoriasis).

Kategori:
AlcoholsCarbohydratesGlycerophosphates +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
VB-309 DB18539
small molecule | CAS: 2699021-75-3

Deskripsi belum tersedia.

Kategori:
Cannabinoids and similars
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
VB-310 DB18537
small molecule | CAS: 2699021-76-4

Deskripsi belum tersedia.

Kategori:
Cannabinoids and similars
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
VB-311 DB18540
small molecule | CAS: 2699021-77-5

Deskripsi belum tersedia.

Kategori:
Cannabinoids and similars
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
VB-312 DB18542
small molecule | CAS: 2699021-78-6

Deskripsi belum tersedia.

Kategori:
Cannabinoids and similars
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
VB-313 DB18541
small molecule | CAS: 2699021-79-7

Deskripsi belum tersedia.

Kategori:
Cannabinoids and similars
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
VB10.16 DB17512
biotech

VB10.16 is a novel therapeutic antigen-presenting cell-targeting DNA vaccine developed to treat HPV16-positive cancers. It is composed of three parts, one encodes the E6/E7 fusion protein of human papillomavirus (HPV) type 16 (HPV16), a dimerization entity, a…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
VCA-894A DB18609
biotech

VCA-894A is a synthetic 2'-O-methoxyethyl phosphorothioate oligoribonucleotide sodium salt consisting of 19 nucleotide residues with the sequence 5'-MeCMeUGMeUGGAAGMeUGAGGGMeCMeCAG-3'

Waktu Paruh-
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Genetik -
VCN-01 DB18193
biotech

VCN-01 is an investigational, genetically modified human adenovirus encoding human PH20.

Waktu Paruh-
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Genetik -
vCP2292 DB19292
biotech

vCP2292 is under investigation in clinical trial NCT01982487 (Vaccine Therapy and IDO1 Inhibitor INCB024360 in Treating Patients With Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Who Are in Remission).

Waktu Paruh-
Vol. Distribusi-
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Genetik -
VE303 DB17794
biotech

VE303 is under clinical development by Vedanta Biosciences.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Vebicorvir DB18784
small molecule | CAS: 2090064-66-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Vebreltinib DB16823
small molecule | CAS: 1440964-89-5

Deskripsi belum tersedia.

Target Protein:
Hepatocyte growth factor receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Vecabrutinib DB16657
small molecule | CAS: 1510829-06-7

Vecabrutinib is under investigation in clinical trial NCT03037645 (Safety, PK, PD, and Antitumor Activity of Vecabrutinib (SNS-062) in B Lymphoid Cancers).

Kategori:
Amines
Target Protein:
Tyrosine-protein kinase BTK
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Vecuronium Approved DB01339
small molecule | CAS: 86029-43-8

Monoquaternary homolog of pancuronium. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as i…

Kategori:
AndrostanesAndrostanolsAnticholinergic Agents +15
Target Protein:
Neuronal acetylcholine receptor subunit alpha-2
Waktu Paruh51–80 minutes
Vol. Distribusi-
Klirens-
Genetik -
Vedolizumab Approved DB09033
biotech | CAS: 943609-66-3

Vedolizumab is a recombinant humanized IgG1 monoclonal antibody directed against the human lymphocyte ?4?7 integrin, a key mediator of gastrointestinal inflammation implicated in diseases like ulcerative colitis or Crohn's disease.[L48216] ?4?7 integrin facil…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +15
Target Protein:
Integrin alpha-4Integrin beta-7
Waktu ParuhVedolizumab has a l…
Vol. DistribusiSerum apparent volu…
KlirensVedolizumab clearan…
Genetik -
Vedroprevir DB12037
small molecule | CAS: 1098189-15-1

Vedroprevir has been investigated for the treatment of Hepatitis C, Chronic.

Kategori:
Antiviral AgentsHeterocyclic Compounds, Fused-Ring
Target Protein:
Genome polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 15966-93-5

Deskripsi belum tersedia.

Target Protein:
Vascular endothelial growth factor receptor 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
VEGFR2-169 DB16152
small molecule | CAS: 673478-49-4

VEGFR2-169 is under investigation in clinical trial NCT00655785 (Antiangiogenic Peptide Vaccine Therapy With Gemcitabine in Treating Patient With Pancreatic Cancer (Phase1/2)).

Kategori:
Amino Acids, Peptides, and ProteinsCancer VaccinesEnzymes +15
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Veglin DB05890
small molecule | CAS: 1220118-27-3

VEGF-AS (Veglin) is an anti-angiogenesis non-chemotherapy drug (angiogenesis inhibitor) that was developed by VasGene Therapeutics, Inc. for the treatment of a variety of malignancies including mesothelioma. Veglin is one of several newly developed non-chemot…

Target Protein:
Vascular endothelial growth factor A, long form
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Velafermin DB06493
small molecule | CAS: 697766-75-9

Velafermin was a novel investigational protein therapeutic, also known as fibroblast growth factor-20 (FGF-20), which promotes both epithelial and mesenchymal cell proliferation in vitro and has demonstrated activity in multiple animal models. Velafermin was …

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsIntercellular Signaling Peptides and Proteins +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Velaglucerase alfa Approved DB06720
biotech | CAS: 884604-91-5

Velaglucerase alfa is a gene-activated human recombinant glucocerebrosidase used for the treatment of Type 1 Gaucher disease, caused by a deficiency of the lysosomal enzyme glucocerebrosidase. Additionally, Velaglucerase alfa has also been investigated for us…

Kategori:
Alimentary Tract and MetabolismEnzymesEnzymes and Coenzymes +1
Target Protein:
Lysosomal acid glucosylceramidase
Waktu Paruh11-12 minutes.
Vol. DistribusiThe mean volume of …
KlirensMean clearance rang…
Genetik -
Veldoreotide DB12777
biotech | CAS: 252845-37-7

Somatoprim is under investigation for the treatment of Acromegaly.

Kategori:
Amino Acids, Peptides, and ProteinsHormonesHormones, Hormone Substitutes, and Hormone Antagonists +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Veledimex DB12170
small molecule | CAS: 1093130-72-3

Veledimex has been used in trials studying the treatment of Glioblastoma Multiforme, Metastatic Breast Cancer, and Anaplastic Oligoastrocytoma.

Kategori:
Heterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Veliflapon DB16346
small molecule | CAS: 128253-31-6

Veliflapon is under investigation in clinical trial NCT00353067 (Veliflapon (Dg-031)to Prevent Heart Attacks or Stroke in Patients With a History of Heart Attack or Unstable Angina).

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Inflammatory Agents +7
Target Protein:
Arachidonate 5-lipoxygenase-activating protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Veligrotug DB18976
biotech | CAS: 2728655-31-8

Veligrotug is under investigation in clinical trial NCT00791544 (Dose Finding Study of AVE1642 in Patients With Advanced or Metastatic Liver Carcinoma).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Veliparib DB07232
small molecule | CAS: 912444-00-9

Deskripsi belum tersedia.

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsEnzyme Inhibitors +3
Target Protein:
Poly [ADP-ribose] polymerase 1Poly [ADP-ribose] polymerase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Velmanase alfa Approved DB12374
biotech | CAS: 1492823-75-2

Velmanase alfa is a recombinant human lysosomal alpha-mannosidase developed for enzyme replacement therapy to treat alpha-mannosidosis. Alpha-mannosidosis is a rare autosomal recessive lysosomal storage disorder. Patients with alpha-mannosidosis have a geneti…

Kategori:
Alimentary Tract and MetabolismEnzyme Replacement TherapyEnzymes +2
Waktu ParuhAt the end of intra…
Vol. DistribusiThe steady-state vo…
KlirensThe mean clearance …
Genetik -
Velmupressin DB18783
small molecule | CAS: 1647119-61-6

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Velneperit DB12889
small molecule | CAS: 342577-38-2

Velneperit has been used in trials studying the treatment of Obesity.

Target Protein:
Neuropeptide Y receptor type 5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Velpatasvir Approved DB11613
small molecule | CAS: 1377049-84-7

Velpatasvir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized in…

Kategori:
Acids, AcyclicAnti-Infective AgentsAntiinfectives for Systemic Use +22
Target Protein:
Nonstructural protein 5A
Waktu Paruh15h [FDA Label].
Vol. Distribusi1.4-1.6 L/kg [A191…
KlirensEstimated 0.12 L/h/…
Genetik -
Velsecorat DB16347
small molecule | CAS: 1196509-60-0

Velsecorat is under investigation in clinical trial NCT02479412 (A Multiple Dosing (14 Days) Study to Assess Efficacy and Safety of Three Dose Levels of AZD7594, Given Once Daily by Inhalation, in Patients With Mild to Moderate Asthma).

Kategori:
Dioxins and Dioxin-like CompoundsHeterocyclic Compounds, Fused-RingPyrazoles
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 13051–13100 dari 13591
Sebelumnya Halaman 262 / 272 Berikutnya