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16004

Total database: 17430
Struktur (SMILES)
12010 (75.0%)
Target
9041 (56.5%)
Genomik
112 (0.7%)
Referensi
16004 (100.0%)

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Hasil Pencarian (16004)

Halaman 259 / 321
QGC-001 DB13107
small molecule | CAS: 648927-86-0

QGC001 has been used in trials studying the treatment of Essential Hypertension.

Kategori:
AcidsAcids, NoncarboxylicAnions +9
Target Protein:
Glutamyl aminopeptidaseAspartyl aminopeptidase
Waktu Paruh-
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Genetik -
QL1706 DB17562
biotech

QL1706 is an investigational bifunctional antibody that combines the activity of both PD-1 and CTLA-4 antibodies.

Waktu Paruh-
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QN-302 DB18156
small molecule | CAS: 2546091-70-5

Deskripsi belum tersedia.

Waktu Paruh-
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QR-1123 DB17869
biotech

QR-1123 is a first-in-class investigational RNA-based oligonucleotide designed to treat autosomal dominant retinitis pigmentosa due to the P23H mutation in the rhodopsin (_RHO_) gene.[L46782]

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QR-313 DB17867
biotech

QR-313 is an antisense oligonucleotide targeting exon 73. It is being investigated for the treatment of dystrophic epidermolysis bullosa.[A259867]

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QR-333 DB05533
small molecule

QR-333 has been investigated as a treatment for diabetic peripheral neuropathy. QR-333 is a concentrated and standardized nutrient based active compounds dosed in a topical cream designed to reduce oxidative stress and treat symptoms of Diabetic Peripheral Ne…

Target Protein:
Aldo-keto reductase family 1 member B1
Waktu Paruh-
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Genetik -
QR-334 DB05473
small molecule

QR-334 is under investigation for the treatment of sialorrhea. Sialorrhea is an excess secretion of saliva produced by the salivary glands, resulting in drooling. No pharmaceutical interventions currently exist to treat sialorrhea. The symptom is associated w…

Waktu Paruh-
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QRX-411 DB17868
biotech

QRX-411 is a first-in-class RNA-based oligonucleotide designed to restore wild-type USH2A mRNA, leading to the production of the functional USH2A protein. It addresses the underlying cause of Usher syndrome due to the c.7595-2144A>G mutation in the _USH2A_ ge…

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QS-21 DB05400
biotech

QS-21 is an investigational adjuvant, which is a substance added to vaccines and other immunotherapies that is designed to enhance the body’s immune response to the antigen contained within the treatment. It is the leading member of the Stimulon family of adj…

Kategori:
Adjuvants, ImmunologicCarbohydratesGlycosides +1
Waktu Paruh-
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Quabodepistat DB17770
small molecule | CAS: 1883747-71-4

Deskripsi belum tersedia.

Waktu Paruh-
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biotech | CAS: 1396823-56-5

Quaratusugene ozeplasmid is under investigation in clinical trial NCT05062980 (Quaratusugene Ozeplasmid (Reqorsa) in Combination With Pembrolizumab in Previously Treated Non-small Lung Cancer).

Waktu Paruh-
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Quarfloxin DB06638
small molecule | CAS: 865311-47-3

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingOxazinesQuinolines
Target Protein:
Nucleolin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Quassia DB13263
biotech | CAS: 84604-10-4

Deskripsi belum tersedia.

Kategori:
Antiparasitic Products, Insecticides and RepellentsEctoparasiticides, Incl. ScabicidesEctoparasiticides, Incl. Scabicides, Insecticides and Repellents
Waktu Paruh-
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Genetik -
Quaternium-15 Approved DB14198
small molecule | CAS: 4080-31-3

Quaternium-15 is a quaternary ammonium salt used as a surfactant and preservative in many products including cosmetics. It is an anti-microbial agent by virtue of being a formaldehyde releaser, however this can also cause contact dermatitis, a symptom of an a…

Kategori:
AminesBridged-Ring CompoundsCell-mediated Immunity +4
Waktu Paruh-
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Quaternium-18 DB11305
small molecule | CAS: 61789-80-8

Quaternium-18 is a mixture of quaternary ammonium chloride salts. Quaternium-18 Hectorite and Bentonite are the reaction products of Quaternium-18 with clays. These compounds are poorly absorbed through the skin. Acute oral and percutaneous toxicity tests in …

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Quaternium-24 DB13969
small molecule | CAS: 32426-11-2

Deskripsi belum tersedia.

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Quavonlimab DB16422
biotech | CAS: 2254059-25-9

Quavonlimab is under investigation in clinical trial NCT03179436 (Study of Quavonlimab (MK-1308) in Combination With Pembrolizumab (MK-3475) in Advanced Solid Tumors (MK-1308-001)).

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Quazepam Approved DB01589
small molecule | CAS: 36735-22-5

Quazepam is a trifluoroethyl benzodiazepine derivative. It was first approved in the US in 1985 and is used as a hypnotic for the treatment of insomnia.[L44913] It appears to be unique amongst other benzodiazepine derivatives in its relatively high affinit…

Kategori:
BenzazepinesBenzodiazepine hypnotics and sedativesBenzodiazepines and benzodiazepine derivatives +13
Target Protein:
Translocator proteinGABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu ParuhThe mean eliminatio…
Vol. Distribusi-
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Quemliclustat DB19160
small molecule | CAS: 2105904-82-1

Quemliclustat is under investigation in clinical trial NCT05329766 (A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies).

Kategori:
Antineoplastic AgentsAntineoplastic Agents, ImmunologicalImmune Checkpoint Inhibitors
Target Protein:
5'-nucleotidase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Quercetin DB04216
small molecule | CAS: 117-39-5

Quercetin is a flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin.

Kategori:
AntioxidantsBCRP/ABCG2 InhibitorsBenzopyrans +26
Target Protein:
Signal transducer and activator of transcription 3Lysophosphatidylcholine acyltransferase 2Lysophosphatidylcholine acyltransferase 1 +29
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1111616-69-3

Quercetin-3'-O-phosphate has been used in trials studying the treatment of Insulin Resistance and Impaired Glucose Tolerance.

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Genetik -
biotech

Quercus acutissima whole is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

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Quercus alba pollen Approved DB10376
biotech

Quercus alba pollen, or oak white pollen, is a non-standardized allergen extract used for the diagnosis and treatment of allergic disease to grass pollen. It can be subcutaneously administered to initiate an immune response in case of an allergic reaction. Di…

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
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Quetiapine Approved DB01224
small molecule | CAS: 111974-69-7

Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder.[L8546] Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects …

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +44
Target Protein:
5-hydroxytryptamine receptor 2AD(2) dopamine receptor5-hydroxytryptamine receptor 1A +21
Waktu ParuhThe average termina…
Vol. DistribusiQuetiapine distribu…
KlirensThe clearance of qu…
Genetik -
Queuine DB14732
small molecule | CAS: 72496-59-4

Queuine is a derivative of [7-Deazaguanine]. Bacteria possess the exclusive ability to synthesize queuine, which is then salvaged and passed on to plants and animals. Quantities of queuine have been found in tomatoes, wheat, coconut water, and milk from human…

Kategori:
Heterocyclic Compounds, Fused-RingPurinesPurinones
Waktu ParuhData regarding the …
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
Quifenadine DB13713
small molecule | CAS: 10447-39-9

Deskripsi belum tersedia.

Kategori:
Antihistamines for Systemic UseBenzene DerivativesHistamine Agents +2
Waktu Paruh-
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Genetik -
Quilizumab DB15176
biotech | CAS: 1228538-47-3

Quilizumab is under investigation in clinical trial NCT01160861 (A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of MEMP1972A in Patients With Allergic Rhinitis).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +4
Waktu Paruh-
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Quilseconazole DB17758
small molecule | CAS: 1340593-70-5

Deskripsi belum tersedia.

Target Protein:
Lanosterol 14-alpha demethylase
Waktu Paruh-
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Quinacrine DB01103
small molecule | CAS: 83-89-6

An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an …

Kategori:
AcridinesAminoacridinesAnti-Infective Agents +15
Target Protein:
DNAPhospholipase A285/88 kDa calcium-independent phospholipase A2 +2
Waktu Paruh5 to 14 days
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 64046-79-3

Deskripsi belum tersedia.

Kategori:
AcridinesAminoacridinesColoring Agents +9
Target Protein:
Trypanothione reductase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Quinagolide Approved DB09097
small molecule | CAS: 87056-78-8

Quinagolide is a non-ergot-derived selective dopamine D2 receptor agonist used for the treatment of elevated levels of prolactin or hyperprolactinaemia. Hyperprolalctinaemia is associated with gonadal dysfunction, including infertility and reduced libido, as …

Kategori:
Dopamine AgentsDopamine AgonistsDopamine D2 Receptor Agonists +6
Target Protein:
D(2) dopamine receptorD(1) dopamine receptor
Waktu ParuhThe terminal half-l…
Vol. DistribusiApproximate volume …
Klirens-
Genetik -
Quinaldic Acid DB02428
small molecule | CAS: 93-10-7

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Quinalizarin DB08660
small molecule | CAS: 81-61-8

Deskripsi belum tersedia.

Kategori:
AnthracenesQuinones
Target Protein:
Casein kinase II subunit alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Quinapril Approved DB00881
small molecule | CAS: 85441-61-8

Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treat…

Kategori:
ACE Inhibitors and DiureticsAgents Acting on the Renin-Angiotensin SystemAgents causing angioedema +12
Target Protein:
Angiotensin-converting enzyme
Waktu ParuhThe active metaboli…
Vol. DistribusiThe mean volume of …
KlirensThe clearance of qu…
Genetik -
Quinaprilat DB14217
small molecule | CAS: 82768-85-2

The active metabolite of the prodrug [quinapril].

Kategori:
Agents Acting on the Renin-Angiotensin SystemAgents causing angioedemaAgents causing hyperkalemia +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Quinbolone DB13484
small molecule | CAS: 2487-63-0

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAnabolic Agents for Systemic UseAnabolic Steroids +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Quinestrol Approved DB04575
small molecule | CAS: 152-43-2

The 3-cyclopentyl ether of ethinyl estradiol.

Kategori:
Estradiol CongenersEstrogenic Steroids, AlkylatedEstrogens +11
Target Protein:
Estrogen receptor
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Quinethazone Approved DB01325
small molecule | CAS: 73-49-4

Quinethazone, marketed as Hydromox, is a thiazide diuretic indicated for hypertension. Patients may experience adverse reactions such as dizziness, dry mouth, nausea, and hypokalemia.

Kategori:
AmidesCardiovascular AgentsDiuretics +10
Target Protein:
Solute carrier family 12 member 1Solute carrier family 12 member 2Solute carrier family 12 member 3 +2
Waktu Paruh-
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Genetik -
Quinfamide DB12780
small molecule | CAS: 62265-68-3

Quinfamide has been used in trials studying the treatment of Amoebiasis and Helminthiasis.

Kategori:
Heterocyclic Compounds, Fused-Ring
Waktu Paruh-
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Genetik -
Quingestanol DB13685
small molecule | CAS: 10592-65-1

Deskripsi belum tersedia.

Kategori:
Adrenal Cortex HormonesCombination Contraceptives (with Estrogen and derivatives)Contraceptive Agents, Female +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 3000-39-3

Deskripsi belum tersedia.

Kategori:
Adrenal Cortex HormonesFused-Ring CompoundsNorpregnanes +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Quinidine Approved DB00908
small molecule | CAS: 56-54-2

Quinidine is a D-isomer of [quinine] present in the bark of the Cinchona tree and similar plant species. This alkaloid was first described in 1848 and has a long history as an antiarrhythmic medication.[A38016,A250050] Quinidine is considered the first antiar…

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +81
Target Protein:
Sodium channel protein type 5 subunit alphaPotassium channel subfamily K member 1Potassium channel subfamily K member 6 +4
Waktu ParuhThe elimination hal…
Vol. DistribusiQuinidine has a vol…
KlirensThe clearance of qu…
Genetik -
Quinine Approved DB00468
small molecule | CAS: 130-95-0

An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and h…

Kategori:
Agents that produce neuromuscular block (indirect)Agents that reduce seizure thresholdAlkaloids +57
Target Protein:
Fe(II)-protoporphyrin IXPlatelet glycoprotein IXIntermediate conductance calcium-activated potassium channel protein 4
Waktu ParuhApproximately 18 ho…
Vol. Distribusi* 1.43 ± 0.18 L/kg …
Klirens* 0.17 L/h/kg [heal…
Genetik -
Quinisocaine DB13683
small molecule | CAS: 86-80-6

Deskripsi belum tersedia.

Kategori:
AnestheticsAnesthetics for Topical UseAnesthetics, Local +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Quinoline DB18050
small molecule | CAS: 91-22-5

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 8004-92-0

Deskripsi belum tersedia.

Kategori:
Agents causing angioedemaAgents that produce hypertensionHeterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Quinolinic Acid DB01796
small molecule | CAS: 89-00-9

A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS. [PubChem]

Kategori:
PyridinesQuinolinic Acids
Target Protein:
Nicotinate-nucleotide pyrophosphorylase [carboxylating]Nicotinate-nucleotide pyrophosphorylase [carboxylating]
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 79647-29-3

Deskripsi belum tersedia.

Target Protein:
Phenylalanine-4-hydroxylase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Quinupramine Approved DB13246
small molecule | CAS: 31721-17-2

Quinupramine has been approved in France under the brand name Kinupril, as an antidepressant [A175003].

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAntidepressive Agents +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Quinupristin Approved DB01369
small molecule | CAS: 120138-50-3

Quinupristin/dalfopristin is a combination of two antibiotics used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin inh…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Bacterial AgentsAnti-Infective Agents +9
Target Protein:
23S ribosomal RNA50S ribosomal protein L1050S ribosomal protein L22
Waktu Paruh3.1 hours
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 12901–12950 dari 16004
Sebelumnya Halaman 259 / 321 Berikutnya