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17430

Total database: 17430
Struktur (SMILES)
12313 (70.6%)
Target
9368 (53.7%)
Genomik
112 (0.6%)
Referensi
17430 (100.0%)

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Hasil Pencarian (17430)

Halaman 258 / 349
small molecule

Deskripsi belum tersedia.

Target Protein:
Immunoglobulin heavy constant gamma 1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Lactase-like protein
Waktu Paruh-
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Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Immunoglobulin heavy constant gamma 1
Waktu Paruh-
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Genetik -
Parachlorophenol Approved DB13154
small molecule | CAS: 106-48-9

P-chlorophenol is a white crystals with a strong phenol odor. Slightly soluble to soluble in water, depending on the isomer, and denser than water. Noncombustible.

Kategori:
Anti-Infective AgentsAnti-Infective Agents, LocalBenzene Derivatives +4
Target Protein:
Sodium channel protein type 4 subunit alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Paraldehyde Approved DB09117
small molecule | CAS: 123-63-7

Paraldehyde was initially introduced into medical practice in the United Kingdom in 1882 by the Italian physician Vincenzo Cervello. It is classified as a central nervous system (CNS) depressant and has also been found to be an effective anticonvulsant, hypno…

Kategori:
AcetaldehydeAnticonvulsantsCentral Nervous System Agents +4
Waktu ParuhThe mean half life …
Vol. Distribusi-
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Paramethadione Approved DB00617
small molecule | CAS: 115-67-3

Paramethadione is an anticonvulsant in the oxazolidinedione class. It is associated with fetal trimethadione syndrome, which is also known as paramethadione syndrome.

Kategori:
AnticonvulsantsCentral Nervous System DepressantsCytochrome P-450 CYP2C8 Substrates +7
Target Protein:
Voltage-dependent T-type calcium channel subunit alpha-1GVoltage-dependent T-type calcium channel subunit alpha-1I
Waktu Paruh12 to 24 hours (how…
Vol. Distribusi-
Klirens-
Genetik -
Paramethasone DB01384
small molecule | CAS: 53-33-8

A glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes…

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroids +27
Target Protein:
Corticosteroid-binding globulinGlucocorticoid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Paramethasone acetate Approved DB14657
small molecule | CAS: 1597-82-6

Deskripsi belum tersedia.

Kategori:
Fused-Ring CompoundsPregnadienesPregnadienetriols +3
Waktu Paruh-
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Paraoxon DB13495
small molecule | CAS: 311-45-5

Deskripsi belum tersedia.

Kategori:
AgrochemicalsAntiglaucoma Preparations and MioticsCholinergic Agents +12
Target Protein:
Carbonic anhydrase 1Cannabinoid receptor 1Acetylcholinesterase +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Parasorbic acid DB14121
small molecule | CAS: 10048-32-5

Sole constituent of "Vogelbeerol" oil obtained by steam distillation of the acidified juice of the ripe berries of the mountain ash.

Waktu Paruh-
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Parathiazine DB15978
small molecule | CAS: 84-08-2

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingSulfur Compounds
Waktu Paruh-
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Genetik -
Parathyroid hormone Approved DB05829
biotech | CAS: 9002-64-6

Parathyroid hormone (PTH) is a single-chain polypeptide composed of 84 amino acids. Available as Preotact, it is an identical form of human recombinant hormome which produced as a fusion protein undergoeing post-translational processing involving the cleava…

Kategori:
Amino Acids, Peptides, and ProteinsCalcium HomeostasisCalcium-Regulating Hormones and Agents +7
Target Protein:
Parathyroid hormone 2 receptorParathyroid hormone/parathyroid hormone-related peptide receptor
Waktu Paruh1.5 hours.
Vol. DistribusiThe volume of distr…
Klirens-
Genetik -
biotech | CAS: 172867-62-8

Parathyroid Hormone-Related Protein 1-36 is under investigation in clinical trial NCT00853723 (Comparison Study of Pthrp and PTH to Treat Osteoporosis).

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsHormones +6
Waktu Paruh-
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Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
AmidesAmino AcidsAmino Acids, Aromatic +5
Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pardoprunox DB12061
small molecule | CAS: 269718-84-5

Pardoprunox has been used in trials studying the treatment of Early Stage Parkinson's Disease and Advanced Stage Parkinson's Disease. Pardoprunox is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
D(2) dopamine receptorD(3) dopamine receptorD(4) dopamine receptor +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Parecoxib Approved DB08439
small molecule | CAS: 198470-84-7

Parecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). As it is injectable, it can be use…

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAnalgesics +18
Target Protein:
Prostaglandin G/H synthase 2Lactotransferrin
Waktu Paruh22 minutes (parecox…
Vol. Distribusi-
Klirens-
Genetik -
Parethoxycaine DB19380
small molecule | CAS: 94-23-5

Parethoxycaine is a local anesthetic that was previously approved in the US.

Waktu Paruh-
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Pargeverine DB15783
small molecule | CAS: 13479-13-5

Deskripsi belum tersedia.

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Pargyline Approved DB01626
small molecule | CAS: 555-57-7

Pargyline is a monoamine oxidase inhibitor with antihypertensive properties.

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAmines +12
Target Protein:
Amine oxidase [flavin-containing] BAmine oxidase [flavin-containing] A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Paricalcitol Approved DB00910
small molecule | CAS: 131918-61-1

Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure.

Kategori:
Anti-Parathyroid AgentsBone Density Conservation AgentsCalcium Homeostasis +16
Target Protein:
Vitamin D3 receptor
Waktu Paruh4 to 6 hours
Vol. Distribusi* 30.8 ± 7.5 L [CKD…
Klirens* 1.49 +/- 0.60 L/h…
Genetik -
biotech | CAS: 2259927-72-3

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector Therapies
Waktu Paruh-
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Paritaprevir Approved DB09297
small molecule | CAS: 1216941-48-8

Paritaprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into ni…

Kategori:
AmidesAmino AcidsAmino Acids, Cyclic +27
Target Protein:
Genome polyproteinGag-Pol polyprotein
Waktu Paruh5.5 hr [FDA Label]
Vol. DistribusiVolume of distribut…
Klirens-
Genetik -
Parkinsonia florida pollen Approved DB11006
biotech

Parkinsonia florida pollen allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
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Klirens-
Genetik -
Parnaparin Approved DB09260
small molecule | CAS: 9005-49-6

Parnaparin is an heparin of low molecular weight with antithrombotic effects.

Kategori:
Agents causing hyperkalemiaAnticoagulantsBlood and Blood Forming Organs +8
Waktu Paruh-
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Paromomycin Approved DB01421
small molecule | CAS: 7542-37-2

An oligosaccharide antibiotic produced by various streptomyces. [PubChem]

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismAmebicides +10
Target Protein:
30S ribosomal protein S1016S ribosomal RNASmall ribosomal subunit protein uS2 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Paroxetine Approved DB00715
small molecule | CAS: 61869-08-7

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. It has a variety of uses, including the treatment of anxiety disorders, major depression, posttraumatic stress disorder, and symptoms of menopause, among others.[T653]…

Kategori:
Agents producing tachycardiaAnticholinergic AgentsAntidepressive Agents +39
Target Protein:
Sodium-dependent serotonin transporterSodium-dependent noradrenaline transporter5-hydroxytryptamine receptor 2A +9
Gen Terkait:
ABCB1 CYP2D6 CYP2D6 +4
Waktu ParuhThe mean eliminatio…
Vol. DistribusiParoxetine has a la…
KlirensThe apparent oral c…
Genetik 7 Varian
PARPI F-18 DB18657
small molecule | CAS: 1883580-48-0

PARPI F-18 is a diagnostic agent under investigation for use in the management of glioblastoma multiforme.

Waktu Paruh-
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Parsaclisib DB14867
small molecule | CAS: 1426698-88-5

Parsaclisib is under investigation in clinical trial NCT03126019 (An Open-Label Study of Parsaclisib in Relapsed or Refractory Follicular Lymphoma (CITADEL-203)).

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsPhosphatidylinositol-3-kinase (Pi3K) inhibitors +1
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Parsatuzumab DB14897
biotech | CAS: 1312797-14-0

Parsatuzumab is under investigation in clinical trial NCT01366131 (Study Evaluating the Safety and Efficacy of MEGF0444A in Combination With Carboplatin, Paclitaxel and Bevacizumab in Patients With Advanced or Recurrent Non-Squamous Non-Small Cell Lung Cancer…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Parsley Approved DB10647
biotech

Parsley allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Parsnip Approved DB10661
biotech

Parsnip allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Parthenolide Approved DB13063
small molecule | CAS: 20554-84-1

Parthenolide has been used in trials studying the diagnostic of Allergic Contact Dermatitis.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Inflammatory Agents +8
Target Protein:
Proto-oncogene c-RelTranscription factor RelBInhibitor of nuclear factor kappa-B kinase subunit beta +3
Waktu Paruh-
Vol. Distribusi-
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Genetik -
PAS-004 DB18611
small molecule

PAS-004 is an allosteric MEK 1/2 inhibitor being developed by Pasithea Therapeutics. It is being investigated for the treatment of neurofibromatosis 1 and Noonan syndrome.

Waktu Paruh-
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PAS219 DB03114
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
Vol. Distribusi-
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Genetik -
PASBN DB03078
small molecule

Deskripsi belum tersedia.

Target Protein:
Proto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pascolizumab DB06560
biotech | CAS: 331243-22-2

Pascolizumab (SB 240683) is a humanized anti-interleukin-4 antibody with therapeutic potential in asthma.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +4
Target Protein:
Interleukin-4
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Pascopyrum smithii pollen Approved DB10719
biotech

Pascopyrum smithii pollen is the pollen of the Pascopyrum smithii plant. Pascopyrum smithii pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityGrass Pollen Allergen ExtractsIncreased Histamine Release +2
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Pasireotide Approved DB06663
small molecule | CAS: 396091-73-9

Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease.

Kategori:
Amino Acids, Peptides, and ProteinsBradycardia-Causing AgentsCytochrome P-450 CYP3A Inhibitors +22
Target Protein:
Somatostatin receptor type 3Somatostatin receptor type 1Somatostatin receptor type 2 +1
Waktu ParuhThe half-life is 12…
Vol. DistribusiPasireotide is wide…
KlirensThe clearance in he…
Genetik -
Paspalum notatum pollen Approved DB10349
biotech

Paspalum notatum pollen is the pollen of the Paspalum notatum plant. Paspalum notatum pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityGrass Pollen Allergen ExtractsIncreased Histamine Release +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Passalora fulva Approved DB10817
biotech

Passalora fulva is a fungus which can provoke allergic reactions. Passalora fulva extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Passiflora incarnata flower Approved DB13974
biotech

Deskripsi belum tersedia.

Kategori:
Central Nervous System DepressantsHerbs and Natural ProductsHypnotics and Sedatives
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PAT-1251 DB16735
small molecule | CAS: 2098884-52-5

PAT-1251 is under investigation in clinical trial NCT04054245 (PAT-1251 in Treating Patients With Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, or Post-essential Thrombocytosis Myelofibrosis).

Waktu Paruh-
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PAT-SM6 DB17406
biotech

Deskripsi belum tersedia.

Waktu Paruh-
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Pateclizumab DB14997
biotech | CAS: 1202526-59-7

Pateclizumab is under investigation in clinical trial NCT01225393 (A Study to Evaluate the Efficacy and Safety of MLTA3698A in Combination With a Disease-Modifying Anti-Rheumatic Drug (DMARD) Compared With Adalimumab in Combination With a DMARD in Patients Wi…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Patent Blue Approved DB13967
small molecule | CAS: 25305-77-5

Patent blue is aniline dye and it is one of the most common dyes used.[A32573] It is a sodium or calcium salt of diethylammonium hydroxide inner salt.[A32574] It has the chemical designation of (4-(alpha-(p-(diethylamino)phenyl)-2,4-disulfobenzylidene)-2,5-cy…

Kategori:
AminesAniline CompoundsColoring Agents +4
Target Protein:
Albumin
Waktu ParuhThe elimination hal…
Vol. DistribusiThis pharmacokineti…
KlirensThis pharmacokineti…
Genetik -
Patidegib DB12655
small molecule | CAS: 1037210-93-7

Patidegib has been investigated for the treatment of Conventional Chondrosarcoma.

Kategori:
Alkaloids
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 2376210-48-7

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector Therapies
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Patiromer Approved DB09263
small molecule | CAS: 1260643-52-4

Patiromer is a powder for suspension in water for oral administration, approved in the U.S. as Veltassa in October, 2015. Patiromer is supplied as patiromer sorbitex calcium which consists of the active moiety, patiromer, a non-absorbed potassium-binding poly…

Kategori:
Cation Exchange ResinsCompounds used in a research, industrial, or household settingMacromolecular Substances +3
Target Protein:
Potassium
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Patisiran Approved DB14582
biotech | CAS: 1420706-45-1

Patisiran is a first in class short interfering RNA for the treatment of patients with polyneuropathy caused by hereditary transthyretin-mediated amyloidosis [L4220]. It is marketed as Onpattro which is formulated as patisiran within a liposome envelope for b…

Kategori:
Antisense Elements (Genetics)Compounds used in a research, industrial, or household settingDecreased RNA Integrity +12
Target Protein:
Transthyretin mRNA
Waktu ParuhPatisiran has a ter…
Vol. DistribusiThe steady state vo…
KlirensThe total body clea…
Genetik -
Patritumab DB12090
biotech | CAS: 1262787-83-6

Patritumab has been used in trials studying the treatment of LUNG CANCER, Solid Tumors, Neoplasms by Site, Head and Neck Neoplasms, and Non-small Cell Lung Cancer, among others.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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