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13591

Total database: 17430
Struktur (SMILES)
10177 (74.9%)
Target
7625 (56.1%)
Genomik
104 (0.8%)
Referensi
13591 (100.0%)

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Hasil Pencarian (13591)

Halaman 256 / 272
biotech

Tribulus terrestris fruit is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
AngiospermsBiological ProductsComplex Mixtures +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tributyltin DB08601
small molecule | CAS: 688-73-3

Deskripsi belum tersedia.

Kategori:
Organometallic CompoundsOrganotin Compounds
Target Protein:
Retinoic acid receptor RXR-alphaNuclear receptor coactivator 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tricaine DB11552
small molecule | CAS: 582-33-2

Tricaine (as tricaine methanesulfonate) is white powder used for anesthesia, sedation, or euthanasia of fish. It is also the only anesthetic licensed in the United States for use in fin fish that are intended for human consumption.

Kategori:
Acids, CarbocyclicAnestheticsBenzene Derivatives +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tricaprylin DB12176
small molecule | CAS: 538-23-8

Tricaprilin has been used in trials studying the supportive care and treatment of Alzheimer's Disease.

Kategori:
Acids, AcyclicAlzheimer Disease, drug therapyCompounds used in a research, industrial, or household setting +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 99-14-9

Deskripsi belum tersedia.

Kategori:
Acids, Acyclic
Target Protein:
Aconitate hydratase, mitochondrial
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tricetin DB08230
small molecule | CAS: 520-31-0

Deskripsi belum tersedia.

Kategori:
AntioxidantsBenzopyransBiological Factors +9
Target Protein:
Serine/threonine-protein kinase pim-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trichlormethiazide Approved DB01021
small molecule | CAS: 133-67-5

A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830)

Kategori:
Antihypertensive AgentsBenzothiadiazinesCardiovascular Agents +13
Target Protein:
Solute carrier family 12 member 3Solute carrier family 12 member 1Sodium/potassium-transporting ATPase subunit alpha-1 +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trichloroacetate Approved DB11152
small molecule | CAS: 76-03-9

Trichloroacetate, or trichloroacetic acid, is a strong acid prepared by the reaction of chlorine with acetic acid in the presence of a suitable catalyst. In clinical chemistry and biochemistry, it is used as a precipitant of macromolecules including proteins,…

Kategori:
AcetatesAcids, AcyclicCaustics +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trichloroethylene Approved DB13323
small molecule | CAS: 79-01-6

Trichloroethylene is a halocarbon commonly used as an industrial solvent, not to be confused with the similar 1,1,1-trichloroethane, also known as chlorothene. It has been sold under a variety of trade names including Trimar and Trilene and used as a volatile…

Kategori:
Agents that produce hypertensionAnestheticsAnesthetics, General +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trichoderma harzianum Approved DB10703
biotech

Trichoderma harzianum is a fungus which can provoke allergic reactions. Trichoderma harzianum extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Triciribine DB12405
small molecule | CAS: 35943-35-2

Triciribine has been used in trials studying the treatment of Leukemia, Ovarian Cancer, HER2/Neu Negative, Breast Adenocarcinoma, and Stage IV Breast Cancer, among others.

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleosides
Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 61966-08-3

Deskripsi belum tersedia.

Kategori:
NaphthalenesNucleic Acids, Nucleotides, and NucleosidesNucleotides
Target Protein:
RAC-gamma serine/threonine-protein kinase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Triclabendazole Approved DB12245
small molecule | CAS: 68786-66-3

Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helmi…

Kategori:
AnthelminticsAnti-Infective AgentsAntihelminthic +34
Target Protein:
CruzipainExcretory Secretory (ES) proteins
Waktu ParuhThe plasma eliminat…
Vol. DistribusiThe apparent volume…
Klirens-
Genetik -
Triclocarban Approved DB11155
small molecule | CAS: 101-20-2

Triclocarban, with the chemical formula C13H9Cl3N2O [L2675] is an antibacterial agent that is particularly effective against Gram-positive bacteria such as *Staphylococcus aureus*. It is a bacteriostatic compound that has been found in antibacterial soaps and…

Kategori:
AmidesAminesAnilides +10
Target Protein:
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Waktu Paruh10 hours [L2680]
Vol. Distribusi-
KlirensAfter a pharmacokin…
Genetik -
Triclofos Approved DB06753
small molecule | CAS: 306-52-5

Deskripsi belum tersedia.

Kategori:
Central Nervous System DepressantsHypnotics and SedativesNervous System +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Triclosan Approved DB08604
small molecule | CAS: 3380-34-5

An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodoran…

Kategori:
Anti-Infective AgentsAnti-Infective Agents, LocalAntiseptics and Disinfectants +11
Target Protein:
Enoyl-[acyl-carrier-protein] reductase [NADH] FabIEnoyl-[acyl-carrier-protein] reductase [NADH]Enoyl-[acyl-carrier-protein] reductase [NADH] FabI +7
Waktu ParuhThe terminal plasma…
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 2433-96-7

Deskripsi belum tersedia.

Kategori:
Fatty AcidsLipids
Target Protein:
Lipase 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tricyclazole DB02891
small molecule | CAS: 41814-78-2

Deskripsi belum tersedia.

Kategori:
Sulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tridecactide DB15687
small molecule | CAS: 22006-64-0

Tridecactide, also known as alpha-corticotropin 1-13, is a deacetylated and deaminated alpha-melanocyte stimulating hormone, which may have antipyretic, anti-inflammatory, and antimicrobial effects.[A203210] Tridecactide, along with [metenkefalin], are under …

Kategori:
Experimental Unapproved Treatments for COVID-19Melanocyte-Stimulating Hormones
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tridolgosir DB02034
small molecule | CAS: 72741-87-8

An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.

Target Protein:
Alpha-mannosidase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 2943-75-1

Deskripsi belum tersedia.

Kategori:
NaphthalenesQuinonesSilicon Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 77-93-0

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicTricarboxylic Acids
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 78-40-0

Deskripsi belum tersedia.

Kategori:
Organophosphorus Compounds
Target Protein:
Parathion hydrolaseCellular tumor antigen p53Parathion hydrolase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 112-27-6

Deskripsi belum tersedia.

Kategori:
AlcoholsCompounds used in a research, industrial, or household settingEthylene Glycols +3
Target Protein:
Acetolactate synthase, catabolicArabinogalactan endo-beta-1,4-galactanasePhosphoserine aminotransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Triethylenetetramine Approved DB06824
small molecule | CAS: 112-24-3

Triethylenetatramine (TETA), also known as trientine, is a potent and selective copper (II)-selective chelator. It is a structural analog of linear polyamine compounds, [spermidine] and [spermine]. TETA was first developed in Germany in 1861 and its chelating…

Kategori:
Alimentary Tract and MetabolismAminesChelating Agents +11
Target Protein:
Carbonic anhydrase 14
Waktu ParuhThe mean terminal h…
Vol. DistribusiTETA is widely dist…
KlirensIn healthy adult vo…
Genetik -
small molecule | CAS: 7360-38-5

Triethylhexanoin is an ingredient of cosmetic products as a fragrant solvent.

Kategori:
Acids, AcyclicCompounds used in a research, industrial, or household settingExcipients +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trifarotene Approved DB12808
small molecule | CAS: 895542-09-3

Trifarotene is a topical retinoid cream used in the treatment of acne vulgaris that was first approved for use in the United States in October 2019.[L9013] Retinoids are a class of medications structurally and functionally analogous to [vitamin A], though lat…

Kategori:
AlkenesAnti-Acne PreparationsAnti-Acne Preparations for Topical Use +11
Target Protein:
Retinoic acid receptor gammaRetinoic acid receptor betaRetinoic acid receptor alpha
Waktu ParuhThe terminal half-l…
Vol. Distribusi-
Klirens-
Genetik -
Trifluoperazine Approved DB00831
small molecule | CAS: 117-89-5

A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic.

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +29
Target Protein:
D(2) dopamine receptorCalmodulin-1Calmodulin-3 +6
Waktu Paruh10-20 hours
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 75-89-8

A non-aqueous co-solvent that serves as tool to study protein folding. It is also used in various pharmaceutical, chemical and engineering applications.

Kategori:
Alcohols
Target Protein:
Alcohol dehydrogenase 1CGTPase HRasAlcohol dehydrogenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, NeutralAmino Acids, Peptides, and Proteins +2
Target Protein:
Methionine--tRNA ligaseMethionine aminopeptidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trifluperidol DB13552
small molecule | CAS: 749-13-3

Deskripsi belum tersedia.

Kategori:
Antipsychotic AgentsButyrophenone DerivativesButyrophenones +11
Target Protein:
Chymase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Triflupromazine Approved DB00508
small molecule | CAS: 146-54-3

A phenothiazine used as an antipsychotic agent and as an antiemetic.

Kategori:
Agents producing tachycardiaAnticholinergic AgentsAntidepressive Agents +26
Target Protein:
D(2) dopamine receptorD(1A) dopamine receptor5-hydroxytryptamine receptor 2B +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trifluridine Approved DB00432
small molecule | CAS: 70-00-8

Trifluridine is a fluorinated pyrimidine nucleoside that is structurally related to [idoxuridine] [A35271]. It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis…

Kategori:
Anti-Infective AgentsAntimetabolitesAntineoplastic Agents +20
Target Protein:
Thymidylate synthaseDNAThymidylate synthase
Waktu ParuhAfter administratio…
Vol. DistribusiFollowing a single …
KlirensFollowing a single …
Genetik -
Triflusal Approved DB08814
small molecule | CAS: 322-79-2

Triflusal is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative. The benefits of this agent are the lack of action over the arachidonic acid pathway, the driven production of nitric oxide and the in…

Kategori:
Acids, CarbocyclicAnticoagulantsAntiplatelet agents +8
Target Protein:
Prostaglandin G/H synthase 1Nuclear factor NF-kappa-B p105 subunitNitric oxide synthase, inducible +1
Waktu ParuhIn the healthy huma…
Vol. DistribusiThe reported volume…
KlirensRenal clearance is …
Genetik -
Trifolium pratense pollen Approved DB15530
biotech

Trifolium pratense pollen allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trigonellamide DB11710
small molecule | CAS: 3106-60-3

Trigonellamide is under investigation in clinical trial NCT01930240 (The Safety of a Hypolipidemic Agent in Healthy Normal Volunteers).

Kategori:
Nicotinic AcidsPyridines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Triheptanoin Approved DB11677
small molecule | CAS: 620-67-7

Triheptanoin is a source of heptanoate fatty acids, which can be metabolized without the enzymes of long chain fatty acid oxidation.[L14612] In clinical trials, patients with long chain fatty acid oxidation disorders (lc-FAODs) treated with triheptanoin are l…

Kategori:
Alimentary Tract and MetabolismCaloric AgentsGlycerides +5
Waktu ParuhDue to multiple pea…
Vol. Distribusi-
KlirensA single dose of 0.…
Genetik -
Trihexyphenidyl Approved DB00376
small molecule | CAS: 144-11-6

Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity.[A229103] Tri…

Kategori:
Agents producing tachycardiaAnti-Dyskinesia AgentsAnti-Parkinson Drugs +8
Target Protein:
Muscarinic acetylcholine receptor M1Beta-3 adrenergic receptorMuscarinic acetylcholine receptor M2 +3
Waktu ParuhThe mean eliminatio…
Vol. Distribusi-
Klirens-
Genetik -
Trilaciclib Approved DB15442
small molecule | CAS: 1374743-00-6

Trilaciclib, or G1T28, is a CDK4 and CDK6 inhibitor, indicated to reduce the incidence of chemotherapy induced myelosuppression in patients before topotecan-containing or platinum and etoposide-containing chemotherapy for extensive stage small cell lung cance…

Kategori:
BCRP/ABCG2 SubstratesCyclin-dependent Kinase 4 InhibitorsCyclin-dependent Kinase 6 Inhibitors +16
Target Protein:
Cyclin-dependent kinase 4Cyclin-dependent kinase 6Cyclin-dependent kinase 9 +3
Waktu ParuhThe mean terminal h…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of tr…
Genetik -
Trilostane Approved DB01108
small molecule | CAS: 13647-35-3

Trilostane is an inhibitor of 3 beta-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome. It was withdrawn from the United States market in April 1994.

Kategori:
Abortifacient AgentsAbortifacient Agents, SteroidalAdrenal Cortex Hormones +20
Target Protein:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 13 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2Estrogen receptor +1
Waktu Paruh8 hours.
Vol. Distribusi-
Klirens-
Genetik -
Trimazosin DB09206
small molecule | CAS: 35795-16-5

Trimazosin is a sympatholytic alpha blocker.

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +7
Target Protein:
Alpha-1D adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trimebutine Approved DB09089
small molecule | CAS: 39133-31-8

Trimebutine is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu opioid agonist effects. It is marketed for the treatment of irritable bowel syndrome (IBS) and lower gastrointestinal…

Kategori:
Acids, CarbocyclicAgents causing hyperkalemiaAgents producing tachycardia +27
Target Protein:
Mu-type opioid receptorVoltage-dependent L-type calcium channelCalcium-activated potassium channel +5
Waktu ParuhThe elimination hal…
Vol. DistribusiTrimebutine is most…
Klirens-
Genetik -
Trimegestone DB13129
small molecule | CAS: 74513-62-5

Trimegestone has been used in trials studying the treatment of Postmenopause.

Kategori:
Fused-Ring CompoundsGenito Urinary System and Sex HormonesNorpregnadienes +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trimesic acid DB08632
small molecule | CAS: 554-95-0

Deskripsi belum tersedia.

Kategori:
Acids, Acyclic
Target Protein:
Hemoglobin subunit alphaHemoglobin subunit beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trimetazidine Approved DB09069
small molecule | CAS: 5011-34-7

Trimetazidine is a piperazine derivative indicated for the symptomatic treatment of stable angina pectoris in patients inadequately controlled or intolerant to first line therapies.[L33015] Trimetazidine has been studied as a treatment for angina pectoris sin…

Kategori:
Cardiac TherapyCardiovascular AgentsPiperazines +1
Target Protein:
3-ketoacyl-CoA thiolase, mitochondrial
Waktu ParuhIn young, healthy s…
Vol. DistribusiThe volume of distr…
KlirensTrimetazidine clear…
Genetik -
Trimethadione Approved DB00347
small molecule | CAS: 127-48-0

An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)

Kategori:
Agents causing hyperkalemiaAnti-epileptic AgentAntiarrhythmic agents +18
Target Protein:
Voltage-dependent T-type calcium channel subunit alpha-1G
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Trimethobenzamide Approved DB00662
small molecule | CAS: 138-56-7

Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is i…

Kategori:
Acids, CarbocyclicAmidesAminoalkyl Ethers +10
Target Protein:
D(2) dopamine receptor
Waktu ParuhThe mean eliminatio…
Vol. Distribusi-
Klirens-
Genetik -
Trimethoprim Approved DB00440
small molecule | CAS: 738-70-5

Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately con…

Kategori:
Agents causing hyperkalemiaAgents Causing Muscle ToxicityAnti-Infective Agents +32
Target Protein:
Dihydrofolate reductaseDihydrofolate reductase
Waktu ParuhTrimethoprim half-l…
Vol. DistribusiTrimethoprim is ext…
KlirensFollowing oral admi…
Genetik -
small molecule | CAS: 13957-55-6

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismDrugs for Functional Gastrointestinal Disorders
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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