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16004

Total database: 17430
Struktur (SMILES)
12010 (75.0%)
Target
9041 (56.5%)
Genomik
112 (0.7%)
Referensi
16004 (100.0%)

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Hasil Pencarian (16004)

Halaman 254 / 321
Pravibismane DB17784
small molecule | CAS: 175880-68-9

Deskripsi belum tersedia.

Kategori:
AlcoholsSulfhydryl CompoundsSulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prazepam Approved DB01588
small molecule | CAS: 2955-38-6

Prazepam is a benzodiazepine that is used in the treatment of anxiety disorders. It is a schedule IV drug in the U.S.

Kategori:
Anti-Anxiety AgentsBenzazepinesBenzodiazepines and benzodiazepine derivatives +14
Target Protein:
Translocator proteinGABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu Paruh36-200 hours
Vol. Distribusi-
Klirens-
Genetik -
Praziquantel Approved DB01058
small molecule | CAS: 55268-74-1

Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic spectrum. Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis.[A263201…

Kategori:
AnthelminticsAnti-Infective AgentsAntihelminthic +12
Target Protein:
Hematopoietic prostaglandin D synthaseSchistosome calcium ion (Ca2+) channels
Waktu ParuhFollowing oral admi…
Vol. DistribusiFollowing a single …
KlirensFollowing a single …
Genetik -
Prazosin Approved DB00457
small molecule | CAS: 19216-56-9

Prazosin is a drug used to treat hypertension. Prazosin is marketed by _Pfizer_ and was initially approved by the FDA in 1988.[L5828] It belongs to the class of drugs known as alpha-1 antagonists. Recently, many studies have evaluated the benefits of thi…

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +16
Target Protein:
Alpha-1A adrenergic receptorAlpha-1B adrenergic receptorAlpha-1D adrenergic receptor +4
Waktu ParuhThe plasma half-lif…
Vol. DistribusiAbout 0.6 L/kg [A17…
KlirensIn patients with co…
Genetik -
Prednicarbate Approved DB01130
small molecule | CAS: 73771-04-7

Prednicarbate is a relatively new topical corticosteroid drug that displays a similar potency as [hydrocortisone]. It is used in the treatment of inflammatory skin diseases, such as atopic dermatitis. It has a favorable benefit-risk ratio, with an inflammator…

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroid Hormone Receptor Agonists +18
Target Protein:
Glucocorticoid receptorSteroid hormone receptor ERR2Estrogen-related receptor gamma +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prednimustine DB12832
small molecule | CAS: 29069-24-7

Prednimustine has been used in trials studying the treatment of Lymphoma.

Kategori:
Alkylating DrugsAntineoplastic AgentsAntineoplastic Agents, Alkylating +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prednisolone Approved DB00860
small molecule | CAS: 50-24-8

Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.[A187463] Prednisolone was granted FDA approval on 21 June 1955.[L9431]

Kategori:
Adrenal Cortex HormonesAdrenalsAgents for Treatment of Hemorrhoids and Anal Fissures for Topical Use +45
Target Protein:
Glucocorticoid receptor
Waktu ParuhPrednisolone has a …
Vol. DistribusiA 0.15mg/kg dose of…
KlirensA 0.15mg/kg dose of…
Genetik -
Prednisolone acetate Approved DB15566
small molecule | CAS: 52-21-1

Prednisolone acetate is a [prednisolone] molecule bound to an acetate functional group by an ester bond.[L9449] Prednisolone acetate was granted FDA approval in 1955.[L9449]

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroids +14
Target Protein:
Glucocorticoid receptor
Waktu ParuhOral prednisolone a…
Vol. DistribusiThe volume of distr…
KlirensData regarding the …
Genetik -
small molecule | CAS: 69164-69-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 2920-86-7

Deskripsi belum tersedia.

Kategori:
Adrenal Cortex HormonesCorticosteroidsCytochrome P-450 CYP3A Inducers +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prednisolone phosphate Approved DB14631
small molecule | CAS: 302-25-0

Prednisolone phosphate is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.[A187463] Prednisolone phosphate was granted FDA Approval on 19 December 1973.[L14144]

Kategori:
Adrenal Cortex HormonesAdrenalsAnti-Inflammatory Agents +30
Target Protein:
Glucocorticoid receptorAnnexin A1
Waktu ParuhThe half life of pr…
Vol. DistribusiThe volume of distr…
Klirens-
Genetik -
Prednisolone tebutate Approved DB14632
small molecule | CAS: 7681-14-3

Deskripsi belum tersedia.

Kategori:
Fused-Ring CompoundsPregnadienesPregnadienetriols +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prednisone Approved DB00635
small molecule | CAS: 53-03-2

A synthetic anti-inflammatory glucocorticoid derived from [cortisone].[A187463] It is biologically inert and converted to [prednisolone] in the liver.[L10502] Prednisone was granted FDA approval on 21 February 1955.[L10496]

Kategori:
Adrenal Cortex HormonesAdrenalsAlimentary Tract and Metabolism +45
Target Protein:
Glucocorticoid receptor
Waktu ParuhPrednisone and its …
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
Prednisone acetate Approved DB14646
small molecule | CAS: 125-10-0

Deskripsi belum tersedia.

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsAntineoplastic Agents +17
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prednylidene DB13208
small molecule | CAS: 599-33-7

Prednylidene is an experimental systemic glucocorticoid.

Kategori:
Adrenal Cortex HormonesCorticosteroidsCorticosteroids for Systemic Use +19
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pregabalin Approved DB00230
small molecule | CAS: 148553-50-8

Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter.[A173995] It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions.[A187190] Although as per the FDA Label …

Kategori:
Acids, AcyclicAgents causing angioedemaAmino Acids +24
Target Protein:
Voltage-dependent calcium channel subunit alpha-2/delta-1
Waktu ParuhThe elimination hal…
Vol. DistribusiAfter oral administ…
KlirensIn young healthy su…
Genetik -
Pregnenolone Approved DB02789
small molecule | CAS: 145-13-1

A 21-carbon steroid, derived from cholesterol and found in steroid hormone-producing tissues. Pregnenolone is the precursor to gonadal steroid hormones and the adrenal corticosteroids.

Kategori:
Adrenal Cortex HormonesCytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 Substrates +11
Target Protein:
Steroid hormone receptor ERR1Nuclear receptor subfamily 1 group I member 2Sulfotransferase 2B1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1778-02-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 485818-40-4

Preimplantation factor is under investigation in clinical trial NCT03593460 (Phase II Autoimmune Hepatitis).

Kategori:
Amino Acids, Peptides, and Proteins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Preladenant DB11864
small molecule | CAS: 377727-87-2

Preladenant has been used in trials studying the treatment of Brain Diseases, Parkinson Disease, Movement Disorders, Antipsychotic Agents, and Parkinsonian Disorders, among others.

Target Protein:
Adenosine receptor A2a
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prenalterol DB13777
small molecule | CAS: 57526-81-5

Deskripsi belum tersedia.

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic and Dopaminergic Agents +20
Target Protein:
Beta-3 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prenoxdiazine DB13397
small molecule | CAS: 47543-65-7

Deskripsi belum tersedia.

Kategori:
Cough and Cold Preparations
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prenylamine Approved DB04825
small molecule | CAS: 390-64-7

Prenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias.

Kategori:
Adrenergic AgentsAgents causing hyperkalemiaAmines +19
Target Protein:
Myosin light chain kinase 2, skeletal/cardiac muscleCalmodulin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prephenic acid DB08427
small molecule | CAS: 126-49-8

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicCyclohexanesCycloparaffins
Target Protein:
Chorismate mutase AroH
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Presatovir DB12165
small molecule | CAS: 1353625-73-6

Presatovir has been used in trials studying the treatment of RSV Infection, Respiratory Syncytial Virus (RSV), Respiratory Syncytial Virus Infections, and Respiratory Syncytial Virus (RSV) Infections.

Kategori:
AmidesHeterocyclic Compounds, Fused-RingPyrazoles +2
Target Protein:
Fusion glycoprotein F0
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prethcamide DB13447
small molecule | CAS: 8015-51-8

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicAmino AcidsAmino Acids, Peptides, and Proteins +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pretomanid Approved DB05154
small molecule | CAS: 187235-37-6

Persistent forms of tuberculosis (TB) have proven to be a major cause of global morbidity and mortality and a cause for significant concern. Research in recent years has been geared toward the development of novel therapies that target persistent forms of thi…

Kategori:
Antiinfectives for Systemic UseAntimycobacterialsCytochrome P-450 CYP3A Substrates +7
Target Protein:
Cyclopropane mycolic acid synthase 1Cyclopropane mycolic acid synthase 2Cyclopropane mycolic acid synthase 3 +5
Waktu ParuhThe elimination hal…
Vol. DistribusiA pharmacokinetic m…
KlirensThe clearance of pr…
Genetik -
Previtamin D(3) DB15614
small molecule | CAS: 1173-13-3

Deskripsi belum tersedia.

Kategori:
CholestanesCholestenesFused-Ring Compounds +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prexasertib DB12008
small molecule | CAS: 1234015-52-1

Prexasertib has been used in trials studying the treatment and basic science of mCRPC, Leukemia, Neoplasm, breast cancer, and Ovarian Cancer, among others.

Kategori:
Enzyme InhibitorsProtein Kinase Inhibitors
Target Protein:
Serine/threonine-protein kinase Chk1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prexigebersen DB17320
biotech | CAS: 202484-91-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prezatide DB11296
small molecule | CAS: 49557-75-7

Prezatide is a tripeptide consisting of glycine, histidine, and lysine which readily forms a complex with copper ions [A19503]. Prezatide is used in cosmetic products for the skin and hair. It is known to aid wound healing and its potential applications in ch…

Kategori:
Amino Acids, Peptides, and ProteinsGrowth SubstancesPeptides
Waktu ParuhPrezatide is rapidl…
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 89030-95-5

Prezatide is a tripeptide consisting of glycine, histidine, and lysine which readily forms a complex with copper ions [A19503]. Prezatide is used in cosmetic products for the skin and hair. It is known to aid wound healing and its potential applications in ch…

Kategori:
Amino Acids, Peptides, and ProteinsNuclear Matrix-Associated ProteinsNuclear Proteins +1
Waktu ParuhPrezatide is rapidl…
Vol. Distribusi-
Klirens-
Genetik -
PRG-A01 DB18613
small molecule

PRG-A01 is a novel inhibitor of Cu, Zn-superoxide dismutase (SOD1) misfolding and aggregation.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PRGN-2012 DB18342
biotech

PRGN-2012 is an adenoviral vector expressing human papillomavirus (HPV) 6 and HPV 11 antigens

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PRGN-3006 DB17229
biotech

PRGN-3006 are autologous CD3+ T cells genetically modified using a non-viral system to express a CD33 CAR, membrane-bound interleukin-15, and a truncated form of human HER1T (kill switch) on the cell surface.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PRI-724 DB15034
small molecule | CAS: 1198780-38-9

PRI-724 is under investigation in clinical trial NCT03620474 (Safety and Effectiveness of PRI-724 for Hepatitis C or B Virus Derived Liver Cirrhosis).

Kategori:
Pyrimidines
Target Protein:
CREB-binding protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pridinol DB13642
small molecule | CAS: 511-45-5

Deskripsi belum tersedia.

Kategori:
Central Nervous System DepressantsMuscle RelaxantsMuscle Relaxants, Centrally Acting Agents +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pridopidine DB11947
small molecule | CAS: 346688-38-8

Pridopidine has been used in trials studying the treatment of Huntington's Disease.

Target Protein:
D(2) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prifinium DB13254
small molecule | CAS: 10236-81-4

Prifinium is an antimuscarinic agent with antispasmodic and antiemetic properties. It may be useful for the treatment of irritable bowel syndrome [A175027].

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAnticholinergic Agents +3
Target Protein:
Muscarinic acetylcholine receptor M5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Priliximab DB16920
biotech | CAS: 147191-91-1

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prilocaine Approved DB00750
small molecule | CAS: 721-50-6

A local anesthetic that is similar pharmacologically to lidocaine. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165)

Kategori:
AmidesAminesAnesthetics +11
Target Protein:
Sodium channel protein type 5 subunit alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Primaquine Approved DB01087
small molecule | CAS: 90-34-6

An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas …

Kategori:
AminoquinolinesAnti-Infective AgentsAntibiotics for Pneumocystis Pneumonia +24
Target Protein:
Fe(II)-protoporphyrin IXKeratin, type II cytoskeletal 7Ribosyldihydronicotinamide dehydrogenase [quinone]
Waktu Paruh3.7-7.4 hours
Vol. Distribusi-
Klirens-
Genetik -
Primidone Approved DB00794
small molecule | CAS: 125-33-7

Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures.[L11112] Primidone was developed by J Yule Bogue and H C Carrington in 1949.[A189522] Primidone was granted FDA Approval on 8 Marc…

Kategori:
Anti-epileptic AgentAnticholinergic AgentsAnticonvulsants +36
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-2Gamma-aminobutyric acid receptor subunit alpha-3Gamma-aminobutyric acid receptor subunit alpha-4 +8
Waktu ParuhThe half life of pr…
Vol. DistribusiThe volume of distr…
KlirensPrimidone is cleare…
Genetik -
Prinaberel DB06832
small molecule | CAS: 524684-52-4

Prinaberel is an estrogen receptor beta agonist.

Kategori:
Receptors, Estrogen, agonists
Target Protein:
Estrogen receptor betaNuclear receptor coactivator 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Prinomastat DB05100
small molecule | CAS: 192329-42-3

Prinomastat is a synthetic hydroxamic acid derivative with potential antineoplastic activity. Prinomastat inhibits matrix metalloproteinases (MMPs) (specifically, MMP-2, 9, 13, and 14), thereby inducing extracellular matrix degradation, and inhibiting angioge…

Kategori:
Enzyme InhibitorsMatrix Metalloproteinase InhibitorsProtease Inhibitors
Target Protein:
72 kDa type IV collagenaseInterstitial collagenaseMatrilysin
Waktu Paruh2-5 hours
Vol. Distribusi-
Klirens-
Genetik -
Priralfinamide DB06649
small molecule | CAS: 133865-88-0

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicBenzene DerivativesFatty Acids +4
Target Protein:
Voltage-dependent N-type calcium channel subunit alpha-1B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pristimerin DB17049
small molecule | CAS: 1258-84-0

Pristimerin is a quinone methide triterpenoid researched for its anti-cancer potential.[A253107]

Kategori:
TerpenesTriterpenes
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pristinamycin DB13704
small molecule | CAS: 270076-60-3

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Bacterial AgentsAnti-Infective Agents +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pritelivir DB11844
small molecule | CAS: 348086-71-5

Pritelivir has been used in trials studying the prevention of HSV-2 and Genital Herpes.

Kategori:
AmidesAnti-Infective AgentsAntiviral Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pritumumab DB17221
biotech | CAS: 499212-74-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 12651–12700 dari 16004
Sebelumnya Halaman 254 / 321 Berikutnya