Hasil Filter

16004

Total database: 17430
Struktur (SMILES)
12010 (75.0%)
Target
9041 (56.5%)
Genomik
112 (0.7%)
Referensi
16004 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (16004)

Halaman 251 / 321
PM-060184 DB13137
small molecule | CAS: 960210-99-5

PM060184 has been used in trials studying Solid Tumors.

Kategori:
LactonesPyrans
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
pM-81 DB17432
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PMC-403 DB18132
biotech

PMC-403 is a novel Tie2-activating antibody being investigated for the treatment of systemic capillary leak syndrome.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PMI-001 DB05730
small molecule

PMI-001 is a stand-alone, disease-modifying, anti-rheumatic drug (DMARD) being developed by Phytomedics Inc. It is an extract of the roots of an undisclosed perennial shrub which interferes with the production of IL-2 and COX-2 proteins, for the potential tre…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Alanine racemase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PMX-205 DB17938
small molecule | CAS: 514814-49-4

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsPeptidesReceptor, Anaphylatoxin C5a, antagonists & inhibitors
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PN0621 DB05218
biotech

PN0621 is an anti-TNF, domain antibody (dAb) based therapeutic. It targets tumour necrosis factor (TNF) to treat auto-immune inflammatory diseases such as rheumatoid arthritis. It is being developed by Peptech.

Target Protein:
Tumor necrosis factor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PNT001 DB18375
biotech

PNT001 is a humanized IgG4 S228P monoclonal antibody targeting the cis conformation of the phosphorylated Thr231-Pro232 motif in tau.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PNU-142721 DB08414
small molecule | CAS: 185220-03-5

Deskripsi belum tersedia.

Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pocapavir DB17736
small molecule | CAS: 146949-21-5

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsAntiviral AgentsBenzene Derivatives +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pociredir DB18070
small molecule | CAS: 2490676-18-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Podofilox Approved DB01179
small molecule | CAS: 518-28-5

A lignan found in podophyllin resin from the roots of podophyllum plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to…

Kategori:
Antimitotic AgentsAntineoplastic Agents, PhytogenicAntiviral Agents +11
Target Protein:
DNA topoisomerase 2-betaTubulin alpha-4A chainTubulin beta chain +1
Waktu Paruh1.0 to 4.5 hours.
Vol. Distribusi-
Klirens-
Genetik -
Podophyllin Approved DB09094
small molecule | CAS: 9000-55-9

Podophyllin is a resin extracted from the roots of _Podophyllum peltatum_ (American mandrake) and _Podophyllum emodi_, which contains numerous compounds, amongst which is podophyllin (as well as the drug [podophyllotoxin]). Podophyllin is the principal active…

Kategori:
Antineoplastic AgentsAntineoplastic Agents, PhytogenicBiological Products +11
Waktu ParuhNo data available.
Vol. DistribusiNo data available.
KlirensNo data available.
Genetik -
Polaprezinc DB09221
small molecule | CAS: 107667-60-7

Polaprezinc is a chelated form of zinc and L-carnosine. It is a zinc-related medicine approved for the first time in Japan, which has been clinically used to treat gastric ulcers [L1307, L1308]. It was determined that polaprezinc may be effective in pressure…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Ulcer AgentsDipeptides +10
Target Protein:
Tumor necrosis factorInterleukin-6Interleukin-3 +5
Waktu ParuhThe half-life of po…
Vol. Distribusi-
Klirens-
Genetik -
Polatuzumab vedotin Approved DB12240
biotech | CAS: 1313206-42-6

Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells.[L6658] The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody speci…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +22
Target Protein:
B-cell antigen receptor complex-associated protein beta chain
Waktu ParuhThe terminal half-l…
Vol. DistribusiThe estimated centr…
KlirensThe predicted clear…
Genetik -
Poldine DB13507
small molecule | CAS: 596-50-9

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAgents producing tachycardiaAlimentary Tract and Metabolism +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Policresulen DB13492
small molecule | CAS: 101418-00-2

Deskripsi belum tersedia.

Kategori:
Antiseptics and DisinfectantsBenzene DerivativesDermatologicals +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Polidocanol Approved DB06811
small molecule | CAS: 9002-92-0

Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins (varicose veins ?1 mm in diameter) and uncomplicated reticular veins (varicose veins 1 to 3 mm in diameter) in the lower extremity. It is marketed under the brand names Asclera an…

Kategori:
AlcoholsAntivaricose TherapyCardiovascular Agents +18
Waktu ParuhThe half-life is ap…
Vol. DistribusiWhen given intraven…
KlirensSytemic clearance w…
Genetik -
Polifeprosan 20 DB16298
small molecule | CAS: 90409-78-2

Polifeprosan 20 is under investigation in clinical trial NCT00003878 (Carmustine Implants in Treating Patients With Brain Metastases).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Poliglusam DB11234
small molecule | CAS: 9012-76-4

Poliglusam, or chitosan, is a linear polysaccharide consisting of D-glucosamine and N-acetyl-D-glucosamine. Naturally-occuring poliglusam is found in the cell walls of fungi, soil and sediments where it is produced from degradation of chitin induced by certai…

Kategori:
Anticholesteremic AgentsBiocompatible MaterialsBiopolymers +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Polihexanide Approved DB12277
small molecule | CAS: 28757-47-3

Polihexanide has been used in trials studying the treatment, prevention, and supportive care of Caries, Neoplasm, Skin Diseases, Nail Diseases, and Dental Plaque, among others.

Kategori:
AmidinesAnti-Infective AgentsAntiseptics and Disinfectants +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Poliovirus type 2 antigen is a suspension of poliovirus Type 2 (MEF-1) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 2. The vaccine contains purified…

Kategori:
Actively Acquired ImmunityInactivated Poliovirus Vaccine
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Polmacoxib DB12399
small molecule | CAS: 301692-76-2

Polmacoxib has been used in trials studying the treatment of Osteoarthritis, Osteoarthritis, Hip, Osteoarthritis, Knee, Localized Primary Osteoarthritis of Hip, and Localized Primary Osteoarthritis of Knee.

Kategori:
AmidesAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-Steroidal +8
Target Protein:
Prostaglandin G/H synthase 2Carbonic anhydrase 1Carbonic anhydrase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Poloxalene DB11451
small molecule | CAS: 691397-13-4

Ethylene oxide/propylene oxide copolymer is used as a food additive. It belongs to the family of Epoxides. These are compounds containing a cyclic ether with three ring atoms (one oxygen and two carbon atoms).

Kategori:
AlcoholsAnti-Infective AgentsCompounds used in a research, industrial, or household setting +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Poloxamer 188 Approved DB11333
small molecule | CAS: 691397-13-4

Poloxamer 188 (P188) is a nonionic block linear copolymer that exhibits rheologic, anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models [A33121]. Composed of two hydrophilic side-chains attached to a hydrophobic ce…

Kategori:
AlcoholsCompounds used in a research, industrial, or household settingEthylene Glycols +9
Waktu ParuhIn humans, P188 has…
Vol. DistribusiThe volume of distr…
KlirensFollowing a 48-hour…
Genetik -
Poloxamer 331 DB17761
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Poloxamer 407 DB11252
small molecule | CAS: 691397-13-4

Poloxamer 407 is a polyoxyethylene polymer and hydrophilic non-ionic surfactant. It consists of a central hydrophobic block of polypropylene glycol that is flanked on each side by polyethylene glycol blocks, both hydrophilic in nature. Poloxamer 407 is used a…

Kategori:
AlcoholsCompounds used in a research, industrial, or household settingEthylene Glycols +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Poloxamine 1304 DB19167
small molecule | CAS: 11111-34-5

Poloxamine 1304 is under investigation in clinical trial NCT00483795 (Pilot Evaluation of Two Multipurpose Solutions in Regards to Corneal Staining).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 26811-96-1

Poly(lactic acid) is under investigation in clinical trial NCT00126308 (Facial Lipoatrophy Trial: Immediate Versus Deferred Injections of Poly-L-Lactic Acid for HIV Facial Lipoatrophy).

Kategori:
Dental ImplantsMacromolecular SubstancesPolymers
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 9003-05-8

Polyacrylamide (crosslinked; 2 mole percent bisacrylamide) is under investigation in clinical trial NCT00629083 (Bulking Agents for the Treatment of Stress Urinary Incontinence in Females).

Kategori:
Biocompatible MaterialsColloidsComplex Mixtures +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 133029-32-0

Deskripsi belum tersedia.

Kategori:
AmidinesGuanidinesPreservatives, Pharmaceutical
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Polycarbophil DB09311
small molecule | CAS: 9003-97-8

Polycarbophil calcium is a synthetic polymer manufactured from the cross-linking of polyacrylic acid with divinyl glycol and a calcium counter-ion. Polycarbophil calcium is a stool stabilizer used to treat constipation. This drug may also be used to help rel…

Kategori:
AntidiarrhealsBulk-Forming LaxativesCompounds used in a research, industrial, or household setting +6
Waktu ParuhCalcium polycarboph…
Vol. DistribusiCalcium polycarboph…
KlirensCalcium polycarboph…
Genetik -
Polydatin Approved DB11263
small molecule | CAS: 27208-80-6

Polydatin, or Piceid, is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of *Picea sitchensis* or *Polygonum cuspidatum*, polydatin may be detected in grape, peanut, hop cones, red win…

Kategori:
Benzene DerivativesBenzylidene CompoundsCarbohydrates +3
Target Protein:
Pyruvate kinase PKM
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Polydextrose DB14836
small molecule | CAS: 68424-04-4

Polydextrose is under investigation in clinical trial NCT02258750 (Assessing a Polydextrose Containing Soup on Food Intake, Appetite and Biomarkers of Satiation and Satiety).

Kategori:
BiopolymersCarbohydratesCompounds used in a research, industrial, or household setting +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Polydioxanone DB14832
small molecule | CAS: 31621-87-1

Polydioxanone is under investigation in clinical trial NCT00998907 (PDS*Plus and Wound Infections After Laparotomy).

Kategori:
Biocompatible MaterialsMacromolecular SubstancesPolyesters +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Polyestradiol phosphate Approved DB09369
small molecule | CAS: 28014-46-2

Polymeric phosphoric acid ester of estradiol.

Kategori:
Antineoplastic and Immunomodulating AgentsEndocrine TherapyEstradiol Congeners +10
Target Protein:
Estrogen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Polyethylene glycol Approved DB09287
small molecule | CAS: 25322-68-3

Polyethylene glycol (PEG) is a synthetic polymer produced via polymerization of ethylene oxide molecules to make joining units of ethylene glycol by an ether linkage.[A190975,A190978] PEGs are water-soluble polymers that can form hydrogen bonds in a ratio of …

Kategori:
AlcoholsAlimentary Tract and MetabolismCompounds used in a research, industrial, or household setting +21
Waktu ParuhFollowing a two-day…
Vol. DistribusiFollowing a two-day…
KlirensThere is limited in…
Genetik -
Polyethylene glycol 300 Approved DB11161
small molecule | CAS: 25322-68-3

Polyethylene glycol 300 (PEG 300) is a water-miscible polyether with an average molecular weight of 300 g/mol. It is a clear viscous liquid at room temperature with non-volatile, stable properties [A33116]. Polyethylene glycols are widely used in biochemistry…

Kategori:
AlcoholsCompounds used in a research, industrial, or household settingEthylene Glycols +3
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
small molecule | CAS: 25322-68-3

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Polyethylene glycol 400 Approved DB11077
small molecule | CAS: 25322-68-3

Polyethylene glycols (PEGs) are products made of condensed ethylene oxide and water that can contain various derivatives and have various functions. Because many PEG types are hydrophilic, they are favorably used as enhancers of penetration, and used heavily …

Kategori:
AlcoholsArtificial TearsCompounds used in a research, industrial, or household setting +8
Target Protein:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1Oxidoreductase HTATIP2
Waktu ParuhGreat than 24h [L17…
Vol. Distribusi-
KlirensIn mice, lease than…
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Polygeline DB15879
biotech | CAS: 66455-30-9

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsBlood SubstitutesHematologic Agents +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 31961-54-3

Deskripsi belum tersedia.

Kategori:
AmidinesFlocculation
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Polymyxin B Approved DB00781
biotech | CAS: 1404-26-8

Polymyxin B was discovered in the 1940s[A176429]. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes[A176426]. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and …

Kategori:
Alimentary Tract and MetabolismAmino Acids, Peptides, and ProteinsAnti-Bacterial Agents +19
Target Protein:
Bacterial outer membraneDihydropteroate synthase
Waktu ParuhIn one study the ha…
Vol. Distribusi1 compartment model…
Klirens1 compartment model…
Genetik -
small molecule | CAS: 81859-24-7

Polyquaternium-10 is a quaternized hydroxyethyl cellulose and a polycationic polymer. It is commonly found in cosmetics and personal care products to mainly reduce static electricity and form films.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Polysilicone-15 Approved DB11271
small molecule | CAS: 207574-74-1

Polysilicone-15 is a silicone based UVB absorber [L2796, L2797, L2799, F87, F88, F89]. The compound is a colorless to pale yellow viscous liquid which is soluble in organic solvents of medium polarity and insoluble in water [L2796, L2797, L2799, F87, F88, F89…

Kategori:
Sunscreen Agents
Waktu ParuhPolysilicone-15 is …
Vol. DistribusiPolysilicone-15 is …
KlirensPolysilicone-15 is …
Genetik -
Polysorbate 20 Approved DB11178
small molecule | CAS: 9005-64-5

Polysorbate 20 is a polysorbate-type nonionic surfactant used in many commercial, household and pharmaceutical products. It is composed of 20 repeated units of polyethylene glycol via ethoxylation. Polysorbate 20 is a wetting agent in food products, as well a…

Kategori:
AlcoholsCompounds used in a research, industrial, or household settingEthylene Glycols +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Polysorbate 60 DB14153
small molecule | CAS: 9005-67-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 12501–12550 dari 16004
Sebelumnya Halaman 251 / 321 Berikutnya