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13591

Total database: 17430
Struktur (SMILES)
10177 (74.9%)
Target
7625 (56.1%)
Genomik
104 (0.8%)
Referensi
13591 (100.0%)

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Hasil Pencarian (13591)

Halaman 250 / 272
small molecule | CAS: 68-11-1

Thioglycolic acid is under investigation in clinical trial NCT03238105 (Treatment of Periorbicular Hyperchromia Comparing 10% Thioglycolic Acid Peeling Versus Pulsed Intense Light).

Kategori:
AcetatesAcids, AcyclicSulfhydryl Compounds +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thiohexam Approved DB14200
small molecule | CAS: 95-33-0

Thiohexam is a rubber cure accelerator. It is also a known allergen and dermatological sensitizer. Sensitivity to Thiohexam may be identified with a clinical patch test.

Kategori:
Cell-mediated ImmunityHeterocyclic Compounds, Fused-RingIncreased Histamine Release +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Glyceraldehyde-3-phosphate dehydrogenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thiopental Approved DB00599
small molecule | CAS: 76-75-5

A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical p…

Kategori:
AnestheticsAnesthetics, GeneralAnesthetics, Intravenous +27
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Gamma-aminobutyric acid receptor subunit alpha-2Gamma-aminobutyric acid receptor subunit alpha-3 +9
Waktu Paruh3-8 hours
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Carbonic anhydrase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thiopropazate DB13557
small molecule | CAS: 84-06-0

Deskripsi belum tersedia.

Kategori:
Antipsychotic AgentsCentral Nervous System DepressantsHeterocyclic Compounds, Fused-Ring +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thioproperazine DB01622
small molecule | CAS: 316-81-4

Thioproperazine is a potent neuroleptic with antipsychotic properties. Thioproperazine has a marked cataleptic and antiapomorphine activity associated with relatively slight sedative, hypothermic and spasmolytic effects. It is virtually without antiserotonin …

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +18
Target Protein:
D(2) dopamine receptorAlpha-1A adrenergic receptorAlpha-1B adrenergic receptor +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 68488-87-9

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicAnions +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thioridazine Approved DB00679
small molecule | CAS: 50-52-2

A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a …

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +37
Target Protein:
D(2) dopamine receptorD(1A) dopamine receptorAlpha-1A adrenergic receptor +3
Waktu Paruh21-25 hours
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 147-93-3

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAlkylmercury CompoundsAnalgesics +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thiosulfuric acid Approved DB09499
small molecule | CAS: 13686-28-7

Thiosulfuric acid is available in its salt forms sodium thiosulfate and sodium thiosulfate pentahydrate. Sodium thiosulfate is part of the World Health Organization’s list of essential medicines, and it has a variety of industrial uses, including food preserv…

Kategori:
AcidsAnti-Infective AgentsAntidotes +14
Waktu ParuhThe half-life of th…
Vol. DistribusiThiosulfate has a m…
KlirensIn patients with fu…
Genetik -
Thiothixene Approved DB01623
small molecule | CAS: 3313-26-6

A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.

Kategori:
Antidepressive AgentsAntipsychotic AgentsAntipsychotic Agents (First Generation [Typical]) +29
Target Protein:
D(2) dopamine receptorD(1A) dopamine receptor5-hydroxytryptamine receptor 2A
Waktu Paruh10-20 hours
Vol. Distribusi-
Klirens-
Genetik -
Thiram Approved DB13245
small molecule | CAS: 137-26-8

Thiram may be used in dermatology as a scabicide [T436]. Thiram is mainly used as a fungicide for plants and treatment for seeds, however, this use is being investigated for safety in many markets including Canada [L5425].

Kategori:
Acids, AcyclicAgrochemicalsAntiparasitic Products, Insecticides and Repellents +16
Target Protein:
Tyrosine-protein kinase JAK2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
THK-5351 DB19222
small molecule | CAS: 1707147-26-9

Deskripsi belum tersedia.

Kategori:
AminesFluorine RadioisotopesHeterocyclic Compounds, Fused-Ring +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
THK-5351 F-18 DB19223
small molecule | CAS: 1707148-68-2

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thonzonium Approved DB09552
small molecule | CAS: 25466-36-8

Thonzonium is a monocationic surface-active agent with surfactant and detergent properties. It is widely used as an additive to in ear and nasal drops to enhance dispersion and penetration of cellular debris and exudate, thereby promoting tissue contact of th…

Kategori:
AminesAmmonium CompoundsNitrogen Compounds +2
Target Protein:
V-type proton ATPase subunit C 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thonzylamine Approved DB11235
small molecule | CAS: 91-85-0

Thonzylamine is an antihistamine and anticholinergic drug. It is available as combination products with [DB04837] or [DB00388] for temporary relief of symptoms of common cold, hay fever (allergic rhinitis) or other upper respiratory allergies.

Kategori:
Agents producing tachycardiaAntiallergic Agents, Excl. CorticosteroidsAnticholinergic Agents +11
Target Protein:
Histamine H1 receptorMuscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M2 +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
THR-184 DB19097
biotech | CAS: 930274-80-9

THR-184 is under investigation in clinical trial NCT01830920 (A Study of THR-184 in Patients at Risk of Developing Cardiac Surgery Associated-acute Kidney Injury (CSA-AKI)).

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 6061-13-8

Deskripsi belum tersedia.

Target Protein:
Methylaspartate ammonia-lyase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Threonic acid DB14228
small molecule | CAS: 3909-12-4

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Threonine Approved DB00156
small molecule | CAS: 72-19-5

An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.

Kategori:
Amino AcidsAmino Acids, EssentialAmino Acids, Neutral +5
Target Protein:
Threonine--tRNA ligase 1, cytoplasmicThreonine--tRNA ligase, mitochondrialBeta-lactamase Toho-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thrombin Approved DB11300
biotech

Also known as coagulation factor II, thrombin is a serine protease that plays a physiological role in regulating hemostasis and maintaining blood coagulation. Once converted from prothrombin, thrombin converts fibrinogen to fibrin, which, in combination with …

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood and Blood Forming Organs +18
Target Protein:
Coagulation factor XICoagulation factor XIII A chainCoagulation factor XIII B chain +7
Waktu ParuhUnfortunately, litt…
Vol. DistribusiLittle has been rep…
KlirensAlthough little has…
Genetik -
Thrombin alfa Approved DB11572
biotech | CAS: 869858-13-9

Thrombin Alfa is a human coagulation protein produced via recombinant DNA technology from a genetically modified CHO cell line. Thrombin Alfa is identical in amino acid sequence and structurally similar to naturally occurring human thrombin. Thrombin Alfa pre…

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood Coagulation Factors +12
Target Protein:
Coagulation factor VCoagulation factor VIIIFibrinogen alpha chain +2
Waktu ParuhFollowing intraveno…
Vol. DistribusiTraditional absorpt…
KlirensTraditional absorpt…
Genetik -
Thrombomodulin Alfa Approved DB05777
biotech | CAS: 120313-91-9

Thrombomodulin Alfa is a novel, recombinant and soluble thrombomodulin (ART-123). It is a human protein with both thrombin inhibiting and protein C stimulating activities, for the potential treatment of thromboembolism and blood clotting disorders, such as di…

Kategori:
Amino Acids, Peptides, and ProteinsCarbohydratesGlycoconjugates +7
Target Protein:
ProthrombinCoagulation factor V
Waktu Paruh2–3 days after sc i…
Vol. Distribusi-
Klirens7-10 days
Genetik -
Thrombopoietin DB06534
biotech | CAS: 9014-42-0

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsCarbohydrates +9
Target Protein:
Thrombopoietin receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thymalfasin DB04900
biotech | CAS: 62304-98-7

Thymalfasin is a chemically synthesized version of thymosin alpha 1 that is identical to human thymosin alpha 1. Thymosin alpha 1 is an acetylated polypeptide. Thymosin alpha 1 is now approved in 35 developing countries for the treatment of Hepatitis B and C.…

Kategori:
Adjuvants, ImmunologicAmino Acids, Peptides, and ProteinsAntineoplastic Agents +7
Waktu ParuhApproximately 2 hou…
Vol. Distribusi-
Klirens-
Genetik -
Thyme Approved DB10983
biotech

Thyme allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thyme oil DB16610
biotech | CAS: 8007-46-3

Deskripsi belum tersedia.

Kategori:
AngiospermsBenzene DerivativesBiological Products +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thymectacin DB05116
small molecule | CAS: 232925-18-7

Thymectacin, a phosphoramidate derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine, is a novel small molecule anticancer agent. Thymectacin is selectively active against tumor cells expressing high levels of thymidylate synthase (TS), a critical enzyme in DNA …

Kategori:
DeoxyribonucleosidesDeoxyuridineNucleic Acids, Nucleotides, and Nucleosides +4
Target Protein:
Thymidylate synthaseThymidylate synthase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 365-08-2

Deskripsi belum tersedia.

Kategori:
DeoxyribonucleotidesNucleic Acids, Nucleotides, and NucleosidesNucleotides +2
Target Protein:
DNA polymerase catalytic subunitGag-Pol polyproteinThymidine kinase, cytosolic +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 365-07-1

5-Thymidylic acid. A thymine nucleotide containing one phosphate group esterified to the deoxyribose moiety.

Kategori:
DeoxyribonucleotidesNucleic Acids, Nucleotides, and NucleosidesNucleotides +3
Target Protein:
Thymidylate synthaseThymidine kinase, cytosolicThymidylate kinase +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
DNA topoisomerase 1Thermonuclease
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Nucleoside diphosphate kinase A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
dTDP-glucose 4,6-dehydrataseDTDP-4-dehydrorhamnose 3,5-epimerase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
DNA polymerase I
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thymine DB03462
small molecule | CAS: 65-71-4

Deskripsi belum tersedia.

Kategori:
PyrimidinesPyrimidinones
Target Protein:
Thymidine phosphorylaseDeoxyribodipyrimidine photo-lyaseThymidine phosphorylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thymol Approved DB02513
small molecule | CAS: 89-83-8

A phenol obtained from thyme oil or other volatile oils. It is used as a stabilizer in pharmaceutic preparations. It has been used for its antiseptic, antibacterial, and antifungal actions, and was formerly used as a vermifuge. (Dorland, 28th ed)

Kategori:
Anti-Infective AgentsAnti-Infective Agents, LocalAntifungal Agents +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thymoquinone DB16447
small molecule | CAS: 490-91-5

Thymoquinone is a natural compound with widespread protective effects, including anti-oxidative, anti-inflammatory, immunomodulatory, anti-cancer, and anti-microbial.

Kategori:
Experimental Unapproved Treatments for COVID-19Quinones
Target Protein:
Cellular tumor antigen p53Apoptosis regulator Bcl-2Apoptosis regulator BAX
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thymosin beta-4 DB12003
biotech | CAS: 77642-24-1

Thymosin Beta 4 has been investigated for the treatment of STEMI, Dry Eye, Diabetes, Pressure Ulcers, and Dry Eye Syndrome, among others.

Kategori:
Amino Acids, Peptides, and ProteinsHormonesHormones, Hormone Substitutes, and Hormone Antagonists +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thyroglobulin Approved DB01584
biotech | CAS: 9010-34-8

Thyroglobulin (also known as Tg) is an enzyme thyroid hormone used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). The active form of thyroxine, triiodothyronine, is produced both within the thyroid gland and per…

Kategori:
Amino Acids, Peptides, and ProteinsCarbohydratesGlobulins +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thyroid, porcine Approved DB09100
biotech

Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since…

Kategori:
Agents used to treat hypothyroidismThyroid Products
Target Protein:
Thyroid hormone receptor alphaThyroid hormone receptor beta
Waktu ParuhData regarding the …
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
Thyrotropin DB15263
biotech | CAS: 9002-71-5

Thyrotropin is under investigation in clinical trial NCT01348191 (Detection of Thyrotrophin Receptor in Human Myometrium).

Kategori:
Amino Acids, Peptides, and ProteinsDiagnostic AgentsHormones +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Thyrotropin alfa Approved DB00024
biotech | CAS: 194100-83-9

Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who …

Kategori:
Agents used to treat hypothyroidismAnterior Pituitary Lobe Hormones and AnaloguesHormones +7
Target Protein:
Thyrotropin receptor
Waktu Paruh25 ± 10 hours
Vol. Distribusi-
Klirens-
Genetik -
Tiadenol DB13348
small molecule | CAS: 6964-20-1

Deskripsi belum tersedia.

Kategori:
AlcoholsHypolipidemic AgentsLipid Modifying Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tiagabine Approved DB00906
small molecule | CAS: 115103-54-3

Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a se…

Kategori:
Anti-epileptic AgentAnticonvulsantsCentral Nervous System Agents +15
Target Protein:
Sodium- and chloride-dependent GABA transporter 1
Waktu Paruh7-9 hours
Vol. Distribusi-
Klirens* 109 mL/min [Healt…
Genetik -
Tianeptine DB09289
small molecule | CAS: 72797-41-2

Tianeptine is a drug used primarily in the treatment of major depressive disorder and has been studied in the treatment of irritable bowel syndrome (IBS) [A31983]. Structurally, it is classified as a tricyclic antidepressant (TCA), however, it possesses diffe…

Kategori:
Agents Causing Muscle ToxicityAgents that produce hypertensionAgents that reduce seizure threshold +20
Target Protein:
Mu-type opioid receptorSodium-dependent serotonin transporterGlutamate receptor 1 +2
Waktu ParuhApproximately 2.5 h…
Vol. Distribusi0.8 L/kg (0.77 +/- …
KlirensRapidly cleared by …
Genetik -
Tiapride DB13025
small molecule | CAS: 51012-32-9

Tiapride is a selective D2 and D3 dopamine receptor blocker in the brain.

Kategori:
Acids, CarbocyclicAminesAntipsychotic Agents +16
Target Protein:
Sodium channel protein type 10 subunit alphaD(2) dopamine receptorD(3) dopamine receptor +3
Waktu Paruh2.9–3.6 hours
Vol. DistribusiTiapride distribute…
Klirens16.6 l/h.
Genetik -
Tiaprofenic acid Approved DB01600
small molecule | CAS: 33005-95-7

Tiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly arthritis pain. It belongs to the _arylpropionic acid_ (profen) group of nonsteroidal anti-inflammatory drugs (NSAIDs).

Kategori:
Acids, AcyclicAgents causing hyperkalemiaAgents that produce hypertension +20
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2
Waktu Paruh1.5-2.5 hours
Vol. Distribusi-
Klirens-
Genetik -
Tiazofurine DB13243
small molecule | CAS: 60084-10-8

Tiazofurine has potential clinical use in cancer treatment as it is a potential inhibitor of Inosine- 5’-monophosphate (IMP) dehydrogenase [A174991].

Kategori:
AntimetabolitesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +5
Target Protein:
Inosine-5'-monophosphate dehydrogenase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 54663-47-7

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAntiinfectives and Antiseptics for Local Oral TreatmentStomatological Preparations
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 12451–12500 dari 13591
Sebelumnya Halaman 250 / 272 Berikutnya