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12560

Total database: 17430
Struktur (SMILES)
9109 (72.5%)
Target
6912 (55.0%)
Genomik
109 (0.9%)
Referensi
12560 (100.0%)

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Hasil Pencarian (12560)

Halaman 249 / 252
Zelpultide alfa DB18587
biotech | CAS: 2245003-06-7

Zelpultide alfa is a recombinant human surfactant protein D.

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Zelquistinel DB19336
small molecule | CAS: 2151842-64-5

Zelquistinel is under investigation in clinical trial NCT06547489 (GATE-251 or Placebo for the Reduction of Symptoms of Major Depressive Disorder).

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Zeluvalimab DB18868
biotech | CAS: 2315361-37-4

Zeluvalimab is under investigation in clinical trial NCT04631601 (Safety and Efficacy of Therapies for Metastatic Castration-resistant Prostate Cancer (Mcrpc)).

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Zemirciclib DB18823
small molecule | CAS: 2057509-72-3

Deskripsi belum tersedia.

Target Protein:
Cyclin-dependent kinase 9
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Zenocutuzumab Approved DB15559
biotech | CAS: 1969309-56-5

Zenocutuzumab is under investigation in clinical trial NCT03321981 (MCLA-128 With Trastuzumab/chemotherapy in HER2+ and With Endocrine Therapy in ER+ and Low HER2 Breast Cancer).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +8
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Zeranol DB11478
small molecule | CAS: 26538-44-3

Zeranol is a non-steroidal estrogen agonist. It is a mycotoxin, derived from fungi in the Fusarium family, and may be found as a contaminant in fungus-infected crops. It is 3-4x more potent as an estrogen agonist than the related compound zearalenone.

Kategori:
Benzene DerivativesEstrogensEstrogens, Non-Steroidal +6
Target Protein:
Estrogen receptorSex hormone-binding globulin
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Zetomipzomib DB16070
small molecule | CAS: 1629677-75-3

Zetomipzomib is under investigation in clinical trial NCT04033926 (A Phase 2 Study of KZR-616 to Evaluate Safety and Efficacy in Patients With Active Polymyositis or Dermatomyositis).

Kategori:
Oxazines
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Ziconotide Approved DB06283
biotech | CAS: 107452-89-1

Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail _Conus magus_ comprising 25 amino acids with three disulphide bonds.[A202835, L13389] Other such peptides, collectively termed conotoxins, exist, and some have shown effica…

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAntiarrhythmic agents +22
Target Protein:
Voltage-dependent N-type calcium channel subunit alpha-1BVoltage-dependent P/Q-type calcium channel subunit alpha-1A
Waktu ParuhIn patients adminis…
Vol. DistribusiIn patients adminis…
KlirensZiconotide CSF clea…
Genetik -
Zicronapine DB12188
small molecule | CAS: 170381-16-5

Zicronapine has been used in trials studying the treatment of Schizophrenia.

Target Protein:
D(2) dopamine receptorD(1A) dopamine receptor5-hydroxytryptamine receptor 2A
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Zidovudine Approved DB00495
small molecule | CAS: 30516-87-1

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compoun…

Kategori:
Agents Causing Muscle ToxicityAnti-HIV AgentsAnti-Infective Agents +37
Target Protein:
Receptor-type tyrosine-protein kinase FLT3Reverse transcriptase/RNaseHGag-Pol polyprotein +1
Waktu ParuhElimination half li…
Vol. DistribusiApparent volume of …
Klirens* 0.65 +/- 0.29 L/h…
Genetik -
small molecule | CAS: 106060-89-3

Deskripsi belum tersedia.

Kategori:
DeoxyribonucleosidesDeoxyribonucleotidesDideoxynucleosides +6
Target Protein:
Nucleoside diphosphate kinase A
Waktu Paruh-
Vol. Distribusi-
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small molecule | CAS: 29706-85-2

Deskripsi belum tersedia.

Kategori:
DeoxyribonucleosidesDeoxyribonucleotidesDideoxynucleosides +6
Target Protein:
Thymidylate kinaseThymidylate kinase
Waktu Paruh-
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Zifibancimig DB19332
biotech | CAS: 2517939-46-5

Zifibancimig is under investigation in clinical trial NCT04567303, focusing on participants with neovascular age-related macular degeneration.

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Ziftomenib DB17171
small molecule | CAS: 2134675-36-6

Deskripsi belum tersedia.

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Zigakibart DB18892
biotech | CAS: 2642175-46-8

Zigakibart is under investigation in clinical trial NCT05852938 (A Study of BION-1301 in Adults With Iga Nephropathy).

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biotech | CAS: 2220231-04-7

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector Therapies
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Zilebesiran DB18929
biotech | CAS: 2380166-33-4

Zilebesiran is under investigation in clinical trial NCT06272487 (Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3)).

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Zileuton Approved DB00744
small molecule | CAS: 111406-87-2

Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These …

Kategori:
Agents to Treat Airway DiseaseAmidesAnalgesics +19
Target Protein:
Polyunsaturated fatty acid 5-lipoxygenase
Waktu Paruh2.5 hours
Vol. Distribusi* 1.2 L/kg
Klirens* Apparent oral cl=…
Genetik -
Zilganersen DB18161
biotech | CAS: 2305355-56-8

Deskripsi belum tersedia.

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Zilovertamab DB18403
biotech | CAS: 2485779-13-1

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
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biotech | CAS: 2376463-48-6

Zilovertamab vedotin is an Antibody-drug conjugate (ADC) comprising an anti-ROR1 monoclonal antibody (UC-961), a proteolytically cleavable maleimidocaproyl-valine-citrulline-para-aminobenzoate linker (mc-vc-PAB), and a monomethyl auristatin E (MMAE) cytotoxin.

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Zilpaterol DB11479
small molecule | CAS: 119520-05-7

Zilpaterol is a ?2 adrenergic agonist sold under the trade name, Zilmax, produced by Intervet, a subsidiary of Merck & Co. Zilpaterol is typically fed to cattle in the last three to six weeks of life with a brief washout period to clear the drug from the tiss…

Kategori:
Heterocyclic Compounds, Fused-RingOrganosilicon CompoundsReceptors, Adrenergic, beta
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Ziltivekimab DB18836
biotech | CAS: 2226654-05-1

Ziltivekimab is under investigation in clinical trial NCT06200207 (A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
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Zilucoplan Approved DB15636
small molecule | CAS: 1841136-73-9

Zilucoplan is a 15 amino-acid, synthetic macrocyclic peptide. It is a complement inhibitor that works to prevent the activation of C5, which is a complement protein involved in the innate immune system to initiate inflammatory responses.[A261841] On October 1…

Kategori:
Amino Acids, Peptides, and ProteinsAntineoplastic and Immunomodulating AgentsBlood Proteins +5
Target Protein:
Complement C5
Waktu ParuhThe mean plasma ter…
Vol. DistribusiThe mean volume of …
KlirensNo information is a…
Genetik -
Zilurgisertib DB18152
small molecule | CAS: 2173389-57-4

Deskripsi belum tersedia.

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Zimberelimab DB17505
biotech | CAS: 2259860-24-5

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
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Zimelidine Approved DB04832
small molecule | CAS: 56775-88-3

Zimelidine has been banned worldwide due to serious, sometimes fatal, cases of central and/or peripheral neuropathy known as Guillain-Barré syndrome and due to a peculiar hypersensitivity reaction involving many organs including skin exanthema, flu-like sympt…

Kategori:
Antidepressive AgentsCentral Nervous System DepressantsCytochrome P-450 CYP3A Inhibitors +16
Target Protein:
Sodium-dependent serotonin transporterAmine oxidase [flavin-containing] BAmine oxidase [flavin-containing] A
Waktu Paruh8.4 +/- 2.0 hours f…
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Zinc Approved DB01593
small molecule | CAS: 7440-66-6

A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with…

Kategori:
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical UseDiet, Food, and NutritionElements +12
Target Protein:
B1 bradykinin receptorMethylated-DNA--protein-cysteine methyltransferaseFructose-bisphosphate aldolase A +121
Waktu ParuhThe half-life of zi…
Vol. DistribusiA pharmacokinetic s…
KlirensIn one study of hea…
Genetik -
Zinc acetate Approved DB14487
small molecule | CAS: 557-34-6

Deskripsi belum tersedia.

Kategori:
AcetatesAcids, AcyclicAgents for Treatment of Hemorrhoids and Anal Fissures for Topical Use +7
Target Protein:
B1 bradykinin receptorMethylated-DNA--protein-cysteine methyltransferaseFructose-bisphosphate aldolase A +121
Waktu ParuhThe half-life of zi…
Vol. DistribusiA pharmacokinetic s…
KlirensIn one study of hea…
Genetik -
Zinc ascorbate Approved DB14485
small molecule | CAS: 331242-75-2

Deskripsi belum tersedia.

Kategori:
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical UseMetal cationsMetal divalent cations +6
Waktu Paruh-
Vol. Distribusi-
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Zinc carbonate DB14494
small molecule | CAS: 5263-02-5

Deskripsi belum tersedia.

Kategori:
AlkaliesAnionsCarbon Compounds, Inorganic +7
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Zinc cation DB14532
small molecule | CAS: 23713-49-7

Deskripsi belum tersedia.

Kategori:
Copper Absorption InhibitorDecreased Copper Ion AbsorptionMetal cations +3
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Zinc chloride Approved DB14533
small molecule | CAS: 7646-85-7

Zinc chloride is a solution of ions indicated for use in total parenteral nutrition to maintain zinc levels and prevent deficiency syndromes.[L14189] Zinc chloride was granted FDA approval before 26 June 1986.[L14189]

Kategori:
AcidsAcids, NoncarboxylicAgents for Treatment of Hemorrhoids and Anal Fissures for Topical Use +20
Target Protein:
B1 bradykinin receptorMethylated-DNA--protein-cysteine methyltransferaseFructose-bisphosphate aldolase A +94
Waktu ParuhUsing a two compart…
Vol. Distribusi-
KlirensIn one study of hea…
Genetik -
Zinc citrate DB11154
small molecule | CAS: 546-46-3

Zinc citrate is a zinc salt of citric acid. It is available as dietary supplements as a treatment of zinc deficiency and source of zinc, which is an essential trace element. Zinc citrate demonstrates effective absorption following oral administration [A27280].

Kategori:
Metal cationsMetal divalent cationsZinc Compounds
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small molecule | CAS: 15281-32-0

Deskripsi belum tersedia.

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Zinc gluconate Approved DB11248
small molecule | CAS: 4468-02-4

Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA [L2081]. It is available as a trace mineral supplement and over the cou…

Kategori:
Acids, AcyclicAgents for Treatment of Hemorrhoids and Anal Fissures for Topical UseAlimentary Tract and Metabolism +8
Waktu Paruh280 days [L2091]
Vol. DistribusiStored primarily in…
KlirensPlease refer to Dru…
Genetik -
Zinc glycinate DB14493
small molecule | CAS: 14281-83-5

Glycoprotein marker of gastrointestinal cancer.

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsAntigens +5
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small molecule | CAS: 955009-96-8

Deskripsi belum tersedia.

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Zinc iodide DB15961
small molecule | CAS: 10139-47-6

Deskripsi belum tersedia.

Kategori:
AnionsElectrolytesIodine Compounds +1
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small molecule | CAS: 14354-67-7

Deskripsi belum tersedia.

Kategori:
Biological FactorsCoordination ComplexesHeterocyclic Compounds, Fused-Ring +5
Waktu Paruh-
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small molecule | CAS: 62008-21-3

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicDermatologicalsDicarboxylic Acids
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Zinc orotate DB15720
small molecule | CAS: 60388-02-5

Deskripsi belum tersedia.

Kategori:
PyrimidinesPyrimidinones
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Zinc phenolsulfonate Approved DB15793
small molecule | CAS: 127-82-2

Deskripsi belum tersedia.

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Zinc picolinate DB11175
small molecule | CAS: 17949-65-4

Zinc picolinate is a zinc salt of picolinic acid. It is available as OTC dietary supplements as a source of zinc to treat and prevent zinc deficiency. The absorption of zinc after oral administration of zinc picolinate is shown to be effective.

Kategori:
Compounds used in a research, industrial, or household settingMetal cationsMetal divalent cations +3
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small molecule

Zinc sulfate is a common zinc supplement in parenteral nutrition.[A216916,L12888]

Kategori:
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical UseMetal cationsMetal divalent cations +2
Target Protein:
B1 bradykinin receptorMethylated-DNA--protein-cysteine methyltransferaseFructose-bisphosphate aldolase A +94
Waktu Paruh-
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Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
Metal cationsMetal divalent cationsZinc Compounds
Target Protein:
Glutathione S-transferase Mu 1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Serine protease 1
Waktu Paruh-
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Zingerone DB15589
small molecule | CAS: 122-48-5

Zingerone is a pungent component of ginger.

Kategori:
Benzene DerivativesCatecholsEthers +3
Waktu Paruh-
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Zinlirvimab DB18867
biotech | CAS: 2417213-75-1

Zinlirvimab is under investigation in clinical trial NCT03707977 (Dual Bnab Treatment in Children).

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biotech | CAS: 1387453-03-3

Zinpentraxin alfa is a recombinant form of PTX-2, a naturally circulating human protein. It is under investigation in clinical trial NCT01981850 (A Phase 2 Study Of PRM-151 In Subjects With Myelofibrosis).

Kategori:
Acute-Phase ProteinsAmino Acids, Peptides, and ProteinsAmyloid +7
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