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14063

Total database: 17430
Struktur (SMILES)
10481 (74.5%)
Target
8038 (57.2%)
Genomik
107 (0.8%)
Referensi
14063 (100.0%)

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Halaman 247 / 282
SR-9009 DB14013
small molecule | CAS: 1379686-30-2

SR-9009 is a REV-ERB agonist. SR-9011 has been demonstrated that it is specifically lethal to cancer cells and oncogene-induced senescent cells, including melanocytic naevi, and has no effect on the viability of normal cells or tissues [A32628].

Kategori:
Sulfur Compounds
Target Protein:
Nuclear receptor subfamily 1 group D member 1Nuclear receptor subfamily 1 group D member 2
Waktu Paruh-
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SR-9011 DB14014
small molecule | CAS: 1379686-29-9

SR-9011 is a REV-ERB agonist. SR-9011 has been demonstrated that it is specifically lethal to cancer cells and oncogene-induced senescent cells, including melanocytic naevi, and has no effect on the viability of normal cells or tissues [A32628].

Kategori:
Sulfur Compounds
Target Protein:
Nuclear receptor subfamily 1 group D member 2Nuclear receptor subfamily 1 group D member 1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
SR11254 DB02258
small molecule

Deskripsi belum tersedia.

Target Protein:
Retinoic acid receptor gamma
Waktu Paruh-
Vol. Distribusi-
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SR12813 DB04466
small molecule | CAS: 126411-39-0

Deskripsi belum tersedia.

Target Protein:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseNuclear receptor subfamily 1 group I member 2
Waktu Paruh-
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Sri-9662 DB03060
small molecule

Deskripsi belum tersedia.

Target Protein:
Peptide deformylase, mitochondrialDihydrofolate reductase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SRP 299 DB05440
small molecule

SRP 299 is a preparation of killed Mycobacterium vaccae that has been tested in uses related to inhibiting periodontal disease, in treating asthma and in treating eczema, itching and inflammation. Mycobacterium vaccae is a non-pathogenic, saprophytic bacteria…

Kategori:
Biological ProductsComplex MixturesVaccines
Waktu Paruh-
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SRP-9005 DB17958
biotech

SRP-9005 is a rAAVrh74 vector containing a codon-optimized human SGCG transgene. Developed by the Kurt+Peter Foundation and Sarepta Therapeutics, it is being investigated for the treatment of Limb-girdle muscular dystrophy (LGMD) type 2C/R5.[A260142]

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SRT-1720 DB17057
small molecule | CAS: 925434-55-5

SRT-1720 is an activator of NAD(+)-dependent histone deacetylase SIRT1.[A253147]

Kategori:
Heterocyclic Compounds, Fused-Ring
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SRT-2104 DB12186
small molecule | CAS: 1093403-33-8

SRT2104 has been investigated for the basic science and treatment of Sepsis, PSORIASIS, Atrophy, Muscular, and Diabetes Mellitus, Type 2.

Kategori:
Enzyme ActivatorsHeterocyclic Compounds, Fused-Ring
Target Protein:
NAD-dependent protein deacetylase sirtuin-1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
SRX-1177 DB17126
biotech

Deskripsi belum tersedia.

Waktu Paruh-
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SRX-246 DB16968
small molecule | CAS: 512784-93-9

Deskripsi belum tersedia.

Kategori:
Antidiuretic Hormone Receptor AntagonistsAzetinesNatriuretic Agents
Target Protein:
Vasopressin V1a receptor
Waktu Paruh-
Vol. Distribusi-
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SSR-126517E DB05362
small molecule

SSR-126517E is a second generation synthetic pentasaccharide that binds antithrombin with such high affinity that it assumes a plasma half-life of 80 hours.

Target Protein:
Coagulation factor X
Waktu Paruh-
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ST-003 DB18197
biotech | CAS: 143896-17-7

ST-003 is a novel galanin receptor inhibitor being investigated for the treatment of primary sclerosing cholangitis.

Kategori:
Amino Acids, Peptides, and ProteinsNerve Tissue ProteinsNeuropeptides +2
Waktu Paruh-
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ST-101 DB12621
biotech | CAS: 887603-94-3

ST-101 is a small peptide antagonist of C/EBP? and T-type calcium channel activator. ST101 has been used in trials studying the treatment of Essential Tremor and Alzheimer's Disease.[A260411]

Kategori:
Indenes
Waktu Paruh-
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ST-36 DB17275
biotech

ST-36 is a cell-penetrating dominant-negative form of activating transcription factor 5. In 2017, it received orphan drug designation by the FDA for the treatment of glioma.[L47341]

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St. John's Wort Approved DB01323
biotech | CAS: 84082-80-4

Deskripsi belum tersedia.

Kategori:
AngiospermsAntidepressive AgentsAntidepressive Agents Indicated for Depression +33
Waktu Paruh-
Vol. Distribusi-
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ST101 peptide DB17272
biotech

ST101 is a cell-penetrating peptide that disrupts the protein-protein interactions driving ATF5-regulated gene transcription.

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ST266 DB18614
biotech

ST266 is an amniotic membrane-derived cellular cytokine solution.

Waktu Paruh-
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Stachyose DB19276
small molecule | CAS: 470-55-3

Deskripsi belum tersedia.

Kategori:
CarbohydratesPolysaccharides
Waktu Paruh-
Vol. Distribusi-
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Stamulumab DB05915
biotech | CAS: 705287-60-1

MYO-029 is a human anti-GDF-8 monoclonal antibody, which is being developed to treat muscle-wasting diseases including muscular dystrophy and age-related sarcopenia.

Kategori:
Amino Acids, Peptides, and ProteinsBlood ProteinsGlobulins +4
Target Protein:
Growth/differentiation factor 8
Waktu Paruh-
Vol. Distribusi-
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Stannous chloride Approved DB11056
small molecule | CAS: 7772-99-8

Stannous chloride is used as a source of tin in radiopharmaceutical kits. Tin reduces technetium-99m, the active radiological agent, allowing it to form a complex with phosphate-containing moeities [A32700]. These complexes localize primarily in bone (40-50%)…

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Stannous fluoride Approved DB11092
small molecule | CAS: 7783-47-3

Stannous Fluoride, or Tn(II) Fluoride, is a compound commonly used in toothpastes for the prevention of gingivitis, dental infections, cavities, and to relieve dental hypersensitivity. Although similar in function and activity to Sodium Fluoride (NaF), the co…

Kategori:
Alimentary Tract and MetabolismCaries Prophylactic AgentsCariostatic Agents +6
Waktu ParuhThe half-life for t…
Vol. DistribusiStannous fluoride i…
KlirensStimulated and nons…
Genetik -
Stannsoporfin DB04912
small molecule | CAS: 106344-20-1

Stannsoporfin is a competitive heme oxygenase (HO) inhibitor being developed by InfaCare, a subsidiary of WellSpring Pharmaceuticals, for the prevention of hyperbilirubinemia in infants at risk of developing jaundice.

Kategori:
Biological FactorsCoordination ComplexesEnzyme Inhibitors +4
Target Protein:
Heme oxygenase 1Heme oxygenase 2
Waktu Paruh3.8 hours following…
Vol. Distribusi-
Klirens-
Genetik -
Stanolone DB02901
small molecule | CAS: 521-18-6

A potent androgenic metabolite of testosterone. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure androgenic steroid.

Kategori:
5-Androstanon (3) DerivativesAlimentary Tract and MetabolismAnabolic Agents for Systemic Use +17
Target Protein:
Androgen receptorEstrogen receptorMineralocorticoid receptor +1
Waktu Paruh-
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Stapokibart DB18990
biotech | CAS: 2734715-10-5

Stapokibart is under investigation in clinical trial NCT06424470 (Study on the Treatment of Prurigo Nodularis With Stapokibart Injection).

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Stapuldencel DB19275
biotech

Deskripsi belum tersedia.

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Starch, corn Approved DB11599
small molecule | CAS: 9005-25-8

Corn starch refers to the starch extracted from the corn grain that is commonly used as a food ingredient and chemical additive. Starch is any of a group of polysaccharides of the general formula (C6-H10-O5)n, composed of a long-chain polymer of glucose in th…

Kategori:
BiopolymersCarbohydratesCompounds used in a research, industrial, or household setting +6
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Starch, tapioca Approved DB10913
biotech | CAS: 9005-25-8

Starch, tapioca allergenic extract is used in allergenic testing.

Waktu Paruh-
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Staurosporine DB02010
small molecule | CAS: 62996-74-1

An indolocarbazole that is a potent protein kinase C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)

Kategori:
AlkaloidsCarbazolesEnzyme Inhibitors +6
Target Protein:
Inhibitor of nuclear factor kappa-B kinase subunit betaMuscarinic acetylcholine receptor M1Tyrosine-protein kinase Lck +12
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Stavudine Approved DB00649
small molecule | CAS: 3056-17-5

A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.

Kategori:
Agents Causing Muscle ToxicityAnti-HIV AgentsAnti-Infective Agents +23
Target Protein:
Gag-Pol polyproteinReverse transcriptase/RNaseH
Waktu Paruh0.8-1.5 hours (in a…
Vol. Distribusi* 46 ± 21 L
Klirens* Renal cl=272 mL/m…
Genetik -
small molecule | CAS: 26194-89-8

Deskripsi belum tersedia.

Kategori:
DeoxyribonucleosidesDeoxyribonucleotidesDideoxynucleosides +6
Target Protein:
Nucleoside diphosphate kinase A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Stearyl alcohol DB15953
small molecule | CAS: 112-92-5

Deskripsi belum tersedia.

Kategori:
AlcoholsLipids
Waktu Paruh-
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Stem bromelain Approved DB12249
biotech | CAS: 37189-34-7

The primary therapeutic use for which stem bromelain is currently and formally indicated is as a burn wound eschar debridement agent that has been approved by the EMA since 2012 and marketed under the brand name Nexobrid [FDA Label]. Bromelain itself belon…

Kategori:
Cysteine EndopeptidasesCysteine ProteasesEndopeptidases +4
Waktu ParuhThe estimated plasm…
Vol. DistribusiNo readily accessib…
KlirensNo readily accessib…
Genetik -
Stemphylium sarciniforme Approved DB10702
biotech

Stemphylium sarciniforme is a fungus which can provoke allergic reactions. Stemphylium sarciniforme extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
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Stepronin DB01423
small molecule | CAS: 72324-18-6

Strepronin is a mucolytic drug. A mucolytic agent is any agent which dissolves thick mucus usually used to help relieve respiratory difficulties. The viscosity of mucous secretions in the lungs is dependent upon the concentrations of mucoprotein as well as th…

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsAnions +10
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Steviolbioside Approved DB12434
small molecule | CAS: 41093-60-1

Steviolbioside has been used in trials studying the treatment of HIV-1 Infection.

Kategori:
AlkaloidsCompounds used in a research, industrial, or household settingDiet, Food, and Nutrition +10
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Stevioside DB16882
small molecule | CAS: 57817-89-7

Deskripsi belum tersedia.

Kategori:
AlkaloidsCarbohydratesCompounds used in a research, industrial, or household setting +12
Waktu Paruh-
Vol. Distribusi-
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STF-31 DB16761
small molecule | CAS: 724741-75-7

Deskripsi belum tersedia.

Waktu Paruh-
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Stibophen DB13236
small molecule | CAS: 15489-16-4

Stibophen is used in the treatment of schistosomiasis, a disease of parasitic flatworms.

Kategori:
AnthelminticsAntiparasitic AgentsAntiparasitic Products, Insecticides and Repellents +7
Waktu Paruh-
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Stiripentol Approved DB09118
small molecule | CAS: 49763-96-4

Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's pote…

Kategori:
AnticonvulsantsBCRP/ABCG2 InhibitorsCentral Nervous System Agents +37
Target Protein:
GABA(A) ReceptorGamma-aminobutyric acid receptor subunit gamma-3L-lactate dehydrogenase A chain +1
Waktu ParuhThe elimination hal…
Vol. DistribusiThe average volume …
KlirensPlasma clearance de…
Genetik -
STM-217 DB17358
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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STP-707 DB18499
biotech

STP-707 is a small interfering RNA (siRNA) targeting TGF-Beta1 and COX-2 mRNA.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
biotech

Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of *Streptococcus pneumoniae* serotype 1 individually conjugated to the CRM197 protein,…

Kategori:
Actively Acquired ImmunityInactivated Pneumococcal Vaccine
Waktu Paruh-
Vol. Distribusi-
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Genetik -
biotech

Streptococcus pneumoniae type 10a capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 10a of *Streptococcus pneumoniae*. It is an active immunization for intramuscular or subc…

Kategori:
Actively Acquired ImmunityInactivated Pneumococcal Vaccine
Waktu Paruh-
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Genetik -
biotech

Streptococcus pneumoniae type 12f capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 12f of *Streptococcus pneumoniae*. It is an active immunization for intramuscular or subc…

Kategori:
Actively Acquired ImmunityInactivated Pneumococcal Vaccine
Waktu Paruh-
Vol. Distribusi-
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Genetik -
biotech

Streptococcus pneumoniae type 12F capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of *Streptococcus pneumoniae* serotype 12F individually conjugated to the CRM197 prot…

Kategori:
Inactivated Pneumococcal Vaccine
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biotech

Streptococcus pneumoniae type 14 capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 14 of *Streptococcus pneumoniae*. It is an active immunization for intramuscular or subcut…

Kategori:
Actively Acquired ImmunityInactivated Pneumococcal Vaccine
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of *Streptococcus pneumoniae* serotype 14 individually conjugated to the CRM197 protei…

Kategori:
Actively Acquired ImmunityInactivated Pneumococcal Vaccine
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Streptococcus pneumoniae type 18c capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of *Streptococcus pneumoniae* serotype 18c individually conjugated to the CRM197 prot…

Kategori:
Actively Acquired ImmunityInactivated Pneumococcal Vaccine
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Streptococcus pneumoniae type 19a capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of *Streptococcus pneumoniae* serotype 19A individually conjugated to the CRM197 prot…

Kategori:
Actively Acquired ImmunityInactivated Pneumococcal Vaccine
Waktu Paruh-
Vol. Distribusi-
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Genetik -
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