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16004

Total database: 17430
Struktur (SMILES)
12010 (75.0%)
Target
9041 (56.5%)
Genomik
112 (0.7%)
Referensi
16004 (100.0%)

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Hasil Pencarian (16004)

Halaman 245 / 321
PF-04937319 DB15009
small molecule | CAS: 1245603-92-2

PF-04937319 is under investigation in clinical trial NCT01513928 (A Study To Compare The Pharmacokinetics Of Different Formulations Of PF-04937319 In Healthy Subjects).

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Hexokinase-4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-04958242 DB11843
small molecule | CAS: 1258963-59-5

PF-04958242 has been used in trials studying the basic science and treatment of Schizophrenia and Hearing Loss, Sensorineural.

Kategori:
AmidesSulfonesSulfur Compounds
Waktu Paruh-
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Genetik -
PF-04991532 DB11765
small molecule | CAS: 1215197-37-7

PF-04991532 has been used in trials studying the basic science of Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2, and Glucose Metabolism Disorders.

Kategori:
Enzyme InhibitorsGlucokinase, antagonists & inhibitorsPyridines
Target Protein:
Hexokinase-4
Waktu Paruh-
Vol. Distribusi-
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Genetik -
PF-04995274 DB12675
small molecule | CAS: 1331782-27-4

Pf 04995274 is under investigation in clinical trial NCT01193062 (Study In Healthy Subjects To Evaluate The Changes In The Protein sAPP-Alpha In Cerebrospinal Fluid Following A Single Oral Dose Of PF-04995274).

Target Protein:
5-hydroxytryptamine receptor 4
Waktu Paruh-
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Genetik -
PF-05089771 DB14856
small molecule | CAS: 1235403-62-9

PF-05089771 is under investigation in clinical trial NCT01529671 (A Safety And Tolerability Study Of PF-05089771 In Healthy Subjects And In Subjects With Otseoarthritis Of The Knee).

Kategori:
AmidesBenzene DerivativesEthers +4
Target Protein:
Sodium channel protein type 9 subunit alphaSolute carrier family 22 member 12
Waktu Paruh-
Vol. Distribusi-
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Genetik -
PF-05105679 DB15450
small molecule | CAS: 1398583-31-7

PF-05105679 is under investigation in clinical trial NCT01393652 (Single Dose, Dose Escalation Healthy Volunteers Study Of PF-05105679).

Target Protein:
Transient receptor potential cation channel subfamily M member 8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-05175157 DB12096
small molecule | CAS: 1301214-47-0

PF-05175157 has been used in trials studying the basic science and treatment of Acne Vulgaris, Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes Mellitus Type 2, and Diabetes Mellitus, Type 2, among others.

Target Protein:
Acetyl-CoA carboxylase 2
Waktu Paruh-
Vol. Distribusi-
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PF-05180999 DB14885
small molecule | CAS: 1394033-54-5

PF-05180999 is under investigation in clinical trial NCT01530529 (A Study to Assess the Relative Bioavailability of a Modified-Release Formulation of PF-05180999).

Waktu Paruh-
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PF-05212377 DB16044
small molecule | CAS: 1226793-34-5

PF-05212377 is under investigation in clinical trial NCT01712074 (Study Evaluating Thesafety and Efficacy of PF-05212377 or Placebo in Subjects With Alzheimer's Disease With Existing Neuropsychiatric Symptoms on Donepezil).

Waktu Paruh-
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Genetik -
PF-05230907 DB18417
biotech

PF-05230907 is a recombinant activated Factor X variant.

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood Coagulation Factors +5
Waktu Paruh-
Vol. Distribusi-
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PF-05241328 DB15124
small molecule | CAS: 1387633-03-5

PF-05241328 is under investigation in clinical trial NCT01165736 (To Calculate the Pharmacokinetics (Concentration of Compound in and Rate of Excretion From the Blood) Following a Very Low Dose of Compound Which Will Not Have Any Pharmacological Activity).

Target Protein:
Sodium channel protein type 9 subunit alpha
Waktu Paruh-
Vol. Distribusi-
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Genetik -
PF-06260414 DB15221
small molecule | CAS: 1612755-71-1

PF-06260414 is under investigation in clinical trial NCT02070939 (Study To Evaluate Safety And Tolerability Of Single And Multiple Ascending Doses Of PF- 06260414 In Healthy Western And Japanese Male Subjects).

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Androgen receptor
Waktu Paruh-
Vol. Distribusi-
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Genetik -
PF-06273340 DB12269
small molecule | CAS: 1402438-74-7

Pf 06273340 is under investigation in clinical trial NCT01934738 (A Study to Evaluate Safety, Toleration and Time Course of Plasma Concentration of Multiple Oral Doses of PF-06273340 in Healthy Subjects of Two AgeGroups, Aged 18-55 Years (Group 1) and Aged 56…

Waktu Paruh-
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PF-06282999 DB11683
small molecule | CAS: 1435467-37-0

Pf 06282999 is under investigation in clinical trial NCT01626976 (A Study To Assess The Safety, Tolerability And Pharmacokinetics Of PF-06282999 Administered Orally In Healthy Adult Subjects).

Kategori:
AcetatesAcids, AcyclicAmides +1
Waktu Paruh-
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PF-06291874 DB15065
small molecule | CAS: 1393124-08-7

PF-06291874 is under investigation in clinical trial NCT02175121 (Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Study of PF-06291874 as Oral Monotherapy To Treat Adults With Type 2 Diabetes Mellitus).

Kategori:
AlanineAmino AcidsAmino Acids, Peptides, and Proteins
Target Protein:
Glucagon receptor
Waktu Paruh-
Vol. Distribusi-
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Genetik -
PF-06305591 DB12106
small molecule | CAS: 1449473-97-5

Pf 06305591 is under investigation in clinical trial NCT01776619 (Safety and Tolerability Study of Multiple Doses of PF-06305591).

Waktu Paruh-
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PF-06459988 DB14768
small molecule | CAS: 1428774-45-1

PF-06459988 is under investigation in clinical trial NCT02297425 (A Study For Patients With EGFRm (Epidermal Growth Factor Receptor Mutant) Lung Cancer).

Waktu Paruh-
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PF-06650833 DB15143
small molecule | CAS: 1817626-54-2

PF-06650833 is under investigation in clinical trial NCT02609139 (Study to Evaluate Pharmacokinetics of A Modified Release Formulation of PF-06650833 in Healthy Subjects).

Kategori:
AmidesHeterocyclic Compounds, Fused-Ring
Waktu Paruh-
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Genetik -
PF-06700841 DB15003
small molecule | CAS: 1883299-62-4

PF-06700841 is under investigation in clinical trial NCT03236493 (Safety and Pharmacokinetic Study of PF-06700841 in Japanese Healthy Volunteers).

Kategori:
Enzyme InhibitorsProtein Kinase Inhibitors
Target Protein:
Non-receptor tyrosine-protein kinase TYK2Tyrosine-protein kinase JAK1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-06751979 DB15105
small molecule | CAS: 1818339-66-0

PF-06751979 is under investigation in clinical trial NCT03126721 (The Study is to Evaluate the Effect of Multiple Doses PF-06751979 on the Pharmacokinetics of Midazolam in Healthy Adults).

Kategori:
Sulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-06815345 DB14862
small molecule | CAS: 1900686-46-5

PF-06815345 is under investigation in clinical trial NCT02654899 (Single Dose Study of PF-06815345 in Healthy Subjects).

Waktu Paruh-
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PF-06821497 DB14799
small molecule | CAS: 1844849-10-0

PF-06821497 is under investigation in clinical trial NCT03460977 (PF-06821497 Treatment Of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma).

Target Protein:
Histone-lysine N-methyltransferase EZH2
Waktu Paruh-
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Genetik -
PF-06835919 DB19163
small molecule | CAS: 2102501-84-6

PF-06835919 is under investigation in clinical trial NCT05463575 (Ketohexokinase Inhibition in NAFLD).

Kategori:
Aza Compounds
Waktu Paruh-
Vol. Distribusi-
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Genetik -
PF-06842874 DB18039
small molecule | CAS: 2516247-98-4

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
PF-06882961 DB16043
small molecule | CAS: 2230198-02-2

PF-06882961 is under investigation in clinical trial NCT03985293 (A 16 Week Study to Evaluate the Efficacy and Safety of PF-06882961 in Adults With Type 2 Diabetes Mellitus).

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Glucagon-like peptide 1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-07038124 DB19143
small molecule | CAS: 2415085-44-6

PF-07038124 is under investigation in clinical trial NCT05298033 (Study of Efficacy, Safety and Tolerability of Crisaborole and PF-07038124 With and Without NBUVB in Vitiligo).

Waktu Paruh-
Vol. Distribusi-
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PF-07059013 DB18122
small molecule | CAS: 2435610-93-6

Deskripsi belum tersedia.

Target Protein:
Hemoglobin subunit beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-07304814 DB16514
small molecule

PF-07304814 is a small molecule prodrug that targets the 3CL<sup>pro</sup> protease (M<sup>pro)</sup>, which is used by viruses like SARS-CoV-2 to assemble and multiply[L31718]. Once administered through intravenous infusion, the compound is cleaved into PF-0…

Kategori:
Amino AcidsAmino Acids, Branched-ChainAmino Acids, Essential +4
Target Protein:
Replicase polyprotein 1ab
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-07799933 DB17489
small molecule

PF-07799933 is a BRAF class 2 inhibitor developed by Pfizer.

Waktu Paruh-
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Genetik -
PF-232798 DB14813
small molecule | CAS: 849753-15-7

PF-232798 is under investigation in clinical trial NCT01140425 (Study To Evaluate The Effect Of A Multiple Oral Dose Of PF-00232798 On QT Intervals In Healthy Subjects).

Kategori:
AlkaloidsAnti-HIV AgentsAnti-Infective Agents +5
Target Protein:
C-C chemokine receptor type 5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-4136309 DB17200
small molecule | CAS: 1341224-83-6

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-4191834 DB11645
small molecule | CAS: 1029317-21-2

PF-4191834 has been investigated for the basic science of Asthma.

Kategori:
AnionsElectrolytesHydrogen Sulfide +2
Target Protein:
Polyunsaturated fatty acid 5-lipoxygenase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
PF-477736 DB12611
small molecule | CAS: 952021-60-2

PF-00477736 has been used in trials studying the treatment of Neoplasms.

Kategori:
BenzazepinesEnzyme InhibitorsHeterocyclic Compounds, Fused-Ring +1
Target Protein:
Serine/threonine-protein kinase Chk1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
PF-5190457 DB14870
small molecule | CAS: 1334782-79-4

PF-5190457 is under investigation in clinical trial NCT01522807 (A Study Of Three PF-05190457 Formulations In Healthy Volunteers).

Kategori:
Azetines
Target Protein:
Growth hormone secretagogue receptor type 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-5212372 DB19212
small molecule | CAS: 916136-25-9

PF-5212372 is under investigation in clinical trial NCT02795832 (A Study to Determine the Safety & Efficacy of ZPL-5212372 in Healthy Subjects and in Subjects With Atopic Dermatitis).

Kategori:
Acids, CarbocyclicAmidesEnzyme Inhibitors +3
Waktu Paruh-
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Genetik -
PG-530742 DB05495
small molecule | CAS: 291533-11-4

PG-530742 selectively inhibits certain matrix metalloproteinases that have been implicated in the cartilage degradation that occurs in osteoarthritis. By inhibiting these MMPs, it potentially limits cartilage degradation and disease progression. Studies are c…

Kategori:
AminesHydroxy AcidsHydroxylamines
Target Protein:
Stromelysin-1Matrix metalloproteinase-9
Waktu Paruh-
Vol. Distribusi-
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Genetik -
PG-701 DB12252
small molecule | CAS: 583028-68-6

Hydroxytriptolide has been investigated for the treatment of Rheumatoid Arthritis.

Waktu Paruh-
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PGX-100 DB06114
small molecule

PGX-100 is an intravenous dosage form of modified heparin. It is developed for treatment of exacerbation of obstructive pulmonary disease (COPD) and for the prevention and treatment of cardiac ischemia reperfusion injury (following acute myocardial infarction…

Waktu Paruh-
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PH-284 DB05452
small molecule

PH-284 belongs to a new family of new chemical entities called vomeropherins. Vomeropherins are self-administered by the patient with a metered nasal spray, or nasal aerosol device so that they can bind to peripheral chemosensory receptors in the nasal passag…

Target Protein:
Vasopressin V1a receptorVasopressin V1b receptor
Waktu Paruh-
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Genetik -
PH-797804 DB07941
small molecule | CAS: 586379-66-0

PH-797804 has been investigated for the treatment of Osteoarthritis.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +3
Target Protein:
Mitogen-activated protein kinase 14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PHA-767491 DB17043
small molecule | CAS: 845714-00-3

PHA-767491 is a Cdc7/CDK9 inhibitor.[A253077]

Kategori:
Piperidines
Target Protein:
Cell division cycle 7-related protein kinase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
PHA-793887 DB12686
small molecule | CAS: 718630-59-2

PHA-793887 has been used in trials studying the treatment of Advanced/Metastatic Solid Tumors.

Kategori:
Cyclin-Dependent Kinases, antagonists & inhibitors
Target Protein:
Cyclin-dependent kinase 2Cyclin-dependent kinase 4Cyclin-dependent kinase 1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Phanquinone DB13469
small molecule | CAS: 84-12-8

Deskripsi belum tersedia.

Kategori:
Antiparasitic Products, Insecticides and RepellentsAntiprotozoalsHeterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
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Genetik -
PHE885 DB18123
biotech

PHE885 is an investigational, autologous B-cell Maturation Antigen (BCMA)-directed chimeric antigen receptor (CAR)-T cell therapy.

Waktu Paruh-
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Phelimin DB18332
small molecule

Phelemin (PHE-MIP) is a methacrylic acid-based copolymer purified to bind to L-phenylalanine and L-phenylalanine-containing peptides.[L48151] It is under investigation for the treatment of hyperphenylalaninemia.

Waktu Paruh-
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Genetik -
biotech

Phellinus linteus mycelium is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
BasidiomycotaBiological ProductsComplex Mixtures +4
Waktu Paruh-
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Genetik -
biotech

Phellodendron amurense bark is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
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Phenacemide Approved DB01121
small molecule | CAS: 63-98-9

Phenacemide is used to control certain seizures in the treatment of epilepsy. This medicine acts on the central nervous system (CNS) to reduce the number and severity of seizures.

Kategori:
AcetamidesAmidesAnticonvulsants +3
Target Protein:
Sodium channel protein type 1 subunit alpha
Waktu Paruh22-25 hours.
Vol. Distribusi-
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Genetik -
Phenacetin DB03783
small molecule | CAS: 62-44-2

Phenacetin was withdrawn from the Canadian market in June 1973 due to concerns regarding nephropathy (damage to or disease of the kidney).

Kategori:
AcetanilidesAmidesAmines +18
Target Protein:
Prostaglandin G/H synthase 1Inosine-5'-monophosphate dehydrogenase 1
Waktu Paruh-
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Genetik -
Phenaglycodol DB19373
small molecule | CAS: 79-93-6

Deskripsi belum tersedia.

Kategori:
AlcoholsGlycols
Waktu Paruh-
Vol. Distribusi-
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Genetik -
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