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16004

Total database: 17430
Struktur (SMILES)
12010 (75.0%)
Target
9041 (56.5%)
Genomik
112 (0.7%)
Referensi
16004 (100.0%)

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Hasil Pencarian (16004)

Halaman 244 / 321
Periciazine Approved DB01608
small molecule | CAS: 2622-26-6

Periciazine is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazin…

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +12
Target Protein:
D(1A) dopamine receptorAlpha-2A adrenergic receptorAlpha-1B adrenergic receptor +1
Waktu Paruh-
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Genetik -
Peridinin DB03001
small molecule | CAS: 33281-81-1

Deskripsi belum tersedia.

Kategori:
AlkenesBiological FactorsCyclohexanes +6
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Perifosine DB06641
small molecule | CAS: 157716-52-4

Perifosine is a novel alkylphospholipid with antiproliferative properties attributed to protein kinase B inhibition.

Kategori:
AminesOnium CompoundsQuaternary Ammonium Compounds +1
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformRAC-alpha serine/threonine-protein kinaseMitogen-activated protein kinase 1 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 18457-55-1

Perillyl alcohol is under investigation in clinical trial NCT02704858 (Safety and Efficacy Study in Recurrent Grade IV Glioma).

Kategori:
Antineoplastic AgentsEnzyme InhibitorsPerilla +1
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Perindopril Approved DB00790
small molecule | CAS: 82834-16-0

Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a po…

Kategori:
ACE Inhibitors and Calcium Channel BlockersACE Inhibitors and DiureticsAgents Acting on the Renin-Angiotensin System +18
Target Protein:
Angiotensin-converting enzymeSecreted frizzled-related protein 4
Waktu ParuhPerindopril, 1.2 ho…
Vol. Distribusi-
Klirens* 219 - 362 mL/min …
Genetik -
Perindoprilat DB14213
small molecule | CAS: 95153-31-4

The active metabolite of the prodrug [Perindopril].

Kategori:
Agents Acting on the Renin-Angiotensin SystemAgents causing angioedemaAgents causing hyperkalemia +6
Waktu Paruh-
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Periplaneta americana Approved DB10417
biotech

American cockroach allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Genetik -
Permethrin Approved DB04930
small molecule | CAS: 52645-53-1

A pyrethroid insecticide commonly used in the treatment of lice infestations and scabies. It is a yellow to light orange-brown, low melt-ing solid or viscous liquid.

Kategori:
AgrochemicalsAntiparasitic Products, Insecticides and RepellentsBenzene Derivatives +22
Target Protein:
Sodium channel protein type 1 subunit alphaEstrogen receptorNuclear receptor subfamily 1 group I member 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Perospirone DB08922
small molecule | CAS: 150915-41-6

Perospirone is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist. Dainippon Sumitomo Pharma devel…

Kategori:
Antipsychotic AgentsAntipsychotic Agents (Second Generation [Atypical])Central Nervous System Agents +13
Target Protein:
5-hydroxytryptamine receptor 2AD(2) dopamine receptor5-hydroxytryptamine receptor 1A +3
Gen Terkait:
HTR1A
Waktu ParuhThe elimination hal…
Vol. DistribusiThe mean volume of …
KlirensApparent clearance …
Genetik 1 Varian
Perphenazine Approved DB00850
small molecule | CAS: 58-39-9

An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine.

Kategori:
Antipsychotic AgentsAntipsychotic Agents (First Generation [Typical])Central Nervous System Agents +28
Target Protein:
D(2) dopamine receptorD(1A) dopamine receptorCalmodulin
Waktu Paruh8-12 hours, but ran…
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 17528-28-8

Deskripsi belum tersedia.

Kategori:
Antipsychotic AgentsCentral Nervous System DepressantsHeterocyclic Compounds, Fused-Ring +3
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Pertuzumab Approved DB06366
biotech | CAS: 380610-27-5

Pertuzumab is a recombinant humanized monoclonal antibody that targets the extracellular dimerization domain (subdomain II) of the human epidermal growth factor receptor 2 protein (HER2). It consists of two heavy chains and two lights chains that have 448 and…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +19
Target Protein:
Receptor tyrosine-protein kinase erbB-2
Waktu ParuhThe median half-lif…
Vol. DistribusiThe average steady-…
KlirensThe median clearanc…
Genetik -
Peruvoside DB13756
small molecule | CAS: 1182-87-2

Deskripsi belum tersedia.

Kategori:
CardanolidesCardiac GlycosidesCardiac Therapy +7
Waktu Paruh-
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Perzinfotel DB12365
small molecule | CAS: 144912-63-0

Perzinfotel has been used in trials studying the treatment of Diabetes Mellitus and Diabetic Neuropathy, Painful.

Kategori:
Aza CompoundsOrganophosphorus Compounds
Waktu Paruh-
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Petesicatib DB15297
small molecule | CAS: 1252637-35-6

Petesicatib is under investigation in clinical trial NCT02295332 (A Study of RG7625 in Healthy Volunteers).

Kategori:
Enzyme Inhibitors
Target Protein:
Cathepsin S
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Petosemtamab DB18948
biotech | CAS: 2213450-26-9

Petosemtamab is under investigation in clinical trial NCT03526835 (A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors).

Waktu Paruh-
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Petrelintide DB19442
biotech | CAS: 2766385-23-1

Petrelintide is under investigation in clinical trial NCT06662539 (Once-weekly Petrelintide Versus Placebo for Obesity or Overweight With Co-morbidities).

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Petrolatum Approved DB11058
small molecule | CAS: 8009-03-8

A colloidal system of semisolid hydrocarbons obtained from petroleum. It is used as an ointment base, topical protectant, and lubricant.

Kategori:
Basic Ointments and ProtectantsCompounds used in a research, industrial, or household settingDermatologicals +4
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PEV3A DB05144
biotech

PEV3A is a prophylactic malaria vaccine that acts against various stages of the disease. It is a two-component vaccine that contains the virosome formulated peptide mimetics PEV301 and PEV302. The two synthetic peptide vaccine components mimic the native stru…

Kategori:
Vaccines
Waktu Paruh-
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Pevonedistat DB11759
small molecule | CAS: 905579-51-3

Pevonedistat has been used in trials studying the treatment of Lymphoma, Solid Tumors, Multiple Myeloma, Hodgkin Lymphoma, and Metastatic Melanoma, among others.

Kategori:
CycloparaffinsEnzyme Inhibitors
Target Protein:
NEDD8-activating enzyme E1 catalytic subunitUbiquitin-like protein NEDD8NEDD8-activating enzyme E1 regulatory subunit
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pexacerfont DB12572
small molecule | CAS: 459856-18-9

Pexacerfont has been investigated for the treatment of Alcoholism, Anxiety Disorder, Alcohol Dependence, and Alcohol-Related Disorders.

Target Protein:
Corticotropin-releasing factor receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 1058624-46-6

Pexastimogene devacirepvec is under investigation in clinical trial NCT00429312 (A Study of Recombinant Vaccinia Virus to Treat Malignant Melanoma).

Waktu Paruh-
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Pexelizumab DB04949
biotech | CAS: 219685-93-5

Pexelizumab is a humanized monoclonal antibody used as an immunosuppressive drug. It is being investigated by Alexion Pharmaceuticals.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +12
Waktu Paruh7.0 hours to 14.5 h…
Vol. Distribusi-
Klirens-
Genetik -
Pexidartinib Approved DB12978
small molecule | CAS: 1029044-16-3

Pexidartinib is a selective tyrosine kinase inhibitor that works by inhibiting the colony-stimulating factor (CSF1)/CSF1 receptor pathway. Pexidartinib was originally developed by Daiichi Sankyo, Inc. and it was approved by the FDA in August 2019 as the first…

Kategori:
AminesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +34
Target Protein:
Macrophage colony-stimulating factor 1 receptorMast/stem cell growth factor receptor KitReceptor-type tyrosine-protein kinase FLT3 +1
Waktu ParuhThe elimination hal…
Vol. DistribusiThe apparent volume…
KlirensThe apparent cleara…
Genetik -
Pexiganan DB16293
biotech | CAS: 147664-63-9

Pexiganan is under investigation in clinical trial NCT01594762 (Pexiganan Versus Placebo Control for the Treatment of Mild Infections of Diabetic Foot Ulcers).

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Bacterial AgentsAnti-Infective Agents +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pexmetinib DB16294
small molecule | CAS: 945614-12-0

Pexmetinib is under investigation in clinical trial NCT04074967 (Study of ARRY-614 Plus Either Nivolumab or Ipilimumab).

Kategori:
AmidesHeterocyclic Compounds, Fused-RingPyrazoles
Target Protein:
Angiopoietin-1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-00217830 DB12998
small molecule | CAS: 846032-02-8

PF-00217830 has been used in trials studying the treatment of Schizophrenia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
D(2) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-00356231 DB03367
small molecule | CAS: 766536-21-4

Deskripsi belum tersedia.

Target Protein:
Macrophage metalloelastase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-00446687 DB12517
small molecule | CAS: 862281-92-3

PF-00446687 has been investigated for the treatment of Erectile Dysfunction.

Kategori:
Receptor, Melanocortin, Type 4, agonists
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-00489791 DB11736
small molecule | CAS: 853003-48-2

PF-00489791 has been used in trials studying the treatment of Hypertension, Raynaud's Disease, Diabetic Nephropathies, Hypertension, Pulmonary, and Peripheral Vascular Disease.

Kategori:
AmidesHeterocyclic Compounds, Fused-RingSulfones +1
Target Protein:
cGMP-specific 3',5'-cyclic phosphodiesterase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-00610355 DB11871
small molecule | CAS: 862541-45-5

PF-00610355 has been used in trials studying the treatment of Lung Disease, Moxifloxacin, Pulmonary Disease, Asthma, Bronchial, and Bronchial Diseases, among others.

Kategori:
AcetamidesAdrenergic AgonistsAdrenergic beta-2 Receptor Agonists +7
Target Protein:
Beta-2 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-03187207 DB05746
small molecule

PF-03187207 is a nitric oxide-donating prostaglandin F2-alpha analogs for the potential treatment of glaucoma. Based on the very promising preclinical results and on the well-known activities of nitric oxide, PF-03187207 is expected to have an increased capac…

Waktu Paruh-
Vol. Distribusi-
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Genetik -
PF-03382792 DB12949
small molecule | CAS: 1400811-63-3

Pf 03382792 is under investigation in clinical trial NCT01045863 (To Evaluate Safety, Tolerability, Plasma Drug Levels And Other Biological Effects In Healthy Volunteers).

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PF-03463275 DB11993
small molecule | CAS: 1173239-39-8

PF-03463275 has been used in trials studying the treatment of Schizophrenia and Cognitive Impairments Associated With Schizophrenia.

Kategori:
Aza CompoundsGlycine Plasma Membrane Transport Proteins, antagonists & inhibitors
Target Protein:
Sodium- and chloride-dependent glycine transporter 1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
PF-03635659 DB12408
small molecule | CAS: 931409-24-4

Pf03635659 has been used in trials studying the treatment of Chronic Obstructive Pulmonary Disease.

Kategori:
Acids, CarbocyclicAzetinesPhenylacetates +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-03654746 DB12201
small molecule | CAS: 935840-31-6

PF-03654746 has been investigated for the treatment of Narcolepsy, Schizophrenia, Tourette's Syndrome, and Excessive Daytime Sleepiness.

Kategori:
CycloparaffinsHistamine H3 Antagonists
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-03654764 DB12360
small molecule | CAS: 935840-35-0

PF-03654764 has been used in trials studying the basic science and treatment of Allergic Rhinitis.

Kategori:
CycloparaffinsHistamine H3 Antagonists
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-03715455 DB12138
small molecule | CAS: 1056164-52-3

PF-03715455 has been used in trials studying the treatment of Asthma, Pulmonary Disease, Chronic Obstructive, and Chronic Obstructive Pulmonary Disease (COPD).

Kategori:
AmidesAnionsAza Compounds +7
Waktu Paruh-
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Klirens-
Genetik -
PF-03758309 DB11775
small molecule | CAS: 898044-15-0

PF-03758309 has been used in trials studying the treatment of Advanced Solid Tumors.

Kategori:
p21-Activated Kinases, antagonists & inhibitors
Target Protein:
Serine/threonine-protein kinase PAK 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-03814735 DB13059
small molecule | CAS: 942487-16-3

PF-03814735 has been used in trials studying the treatment of Solid Tumors.

Kategori:
Heterocyclic Compounds, Fused-RingProtein Kinase Inhibitors
Target Protein:
Aurora kinase AAurora kinase B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-03882845 DB11814
small molecule | CAS: 1023650-66-9

PF-03882845 has been used in trials studying the basic science of Diabetes Mellitus, Type 2 and Type 2 Diabetic Nephropathy.

Kategori:
Benzene DerivativesHeterocyclic Compounds, Fused-RingHydrocarbons, Chlorinated +2
Target Protein:
Mineralocorticoid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-04217903 DB12848
small molecule | CAS: 956905-27-4

PF-04217903 has been used in trials studying the treatment of Neoplasms.

Target Protein:
Hepatocyte growth factor receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-04418948 DB12024
small molecule | CAS: 1078166-57-0

Pf 04418948 is under investigation in clinical trial NCT01002963 (A Study To Investigate The Safety And Toleration Of A Single Dose Of PF-04418948 In Healthy Volunteers).

Kategori:
AzetinesReceptors, Prostaglandin E, EP2 Subtype
Target Protein:
Prostaglandin E2 receptor EP2 subtype
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-04447943 DB11953
small molecule | CAS: 1082744-20-4

PF-04447943 has been investigated for the treatment of Alzheimer's Disease.

Kategori:
Phosphodiesterase InhibitorsPyrimidines
Target Protein:
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-04457845 DB12012
small molecule | CAS: 1020315-31-4

PF-04457845 is under investigation in Fear Conditioning. PF-04457845 has been investigated for the treatment of Tourette Syndrome and Cannabis Dependence.

Kategori:
Amides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Pf-04531083 DB12468
small molecule | CAS: 1079400-07-9

Pf-04531083 has been investigated for the treatment of Pain and Chronic Pain.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-04620110 DB14887
small molecule | CAS: 1109276-89-2

PF-04620110 is under investigation in clinical trial NCT01146327 (A Multiple Dose Study Of PF-04620110 In Healthy Overweight Or Obese Subjects).

Kategori:
AzepinesDiacylglycerol O-Acyltransferase
Target Protein:
Diacylglycerol O-acyltransferase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-04634817 DB14955
small molecule | CAS: 1228111-63-4

PF-04634817 is under investigation in clinical trial NCT01140672 (A Multiple Dose Study To Determine Safety, Tolerability, and Pharmacokinetics Of PF-04634817 In Healthy Adult Subjects).

Kategori:
Aza Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-04691502 DB11974
small molecule | CAS: 1013101-36-4

PF-04691502 has been used in trials studying the treatment of Cancer, Breast Neoplasms, Early Breast Cancer (Phase 2), and Advanced Breast Cancer (Phase 1b).

Kategori:
Phosphatidylinositol 3-Kinases, antagonists & inhibitorsPyridines
Target Protein:
Serine/threonine-protein kinase mTORPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-04856884 DB17550
biotech

PF-04856884 or CVX-060 is a selective angiopoietin (Ang)-2 inhibitor.[A257291] It is under investigation in clinical trial NCT01441414 (PF-04856884 (CVX-060) in Combination With Axitinib in Patients With Previously Treated Metastatic Renal Cell Carcinoma).

Waktu Paruh-
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Genetik -
Menampilkan 12151–12200 dari 16004
Sebelumnya Halaman 244 / 321 Berikutnya