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13591

Total database: 17430
Struktur (SMILES)
10177 (74.9%)
Target
7625 (56.1%)
Genomik
104 (0.8%)
Referensi
13591 (100.0%)

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Hasil Pencarian (13591)

Halaman 242 / 272
Sunflower oil DB14329
biotech | CAS: 8001-21-6

Sunflower oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
Biological ProductsComplex MixturesOils +2
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Sunitinib Approved DB01268
small molecule | CAS: 557795-19-4

Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stroma…

Kategori:
Angiogenesis InhibitorsAngiogenesis Modulating AgentsAntineoplastic Agents +31
Target Protein:
Platelet-derived growth factor receptor betaVascular endothelial growth factor receptor 1Mast/stem cell growth factor receptor Kit +6
Gen Terkait:
CYP3A4
Waktu ParuhFollowing administr…
Vol. Distribusi* 2230 L (apparent …
Klirens* 34 - 62 L/h [Tota…
Genetik 1 Varian
Sunobinop DB18955
small molecule | CAS: 1126793-40-5

Sunobinop is under investigation in clinical trial NCT04035200 (Safety, Tolerability and Efficacy Study of V117957 in Subjects With Insomnia Associated With Alcohol Cessation).

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Sunvozertinib DB18925
small molecule | CAS: 2370013-12-8

Sunvozertinib is under investigation in clinical trial NCT03974022 (Assessing an Oral EGFR Inhibitor, Sunvozertinib in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR or HER2 Mutation (WU-KONG1)).

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Supinoxin DB19010
small molecule | CAS: 888478-45-3

Supinoxin is under investigation in clinical trial NCT02003092 (RX-5902 Treatment of Subjects With Triple Negative Breast Cancer).

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Probable ATP-dependent RNA helicase DDX5
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Suplatast DB19138
small molecule | CAS: 94055-75-1

Suplatast is under investigation in clinical trial NCT05983471 (Efficacy and Safety of ME-015 (Suplatast Tosilate) in Cough Related to Idiopathic Pulmonary Fibrosis (COSMIC-IPF)).

Kategori:
Anti-Allergic AgentsArylsulfonic AcidsHistamine Agents +6
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Suprofen Approved DB00870
small molecule | CAS: 40828-46-4

An ibuprofen-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic. It is no longer approved for use in the United States.

Kategori:
Acids, CarbocyclicAgents causing hyperkalemiaAnalgesics +23
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2
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Suptavumab DB12759
biotech | CAS: 1629615-23-1

Suptavumab has been used in trials studying the treatment and basic science of Respiratory Syncytial Virus Infections.

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Suramin DB04786
small molecule | CAS: 145-63-1

A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p164…

Kategori:
Agents Against Leishmaniasis and TrypanosomiasisAnti-Infective AgentsAntinematodal Agents +12
Target Protein:
HeparanaseP2Y purinoceptor 2NAD-dependent protein deacylase sirtuin-5, mitochondrial +5
Waktu ParuhApproximately 36 to…
Vol. Distribusi-
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Suratadenoturev DB18672
biotech | CAS: 1268642-13-2

Suratadenoturev is a gene-modified oncolytic adenovirus expressing the telomerase reverse transcriptase gene.

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Surinabant DB13070
small molecule | CAS: 288104-79-0

Surinabant has been investigated for the treatment of Smoking Cessation.

Kategori:
Agents producing tachycardiaCannabinoid Receptor AntagonistsCannabinoids and similars +4
Target Protein:
Cannabinoid receptor 1
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Surotomycin DB12076
small molecule | CAS: 1233389-51-9

Surotomycin has been used in trials studying the treatment of Diarrhea and Clostridium Difficile Infection. It is a benzenebutanoic acid derivative patented by Cubist Pharmaceuticals, Inc. as antibacterial agents for the treatment of Gram-positive infections.…

Kategori:
Amino Acids, Peptides, and ProteinsLipidsPeptides
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Surufatinib DB15106
small molecule | CAS: 1308672-74-3

Surufatinib is under investigation in clinical trial NCT02588170 (Phase III Study of Surufatinib in Treating Advanced Extrapancreatic Neuroendocrine Tumors).

Kategori:
AmidesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +4
Target Protein:
Fibroblast growth factor receptor 1Vascular endothelial growth factor receptor 2Vascular endothelial growth factor receptor 3 +2
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SurVaxM DB17397
biotech | CAS: 2416847-76-0

Deskripsi belum tersedia.

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Surzebiclimab DB16669
biotech | CAS: 2342597-90-2

Surzebiclimab is under investigation in clinical trial NCT03744468 (Study of BGB-A425 in Combination With Tislelizumab in Advanced Solid Tumors).

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biotech

Sus scrofa placenta is an animal extract used in some OTC (over-the-counter) products. It is not an approved drug.

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biotech

Deskripsi belum tersedia.

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Susoctocog alfa Approved DB11606
biotech | CAS: 1339940-90-7

Intravenous susoctocog alfa is a recombinant, B-domain deleted, porcine sequence antihaemophilic factor VIII (FVIII) product that has recently been approved for the treatment of bleeding episodes in adults with acquired haemophilia A (AHA). AHA is a rare blee…

Kategori:
Blood and Blood Forming OrgansBlood Coagulation FactorsHemostatics
Target Protein:
von Willebrand factor
Waktu ParuhThe terminal half-l…
Vol. DistribusiFollowing intraveno…
KlirensFollowing intraveno…
Genetik -
Sutetinib DB18841
small molecule | CAS: 1259519-20-4

Sutetinib is under investigation in clinical trial NCT05168566 (Study to Evaluate Sutetinib Maleate Capsule in Locally Advanced or Metastatic Non-small Cell Lung Cancer).

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Sutezolid DB11905
small molecule | CAS: 168828-58-8

Sutezolid has been used in trials studying the treatment of Tuberculosis.

Kategori:
AcetatesAcids, AcyclicAmides +2
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Sutilain Approved DB09379
biotech | CAS: 12211-28-8

Sutilain is a member of the keratase family which includes agents such as papain. It is able to dissolve the intercellular matrix which helps with desquamation. Sutilain contains proteolytic enzymes derived from _Bacillus subtilis_ and it is available as a cr…

Kategori:
EndopeptidasesEnzymesEnzymes and Coenzymes +4
Waktu ParuhThis pharmacokineti…
Vol. DistribusiThis pharmacokineti…
KlirensThis pharmacokineti…
Genetik -
Sutimlimab Approved DB14996
biotech | CAS: 2049079-64-1

Cold agglutinin disease (CAD) is a type of autoimmune hemolytic anemia (AIHA) in which autoantibodies directed against red blood cell surface antigens cause hemolysis at low (3-4°C) temperatures.[A245154,L40114] This cold subtype accounts for approximately 15…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +11
Target Protein:
Complement C1s subcomponent
Waktu ParuhAt the approved rec…
Vol. DistribusiAt steady-state, th…
KlirensAt the approved rec…
Genetik -
Suvecaltamide DB19139
small molecule | CAS: 953778-58-0

Suvecaltamide is under investigation in clinical trial NCT05122650 (A Study to Assess the Safety and Efficacy of JZP385 in the Treatment of Adults With Moderate to Severe Essential Tremor (ET)).

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SUVN-G3031 DB14835
small molecule | CAS: 1394808-82-2

SUVN-G3031 is under investigation in clinical trial NCT02342041 (A Study to Investigate the Safety, Tolerability and Pharmacokinetics of SUVN-G3031 in Healthy Subjects).

Kategori:
Oxazines
Target Protein:
Histamine H3 receptor
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Suvorexant Approved DB09034
small molecule | CAS: 1030377-33-3

Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia.

Kategori:
Central Nervous System AgentsCentral Nervous System DepressantsCytochrome P-450 CYP3A Inhibitors +13
Target Protein:
Orexin/Hypocretin receptor type 1Orexin receptor type 2
Waktu ParuhMean half life is a…
Vol. DistribusiMean volume of dist…
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Suvratoxumab DB15172
biotech | CAS: 1629620-18-3

Suvratoxumab is under investigation in clinical trial NCT02296320 (Study of the Efficacy and Safety of MEDI4893).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
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Suxibuzone DB13232
small molecule | CAS: 27470-51-5

Deskripsi belum tersedia.

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAnalgesics +13
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Suzetrigine DB18927
small molecule | CAS: 2649467-58-1

Suzetrigine is under investigation in clinical trial NCT05558410 (Evaluation of Efficacy and Safety of VX-548 for Acute Pain After an Abdominoplasty).

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Sweet cherry Approved DB10853
biotech

Sweet cherry allergenic extract is used in allergenic testing.

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SX-682 DB19210
small molecule | CAS: 1648843-04-2

SX-682 is under investigation in clinical trial NCT04574583 (Phase I/II Trial Investigating the Safety, Tolerability, Pharmacokinetics, Immune and Clinical Activity of SX-682 in Combination With Bintrafusp Alfa (M7824 or Tgf-beta "Trap"/pd-l1) With CV301 TRIC…

Target Protein:
C-X-C chemokine receptor type 2C-X-C chemokine receptor type 1
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SXR-1096 DB18119
small molecule | CAS: 1087624-28-9

Deskripsi belum tersedia.

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SY-5609 DB17099
small molecule | CAS: 2417302-07-7

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
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SYD-003 DB17106
small molecule | CAS: 249937-52-8

Deskripsi belum tersedia.

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small molecule | CAS: 30344-00-4

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, BasicAmino Acids, Diamino +1
Target Protein:
Haloalkane dehalogenase
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SYNB1020 DB17667
biotech

SYNB1020 is an engineered strain of _Escherichia coli_ Nissle 1917 developed by Synlogic Inc. It was initially designed to convert ammonia to L-arginine [A258838] and granted orphan designation by the FDA for the treatment of urea cycle disorders in August 20…

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SYNB1353 DB17666
biotech

SYNB1353 is a strain of the probiotic bacteria _Escherichia coli_ (_E. coli_) type Nissle and an engineered probiotic drug.[A258833] Developed by Synlogic Operating Company, Inc., SYNB1353 is being investigated for the treatment of homocystinuria. It is desig…

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SYNB1891 DB17541
biotech

SYNB1891 is a live, modified strain of the probiotic _Escherichia coli_ Nissle engineered to produce cyclic di-AMP (CDA), a stimulator of the STING (STimulator of INterferon Genes) pathway.[A256733] SYNB1891 is under investigation in clinical trial NCT0416713…

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Synephrine DB09203
small molecule | CAS: 94-07-5

Synephrine, also referred to as, p-synephrine, is naturally occurring alkaloid. It is present in approved drug products as neo-synephrine, its m-substituted analog. p-synephrine and m-synephrine are known for their longer acting adrenergic effects compared to…

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-Agonists +23
Target Protein:
Alpha-1 adrenergic receptors
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SynKIR-110 DB17365
biotech

SynKIR-110 are autologous T cells genetically engineered to express an anti-mesothelin killer immunoglobulin-like receptor-chimeric antigen receptor (KIR-CAR).

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SynOV1.1 DB17539
biotech

SynOV1.1 is an investigational cancer immunotherapy developed by SyngenTech. It is a recombinant oncolytic adenovirus, controlled by synthetic gene circuit, encoding the human immunostimulating factor cytokine granulocyte-macrophage colony-stimulating factor …

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small molecule

Synthetic conjugated estrogens A are composed of a blend of the following nine synthetic estrogenic substances: estrone sulfate, sodium equilin sulfate, sodium 17?-dihydroequilin sulfate, sodium 17?-estradiol sulfate, sodium 17?­ dihydroequilin sulfate, sodiu…

Kategori:
Cytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 SubstratesCytochrome P-450 Substrates +7
Target Protein:
Estrogen receptor
Waktu ParuhThe half life of ba…
Vol. DistribusiThe distribution of…
Klirens-
Genetik -
small molecule | CAS: 746658-13-9

Synthetic conjugated estrogens, B tablets contain a blend of ten synthetic estrogenic substances. The estrogenic substances are: sodium estrone sulfate, sodium equilin sulfate, sodium 17?-dihydroequilin sulfate, sodium 17?-estradiol sulfate, sodium 17?­ dihyd…

Kategori:
Cytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 SubstratesCytochrome P-450 Substrates +7
Target Protein:
Estrogen receptor
Waktu ParuhThe half life of ba…
Vol. DistribusiThe distribution of…
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Syrosingopine Approved DB19379
small molecule | CAS: 84-36-6

Deskripsi belum tersedia.

Kategori:
AlkaloidsAntihypertensive AgentsHeterocyclic Compounds, Fused-Ring +5
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T-5224 DB05998
small molecule | CAS: 530141-72-1

T-5224 is an investigational drug developed to treat Sepsis-induced Acute Kidney Injury. It's mechanism of action is to inhibit c-Fos/activator protein-1.

Kategori:
Benzene DerivativesKetones
Target Protein:
Transcription factor Jun
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T-62 DB12919
small molecule | CAS: 40312-34-3

T-62 has been used in trials studying the treatment of Postherpetic Neuralgia.

Target Protein:
Adenosine receptor A2a
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T-900607 DB12068
small molecule | CAS: 261944-52-9

T900607 has been used in trials studying the treatment of Liver Cancer and Gastric Cancer.

Kategori:
AmidesSulfonesSulfur Compounds
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small molecule | CAS: 1948-33-0

Deskripsi belum tersedia.

Kategori:
AntioxidantsBenzene DerivativesBiological Factors +5
Target Protein:
HemagglutininHemagglutinin
Waktu Paruh-
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T-Guard DB18357
biotech

Deskripsi belum tersedia.

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T487 DB05474
small molecule

T487 is a small molecule chemokine receptor antagonist to correct or modify immune system responses. It binds selectively and potently to CXCR3. The formulation is administered orally and has anti-inflammatory effects in conditions such as rheumatoid arthriti…

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T611 DB06391
small molecule | CAS: 350595-61-8

T611 is an investigational oral anti-cytomegalovirus (CMV) drug candidate.

Target Protein:
Transmembrane anterior posterior transformation protein 1 homolog
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